P. Hyslop

发表

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Weiming Xia, Paul Fraser, J. Rommens, 1997, Nature Medicine.

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Caleb Webber, Guy B. Williams, Mara Cercignani, 2019, Brain : a journal of neurology.

Mice lacking both presenilin genes exhibit early embryonic patterning defects.

A. Bernstein, A. Hadjantonakis, Hui Zheng, 1999, Genes & development.

Enhanced accumulation of tau in doubly transgenic mice expressing mutant βAPP and presenilin-1

D. Westaway, E. Matsubara, M. Shoji, 2006, Brain Research.

Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy

D. Westaway, E. Matsubara, M. Shoji, 2011, Journal of neuroscience research.

The APOE-epsilon4 allele and Alzheimer disease among African Americans, Hispanics, and whites.

W. Barker, D. Harwood, P. Hyslop, 1998, JAMA.

Enhanced accumulation of phosphorylated α‐synuclein in double transgenic mice expressing mutant β‐amyloid precursor protein and presenilin‐1

D. Westaway, E. Matsubara, M. Shoji, 2007 .

An African American family with early-onset Alzheimer disease and an APP (T714I) mutation

J. Hardy, J. Ringman, E. Rogaeva, 2005, Neurology.

Additive Effects of PS1 and APP Mutations on Secretion of the 42-Residue Amyloid β-Protein

D. Selkoe, S. Younkin, M. Citron, 1998, Neurobiology of Disease.

Functional characterization of novel presenilin-2 variants identified in human breast cancers

I. Andrulis, J. Knight, A. Bernstein, 2006, Oncogene.

Germline mutational analysis of presenilin 1 and APP genes in Jewish-Israeli individuals with familial or early-onset Alzheimer disease using denaturing gradient gel electrophoresis (DGGE)

J. Aharon-Peretz, J. Chapman, A. Korczyn, 1998, European Journal of Human Genetics.

A novel mutation of presenilin 1 in familial Alzheimer’s disease in Israel detected by denaturing gradient gel electrophoresis

J. Aharon-Peretz, J. Chapman, A. Korczyn, 1996, Human Genetics.

Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP

F. Checler, C. Sunyach, C. A. D. Costa, 2005, Neuron.

Meta-analysis of the Association Between Variants in SORL 1 and Alzheimer Disease

J. Haines, M. Pericak-Vance, M. Owen, 2011 .

The effects of APOE and tau gene variability on risk of frontotemporal dementia

E. Rogaeva, T. Kawarai, L. Bernardi, 2006, Neurobiology of Aging.

A randomized double-blind trial of the effects of hormone therapy on delayed verbal recall in older women

W. Snow, M. Tierney, R. Moineddin, 2009, Psychoneuroendocrinology.

Dietary composition modulates brain mass and solubilizable Aβ levels in a mouse model of aggressive Alzheimer's amyloid pathology

Patrick R Hof, Lap Ho, J. Buxbaum, 2009, Molecular Neurodegeneration.

Amyloid β accelerates phosphorylation of tau and neurofibrillary tangle formation in an amyloid precursor protein and tau double‐transgenic mouse model

D. Westaway, E. Matsubara, M. Shoji, 2010, Journal of neuroscience research.

A large Calabrian kindred segregating frontotemporal dementia

A. Paterson, T. Kawarai, A. Bruni, 2002, Journal of Neurology.

Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo

D. Holtzman, M. Sano, D. Westaway, 2009, Molecular Neurodegeneration.

Genetic and Real-World Clinical Data , Combined with Empirical Validation , Nominate Jak-Stat Signaling as a Target for Alzheimer ’ s Disease Therapeutic Development

Guy B. Williams, Nicole, Tobias C. Wood, 2019 .

Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta).

D. Holtzman, F. Heppner, A. Aguzzi, 2004, Alzheimer disease and associated disorders.

No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found

Janel O. Johnson, A. Singleton, J. Morris, 2004, Neuroscience Letters.

Enhanced accumulation of phosphorylated alpha-synuclein in double transgenic mice expressing mutant beta-amyloid precursor protein and presenilin-1.

D. Westaway, E. Matsubara, M. Shoji, 2007, Journal of neuroscience research.

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin,a component of the presenilin protein complex

R. Rozmahel, J. Woodgett, D. Westaway, 1999, Nature Medicine.

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Tobias C. Wood, Karen H. Adams, C. Webber, 2019, Brain : a journal of neurology.

Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease

Karen H. Adams, E. Bullmore, F. Turkheimer, 2023, Journal of Neuroinflammation.

Alzheimer Aβ Vaccination of Rhesus Monkeys (Macaca Mulatta)

D. Holtzman, F. Heppner, A. Aguzzi, 2004 .

Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes

J. Roder, D. Westaway, G. Carlson, 2000, Neurobiology of Aging.

Alzheimer’s Aβ vaccination of rhesus monkeys (Macaca mulatta)

D. Holtzman, F. Heppner, A. Aguzzi, 2004, Mechanisms of Ageing and Development.

Meta-analysis of the association between variants in SORL1 and Alzheimer disease.

Sandro Sorbi, Masatoshi Takeda, Eng King Tan, 2011, Archives of neurology.

Alzheimer's disease: advances in trafficking

R. Mayeux, P. Hyslop, 2008, The Lancet Neurology.