J. Yerbury

发表

Network Approaches to the Understanding of Alzheimer's Disease: From Model Organisms to Humans.

Giorgio Favrin, G. Favrin, D. Bean, 2016, Methods in molecular biology.

Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles

D. Saunders, K. Vine, J. Yerbury, 2017, Front. Neurosci..

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

A. Hill, I. Mackenzie, S. Plotkin, 2014, Proceedings of the National Academy of Sciences.

High-content analysis of proteostasis capacity in cellular models of amyotrophic lateral sclerosis (ALS)

D. Saunders, J. Yerbury, Isabella A. Lambert-Smith, 2021, bioRxiv.

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

M. Molloy, B. Shi, K. Williams, 2019, Cellular and Molecular Life Sciences.

The Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron Di ff erentiation

C. Stevens, M. Cabral-da-Silva, D. Saunders, 2019 .

The Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron Differentiation

C. Stevens, M. Cabral-da-Silva, D. Saunders, 2019, Cells.

TDP-43 is a ubiquitylation substrate of the SCFcyclin F complex

A. G. Redondo, I. Blair, Shu Yang, 2022, Neurobiology of Disease.

A copper chaperone–mimetic polytherapy for SOD1-associated amyotrophic lateral sclerosis

J. Yerbury, Gareth S. A. Wright, L. McAlary, 2022, The Journal of biological chemistry.

Non-Viral Vector-Mediated Gene Therapy for ALS: Challenges and Future Perspectives.

Gayathri R. Ediriweera, K. Vine, K. Thurecht, 2021, Molecular pharmaceutics.

Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity

J. Aquilina, J. Yerbury, L. McAlary, 2016, Frontiers in neuroscience.

Progress in biophysics and molecular biology proteostasis impairment and ALS.

D. Saunders, J. Yerbury, Isabella A. Lambert-Smith, 2022, Progress in biophysics and molecular biology.

Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS

D. Saunders, K. Vine, Jeremy S. Lum, 2020, iScience.

SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS

D. Saunders, K. Vine, J. Yerbury, 2018, Journal of Cell Science.

Extracellular wildtype and mutant SOD1 induces ER–Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells

A. Walker, J. Yerbury, J. Atkin, 2013, Cellular and Molecular Life Sciences.

P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons

N. Cashman, J. Yerbury, R. Sluyter, 2022, Purinergic Signalling.

Strategies to promote the maturation of ALS-associated SOD1 mutants: small molecules return to the fold

J. Yerbury, L. McAlary, 2019, Neural regeneration research.

Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis

J. Aquilina, J. Yerbury, L. McAlary, 2013, Scientific Reports.

Protein Aggregation in Amyotrophic Lateral Sclerosis

J. Yerbury, L. McAlary, Christen G. Chisholm, 2021, Spectrums of Amyotrophic Lateral Sclerosis.

Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions

D. Saunders, I. Blair, S. Warraich, 2015, Scientific Reports.

Quality control of protein folding in extracellular space

Elise M. Stewart, Mark R. Wilson, E. Stewart, 2005, EMBO reports.

CuATSM Protects Against the In Vitro Cytotoxicity of Wild-Type-Like Copper-Zinc Superoxide Dismutase Mutants but not Mutants That Disrupt Metal Binding.

S. Plotkin, J. Yerbury, L. McAlary, 2018, ACS chemical neuroscience.

The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS

C. Dobson, M. Vendruscolo, I. Blair, 2019, Neuroscience Letters.

The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis

C. Dobson, J. Kumita, J. Yerbury, 2017, Biochimica et biophysica acta. Molecular basis of disease.

Addition of exogenous SOD1 aggregates causes TDP-43 mislocalisation and aggregation

J. Yerbury, Rafaa Zeineddine, Isabella A. Lambert-Smith, 2017, Cell Stress and Chaperones.

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation

Mark R. Wilson, J. Kumita, J. Yerbury, 2017, Prion.

SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation

Elise M. Stewart, C. Dobson, G. Guillemin, 2015, Molecular Neurodegeneration.

Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms

C. Dobson, Mark R. Wilson, H. Ecroyd, 2013, FEBS letters.

α2-Macroglobulin and Haptoglobin Suppress Amyloid Formation by Interacting with Prefibrillar Protein Species*

C. Dobson, Mark R. Wilson, Sarah Meehan, 2009, Journal of Biological Chemistry.

Evaluation of Skin Fibroblasts from Amyotrophic Lateral Sclerosis Patients for the Rapid Study of Pathological Features

I. Blair, G. Nicholson, Katharine Y. Zhang, 2015, Neurotoxicity Research.

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

K. Schroder, T. Woodruff, Eduardo A. Albornoz, 2020, Glia.

Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex

M. Molloy, B. Shi, K. Williams, 2017, Open Biology.

Misfolding at the synapse: A role in amyotrophic lateral sclerosis pathogenesis?

Jeremy S. Lum, J. Yerbury, 2022, Frontiers in Molecular Neuroscience.

Mutant Cu/Zn Superoxide Dismutase (A4V) Turnover Is Altered in Cells Containing Inclusions

J. Yerbury, N. Farrawell, 2021, Frontiers in Molecular Neuroscience.

The small heat shock proteins B-crystallin and Hsp 27 suppress SOD 1 aggregation in vitro

H. Ecroyd, J. Yerbury, D. Gower, 2016 .

ALS-associated mutants of SOD1, TDP-43, FUS, C9ORF72 and UBQLN2 disrupt proteostasis in neuronal cell culture

J. Yerbury, Isabella A. Lambert-Smith, N. Farrawell, 2014 .

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

Jacob I. Ayers, D. Borchelt, N. Cashman, 2020, PloS one.

Chapter 6: The chaperone action of Clusterin and its putative role in quality control of extracellular protein folding.

Mark R. Wilson, S. Poon, J. Yerbury, 2009, Advances in cancer research.

Assessment of protein inclusions in cultured cells using automated image analysis

S. Plotkin, N. Cashman, J. Yerbury, 2022, STAR protocols.

Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways

A. Hill, B. J. Turner, N. Cashman, 2016, Cellular and Molecular Neurobiology.

The pivotal role of Ubiquitin-activating enzyme E1 (UBA1) in neuronal health and neurodegeneration.

D. Saunders, J. Yerbury, Isabella A. Lambert-Smith, 2020, The international journal of biochemistry & cell biology.

The trajectory taken by dimeric Cu/Zn superoxide dismutase through the protein unfolding and dissociation landscape is modulated by salt-bridge formation.

J. Benesch, J. Aquilina, J. Yerbury, 2019, Analytical chemistry.

Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons

Adam J. Svahn, M. Graeber, J. Yerbury, 2018, Acta Neuropathologica.

Extracellular chaperones and proteostasis.

Mark R. Wilson, H. Ecroyd, J. Yerbury, 2013, Annual review of biochemistry.

Clusterin facilitates in vivo clearance of extracellular misfolded proteins

Christopher M. Dobson, Andrew Katsifis, Paula Berghofer, 2011, Cellular and Molecular Life Sciences.

Clusterin facilitates in vivo clearance of extracellular misfolded proteins.

C. Dobson, Mark R. Wilson, I. Greguric, 2011, Cellular and molecular life sciences : CMLS.

Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells

N. Cashman, J. Yerbury, Neil R Cashman, 2018, Scientific Reports.

Dysregulation of microRNA biogenesis machinery and microRNA/RNA ratio in skeletal muscle of amyotrophic lateral sclerosis mice

A. Russell, S. Lamon, S. Ngo, 2017, Muscle & nerve.

Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

S. Plotkin, N. Cashman, J. Yerbury, 2019, Front. Mol. Neurosci..

The heat shock response in neurons and astroglia and its role in neurodegenerative diseases

H. Ecroyd, L. Ooi, J. Yerbury, 2017, Molecular Neurodegeneration.

Clusterin protects neurons against intracellular proteotoxicity

C. Dobson, Colin Smith, Mark R. Wilson, 2017, Acta Neuropathologica Communications.

Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises

Yee Lian Chew, Jeremy S. Lum, N. Cashman, 2020, Frontiers in Cellular Neuroscience.

