Jim Z Wu

发表

Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure.

Gary Larson, Shunqi Yan, J. Wu, 2007, Bioorganic & medicinal chemistry letters.

Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: convergence of structure-based drug design and X-ray crystallographic study.

Gary Larson, Shunqi Yan, Jim Z Wu, 2007, Bioorganic & medicinal chemistry letters.

Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors.

Gary Larson, Shunqi Yan, J. Wu, 2006, Bioorganic & medicinal chemistry letters.

Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors.

Shunqi Yan, C. Varaprasad, D. Barawkar, 2006, Bioorganic & medicinal chemistry letters.

Comparison of antiviral resistance across acute and chronic viral infections

J. Wu, S. Toovey, J. Devincenzo, 2018, Antiviral research.

Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase.

I. W. Cheney, Shunqi Yan, J. Wu, 2007, Bioorganic & medicinal chemistry letters.

Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors.

C. Varaprasad, D. Barawkar, Hassan El Abdellaoui, 2006, Bioorganic & medicinal chemistry letters.

Identification and Characterization of Multiple TRIM Proteins That Inhibit Hepatitis B Virus Transcription

Shijian Zhang, J. Wu, Jim Z Wu, 2013, PloS one.

Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.

J. Wong, J. Wu, N. Zhang, 2014, Journal of medicinal chemistry.

Chapter Seventeen – Novel Therapeutics in Discovery and Development for Treatment of Chronic HBV Infection

J. Wu, A. Mayweg, Guozhi Tang, 2013 .

Canonical 3'-deoxyribonucleotides as a chain terminator for HCV NS5B RNA-dependent RNA polymerase.

J. Wu, J. Shim, Jim Z Wu, 2003, Antiviral research.

Selection of 3′-Template Bases and Initiating Nucleotides by Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase

Z. Hong, G. Larson, J. Shim, 2002, Journal of Virology.

Polo-like Kinase Inhibitor Ro5203280 Has Potent Antitumor Activity in Nasopharyngeal Carcinoma

J. Wu, A. Cheung, H. Lung, 2013, Molecular Cancer Therapeutics.

Small Molecule Therapeutics Polo-like Kinase Inhibitor Ro 5203280 Has Potent Antitumor Activity in Nasopharyngeal Carcinoma

J. Wu, A. Cheung, H. Lung, 2013 .

Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors.

J. Wu, Min Jiang, Zheng Zhou, 2016, Journal of medicinal chemistry.

Potential drug interventions for diabetic retinopathy.

J. Wong, J. Wu, Jim Z Wu, 2013, Drug discovery today.

Virus infection facilitates the development of severe pneumonia in transplant patients with hematologic malignancies

Zhijie Kang, Quentin Liu, J. Wu, 2016, Oncotarget.

Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors.

J. Wu, J. Young, Zheng Zhou, 2017, Journal of medicinal chemistry.

Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine, and valproate in the mouse maximal electroshock-induced seizure model

J. Wu, G. Raszewski, J. Luszczki, 2009, Naunyn-Schmiedeberg's Archives of Pharmacology.

Parallel synthesis of pteridine derivatives as potent inhibitors for hepatitis C virus NS5B RNA-dependent RNA polymerase.

J. Wu, W. Zhong, G. Larson, 2005, Bioorganic & medicinal chemistry letters.

Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase.

I. W. Cheney, Shunqi Yan, R. Hamatake, 2007, Bioorganic & medicinal chemistry letters.

Activation and Deactivation of a Broad-Spectrum Antiviral Drug by a Single Enzyme: Adenosine Deaminase Catalyzes Two Consecutive Deamination Reactions

J. Wu, Z. Hong, Jim Z Wu, 2003, Antimicrobial Agents and Chemotherapy.

Discovery of Ziresovir as a Potent, Selective and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor.

J. Wu, Bo Zhang, Lisha Wang, 2019, Journal of medicinal chemistry.

Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors.

