A. Agoulnik

发表

Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene.

M Dietel, M. Dietel, R. Schäfer, 2001, The American journal of pathology.

Rethinking dog domestication by integrating genetics, archeology, and biogeography

Leif Andersson, Keith Dobney, Merete Fredholm, 2012, Proceedings of the National Academy of Sciences.

Constitutive Notch Signaling Causes Abnormal Development of the Oviducts, Abnormal Angiogenesis, and Cyst Formation in Mouse Female Reproductive Tract1

A. Agoulnik, Lydia E. Ferguson, E. Kaftanovskaya, 2016, Biology of reproduction.

Synthetic non‐peptide low molecular weight agonists of the relaxin receptor 1

Xin Hu, J. Marugan, I. Agoulnik, 2017, British journal of pharmacology.

Relaxin‐like peptides in male reproduction – a human perspective

R. Ivell, R. Anand-Ivell, A. Agoulnik, 2017, British journal of pharmacology.

Mutations in the Insulin‐Like Factor 3 Receptor Are Associated With Osteoporosis

M. Zaccolo, S. Giannini, C. Foresta, 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Reduced Androgen Receptor Expression Accelerates the Onset of ERBB2 Induced Breast Tumors in Female Mice

I. Agoulnik, A. Agoulnik, R. Poppiti, 2013, PloS one.

Developmental Expression and Gene Regulation of Insulin-like 3 Receptor RXFP 2 in Mouse Male Reproductive Organs 1

C. Bishop, B. Korchin, T. Klonisch, 2007 .

Developmental Expression and Gene Regulation of Insulin-like 3 Receptor RXFP2 in Mouse Male Reproductive Organs1

C. Bishop, B. Korchin, T. Klonisch, 2007, Biology of reproduction.

Targeting the relaxin/insulin-like family peptide receptor 1 and 2 with small molecule compounds

A. Agoulnik, M. Esteban-López, H. H. Ng, 2019, Molecular and Cellular Endocrinology.

Relaxin receptor deficiency promotes vascular inflammation and impairs outward remodeling in arteriovenous fistulas

P. Quax, N. Eijkelkamp, J. Rotmans, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Jingbo Xiao, J. Marugan, R. Summers, 2017, Scientific Reports.

Diverse functions of insulin-like 3 peptide.

A. Agoulnik, M. Esteban-López, Maria Esteban-Lopez, 2020, The Journal of endocrinology.

Spermatogenesis in cryptorchidism.

A. Agoulnik, Lydia E. Ferguson, Zaohua Huang, 2012, Methods in molecular biology.

Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis.

C. Creighton, A. Sood, M. Ittmann, 2010, Endocrine-related cancer.

Relaxin Signaling in Uterine Fibroids

Matthew L. Anderson, A. Rajkovic, X. Tong, 2009, Annals of the New York Academy of Sciences.

INSL3 has tumor‐promoting activity in thyroid cancer

C. Hoang‐Vu, T. Klonisch, E. Weber, 2010, International journal of cancer.

Suppression of insulin-like3 receptor reveals the role of β-catenin and Notch signaling in gubernaculum development.

I. Gorlov, Sukhjinder Kaur, A. Agoulnik, 2011, Molecular endocrinology.

Short Communication Caveolin-1 Is Down-Regulated in Human Ovarian Carcinoma and Acts as a Candidate Tumor Suppressor Gene

M. Dietel, L. Diatchenko, C. Sers, 2001 .

Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas.

M. Dietel, P. Schlag, C. Sers, 2001, The American journal of pathology.

The low-density lipoprotein class A module of the relaxin receptor (leucine-rich repeat containing G-protein coupled receptor 7): its role in signaling and trafficking to the cell membrane.