Unbiased Label-Free Quantitative Proteomics of Cells Expressing Amyotrophic Lateral Sclerosis (ALS) Mutations in CCNF Reveals Activation of the Apoptosis Pathway: A Workflow to Screen Pathogenic Gene Mutations

C. Stevens, B. Shi, I. Blair, 2021, Frontiers in Molecular Neuroscience.

The prion-like nature of amyotrophic lateral sclerosis.

N. Cashman, J. Yerbury, L. McAlary, 2020, Progress in molecular biology and translational science.

Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS

C. Dobson, G. Favrin, M. Vendruscolo, 2017, Proceedings of the National Academy of Sciences.

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

Robert H. Brown, R. Petersen, B. Boeve, 2016, Nature Communications.

Evaluation of Skin Fibroblasts from Amyotrophic Lateral Sclerosis Patients for the Rapid Study of Pathological Features

I. Blair, G. Nicholson, Katharine Y. Zhang, 2015, Neurotoxicity Research.

The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro

Jodi A. Lee, H. Ecroyd, J. Yerbury, 2013, Cell Stress and Chaperones.

The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseases

J. Yerbury, Rafaa Zeineddine, 2015, Front. Physiol..

Novel behavioural characteristics of the superoxide dismutase 1 G93A (SOD1G93A) mouse model of amyotrophic lateral sclerosis include sex‐dependent phenotypes

J. Yerbury, T. Karl, F. Kreilaus, 2020, Genes, brain, and behavior.

Walking the tightrope: proteostasis and neurodegenerative disease

A. Dillin, D. Saunders, P. Beart, 2016, Journal of neurochemistry.

Extracellular Chaperones

Mark R. Wilson, H. Ecroyd, J. Yerbury, 2012 .

Extracellular Chaperones.

Mark R. Wilson, H. Ecroyd, J. Yerbury, 2010, Topics in current chemistry.

The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro

Jodi A. Lee, H. Ecroyd, J. Yerbury, 2012, Cell Stress and Chaperones.

Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis: A Study of Humans and a Transgenic Mouse Model

G. Stewart, D. Booth, S. Nutt, 2018, JAMA neurology.

Roles of extracellular chaperones in amyloidosis.

Mark R. Wilson, J. Yerbury, A. Wyatt, 2012, Journal of molecular biology.

Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity.

Mark R. Wilson, S. Poon, J. Yerbury, 2008, Molecular bioSystems.

Protease activation of alpha2-macroglobulin modulates a chaperone-like action with broad specificity.

Mark R. Wilson, J. Yerbury, K. French, 2008, Biochemistry.

The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures

C. Dobson, Mark R. Wilson, Sarah Meehan, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

ANS binding reveals common features of cytotoxic amyloid species.

C. Dobson, G. Favrin, Mark R. Wilson, 2010, ACS chemical biology.

Rapid flow cytometric measurement of protein inclusions and nuclear trafficking

M. Wilson, H. Ecroyd, J. Yerbury, 2016, Scientific Reports.

p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death

R. Layfield, J. Yerbury, L. L. Flynn, 2021, Scientific Reports.

Proteome Homeostasis Dysfunction: A Unifying Principle in ALS Pathogenesis

J. Yerbury, L. McAlary, N. Farrawell, 2020, Trends in Neurosciences.

SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation

A. Suhrbier, W. Schroder, D. Saunders, 2015, PloS one.

Protein aggregates stimulate macropinocytosis facilitating their propagation

J. Yerbury, 2016, Prion.

Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype

I. Campbell, J. Yerbury, Wen Li, 2013, Glia.

Assessment of metal concentrations in the SOD1G93A mouse model of amyotrophic lateral sclerosis and its potential role in muscular denervation, with particular focus on muscle tissue

