D. Yule

发表

On the dynamical structure of calcium oscillations

Michael J. Sanderson, Vivien Kirk, James Sneyd, 2017, Proceedings of the National Academy of Sciences.

A kinetic model of the inositol trisphosphate receptor based on single-channel data.

Martin Falcke, James Sneyd, Larry E Wagner, 2009, Biophysical journal.

A Role for Phosphorylation of Inositol 1,4,5-Trisphosphate Receptors in Defining Calcium Signals Induced by Peptide Agonists in Pancreatic Acinar Cells*

S. V. Straub, D. Yule, D. Giovannucci, 2002, The Journal of Biological Chemistry.

All three IP3 receptor isoforms generate Ca2+ puffs that display similar characteristics

I. Parker, D. Yule, J. T. Lock, 2018, Science Signaling.

Phospholipase Cε Hydrolyzes Perinuclear Phosphatidylinositol 4-Phosphate to Regulate Cardiac Hypertrophy

B. Blaxall, A. Smrcka, D. Yule, 2013, Cell.

Modulation of [Ca2+]i Signaling Dynamics and Metabolism by Perinuclear Mitochondria in Mouse Parotid Acinar Cells*

D. Yule, T. Shuttleworth, D. Giovannucci, 2004, Journal of Biological Chemistry.

IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer

K. Mikoshiba, G. Hajnóczky, G. Csordás, 2019, Nature Communications.

U73122 inhibits Ca2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells.

J. Williams, D. Yule, J. Williams, 1992, The Journal of biological chemistry.

Impaired TNF-alpha control of IP3R-mediated Ca2+ release in Alzheimer's disease mouse neurons.

W. Bowers, D. Yule, Keigan M. Park, 2010, Cellular signalling.

Tumor Necrosis Factor-α-mediated Regulation of the Inositol 1,4,5-Trisphosphate Receptor Promoter*

W. Bowers, D. Yule, Keigan M. Park, 2009, The Journal of Biological Chemistry.

Receptor-activated cytoplasmic Ca2+ oscillations in pancreatic acinar cells: generation and spreading of Ca2+ signals.

C. Petersen, O. Petersen, M. Wakui, 1991, Cell calcium.

Ca2+ release dynamics in parotid and pancreatic exocrine acinar cells evoked by spatially limited flash photolysis.

T. Foster, D. Yule, W. J. Cottrell, 2007, American journal of physiology. Gastrointestinal and liver physiology.

Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells

G. Hajnóczky, Mehboob Ali, D. Yule, 2018, The Journal of Biological Chemistry.

Pancreatic acinar cells: molecular insight from studies of signal-transduction using transgenic animals.

D. Yule, 2010, The international journal of biochemistry & cell biology.

Effects of alanine on insulin-secreting cells: patch-clamp and single cell intracellular Ca2+ measurements.

O. Petersen, O. Petersen, D. Yule, 1990, Biochimica et biophysica acta.

Ultrastructure and cell-cell coupling of cardiac myocytes differentiating in embryonic stem cell cultures.

L. Samuelson, J. Metzger, D. Yule, 1997, Cell motility and the cytoskeleton.

A KRAP(y) job: Defining the localization of active IP3R.

D. Yule, Vikas Arige, 2021, Cell calcium.

Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1.

O. Benzakour, J. Griffin, B. Zlokovic, 2003, Blood.

The native ORAI channel trio underlies the diversity of Ca2+ signaling events

V. Walter, J. Sneyd, N. Hempel, 2020, Nature Communications.

Modeling calcium waves in an anatomically accurate three-dimensional parotid acinar cell.

J. Sneyd, S. Means, D. Yule, 2017, Journal of theoretical biology.

Multiscale modelling of saliva secretion.

E. Crampin, J. Sneyd, D. Yule, 2014, Mathematical biosciences.

Targeted Phosphorylation of Inositol 1,4,5-Trisphosphate Receptors Selectively Inhibits Localized Ca2+ Release and Shapes Oscillatory Ca2+ Signals*

J. Sneyd, D. Yule, D. Giovannucci, 2000, The Journal of Biological Chemistry.

Oscillations of cytosolic calcium in single pancreatic acinar cells stimulated by acetylcholine

D. Yule, D. Gallacher, 1988, FEBS letters.

Agonist‐Specific Calcium Signaling and Phosphoinositide Hydrolysis in Human SK‐N‐MCIXC Neuroepithelioma Cells

John A. Williams, R. K. Palmer, E. McEwen, 1994, Journal of neurochemistry.

Evidence That Calcium Entry Into Calcium-Transporting Dental Enamel Cells Is Regulated by Cholecystokinin, Acetylcholine and ATP

R. Lacruz, J. Saint-Jeannet, D. Yule, 2018, Front. Physiol..

Extracellular ATP mediates Ca2+ signaling in cultured myenteric neurons via a PLC-dependent mechanism.

M. Mulholland, D. Yule, B. Kimball, 1996, The American journal of physiology.

Sex-Specific Platelet Activation Through Protease-Activated Receptors Reverses in Myocardial Infarction

R. Bhandari, D. Rich, I. Goldenberg, 2020, Arteriosclerosis, thrombosis, and vascular biology.

Structural dynamics underlying gating and regulation in IP3R channel

M. Baker, M. R. Baker, S. Ludtke, 2022, bioRxiv.

BASIC AND TRANSLATIONAL—PANCREAS Irbit Mediates Synergy Between Ca 2D and cAMP Signaling Pathways During Epithelial Transport in Mice

K. Mikoshiba, T. Abe, H. Kiyonari, 2013 .

Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice.