A. Agoulnik, G. Bryant-greenwood, A. Kern, 2007, Endocrinology.

Protective Role of Testicular Hormone INSL3 From Atrophy and Weakness in Skeletal Muscle

M. Sandri, C. Foresta, A. Ferlin, 2018, Front. Endocrinol..

INSL3 Plays a Role in the Balance between Bone Formation and Resorption

C. Foresta, A. Ferlin, A. Agoulnik, 2009, Annals of the New York Academy of Sciences.

Genetic Targeting of Relaxin and Insl3 Signaling in Mice

A. Kamat, A. Agoulnik, N. Bogatcheva, 2005, Annals of the New York Academy of Sciences.

GREAT/LGR8 is the only receptor for insulin-like 3 peptide.

I. Adham, W. Engel, A. Agoulnik, 2003, Molecular endocrinology.

A transgenic insertion causing cryptorchidism in mice

C. Bishop, I. Gorlov, P. Overbeek, 2001, Genesis.

Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice.

M. Grant, K. Conrad, J. Kielczewski, 2012, Blood.

INSL3 in the muscolo-skeletal system

M. Sandri, C. Foresta, A. Ferlin, 2019, Molecular and Cellular Endocrinology.

Insulin-Like 3 Signaling Is Important for Testicular Descent but Dispensable for Spermatogenesis and Germ Cell Survival in Adult Mice1

A. Agoulnik, Zaohua Huang, Bryan Rivas, 2012, Biology of reproduction.

Mutations of the GREAT gene cause cryptorchidism.

C. Bishop, I. Gorlov, D. Lamb, 2002, Human molecular genetics.

Expression of LDL-A module of relaxin receptor in prostate cancer cells inhibits tumorigenesis.

A. Agoulnik, S. Feng, 2011, International journal of oncology.

Insulin-like 3 signalling in testicular descent.

I. Adham, A. Agoulnik, 2004, International journal of andrology.

Identification and sequencing the juvenile spermatogonial depletion critical interval on mouse chromosome 1 reveals the presence of eight candidate genes.

C. Bishop, Y. Nishimune, J. Rohozinski, 2001, Biochemical and biophysical research communications.

INSL3/RXFP2 Signaling in Testicular Descent

J. Wade, D. Lamb, Shuo Han, 2009, Annals of the New York Academy of Sciences.

A major locus on mouse chromosome 18 controls XX sex reversal in Odd Sex (Ods) mice.

C. Bishop, C. Truong, A. Agoulnik, 2003, Human molecular genetics.

Genetic ablation of androgen receptor signaling in fetal Leydig cell lineage affects Leydig cell functions in adult testis

A. Agoulnik, Lydia E. Ferguson, E. Kaftanovskaya, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Left‐sided cryptorchidism in mice with Wilms' tumour 1 gene deletion in gubernaculum testis

V. Huff, A. Agoulnik, E. Kaftanovskaya, 2013, The Journal of pathology.

Cryptorchidism in mice with an androgen receptor ablation in gubernaculum testis.

I. Gorlov, A. Agoulnik, K. de Gendt, 2012, Molecular endocrinology.

Normal prostate morphology in relaxin-mutant mice.

T. Klonisch, L. Parry, A. Agoulnik, 2009, Reproduction, fertility, and development.

Uterine cysts in female mice deficient for caveolin-1 and insulin-like 3 receptor RXFP2.

Matthew L. Anderson, A. Agoulnik, E. Kaftanovskaya, 2011, Endocrinology.

Insulin-like factor 3 gene mutations in testicular dysgenesis syndrome: clinical and functional characterization.

C. Foresta, A. Ferlin, A. Agoulnik, 2006, Molecular human reproduction.

Mutation analysis of INSL3 and GREAT/LGR8 genes in familial cryptorchidism.