B. Kalmar, H. Ecroyd, J. Yerbury, 2018, Molecular and Cellular Neuroscience.

Assessment of metal concentrations in the SOD 1 G 93 A mouse model of 1 amyotrophic lateral sclerosis and its potential role in muscular denervation , with 2 particular focus on muscle tissue 3 4

B. Kalmar, H. Ecroyd, J. Yerbury, 2018 .

Longitudinal assessment of metal concentrations and copper isotope ratios in the G93A SOD1 mouse model of amyotrophic lateral sclerosis.

H. Ecroyd, J. Yerbury, A. Dosseto, 2017, Metallomics : integrated biometal science.

Misfolded Polyglutamine, Polyalanine, and Superoxide Dismutase 1 Aggregate via Distinct Pathways in the Cell*

A. Hill, B. J. Turner, D. Hatters, 2014, The Journal of Biological Chemistry.

Protein Chemistry of Amyloid Fibrils and Chaperones: Implications for Amyloid Formation and Disease

J. Kumita, J. Yerbury, 2010 .

Extracellular Chaperones and Amyloids

Mark R. Wilson, S. Poon, J. Yerbury, 2008 .

Structural Characterization of Clusterin-Chaperone Client Protein Complexes*

Mark R. Wilson, J. Yerbury, A. Wyatt, 2009, The Journal of Biological Chemistry.

Extracellular chaperones modulate the effects of Alzheimer’s patient cerebrospinal fluid on Aβ1-42 toxicity and uptake

Mark R. Wilson, J. Yerbury, 2009, Cell Stress and Chaperones.

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation

S. Antonyuk, S. Hasnain, L. Banci, 2018, Nature Communications.

Disabled in academia: to be or not to be, that is the question

J. Yerbury, Rachel Yerbury, 2021, Trends in Neurosciences.

Behavioural effects of cage systems on the G93A Superoxide Dismutase 1 transgenic mouse model for amyotrophic lateral sclerosis

J. Yerbury, R. Chung, T. Karl, 2021, Genes, brain, and behavior.

The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice

B. J. Turner, J. Yerbury, D. Watson, 2020, Purinergic Signalling.

Characterisation of novel extracellular molecular chaperones and their effects on amyloid formation

J. Yerbury, 2007 .

The acute phase protein haptoglobin is a mammalian extracellular chaperone with an action similar to clusterin.

M. Rybchyn, Mark R. Wilson, J. Yerbury, 2005, Biochemistry.

Cells Overexpressing ALS-Associated SOD1 Variants Are Differentially Susceptible to CuATSM-Associated Toxicity.

Jeremy S. Lum, J. Yerbury, L. McAlary, 2022, ACS chemical neuroscience.

Distinct Pathways in the Cell Superoxide Dismutase 1 Aggregate via Misfolded Polyglutamine , Polyalanine , and Molecular Bases of Disease :

A. Hill, B. J. Turner, D. Hatters, 2014 .

P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice

J. Yerbury, D. Watson, R. Sluyter, 2017, PeerJ.

P2X7 Receptor Activation Induces Reactive Oxygen Species Formation and Cell Death in Murine EOC13 Microglia

J. Yerbury, R. Sluyter, Rachael Bartlett, 2013, Mediators of inflammation.

P 2 X 7 receptor activation induces reactive oxygen species formation and cell death in murine EOC 13 microglia

J. Yerbury, R. Sluyter, Rachael Bartlett, 2017 .

Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis

C. Dobson, Mark R. Wilson, J. Kumita, 2019, Biochemistry.

CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1G93A mice with a C57BL/6 background

P. Crouch, K. Vine, Jeremy S. Lum, 2021, Scientific Reports.

Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells

D. Cox, A. Walker, H. Ecroyd, 2020, Journal of Cell Science.

Ubiquitin homeostasis disruption, a common cause of proteostasis collapse in amyotrophic lateral sclerosis?