K. Mikoshiba, T. Abe, H. Kiyonari, 2013, Gastroenterology.

Control of calcium oscillations by membrane fluxes.

J L Thompson, K. Tsaneva-Atanasova, J. Sneyd, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Resveratrol-induced autophagy is dependent on IP3Rs and on cytosolic Ca2.

J. Parys, G. Bultynck, Liwei Wang, 2017, Biochimica et biophysica acta. Molecular cell research.

Na+/Ca2+ exchangers regulate the migration and proliferation of human gastric myofibroblasts.

P. Hegyi, Z. Rakonczay, T. Wittmann, 2013, American journal of physiology. Gastrointestinal and liver physiology.

Trafficking in NCAM Knockout Mice Adrenal Chromaffin Cells Exhibit Impaired Granule

L. Landmesser, Ksenia V. Kastanenka, L. Polo-Parada, 2015 .

Sphingosine metabolism induces Ca2+ oscillations in rat pancreatic acinar cells.

T. Essington, J. Shayman, D. Yule, 1993, The Journal of biological chemistry.

Tyrosine kinase inhibitors attenuate "capacitative" Ca2+ influx in rat pancreatic acinar cells.

D. Yule, E. Kim, J. Williams, 1994, Biochemical and biophysical research communications.

Ca2+ signaling through secretagogue and growth factor receptors on pancreatic AR42J cells

C. Logsdon, John A. Williams, D. Simeone, 1995, Regulatory Peptides.

Subtype-Specific Regulation of Inositol 1,4,5-Trisphosphate Receptors

D. Yule, 2001, The Journal of general physiology.

Spatiotemporal analysis of exocytosis in mouse parotid acinar cells.

D. Yule, D. Giovannucci, Ying Chen, 2005, American journal of physiology. Cell physiology.

Heterotrimeric G-protein Gq/11 Localized on Pancreatic Zymogen Granules Is Involved in Calcium-regulated Amylase Secretion*

John A. Williams, S. A. Ernst, H. Ohnishi, 1997, The Journal of Biological Chemistry.

Inositol 1,4,5-trisphosphate Receptor Mutations associated with Human Disease.

D. Yule, K. Alzayady, L. Terry, 2018, Messenger.

A Model of Ca 2+ Dynamics in an Accurate Reconstruction of Parotid Acinar Cells

V. Kirk, J. Sneyd, D. Yule, 2019 .

Acetylcholine Inhibits Platelet Activation

C. Lowenstein, S. Cameron, C. Morrell, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Acetylcholine inhibits platelet activation and regulates hemostasis

C. Lowenstein, S. Cameron, C. Morrell, 2018, bioRxiv.

Calcium techniques : a laboratory manual

M. Bootman, J. Parys, G. Bultynck, 2014 .

Structural dynamics underlying gating and regulation in IP3R channel

M. Baker, M. R. Baker, S. Ludtke, 2022, bioRxiv.

Apical Ca2+-activated potassium channels in mouse parotid acinar cells

T. Begenisich, J. Almássy, D. Yule, 2012, The Journal of general physiology.

Apical Ca-activated potassium channels in mouse parotid acinar cells

T. Begenisich, J. Almássy, D. Yule, 2012 .

physiological function of parotid acinar cells is the production of saliva , a watery fluid containing electrolytes and a complex mixture of proteins (

T. Begenisich, J. Almássy, D. Yule, 2012 .

Critical role for NHE1 in intracellular pH regulation in pancreatic acinar cells.

J. E. Melvin, D. Brown, D. Yule, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Critical role for NHE 1 in intracellular pH regulation in pancreatic acinar cells

J. E. Melvin, D. Brown, D. Yule, 2003 .

Agonist activation of arachidonate‐regulated Ca2+‐selective (ARC) channels in murine parotid and pancreatic acinar cells

O. Mignen, D. Yule, T. Shuttleworth, 2005, The Journal of physiology.

Pivotal role of type-1 inositol 1,4,5-trisphosphate receptor for glucagon-induced gluconeogenesis.

D. Yule, Vikas Arige, 2020, Cell calcium.

New saliva secretion model based on the expression of Na+-K+ pump and K+ channels in the apical membrane of parotid acinar cells

J. Sneyd, P. Nanasi, J. Almássy, 2018, Pflügers Archiv - European Journal of Physiology.

Endothelin increases [Ca2+]i in rat pancreatic acinar cells by intracellular release but fails to increase amylase secretion.

D. Yule, J. Williams, G. T. Blevins, 1992, Biochimica et biophysica acta.

Bok regulates mitochondrial fusion and morphology

R. Wojcikiewicz, Jacqualyn J Schulman, D. Yule, 2019, Cell Death & Differentiation.

Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms

Doran S. Mix, John M. Ashton, C. Lowenstein, 2022, The Journal of clinical investigation.

IP3R deficit underlies loss of salivary fluid secretion in Sjögren’s Syndrome

W. Swaim, I. Ambudkar, S. Jang, 2015, Scientific Reports.

Regulation of Ca²⁺ release through inositol 1,4,5-trisphosphate receptors by adenine nucleotides in parotid acinar cells.

M. Betzenhauser, D. Yule, H. Park, 2012, American journal of physiology. Gastrointestinal and liver physiology.

Regulation of Ca 2 release through inositol 1 , 4 , 5-trisphosphate receptors by adenine nucleotides in parotid acinar cells

M. Betzenhauser, D. Yule, H. Park, 2011 .

The Type 2 Inositol (1,4,5)-Trisphosphate (InsP3) Receptor Determines the Sensitivity of InsP3-induced Ca2+ Release to ATP in Pancreatic Acinar Cells*

Ju Chen, M. Betzenhauser, D. Yule, 2008, Journal of Biological Chemistry.