J. Wu, Lisha Wang, Li Chen, 2018, Journal of medicinal chemistry.

Targeting NS5B RNA-dependent RNA polymerase for anti-HCV chemotherapy.

J. Wu, Z. Hong, Jim Z Wu, 2003, Current drug targets. Infectious disorders.

Characterization of Nucleosome Positioning in Hepadnaviral Covalently Closed Circular DNA Minichromosomes

J. Wu, Wen-gang Yang, Shuiming Qian, 2012, Journal of Virology.

Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2

J. Wu, Z. Hong, D. Delia, 2007, Molecular Cancer Therapeutics.

Phosphorylation of Ribavirin and Viramidine by Adenosine Kinase and Cytosolic 5′-Nucleotidase II: Implications for Ribavirin Metabolism in Erythrocytes

J. Wu, Z. Hong, G. Larson, 2005, Antimicrobial Agents and Chemotherapy.

Crystal Structure of Complete Rhinovirus RNA Polymerase Suggests Front Loading of Protein Primer

I. W. Cheney, J. Wu, Z. Hong, 2005, Journal of Virology.

The molecular basis of ABA-independent inhibition of PP2Cs by a subclass of PYL proteins.

S. F. Yan, Chuangye Yan, N. Yan, 2011, Molecular cell.

Viability of Poliovirus/Rhinovirus VPg Chimeric Viruses and Identification of an Amino Acid Residue in the VPg Gene Critical for Viral RNA Replication

I. W. Cheney, J. Wu, Z. Hong, 2003, Journal of Virology.

Functional Properties of a Monoclonal Antibody Inhibiting the Hepatitis C Virus RNA-dependent RNA Polymerase*

T. Hügle, R. Bartenschlager, J. Wu, 2002, The Journal of Biological Chemistry.

Replicon Cell Culture System as a Valuable Tool in Antiviral Drug Discovery against Hepatitis C Virus

J. Wu, Z. Hong, W. Zhong, 2005, Antiviral chemistry & chemotherapy.

Characterization of Nucleosome Positioning in Hepadnaviral Covalently Closed Circular DNA Minichromosomes

Wen-gang Yang, Shuiming Qian, Jim Z Wu, 2012, Journal of Virology.

Dual-Action Mechanism of Viramidine Functioning as a Prodrug and as a Catabolic Inhibitor for Ribavirin

J. Wu, Z. Hong, G. Larson, 2004, Antimicrobial Agents and Chemotherapy.

Design and synthesis of benzenesulfonamide derivatives as potent anti-influenza hemagglutinin inhibitors.

J. Wu, Lisha Wang, Wen-gang Yang, 2011, ACS medicinal chemistry letters.

Syntheses and antitumor activities of N'1,N'3-dialkyl-N'1,N'3-di-(alkylcarbonothioyl) malonohydrazide: the discovery of elesclomol.

Lijun Sun, Jim Z Wu, Shoujun Chen, 2013, Bioorganic & Medicinal Chemistry Letters.

Inhibition of Influenza A Virus (H1N1) Fusion by Benzenesulfonamide Derivatives Targeting Viral Hemagglutinin

J. Wu, Wen-gang Yang, Guozhi Tang, 2011, PloS one.

Conversion of Viramidine to Ribavirin in Vivo by Adenosine Deaminase and its Inhibition by 2′-Deoxycoformycin

J. Wu, Z. Hong, Jim Z Wu, 2006, Antiviral chemistry & chemotherapy.

Ribavirin, viramidine and adenosine-deaminase-catalysed drug activation: implication for nucleoside prodrug design

J. Wu, Z. Hong, Jim Z Wu, 2003, The Journal of antimicrobial chemotherapy.

Safety and efficacy of AK0529 in respiratory syncytial virus‐infected infant patients: A phase 2 proof‐of‐concept trial

Yhu-Chering Huang, S. Toovey, C. Chieng, 2023, Influenza and other respiratory viruses.