Toru Komatsu

发表

Development of a Sensitive Bioluminogenic Probe for Imaging Highly Reactive Oxygen Species in Living Rats.

Mako Kamiya, Y. Urano, K. Hanaoka, 2015, Angewandte Chemie.

Establishment of Molecular Design Strategy To Obtain Activatable Fluorescent Probes for Carboxypeptidases.

Mako Kamiya, Y. Urano, K. Hanaoka, 2018, Journal of the American Chemical Society.

Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling method.

Yasuteru Urano, Toru Komatsu, Takanari Inoue, 2011, Journal of the American Chemical Society.

Rapidly rendering cells phagocytic through a cell surface display technique and concurrent Rac activation

Toru Komatsu, Makoto Arita, Takanari Inoue, 2014, Science Signaling.

A Gd3+-based magnetic resonance imaging contrast agent sensitive to beta-galactosidase activity utilizing a receptor-induced magnetization enhancement (RIME) phenomenon.

K. Hanaoka, K. Kikuchi, Takuya Terai, 2008, Chemistry.

Analysis of chemical equilibrium of silicon-substituted fluorescein and its application to develop a scaffold for red fluorescent probes.

Mako Kamiya, Y. Urano, K. Hanaoka, 2015, Analytical chemistry.

Red‐Shifted Fluorogenic Substrate for Detection of lac Z‐Positive Cells in Living Tissue with Single‐Cell Resolution

Mako Kamiya, Y. Urano, K. Hanaoka, 2018, Angewandte Chemie.

Red-Shifted Fluorogenic Substrate for Detection of lacZ-Positive Cells in Living Tissue with Single-Cell Resolution.

Mako Kamiya, Y. Urano, K. Hanaoka, 2018, Angewandte Chemie.

Development of a highly selective fluorescence probe for hydrogen sulfide.

K. Hanaoka, Takuya Terai, T. Nagano, 2011, Journal of the American Chemical Society.

Development of an Azo-Based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy.

Y. Urano, K. Hanaoka, Takuya Terai, 2017, Journal of the American Chemical Society.

Development of azo-based fluorescent probes to detect different levels of hypoxia.

K. Morokuma, T. Nakazawa, K. Hanaoka, 2013, Angewandte Chemie.

Antibody Clicking as a Strategy to Modify Antibody Functionalities on the Surface of Targeted Cells.

Y. Urano, K. Hanaoka, A. Yamaguchi, 2020, Journal of the American Chemical Society.

Development of a highly selective fluorescence probe for alkaline phosphatase.

K. Hanaoka, Takuya Terai, T. Nagano, 2011, Bioorganic & medicinal chemistry letters.

Development of a Novel Intraocular-Pressure-Lowering Therapy Targeting ATX.

H. Nishimasu, O. Nureki, M. Aihara, 2019, Biological & pharmaceutical bulletin.

Development of a platform for activatable fluorescent substrates of glucose transporters (GLUTs).

Y. Urano, K. Hanaoka, Katsuya Yamada, 2019, Bioorganic & medicinal chemistry.

Boron dipyrromethene as a fluorescent caging group for single-photon uncaging with long-wavelength visible light.

Mako Kamiya, Y. Urano, K. Hanaoka, 2014, ACS chemical biology.

MITOL promotes cell survival by degrading Parkin during mitophagy

Y. Fujikawa, Y. Urano, S. Yanagi, 2021, EMBO reports.

Covalent Self-Labeling of Tagged Proteins with Chemical Fluorescent Dyes in BY-2 Cells and Arabidopsis Seedlings

Ryu J. Iwatate, W. Frommer, Mako Kamiya, 2020, Plant Cell.

Covalent Self-Labeling of Tagged Proteins with Chemical Fluorescent Dyes in BY-2 Cells and Arabidopsis Seedlings.

Ryu J. Iwatate, W. Frommer, Mako Kamiya, 2020, The Plant cell.