Mastoparan induces oscillations of cytosolic Ca2+ in rat pancreatic acinar cells.

D. Yule, J. Williams, J. Williams, 1991, Biochemical and biophysical research communications.

Functional Communication between IP3R and STIM2 at sub-threshold stimuli is a critical checkpoint for initiation of SOCE

I. Ambudkar, M. Trebak, D. Yule, 2021, bioRxiv.

Isoform- and Species-specific Control of Inositol 1,4,5-Trisphosphate (IP3) Receptors by Reactive Oxygen Species*

M. Madesh, G. Hajnóczky, G. Csordás, 2014, The Journal of Biological Chemistry.

Isoform- and Species-specific Control of Inositol 1,4,5-Trisphosphate (IP 3 ) Receptors by Reactive

M. Madesh, K. Sharma, Satish P RamachandraRao, 2014 .

Disrupted Ca2+ homeostasis and immunodeficiency in patients with functional IP3 receptor subtype 3 defects

Susan M. Schlenner, M. R. Baker, A. Liston, 2022, Cellular & Molecular Immunology.

Missense mutations in inositol 1,4,5-trisphosphate receptor type 3 result in leaky Ca2+ channels and activation of store-operated Ca2+ entry

A. Liston, D. Yule, S. Malik, 2022, iScience.

Region-specific proteolysis differentially modulates type 2 and type 3 inositol 1,4,5-trisphosphate receptor activity in models of acute pancreatitis

Liwei Wang, D. Yule, L. Wagner, 2018, The Journal of Biological Chemistry.

ATP Modulation of Ca2+ Release by Type-2 and Type-3 Inositol (1, 4, 5)-Triphosphate Receptors

K. Mikoshiba, T. Michikawa, M. Betzenhauser, 2008, Journal of Biological Chemistry.

Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output

K. Mikoshiba, L. Martens, J. Parys, 2019, Cellular and Molecular Life Sciences.

Bcl-2-Protein Family as Modulators of IP 3 Receptors and Other Organellar Ca 2+ Channels

M. R. Baker, J. Parys, I. Serysheva, 2020 .

Calcium Oscillations and Membrane Transport: The Importance of Two Time Scales

John L. Thompson, James Sneyd, David I. Yule, 2005, Multiscale Model. Simul..

The BRCA1 Tumor Suppressor Binds to Inositol 1,4,5-Trisphosphate Receptors to Stimulate Apoptotic Calcium Release*

G. Hankins, D. V. van Rossum, S. Chintapalli, 2015, The Journal of Biological Chemistry.

The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation

J. Sneyd, G. Dupont, N. Hempel, 2021, The Journal of biological chemistry.

Regulation of Interorganellar Ca2+ Transfer and NFAT Activation by the Mitochondrial Ca2+ Uniporter

J. Sneyd, G. Dupont, N. Hempel, 2021, bioRxiv.

Conformational motions and ligand-binding underlying gating and regulation in IP3R channel

M. Baker, M. R. Baker, S. Ludtke, 2022, Nature Communications.

A Mathematical Model of Salivary Gland Duct Cells

J. Sneyd, V. Suresh, D. Yule, 2022, Bulletin of Mathematical Biology.

Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis

Nikolaos N. Louros, K. Mikoshiba, D. Andrews, 2021, Cell Death & Differentiation.

Fluoride exposure alters Ca2+ signaling and mitochondrial function in enamel cells

Y. Idaghdour, Veronica Costiniti, R. Lacruz, 2020, Science Signaling.

Simulation of Calcium Dynamics in Realistic Three-Dimensional Domains

J. Sneyd, V. Suresh, D. Yule, 2022, Biomolecules.

Calcium Dynamics and Water Transport in Salivary Acinar Cells

J. Sneyd, D. Yule, J. Rugis, 2021, Bulletin of Mathematical Biology.

Mutation of carboxyl-terminal threonine residues in human m3 muscarinic acetylcholine receptor modulates the extent of sequestration and desensitization.

C. Logsdon, D. Yule, J. Yang, 1995, Molecular pharmacology.

Spatial and temporal crosstalk between the cAMP and Ca2+ signaling systems.

D. Yule, Vikas Arige, 2022, Biochimica et biophysica acta. Molecular cell research.

CCK antagonists reveal that CCK-8 and JMV-180 interact with different sites on the rat pancreatic acinar cell CCKA receptor

John A. Williams, D. Yule, 1994, Peptides.

Calcium wave propagation in pancreatic acinar cells: functional interaction of inositol 1,4,5-trisphosphate receptors, ryanodine receptors, and mitochondria.

S. V. Straub, D. Yule, D. Giovannucci, 2000 .

cAMP Potentiates ATP-evoked Calcium Signaling in Human Parotid Acinar Cells*

D. Brown, S. V. Straub, D. Yule, 2004, Journal of Biological Chemistry.

Paracrine mediation of calcium signaling in human SK-N-MCIXC neuroepithelioma cells.

R. K. Palmer, D. Yule, D. Shewach, 1996, The American journal of physiology.

Calcium and mitochondria

K. Gunter, T. Gunter, D. Yule, 2004, FEBS letters.

Calcium oscillations in a triplet of pancreatic acinar cells.

K. Tsaneva-Atanasova, J. Sneyd, D. Yule, 2005, Biophysical journal.

Measurement of intracellular calcium concentration in pancreatic acini

M. Betzenhauser, D. Yule, J. Won, 2011 .

Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells

O. Petersen, D. Yule, M. Dunne, 1990, The Journal of Membrane Biology.

Stimulant-evoked depolarization and increase in [Ca2+]i in insulin-secreting cells is dependent on external Na+

O. Petersen, D. Yule, M. Dunne, 1990, The Journal of Membrane Biology.

Manganese transport via the transferrin mechanism.