Jeremy S. Lum, J. Yerbury, N. Farrawell, 2022, Neural regeneration research.

Dynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosis

Yossi Buskila, Lezanne Ooi, Y. Buskila, 2019, Cell Death & Disease.

Selenium-based compounds: Emerging players in the ever-unfolding story of SOD1 in amyotrophic lateral sclerosis.

N. Cashman, J. Yerbury, 2020, EBioMedicine.

Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

S. Plotkin, N. Cashman, J. Yerbury, 2020, Frontiers in Molecular Neuroscience.

Clusterin interacts with Paclitaxel and confer Paclitaxel resistance in ovarian cancer.

M. Birrer, S. Mok, K. Wong, 2008, Neoplasia.

The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species.

Mireille Dumoulin, Christopher M Dobson, Elise M. Stewart, 2007, Journal of molecular biology.

ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis.

D. Saunders, I. Blair, L. Ooi, 2023, Human Molecular Genetics.

CRISPR-mediated adaptive immune systems in bacteria and archaea.

Rotem Sorek, Mark R. Wilson, J. Berger, 2013, Annual review of biochemistry.

P2X7 receptor antagonism in amyotrophic lateral sclerosis

J. Yerbury, R. Sluyter, D. Ly, 2017, Neural Regeneration Research.

Photosystem II: the reaction center of oxygenic photosynthesis.

David W. Russell, J. Berger, David J. Vinyard, 2013, Annual review of biochemistry.

Vulnerability of the spinal motor neuron presynaptic terminal sub-proteome in ALS

M. Vendruscolo, Jeremy S. Lum, J. Yerbury, 2022, Neuroscience Letters.

SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS

J. Yerbury, P. Ciryam, J. McKenna, 2017, bioRxiv.

Research Online Research Online The metastability of the proteome of spinal motor neurons underlies their The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS selective vulnerability in ALS

L. Ooi, J. Yerbury, P. Ciryam, 2020 .

α2-Macroglobulin and Haptoglobin Suppress Amyloid Formation by Interacting with Prefibrillar Protein Species*

C. Dobson, Mark R. Wilson, Sarah Meehan, 2009, Journal of Biological Chemistry.

Extracellular chaperones.

Mark R. Wilson, H. Ecroyd, J. Yerbury, 2013, Topics in current chemistry.

Therapeutic targets in extracellular protein deposition diseases.

S. Poon, J. Yerbury, A. Wyatt, 2009, Current medicinal chemistry.

Roles of extracellular chaperones in amyloidosis.

Mark R. Wilson, J. Yerbury, A. Wyatt, 2012, Journal of molecular biology.

Rapid flow cytometric measurement of protein inclusions and nuclear trafficking

H. Ecroyd, J. Yerbury, L. McAlary, 2016, Scientific Reports.

RNA-binding properties orchestrate TDP-43 homeostasis through condensate formation in vivo

J. Yerbury, M. Morsch, R. Radford, 2024, Nucleic acids research.

Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS

Jared R. Auclair, Joseph P. Salisbury, G. Petsko, 2024, PLoS biology.

THEME 9 IN VITRO EXPERIMENTAL MODELS

J. Yerbury, Isabella A. Lambert-Smith, N. Farrawell, 2014, Amyotrophic lateral sclerosis & frontotemporal degeneration.

High-content analysis of proteostasis capacity in cellular models of amyotrophic lateral sclerosis (ALS)

J. Yerbury, Isabella A. Lambert-Smith, Darren N. Saunders, 2024, Scientific reports.