Self-labeling of proteins with chemical fluorescent dyes in BY-2 cells and Arabidopsis seedlings

Ryu J. Iwatate, W. Frommer, Mako Kamiya, 2020, bioRxiv.

An Activatable Photosensitizer Targeted to γ-Glutamyltranspeptidase.

Mako Kamiya, Y. Urano, Y. Ichikawa, 2017, Angewandte Chemie.

Selective ablation of β-galactosidase-expressing cells with a rationally designed activatable photosensitizer.

Masayuki Miura, Yasuteru Urano, Toru Komatsu, 2014, Angewandte Chemie.

Rapid imaging of lung cancer using a red fluorescent probe to detect dipeptidyl peptidase 4 and puromycin-sensitive aminopeptidase activities

Mako Kamiya, Y. Urano, J. Nakajima, 2022, Scientific Reports.

Identification of Lung Inflammation-Related Elevation of Acylamino Acid Releasing Enzyme (APEH) Activity Using an Enzymomics Approach.

Y. Urano, K. Hanaoka, Takuya Terai, 2016, Chemical & pharmaceutical bulletin.

Thermal or mechanical stimuli-induced photoluminescence color change of a molecular assembly composed of an amphiphilic anthracene derivative in water.

K. Hanaoka, Takuya Terai, T. Nagano, 2014, Chemistry.

A Water‐Soluble Mechanochromic Luminescent Pyrene Derivative Exhibiting Recovery of the Initial Photoluminescence Color in a High‐Humidity Environment

K. Hanaoka, T. Nagano, Takashi Kato, 2013 .

Red fluorescent scaffold for highly sensitive protease activity probes.

K. Hanaoka, Takuya Terai, T. Nagano, 2012, Bioorganic & medicinal chemistry letters.

High-throughput single-molecule bioassay using micro-reactor arrays with a concentration gradient of target molecules.

Y. Urano, H. Noji, Toru Komatsu, 2018, Lab on a Chip.

Artificial Ligands of Streptavidin (ALiS): Discovery, Characterization, and Application for Reversible Control of Intracellular Protein Transport.

Y. Urano, K. Hanaoka, F. Perez, 2015, Journal of the American Chemical Society.

Rational design of boron dipyrromethene (BODIPY)-based photobleaching-resistant fluorophores applicable to a protein dynamics study.

Y. Urano, K. Hanaoka, Takuya Terai, 2011, Chemical communications.

Development of a highly sensitive fluorescence probe for hydrogen peroxide.

Y. Urano, K. Hanaoka, Takuya Terai, 2011, Journal of the American Chemical Society.

Fluorometric assay of integrin activity with a small-molecular probe that senses the binding site microenvironment.

Y. Urano, K. Hanaoka, Takuya Terai, 2014, Chemical communications.

Unexpected Photo‐instability of 2,6‐Sulfonamide‐Substituted BODIPYs and Its Application to Caged GABA

N. Matsuki, Y. Ikegaya, Y. Urano, 2016, Chembiochem : a European journal of chemical biology.

Development of ratiometric carbohydrate sensor based on boron dipyrromethene (BODIPY) scaffold.

Y. Urano, K. Hanaoka, Tasuku Ueno, 2019, Bioorganic & medicinal chemistry letters.

Detection of NAD(P)H-dependent enzyme activity with dynamic luminescence quenching of terbium complexes.

Y. Urano, K. Hanaoka, Takuya Terai, 2015, Chemical communications.

Protein-Coupled Fluorescent Probe To Visualize Potassium Ion Transition on Cellular Membranes.

Y. Urano, K. Hanaoka, Takuya Terai, 2016, Analytical chemistry.

Gliotoxin suppresses NF-κB activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC).

K. Hanaoka, K. Iwai, Y. Sasaki, 2015, ACS chemical biology.

Design of spontaneously blinking fluorophores for live-cell super-resolution imaging based on quantum-chemical calculations.