M. Aschner, R. Gelein, Jonathan M. Malecki, 2013, Neurotoxicology.

Modulation of cytosolic calcium signaling by protein kinase A-mediated phosphorylation of inositol 1,4,5-trisphosphate receptors.

Larry E Wagner, S. V. Straub, D. Yule, 2004, Biological research.

Recessive and Dominant De Novo ITPR1 Mutations Cause Gillespie Syndrome.

A. Munnich, A. Durr, C. Orssaud, 2016, American journal of human genetics.

CCK-B receptors produce similar signals but have opposite growth effects in CHO and Swiss 3T3 cells.

K. Detjen, C. Logsdon, M. Tseng, 1997, The American journal of physiology.

CCK-B receptors produce similar signals but have opposite growth effects in CHO and Swiss 3T3 cells.

K. Detjen, C. Logsdon, John A. Williams, 1997, American journal of physiology. Cell physiology.

Effects of okadaic acid indicate a role for dephosphorylation in pancreatic stimulus-secretion coupling.

M. Wishart, D. Yule, A. C. Wagner, 1992, The American journal of physiology.

A dynamic model of saliva secretion.

E. Crampin, J. Sneyd, D. Yule, 2010, Journal of theoretical biology.

A mathematical model of fluid secretion from a parotid acinar cell.

Edmund J Crampin, James Sneyd, E. Crampin, 2007, Journal of theoretical biology.

A method for determining the dependence of calcium oscillations on inositol trisphosphate oscillations.

K. Tsaneva-Atanasova, J. Sneyd, M. Sanderson, 2006, Proceedings of the National Academy of Sciences of the United States of America.

A model of calcium waves in pancreatic and parotid acinar cells.

K. Tsaneva-Atanasova, J. Sneyd, S. V. Straub, 2003, Biophysical journal.

Cytosolic Ca2+ and Ca2+‐activated Cl− current dynamics: insights from two functionally distinct mouse exocrine cells

James Sneyd, J. Sneyd, J. Arreola, 2002, The Journal of physiology.

Traveling waves of calcium in a pancreatic acinar cells: model construction and bifurcation analysis

James Sneyd, David I. Yule, J. Sneyd, 2000 .

Agonist-dependent Phosphorylation of the Inositol 1,4,5-Trisphosphate Receptor

J. Sneyd, D. Yule, A. LeBeau, 1999, The Journal of general physiology.

Intercellular calcium waves in rat pancreatic acini: mechanism of transmission.

E. Stuenkel, D. Yule, D I Yule, 1996, The American journal of physiology.

Acetylcholine and cholecystokinin induce different patterns of oscillating calcium signals in pancreatic acinar cells.

A. Lawrie, D. Yule, D. Gallacher, 1991, Cell calcium.

Electrophysiology of pancreatic acinar cells.

O. Petersen, M. Wakui, D. Yule, 1990, Methods in enzymology.

Ca 2 + Signaling in Pancreatic Acinar Cells

D. Yule, 2016 .

Ca2+ Signaling in Pancreatic Acinar Cells

D. Yule, 2015 .

Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.

S. V. Straub, D. Yule, J. Bruce, 2003, Cell calcium.

Cytoplasmic Ca2+ oscillations evoked by receptor stimulation, G‐protein activation, internal application of inositol trisphosphate or Ca2+: simultaneous microfluorimetry and Ca2+ dependent Cl‐ current recording in single pancreatic acinar cells.

M. Wakui, D. Yule, Y. Osipchuk, 1990, The EMBO journal.

Optical measurement of stimulus-evoked membrane dynamics in single pancreatic acinar cells.

E. Stuenkel, D. Yule, D. Giovannucci, 1998, American journal of physiology. Cell physiology.

Ca2+-dependent Protein Kinase-A Modulation of the Plasma Membrane Ca2+-ATPase in Parotid Acinar Cells*

D. Yule, T. Shuttleworth, J. Bruce, 2002, The Journal of Biological Chemistry.

A cloned CCK-A receptor transduces multiple signals in response to full and partial agonists.

M. Tseng, D. Yule, J. Williams, 1993, The American journal of physiology.

Critical Role of Mortalin/GRP75 In Endothelial Cell Dysfunction Associated With Acute Lung Injury.

P. Su, F. Fazal, Arshad Rahman, 2019, Shock.

InsP3R-associated cGMP Kinase Substrate Determines Inositol 1,4,5-Trisphosphate Receptor Susceptibility to Phosphoregulation by Cyclic Nucleotide-dependent Kinases*

M. Betzenhauser, D. Yule, W. Masuda, 2010, The Journal of Biological Chemistry.

Characterization of cholecystokininA receptor agonist activity by a family of cholecystokininB receptor antagonists.

D. Yule, E. V. D. van de Westerlo, G. T. Blevins, 1994, The Journal of pharmacology and experimental therapeutics.

Markov chain Monte Carlo fitting of single-channel data from inositol trisphosphate receptors.

J. Sneyd, M. Falcke, D. Yule, 2009, Journal of theoretical biology.

Regulation of single inositol 1,4,5‐trisphosphate receptor channel activity by protein kinase A phosphorylation

Larry E Wagner, D. Yule, S. Joseph, 2008, The Journal of physiology.

Regulation of fluid and electrolyte secretion in salivary gland acinar cells.

