Mala Mani

Binding of two zinc finger nuclease monomers to two specific sites is required for effective double-strand DNA cleavage.

Jeremy M Berg, Srinivasan Chandrasegaran, J. Berg, 2005, Biochemical and biophysical research communications.

BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, and angiogenic properties to cancer cells.

D. Carrasco, Yunyu Zhang, K. Anderson, 2009, Cancer research.

Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression.

A. Letai, D. Carrasco, Yunyu Zhang, 2009, Blood.

A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma.

Jeffrey Ecsedy, Loredana Santo, Paul Richardson, 2009, Blood.

Targeted manipulation of mammalian genomes using designed zinc finger nucleases.

Vitali Alexeev, Srinivasan Chandrasegaran, Curt I. Civin, 2009, Biochemical and biophysical research communications.

Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells

Srinivasan Chandrasegaran, S. Chandrasegaran, K. Kandavelou, 2005, Nucleic acids research.