Y. Urano, K. Hanaoka, Toshitada Yoshihara, 2020, Chemical communications.

A protein-coupled fluorescent probe for organelle-specific imaging of Na+

Y. Urano, K. Hanaoka, R. Taguchi, 2018, Sensors and Actuators B: Chemical.

General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process.

Kazuki Tainaka, Y. Urano, K. Hanaoka, 2022, Journal of the American Chemical Society.

Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase and application for activity imaging in living cells.

Y. Fujikawa, Y. Urano, K. Hanaoka, 2008, Journal of the American Chemical Society.

Discovery of a pyruvylated peptide-metabolizing enzyme using a fluorescent substrate-based protein discovery technique.

Y. Urano, K. Hanaoka, Takuya Terai, 2016, Chemical communications.

Development of a far-red to near-infrared fluorescence probe for calcium ion and its application to multicolor neuronal imaging.

N. Matsuki, Y. Ikegaya, Naoya Takahashi, 2011, Journal of the American Chemical Society.

Enzyme-Loaded Polyion Complex Vesicles as in Vivo Nanoreactors Working Sustainably under the Blood Circulation: Characterization and Functional Evaluation.

Y. Anraku, D. Sueyoshi, Y. Urano, 2017, Biomacromolecules.

Fluorescence detection of serum albumin with a turnover-based sensor utilizing Kemp elimination reaction.

Y. Urano, K. Hanaoka, Tasuku Ueno, 2017, Bioorganic & medicinal chemistry letters.

Covalent attachment of mechanoresponsive luminescent micelles to glasses and polymers in aqueous conditions.

K. Hanaoka, T. Nagano, Takashi Kato, 2014, Journal of the American Chemical Society.

Molecular design of near-infrared (NIR) fluorescent probes targeting exopeptidase and application for detection of dipeptidyl peptidase 4 (DPP-4) activity

Y. Urano, K. Hanaoka, E. Sasaki, 2022, RSC chemical biology.

Development of practical red fluorescent probe for cytoplasmic calcium ions with greatly improved cell-membrane permeability.

Y. Ikegaya, Y. Urano, K. Hanaoka, 2016, Cell calcium.

New class of bioluminogenic probe based on bioluminescent enzyme-induced electron transfer: BioLeT.

Y. Urano, K. Hanaoka, Takuya Terai, 2015, Journal of the American Chemical Society.

Red fluorescent probe for monitoring the dynamics of cytoplasmic calcium ions.

N. Matsuki, Y. Ikegaya, Naoya Takahashi, 2013, Angewandte Chemie.

Development of a potassium ion-selective fluorescent sensor based on 3-styrylated BODIPY.

K. Hanaoka, Takuya Terai, T. Nagano, 2011, Bioorganic & medicinal chemistry letters.

Development of a fluorescein analogue, TokyoMagenta, as a novel scaffold for fluorescence probes in red region.

K. Hanaoka, Takuya Terai, T. Nagano, 2011, Chemical communications.

Development of 2,6-carboxy-substituted boron dipyrromethene (BODIPY) as a novel scaffold of ratiometric fluorescent probes for live cell imaging.

Y. Fujikawa, Y. Urano, K. Hanaoka, 2009, Chemical communications.

Multiplexed single-molecule enzyme activity analysis for counting disease-related proteins in biological samples

Y. Urano, H. Noji, T. Okusaka, 2020, Science Advances.

Highly activatable and environment-insensitive optical highlighters for selective spatiotemporal imaging of target proteins.

M. Gonzalez-Gaitan, Y. Urano, K. Hanaoka, 2012, Journal of the American Chemical Society.

Detection of NAD(P)H-dependent enzyme activity by time-domain ratiometry of terbium luminescence.

Y. Urano, K. Hanaoka, Takuya Terai, 2016, Bioorganic & medicinal chemistry letters.

Evaluation of Enzymatic Activities in Living Systems with Small-molecular Fluorescent Substrate Probes

Y. Urano, Toru Komatsu, 2015, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

Near-infrared fluorescence probes for enzymes based on binding affinity modulation of squarylium dye scaffold.