T. Begenisich, J. E. Melvin, D. Yule, 2005, Annual review of physiology.

Calcium Dynamics and Water Transport in Salivary Acinar Cells

J. Sneyd, D. Yule, J. Rugis, 2021, Bulletin of Mathematical Biology.

salivary duct A quantitative analysis of electrolyte exchange in the

J. Sneyd, J. E. Melvin, D. Yule, 2013 .

A quantitative analysis of electrolyte exchange in the salivary duct.

E. Crampin, J. Sneyd, J. E. Melvin, 2012, American journal of physiology. Gastrointestinal and liver physiology.

Distinct contributions by ionotropic purinoceptor subtypes to ATP‐evoked calcium signals in mouse parotid acinar cells

D. Yule, D. Giovannucci, Sumit K. Bhattacharya, 2012, The Journal of physiology.

Differential regulation of the InsP3 receptor type‐1 and ‐2 single channel properties by InsP3, Ca2+ and ATP

D. Yule, Larry E. Wagner II, David I. Yule, 2012, The Journal of physiology.

Highly localized intracellular Ca2+ signals promote optimal salivary gland fluid secretion

T. Takano, J. Sneyd, D. Yule, 2021, eLife.

The characteristics of intracellular Ca2+ signals in vivo necessitate a new model for salivary fluid secretion

T. Takano, J. Sneyd, D. Yule, 2021, bioRxiv.

A Multicellular Model of Primary Saliva Secretion in the Parotid Gland

J. Sneyd, D. Yule, J. Rugis, 2020, Bulletin of Mathematical Biology.

A Multicellular Model of Primary Saliva Secretion in the Parotid Gland

J. Sneyd, D. Yule, J. Rugis, 2020, Bulletin of Mathematical Biology.

A Mathematical Model of Fluid Transport in an Accurate Reconstruction of Parotid Acinar Cells

J. Sneyd, D. Yule, J. Rugis, 2018, Bulletin of Mathematical Biology.

A Mathematical Model of Fluid Transport in an Accurate Reconstruction of Parotid Acinar Cells

J. Sneyd, D. Yule, J. Rugis, 2018, Bulletin of Mathematical Biology.

Protein kinase A regulation of P2X(4) receptors: requirement for a specific motif in the C-terminus.

D. Brown, D. Yule, 2010, Biochimica et biophysica acta.

Protein Kinase A Increases Type-2 Inositol 1,4,5-Trisphosphate Receptor Activity by Phosphorylation of Serine 937*

M. Betzenhauser, D. Yule, L. Wagner, 2009, The Journal of Biological Chemistry.

Phosphorylation of Inositol 1,4,5-Trisphosphate Receptors in Parotid Acinar Cells

D. Yule, T. Shuttleworth, D. Giovannucci, 2002, The Journal of Biological Chemistry.

Visualizing form and function in organotypic slices of the adult mouse parotid gland.

M. Betzenhauser, W. Gunning, D. Yule, 2008, American journal of physiology. Gastrointestinal and liver physiology.

A kinetic model for type I and II IP3R accounting for mode changes.

Edmund J Crampin, James Sneyd, Ivo Siekmann, 2012, Biophysical journal.

Identification of a Ryanodine Receptor in Rat Heart Mitochondria*

S. Sheu, D. Yule, D. Giovannucci, 2001, The Journal of Biological Chemistry.

Metabolic adaptation to the chronic loss of Ca2+ signaling induced by KO of IP3 receptors or the mitochondrial Ca2+ uniporter

K. Mikoshiba, G. Hajnóczky, D. Yule, 2021, The Journal of biological chemistry.

Capture at the ER-mitochondrial contacts licenses IP3 receptors to stimulate local Ca2+ transfer and oxidative metabolism

P. Várnai, G. Hajnóczky, G. Csordás, 2022, Nature Communications.

Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling

J. Sneyd, N. Hempel, M. Trebak, 2021, Cell reports.

Omnitemporal choreographies of IP3R and all five STIM/Orai underlie the complexity of mammalian Ca2+ signaling

J. Sneyd, N. Hempel, M. Trebak, 2020 .

Unique Regulatory Properties of Heterotetrameric Inositol 1,4,5-Trisphosphate Receptors Revealed by Studying Concatenated Receptor Constructs*♦

D. Yule, L. Wagner, K. Alzayady, 2016, The Journal of Biological Chemistry.

Akt Kinase Phosphorylation of Inositol 1,4,5-Trisphosphate Receptors*

D. Yule, S. Joseph, L. Wagner, 2006, Journal of Biological Chemistry.

Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury

V. Grose, F. Fazal, Arshad Rahman, 2019, Scientific Reports.

ATP Binding to a Unique Site in the Type-1 S2- Inositol 1,4,5-Trisphosphate Receptor Defines Susceptibility to Phosphorylation by Protein Kinase A*

M. Betzenhauser, D. Yule, L. Wagner, 2006, Journal of Biological Chemistry.

The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition

J. Parys, H. de Smedt, N. Prevarskaya, 2016, Oncotarget.

Bcl-2-Protein Family as Modulators of IP3 Receptors and Other Organellar Ca2+ Channels.

M. R. Baker, J. Parys, I. Serysheva, 2019, Cold Spring Harbor perspectives in biology.

Regulation of inositol 1,4,5-trisphosphate receptors by phosphorylation and adenine nucleotides.

M. Betzenhauser, D. Yule, 2010, Current topics in membranes.

Functional Consequences of Phosphomimetic Mutations at Key cAMP-dependent Protein Kinase Phosphorylation Sites in the Type 1 Inositol 1,4,5-Trisphosphate Receptor*

Wen-hong Li, D. Yule, S. Joseph, 2004, Journal of Biological Chemistry.