V. Cortessis, B. Hardy, C. Koh, 2004, Urology.

Developmental Expression and Gene Regulation of Insulin-like 3 Receptor RXFP2 in Mouse Male Reproductive Organs

C. Bishop, B. Korchin, T. Klonisch, 2007 .

Normal fertility in male mice with deletion of β‐catenin gene in germ cells

A. Agoulnik, Zaohua Huang, Bryan Rivas, 2014, Genesis.

NOTCH1 Gain of Function in Germ Cells Causes Failure of Spermatogenesis in Male Mice

A. Agoulnik, Zaohua Huang, Bryan Rivas, 2013, PloS one.

Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile.

Catherine Z. Chen, M. Ferrer, Noel Southall, 2018, European journal of medicinal chemistry.

Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis

M. Ferrer, C. Bishop, Noel Southall, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Expression patterns and the roles of phosphatidylinositol phosphatases in testis

I. Agoulnik, A. Agoulnik, Y. Ceyhan, 2022, Biology of Reproduction.

Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2

M. Ferrer, Noel Southall, K. Wilson, 2022, Communications Biology.

Identification of Small-Molecule Agonists of Human Relaxin Family Receptor 1 (RXFP1) by Using a Homogenous Cell-Based cAMP Assay

Raisa E Jones, Catherine Z. Chen, M. Ferrer, 2013, Journal of biomolecular screening.

A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism

J. Jameson, A. Agoulnik, C. Finlayson, 2010, Mammalian Genome.

Relative Roles of the Epithelial and Stromal Tissue Compartment(s) in Mediating the Actions of Relaxin and Estrogen on Cell Proliferation and Apoptosis in the Mouse Lower Reproductive Tract

P. Cooke, D. D. Meling, A. Agoulnik, 2009, Annals of the New York Academy of Sciences.

Relaxin/RXFP1 Signaling in Prostate Cancer Progression

A. Sood, M. Ittmann, G. Lopez-Berestein, 2009, Annals of the New York Academy of Sciences.

Relaxin acts on stromal cells to promote epithelial and stromal proliferation and inhibit apoptosis in the mouse cervix and vagina.

P. Cooke, D. D. Meling, A. Agoulnik, 2008, Endocrinology.

T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane.

C. Foresta, A. Ferlin, A. Agoulnik, 2007, American journal of physiology. Endocrinology and metabolism.

Relaxin and Related Peptides

A. Agoulnik, 2007 .

The role of relaxin in endometrial cancer

A. Sood, I. Agoulnik, F. Kheradmand, 2006, Cancer biology & therapy.

Endocrine effects of relaxin overexpression in mice.

A. Kamat, A. Agoulnik, Aparna A. Kamat, 2006, Endocrinology.

Genetic targeting of relaxin and insulin-like factor 3 receptors in mice.

C. Bishop, A. Kamat, A. Agoulnik, 2004, Endocrinology.

The Fate of Spermatogonial Stem Cells in the Cryptorchid Testes of RXFP2 Deficient Mice

Javier J. How, A. Agoulnik, Lydia E. Ferguson, 2013, PloS one.

Testicular Cancer and Cryptorchidism

A. Agoulnik, Lydia E. Ferguson, 2013, Front. Endocrinol..

Over expression of insulin-like 3 does not prevent cryptorchidism in GNRHR or HOXA10 deficient mice.

I. Adham, W. Engel, A. Agoulnik, 2006, The Journal of urology.

INSL3/LGR8 role in testicular descent and cryptorchidism.

A. Agoulnik, N. Bogatcheva, 2005, Reproductive biomedicine online.

J. Wade, D. Lamb, Shuo Han, 2009 .

The Genetics of Cryptorchidism

A. Agoulnik, S. Feng, 2007 .

A. Agoulnik, 2007, Advances in experimental medicine and biology.

Transabdominal testicular descent is disrupted in mice with deletion of insulinlike factor 3 receptor.