K. Hanaoka, Takuya Terai, T. Nagano, 2012, Analytical chemistry.

Initial elementary processes in tetrafluoroethylene plasma: An ab initio molecular orbital study

Toru Komatsu, Kota Sato, S. Iwabuchi, 1993 .

Establishment of live-cell-based coupled assay system for identification of compounds to modulate metabolic activities of cells.

Y. Urano, K. Hanaoka, T. Nagano, 2021, Cell reports.

Fluorescence probe for lysophospholipase C/NPP6 activity and a potent NPP6 inhibitor.

Y. Fujikawa, K. Hanaoka, J. Aoki, 2011, Journal of the American Chemical Society.

Identification of tissue-restricted bioreaction suitable for in vivo targeting by fluorescent substrate library-based enzyme discovery.

Y. Urano, K. Hanaoka, Takuya Terai, 2015, Journal of the American Chemical Society.

Organelle-Specific, Rapid Induction of Molecular Activities and Membrane Tethering

Toru Komatsu, Takanari Inoue, Takanari Inoue, 2010, Nature Methods.

Optical properties of small Si-skeleton sheets: Ladder polysilanes

Y. Masumoto, Y. Kanemitsu, Katsunori Suzuki, 1993 .

Selective two-step labeling of proteins with an off/on fluorescent probe.

K. Hanaoka, Takuya Terai, T. Nagano, 2011, Chemistry.

A design strategy for small molecule-based targeted MRI contrast agents: their application for detection of atherosclerotic plaques.

K. Tamura, Yusuke Adachi, K. Hanaoka, 2014, Organic & biomolecular chemistry.

Meeting Proceedings ICBS2016-Translating the Power of Chemical Biology to Clinical Advances.

Toru Komatsu, Yugo Kuriki, Peter D Ycas, 2017, ACS chemical biology.

Development of a reversible fluorescent probe for reactive sulfur species, sulfane sulfur, and its biological application.

Y. Urano, K. Hanaoka, Takuya Terai, 2017, Chemical communications.

Reversible off-on fluorescence probe for hypoxia and imaging of hypoxia-normoxia cycles in live cells.

K. Hanaoka, Takuya Terai, T. Nagano, 2012, Journal of the American Chemical Society.

Design and synthesis of an enzyme activity-based labeling molecule with fluorescence spectral change.

Yasuteru Urano, Kazuya Kikuchi, Toru Komatsu, 2006, Journal of the American Chemical Society.

ICBS and ECBS Chemical Biology Meeting 2015 - Let Them Come to Berlin!

Toru Komatsu, Satpal Virdee, Toru Komatsu, 2016, ACS chemical biology.

Development of a Series of Practical Fluorescent Chemical Tools To Measure pH Values in Living Samples.

Y. Urano, K. Hanaoka, H. Arai, 2018, Journal of the American Chemical Society.

Toward total synthesis of cell function: Reconstituting cell dynamics with synthetic biology

Benjamin Lin, Toru Komatsu, Robert DeRose, 2016, Science Signaling.

Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide

Y. Urano, Yasuo Watanabe, K. Hanaoka, 2017, Scientific Reports.

A Fluorescent Probe for Rapid, High-Contrast Visualization of Folate-Receptor-Expressing Tumors in Vivo.

Y. Urano, K. Hanaoka, M. Miura, 2020, Angewandte Chemie.

A reversible near-infrared fluorescence probe for reactive oxygen species based on Te-rhodamine.

Y. Urano, K. Hanaoka, Takuya Terai, 2012, Chemical communications.

Rapid detection of metastatic lymph nodes of colorectal cancer with a gamma-glutamyl transpeptidase-activatable fluorescence probe

Y. Urano, K. Hanaoka, E. Otsuji, 2018, Scientific Reports.

Chemical toolbox for "live" biochemistry to understand enzymatic functions in living systems.

Yasuteru Urano, Toru Komatsu, Y. Urano, 2019, Journal of biochemistry.