Phenotypic changes in mouse pancreatic stellate cell Ca2+ signaling events following activation in culture and in a disease model of pancreatitis

B. Ji, C. Logsdon, D. Yule, 2011, Molecular biology of the cell.

Secretagogues cause ubiquitination and down-regulation of inositol 1, 4,5-trisphosphate receptors in rat pancreatic acinar cells.

R. Wojcikiewicz, S. A. Ernst, D. Yule, 1999, Gastroenterology.

Tracing the Evolutionary History of Inositol, 1, 4, 5-Trisphosphate Receptor: Insights from Analyses of Capsaspora owczarzaki Ca2+ Release Channel Orthologs.

A. Sebé-Pedrós, I. Ruiz-Trillo, Liwei Wang, 2015, Molecular biology and evolution.

5-Trisphosphate Receptor: Insights from Analyses of Capsaspora owczarzaki Ca Release Channel Orthologs

Liwei Wang, D. Yule, K. Alzayady, 2015 .

Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function

D. Yule, S. Malik, K. Alzayady, 2020, The Journal of Biological Chemistry.

A protocol for detecting elemental calcium signals (Ca2+ puffs) in mammalian cells using total internal reflection fluorescence microscopy

M. Trebak, D. Yule, Vikas Arige, 2021, STAR protocols.

Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release

F. van Petegem, Liwei Wang, D. Yule, 2016, Science Signaling.

Functional Inositol 1,4,5-Trisphosphate Receptors Assembled from Concatenated Homo- and Heteromeric Subunits*♦

G. Tall, D. Yule, S. Joseph, 2013, The Journal of Biological Chemistry.

Fragmented Inositol 1,4,5-Trisphosphate Receptors Retain Tetrameric Architecture and Form Functional Ca2+ Release Channels*

D. Yule, K. Alzayady, Rahul Chandrasekhar, 2013, The Journal of Biological Chemistry.

Linking structure to function: Recent lessons from inositol 1,4,5-trisphosphate receptor mutagenesis.

M. Betzenhauser, D. Yule, S. Joseph, 2010, Cell calcium.

Molecular Characterization of the Inositol 1,4,5-Trisphosphate Receptor Pore-forming Segment*

E. Morris, P. D. da Fonseca, D. Yule, 2008, Journal of Biological Chemistry.

Disrupted Ca2+ homeostasis and immunodeficiency in patients with functional Inositol 1,4,5-trisphosphate receptor subtype 3 defects

M. R. Baker, A. Liston, I. Serysheva, 2021, medRxiv.

Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function.

S. Feske, C. Weidinger, I. Meyts, 2016, The Journal of clinical investigation.

Calcium signaling in rat pancreatic acinar cells: a role for Gαq, Gα11, and Gα14.

John A. Williams, D. Yule, C. W. Baker, 1999, American journal of physiology. Gastrointestinal and liver physiology.

The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling

S. Feske, Jingjie Zhu, Menghan Liu, 2022, Nature Immunology.

Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes

C. Grimm, Taufiq Rahman, S. Bolsover, 2022, Nature Communications.

Spontaneous calcium oscillations in clonal endocrine pancreatic glucagon-secreting cells.

B. Göke, H. Bode, D. Yule, 1994, Biochemical and biophysical research communications.

Phosphorylation of the rat Ins(1,4,5)P3 receptor at T930 within the coupling domain decreases its affinity to Ins(1,4,5)P3

D. Yule, K. Machaca, Satanay Z Hubrack, 2012, Channels.

InsP3R–RyR Ca2+ channel crosstalk facilitates arrhythmias in the failing human ventricle

H. Roderick, K. Sipido, P. Vanden Berghe, 2022, Basic Research in Cardiology.

Studying isoform-specific inositol 1,4,5-trisphosphate receptor function and regulation.

M. Betzenhauser, D. Yule, L. Wagner, 2008, Methods.

Functional communication between IP3R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE

I. Ambudkar, M. Trebak, D. Yule, 2022, Proceedings of the National Academy of Sciences.

Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production

A. Anantharam, A. Smrcka, D. Yule, 2018, Science Signaling.

Substance P and bombesin elevate cytosolic Ca2+ by different molecular mechanisms in a rat pancreatic acinar cell line.

O. Petersen, M. Hanley, D. Yule, 1990, The Journal of physiology.

The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling

S. Feske, Jingjie Zhu, W. Coetzee, 2022, Nature Immunology.

Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors

M. R. Baker, G. Fan, I. Serysheva, 2022, bioRxiv.

The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca²⁺-release channel.

J. Parys, G. Bultynck, D. Yule, 2015, Biochimica et biophysica acta.

Phosphorylation of Type-1 Inositol 1,4,5-Trisphosphate Receptors by Cyclic Nucleotide-dependent Protein Kinases

Wen-hong Li, D. Yule, L. Wagner, 2003, Journal of Biological Chemistry.

An inside job: Annexin 1A-Inositol 1,4,5-trisphosphate receptor interaction conveys endoplasmic reticulum luminal Ca2+ sensitivity.

D. Yule, Amanda M. Wahl, 2020, Cell calcium.

Region-specific proteolysis differentially regulates type 1 inositol 1,4,5-trisphosphate receptor activity

Liwei Wang, D. Yule, L. Wagner, 2017, The Journal of Biological Chemistry.

Characterization of ryanodine receptor type 1 single channel activity using "on-nucleus" patch clamp.

L. Groom, R. Dirksen, D. Yule, 2014, Cell calcium.

Inositol trisphosphate receptor and ion channel models based on single-channel data.