J. Hutson, A. Agoulnik, A. Truong, 2003, Journal of pediatric surgery.

Successful targeting of mouse Y chromosome genes using a site‐directed insertion vector

C. Bishop, J. Rohozinski, A. Agoulnik, 2002, Genesis.

Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice

J. Vacher, I. Agoulnik, A. Agoulnik, 2020, PloS one.

A transgenic insertion upstream of Sox9 is associated with dominant XX sex reversal in the mouse

Paul A. Overbeek, Richard R. Behringer, Irina U. Agoulnik, 2000, Nature Genetics.

A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd.

C. Bishop, K. Chada, Qichao Zhu, 2002, Human molecular genetics.

Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression

Leif E. Peterson, K. Rajapakshe, M. Ittmann, 2016, Clinical Cancer Research.

Gene expression profiling in RAS oncogene-transformed cell lines and in solid tumors using subtractive suppression hybridization and cDNA arrays.

J. Zuber, R. Schäfer, L. Diatchenko, 2002, Advances in enzyme regulation.

INPP4B protects from metabolic syndrome and associated disorders

J. Vacher, M. Ittmann, F. Knop, 2021, Communications Biology.

INPP4B protects from metabolic syndrome and associated disorders

J. Vacher, M. Ittmann, F. Knop, 2021, Communications Biology.

Isolation and Expression Analysis of the Canine Insulin-Like Factor 3 Gene1

A. Agoulnik, C. Schelling, N. Bogatcheva, 2003, Biology of reproduction.

Relaxin Promotes Prostate Cancer Progression

M. Ittmann, Rile Li, G. Ayala, 2007, Clinical Cancer Research.

Estrogen and TCDD Influence RLN2 Gene Activity in Estrogen Receptor‐Positive Human Breast Cancer Cells

A. Agoulnik, S. Hombach-Klonisch, S. Kietz, 2009, Annals of the New York Academy of Sciences.

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Jingbo Xiao, J. Marugan, ossain, 2017, Scientific Reports.

Anti-apoptotic and Matrix Remodeling Actions of a Small Molecule Agonist of the Human Relaxin Receptor, ML290 in Mice With Unilateral Ureteral Obstruction

K. Wilson, J. Marugan, A. Agoulnik, 2021, Frontiers in Physiology.

Conditional Deletion of the Relaxin Receptor Gene in Cells of Smooth Muscle Lineage Affects Lower Reproductive Tract in Pregnant Mice1

K. Conrad, A. Agoulnik, E. Kaftanovskaya, 2015, Biology of reproduction.

Human Relaxin Receptor Is Fully Functional in Humanized Mice and Is Activated by Small Molecule Agonist ML290

Javier J. How, J. Marugan, C. Yoo, 2017, Journal of the Endocrine Society.

Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290

M. Ferrer, Noel Southall, Xin Hu, 2015, Front. Endocrinol..

GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation

M. Cohn, Anbarasi Kothandapani, J. Jorgensen, 2020, PLoS genetics.

Mechanisms of INSL3 signaling in male reproductive organs.

A. Agoulnik, E. Kaftanovskaya, Zaohua Huang, 2013, Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia.

Novel mutations involving the INSL3 gene associated with cryptorchidism.

H. Rouba, A. Barakat, K. McElreavey, 2007, The Journal of urology.

Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists.

M. Ferrer, Noel Southall, Xin Hu, 2016, Biochemistry.

New Roles for INSL3 in Adults

C. Foresta, A. Ferlin, A. Garolla, 2009, Annals of the New York Academy of Sciences.

Protein expression profiling of endometriosis: validation of 2-mm tissue microarrays.

T. Wheeler, M. Sayeeduddin, J. Simpson, 2004, Fertility and sterility.

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1

Raisa E Jones, Catherine Z. Chen, M. Ferrer, 2013, Nature Communications.

Relaxin family peptide receptors in GtoPdb v.2023.1

T. Dschietzig, A. Gundlach, R. Summers, 2023, IUPHAR/BPS Guide to Pharmacology CITE.

Long-Lasting Consequences of Testosterone Exposure.

I. Agoulnik, A. Agoulnik, 2015, Endocrinology.