Rapid and sensitive detection of early esophageal squamous cell carcinoma with fluorescence probe targeting dipeptidylpeptidase IV

Y. Urano, Y. Seto, M. Fukayama, 2016, Scientific Reports.

A cytosolically localized far-red to near-infrared rhodamine-based fluorescent probe for calcium ions.

Y. Ikegaya, Y. Urano, K. Hanaoka, 2020, The Analyst.

Design strategy for a near-infrared fluorescence probe for matrix metalloproteinase utilizing highly cell permeable boron dipyrromethene.

K. Hanaoka, Takuya Terai, T. Nagano, 2012, Journal of the American Chemical Society.

Synthesis of unsymmetrical Si-rhodamine fluorophores and application to a far-red to near-infrared fluorescence probe for hypoxia.

Y. Urano, K. Hanaoka, Takuya Terai, 2018, Chemical communications.

TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1.

Y. Urano, K. Hanaoka, Takuya Terai, 2013, Chemical communications.

Discovery of an F-actin–binding small molecule serving as a fluorescent probe and a scaffold for functional probes

Y. Urano, K. Hanaoka, K. Hirose, 2021, Science advances.

Design and Synthesis of an Activatable Photoacoustic Probe for Hypochlorous Acid.

Y. Urano, K. Hanaoka, T. Nagano, 2019, Analytical chemistry.

Development of a series of near-infrared dark quenchers based on Si-rhodamines and their application to fluorescent probes.

Y. Urano, K. Hanaoka, Takuya Terai, 2015, Journal of the American Chemical Society.

Development of hypoxia-sensitive Gd3+-based MRI contrast agents.

K. Hanaoka, Takuya Terai, T. Nagano, 2012, Bioorganic & medicinal chemistry letters.

Metabolic-Pathway-Oriented Screening Targeting S-Adenosyl-l-methionine Reveals the Epigenetic Remodeling Activities of Naturally Occurring Catechols.

Y. Urano, Yukihiro Itoh, Takayoshi Suzuki, 2019, Journal of the American Chemical Society.

Rational design of a near-infrared fluorescence probe for Ca2+ based on phosphorus-substituted rhodamines utilizing photoinduced electron transfer.

M. Iino, Y. Urano, K. Hanaoka, 2020, Chemistry, an Asian journal.

Synthesis of practical red fluorescent probe for cytoplasmic calcium ions with greatly improved cell-membrane permeability

Y. Ikegaya, Y. Urano, K. Hanaoka, 2017, Data in Brief.

A Fluorescent Probe for Rapid, High‐Contrast Visualization of Folate‐Receptor‐Expressing Tumors In Vivo

Y. Urano, K. Hanaoka, T. Nagano, 2020, Angewandte Chemie.

A protease activity-based machine-learning approach as a complementary tool for conventional diagnosis of diarrhea-predominant irritable bowel syndrome

Y. Urano, S. Fukudo, Toru Komatsu, 2023, Frontiers in microbiology.

Development of Chemical Tools to Monitor and Control Isoaspartyl Peptide Methyltransferase Activity.

Y. Urano, K. Hanaoka, Takuya Terai, 2017, Angewandte Chemie.

A Method to Rapidly Induce Organelle-Specific Molecular Activities and Membrane Tethering

Takanari Inoue, Toru Komatsu, 2014, Methods in molecular biology.

Rapid detection of metastatic lymph nodes of colorectal cancer with a gamma-glutamyl transpeptidase-activatable fluorescence probe

Y. Urano, K. Hanaoka, E. Otsuji, 2018, Scientific Reports.

Diced electrophoresis gel assay for screening enzymes with specified activities.

K. Hanaoka, B. Cravatt, Takuya Terai, 2013, Journal of the American Chemical Society.

Gliotoxin suppresses NF-κB activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC).

K. Hanaoka, K. Iwai, Y. Sasaki, 2015, ACS chemical biology.

Toward total synthesis of cell function: Reconstituting cell dynamics with synthetic biology

Allen K. Kim, Takanari Inoue, Benjamin Lin, 2016, Science Signaling.