James Sneyd, David I. Yule, Elan Gin, 2009, Chaos.

ATP Regulation of Type-1 Inositol 1,4,5-Trisphosphate Receptor Activity Does Not Require Walker A-type ATP-binding Motifs*

M. Betzenhauser, D. Yule, L. Wagner, 2009, The Journal of Biological Chemistry.

Protein kinase C regulation of P2X3 receptors is unlikely to involve direct receptor phosphorylation.

D. Brown, D. Yule, 2007, Biochimica et biophysica acta.

Respective Contribution of Mitochondrial Superoxide and pH to Mitochondria-targeted Circularly Permuted Yellow Fluorescent Protein (mt-cpYFP) Flash Activity*

David I. Yule, Heping Cheng, Xianhua Wang, 2013, The Journal of Biological Chemistry.

Control of IP 3 receptors by reactive oxygen species 1 Isoform-and species-specific control of IP 3 receptors by reactive oxygen species *

M. Madesh, G. Hajnóczky, G. Csordás, 2017 .

Overexpression of Rab3D enhances regulated amylase secretion from pancreatic acini of transgenic mice.

John A. Williams, L. Samuelson, S. A. Ernst, 1997, The Journal of clinical investigation.

MCMC estimation of Markov models for ion channels.

Edmund J Crampin, David Bryant, Colin Fox, 2011, Biophysical journal.

DPB162-AE, an inhibitor of store-operated Ca2+ entry, can deplete the endoplasmic reticulum Ca2+ store.

K. Mikoshiba, J. Parys, H. de Smedt, 2017, Cell calcium.

Calcium Wave Propagation in Pancreatic Acinar Cells

S. V. Straub, D. Yule, D. Giovannucci, 2000, The Journal of general physiology.

Multiple inhibitory effects of genistein on stimulus-secretion coupling in rat pancreatic acini.

R. Duan, D. Yule, A. C. Wagner, 1994, The American journal of physiology.

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.

D. Yule, K. Alzayady, Rahul Chandrasekhar, 2015, Biochemical Society transactions.

Alpha-Helical Destabilization of the Bcl-2-BH4-Domain Peptide Abolishes Its Ability to Inhibit the IP3 Receptor

L. Missiaen, J. Parys, H. de Smedt, 2013, PloS one.

Pancreas-specific CHRM3 activation causes pancreatitis in mice

D. Mukhopadhyay, B. Ji, Jiaxiang Chen, 2021, JCI insight.

Vasopressin directly closes ATP‐sensitive potassium channels evoking membrane depolarization and an increase in the free intracellular Ca2+ concentration in insulin‐secreting cells.

D. Yule, M. Dunne, O. Petersen, 1989, The EMBO journal.

Tracing the evolutionary history of Ca2+-signaling modulation by human Bcl-2: Insights from the Capsaspora owczarzaki IP3 receptor ortholog.

A. Sebé-Pedrós, G. Bultynck, D. Yule, 2021, Biochimica et biophysica acta. Molecular cell research.

Carbohydrate Loading to Combat Acute Pancreatitis.

G. Bultynck, D. Yule, T. Vervliet, 2018, Trends in biochemical sciences.

Can pancreatitis be treated by inhibiting Ca2+ signaling?

John A. Williams, D. Yule, 2018, Annals of translational medicine.

Modulation of Ca2+ oscillations by phosphorylation of Ins(1,4,5)P3 receptors.

S. V. Straub, D. Yule, J. Bruce, 2003, Biochemical Society transactions.

Endothelin-activated calcium signaling in enteric glia derived from neonatal guinea pig.

M. Mulholland, G. Sarosi, D. Yule, 1997, The American journal of physiology.

Expression of BK channels and Na+-K+ pumps in the apical membrane of lacrimal acinar cells suggests a new molecular mechanism for primary tear-secretion.

P. Nanasi, J. Almássy, Zsuzsanna Magyar, 2019, The ocular surface.

Investigating ion channel distribution using a combination of spatially limited photolysis, Ca(2+) imaging, and patch clamp recording.

J. Almássy, D. Yule, 2013, Cold Spring Harbor protocols.

Magnesium Acts as a Second Messenger in the Regulation of NMDA Receptor-Mediated CREB Signaling in Neurons

H. Xia, Liwei Wang, D. Yule, 2020, Molecular Neurobiology.

Understanding IP3R channels: From structural underpinnings to ligand-dependent conformational landscape.

M. R. Baker, G. Fan, I. Serysheva, 2023, Cell calcium.

Differential regulation of ion channels function by proteolysis.

Liwei Wang, D. Yule, 2018, Biochimica et biophysica acta. Molecular cell research.

Tumor Necrosis Factor-α Potentiates Intraneuronal Ca2+ Signaling via Regulation of the Inositol 1,4,5-Trisphosphate Receptor*

W. Bowers, D. Yule, Keigan M. Park, 2008, Journal of Biological Chemistry.

Proteolytic fragmentation of inositol 1,4,5‐trisphosphate receptors: a novel mechanism regulating channel activity?

Liwei Wang, D. Yule, Kamil J. Alzayady, 2016, The Journal of physiology.

CREB regulates the expression of Type 1 Inositol 1,4,5-trisphosphate receptors

D. Yule, L. Wagner, Vikas Arige, 2021, bioRxiv.

Evidence That Zymogen Granules Are Not a Physiologically Relevant Calcium Pool

R. Wojcikiewicz, S. A. Ernst, H. Ohnishi, 1997, The Journal of Biological Chemistry.

Ca2+ signals in pancreatic acinar cells in response to physiological stimulation in vivo

T. Takano, D. Yule, 2023, The Journal of physiology.

Measurement of Ca2+ signaling dynamics in exocrine cells with total internal reflection microscopy.

D. Yule, J. Won, 2006, American journal of physiology. Gastrointestinal and liver physiology.

Regulation of Store-Operated Ca2+ Entry by IP3 Receptors Independent of Their Ability to Release Ca2+

Colin W. Taylor, G. Hasan, D. Yule, 2021, bioRxiv.

Calcium signaling in rat pancreatic acinar cells: a role for Galphaq, Galpha11, and Galpha14.

D. Yule, C. W. Baker, J. Williams, 1999, American Journal of Physiology.

Pilocarpine and carbachol exhibit markedly different patterns of Ca2+ signaling in rat pancreatic acinar cells.

T. Essington, D. Yule, J. Williams, 1993, The American journal of physiology.

Cromakalim (BRL 34915) and diazoxide activate ATP-regulated potassium channels in insulin-secreting cells

O. Petersen, D. Yule, M. Dunne, 2004, Pflügers Archiv.

A Model of $$\hbox {Ca}^{2+}$$Ca2+ Dynamics in an Accurate Reconstruction of Parotid Acinar Cells

V. Kirk, J. Sneyd, D. Yule, 2019, Bulletin of mathematical biology.

Chloride channels in the small intestinal cell line IEC‐18

U. Sundaram, D. Yule, S. Basavappa, 2005, Journal of cellular physiology.

Studying the activation of epithelial ion channels using global whole-field photolysis.

J. Almássy, D. Yule, 2013, Cold Spring Harbor Protocols.

Extracellular ATP and P2Y2 receptors mediate intercellular Ca(2+) waves induced by mechanical stimulation in submandibular gland cells: Role of mitochondrial regulation of store operated Ca(2+) entry.

P. Peixoto, Shin-Young Ryu, K. Kinnally, 2010, Cell calcium.

Photolysis of caged compounds: studying Ca(2+) signaling and activation of Ca(2+)-dependent ion channels.

J. Almássy, D. Yule, 2013, Cold Spring Harbor protocols.

Caffeine- and ryanodine-sensitive Ca2+ stores in cultured guinea pig myenteric neurons.

M. Mulholland, D. Yule, B. Kimball, 1996, The American journal of physiology.

Stimulus-secretion coupling in pancreatic acinar cells.

D. B. Burnham, John A. Williams, D. Yule, 1984 .

Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+

G. Hasan, D. Yule, S. Malik, 2023, bioRxiv.

Comparison of fura-2 imaging and electrophysiological analysis of murine calcium channel alpha 1 subunits coexpressed with novel beta 2 subunit isoforms.

R. Macdonald, M. Uhler, K. Kelly, 1995, Molecular pharmacology.

CREB regulates the expression of Type 1 Inositol 1,4,5-trisphosphate receptors.

D. Yule, S. Malik, L. Wagner, 2021, Journal of cell science.

Structural and functional analysis of salivary intercalated duct cells reveals a secretory phenotype

J. Sneyd, P. Pérez, D. Yule, 2023, The Journal of physiology.

Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury

F. Fazal, Arshad Rahman, J. Paton, 2019, Scientific Reports.

A multiple-oscillator mechanism underlies antigen-induced Ca2+ oscillations in Jurkat T-cells

V. Kirk, J. Sneyd, M. Trebak, 2023, The Journal of biological chemistry.

Stimulus-secretion coupling of pancreatic digestive enzyme secretion.

H. Ohnishi, D. Yule, G. Groblewski, 1997, Digestion.

Magnesium Acts as a Second Messenger in the Regulation of NMDA Receptor-Mediated CREB Signaling in Neurons

H. Xia, Liwei Wang, D. Yule, 2020, Molecular Neurobiology.

Differential regulation of the InsP3 receptor type‐1 and ‐2 single channel properties by InsP3, Ca2+ and ATP

D. Yule, Larry E. Wagner II, 2012, Journal of Physiology.

Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output

K. Mikoshiba, L. Martens, J. Parys, 2019, Cellular and Molecular Life Sciences.

Modeling calcium waves in an anatomically accurate three-dimensional parotid acinar cell.

J. Sneyd, S. Means, D. Yule, 2017, Journal of theoretical biology.

Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice.

K. Mikoshiba, T. Abe, H. Kiyonari, 2013, Gastroenterology.

New saliva secretion model based on the expression of Na+-K+ pump and K+ channels in the apical membrane of parotid acinar cells

J. Sneyd, P. Nanasi, J. Almássy, 2018, Pflügers Archiv - European Journal of Physiology.

ATP Regulation of Type-1 Inositol 1,4,5-Trisphosphate Receptor Activity Does Not Require Walker A-type ATP-binding Motifs*

M. Betzenhauser, D. Yule, H. Park, 2009, The Journal of Biological Chemistry.

Inflammation, lipid dysregulation, and transient receptor potential cation channel subfamily V member 4 signaling perpetuate chronic vulvar pain

D. Yule, M. Falsetta, Krishna Rao Maddipati, 2023, Pain.

Characterization of ryanodine receptor type 1 single channel activity using "on-nucleus" patch clamp.

L. Groom, R. Dirksen, D. Yule, 2014, Cell calcium.

IP3RPEP6, a novel peptide inhibitor of IP3 receptor channels that does not affect connexin‐43 hemichannels

G. Bultynck, D. Yule, Siyu Tao, 2024, Acta physiologica.

Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling.

D. Yule, T. Shuttleworth, D. Giovannucci, 2002, The Journal of biological chemistry.