Development of a far-red to near-infrared fluorescence probe for calcium ion and its application to multicolor neuronal imaging.

N. Matsuki, Y. Ikegaya, Naoya Takahashi, 2011, Journal of the American Chemical Society.

Development of an Azoreductase-based Reporter System with Synthetic Fluorogenic Substrates.

Y. Urano, K. Hanaoka, M. Tanokura, 2017, ACS chemical biology.

Development of a reversible fluorescent probe for reactive sulfur species, sulfane sulfur, and its biological application.

Y. Urano, K. Hanaoka, Takuya Terai, 2017, Chemical communications.

Highly activatable and environment-insensitive optical highlighters for selective spatiotemporal imaging of target proteins.

M. Gonzalez-Gaitan, Y. Urano, K. Hanaoka, 2012, Journal of the American Chemical Society.

Design strategy for germanium-rhodamine based pH-activatable near-infrared fluorescence probes suitable for biological applications

Hisataka Kobayashi, Y. Urano, K. Hanaoka, 2019, Communications Chemistry.

Selective ablation of β-galactosidase-expressing cells with a rationally designed activatable photosensitizer.

Y. Urano, Y. Ichikawa, K. Hanaoka, 2014, Angewandte Chemie.

Development of a fluorescein analogue, TokyoMagenta, as a novel scaffold for fluorescence probes in red region.

K. Hanaoka, Takuya Terai, T. Nagano, 2011, Chemical communications.

Development of a Sensitive Bioluminogenic Probe for Imaging Highly Reactive Oxygen Species in Living Rats.

Y. Urano, K. Hanaoka, Takuya Terai, 2015, Angewandte Chemie.

Synthesis of unsymmetrical Si-rhodamine fluorophores and application to a far-red to near-infrared fluorescence probe for hypoxia.

Y. Urano, K. Hanaoka, Takuya Terai, 2018, Chemical communications.

Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling method.

H. Okuno, Y. Urano, H. Bito, 2011, Journal of the American Chemical Society.

A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT)

Y. Urano, K. Hanaoka, Kazuo Takayama, 2024, Science advances.

Selective two-step labeling of proteins with an off/on fluorescent probe.

K. Hanaoka, Takuya Terai, T. Nagano, 2011, Chemistry.

Development of a fluorescent probe library enabling efficient screening of tumour-imaging probes based on discovery of biomarker enzymatic activities

Y. Urano, K. Hanaoka, H. Takamaru, 2022, Chemical science.

Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer.

Y. Urano, K. Hanaoka, Y. Seto, 2019, Bioconjugate chemistry.

Establishment of Molecular Design Strategy To Obtain Activatable Fluorescent Probes for Carboxypeptidases.

Y. Urano, K. Hanaoka, T. Ishizawa, 2018, Journal of the American Chemical Society.

Diced electrophoresis gel assay for screening enzymes with specified activities.

K. Hanaoka, B. Cravatt, Takuya Terai, 2013, Journal of the American Chemical Society.

Development and validation of an improved diced electrophoresis gel assay cutter-plate system for enzymomics studies.

Y. Urano, T. Nagano, Toru Komatsu, 2019, Biochimica et biophysica acta. Proteins and proteomics.

Discovery of Cell-Type-Specific and Disease-Related Enzymatic Activity Changes via Global Evaluation of Peptide Metabolism.

Y. Urano, K. Hanaoka, Takuya Terai, 2017, Journal of the American Chemical Society.

Rational design of boron dipyrromethene (BODIPY)-based photobleaching-resistant fluorophores applicable to a protein dynamics study.

Y. Urano, K. Hanaoka, Takuya Terai, 2011, Chemical communications.

Boron dipyrromethene as a fluorescent caging group for single-photon uncaging with long-wavelength visible light.

Y. Urano, K. Hanaoka, Takuya Terai, 2014, ACS chemical biology.