P. D. Lawley

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Effects of some chemical mutagens and carcinogens on nucleic acids.

P. D. Lawley, 1966, Progress in nucleic acid research and molecular biology.

Interaction studies with DNA. III. The effect of changes in sodium ion concentration, pH and temperature on the ultra-violet absorption spectrum of sodium thymonucleate.

P. D. Lawley, 1956, Biochimica et biophysica acta.

The reaction of melphalan with deoxyguanosine and deoxyguanylic acid.

P. D. Lawley, M. Osborne, 1992, Chemico-biological interactions.

The reaction of mono- and di-functional alkylating agents with nucleic acids.

P. D. Lawley, P. Brookes, 1961, The Biochemical journal.

766. The alkylation of guanosine and guanylic acid

P. D. Lawley, P. Brookes, 1961 .

The reaction of mustard gas with nucleic acids in vitro and in vivo.

P. D. Lawley, P. Brookes, 1960, The Biochemical journal.

Methylation of ribonucleic acid by the carcinogens dimethyl sulphate, N-methyl-N-nitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine. Comparisons of chemical analyses at the nucleoside and base levels.

P. D. Lawley, S. A. Shah, By P. D. Lawley, 1972, The Biochemical journal.

Methylation of DNA by N-Methyl-N-nitrosourethane and N-Methyl-N-nitroso-N′-nitroguanidine

P. D. Lawley, P. D. LAWLEY, 1968, Nature.

Increased urinary excretion of nucleic acid and nicotinamide derivatives by rats after treatment with alkylating agents.

B. Chu, P. D. Lawley, 1975, Chemico-biological interactions.

Ionization of DNA bases or base analogues as a possible explanation of mutagenesis, with special reference to 5-bromodeoxyuridine.

P. D. Lawley, P. Brookes, 1962, Journal of molecular biology.

Alkylation of DNA by the nitrogen mustard bis(2-chloroethyl)methylamine.

P. D. Lawley, M. Osborne, D. E. Wilman, 1995, Chemical research in toxicology.

Nature of Alkylation Lesions and Their Repair: Significance for Ideas on Mutagenesis

S. Venitt, P. D. Lawley, P. Brookes, 2008 .

Effects on DNA: Chemical Methods

P. D. Lawley, P. Brookes, 1971 .

Mode of action of methylating carcinogens: comparative studies of murine and human cells.

P. D. Lawley, I. Olsen, G. Harris, 1981, Carcinogenesis.

Alkylation of deoxyribonucleic acid by carcinogens dimethyl sulphate, ethyl methanesulphonate, N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea. Relative reactivity of the phosphodiester site thymidylyl(3'-5')thymidine.

P. D. Lawley, D. Swenson, Pollards, 1978, The Biochemical journal.

Identification of the methyl phosphotriester of thymidylyl (3',5')thymidine as a product from reaction of DNA with the carcinogen N-methyl-N-nitrosourea.

P. Farmer, P. D. Lawley, D. Swenson, 1976, Chemico-biological interactions.

Some chemical aspects of dose-response relationships in alkylation mutagenesis.

P. D. Lawley, 1974, Mutation research.

Crystal Size and Fluorescence Intensity

E. J. Bowen, P. D. Lawley, 1949, Nature.

FURTHER STUDIES ON THE ALKYLATION OF NUCLEIC ACIDS AND THEIR CONSTITUENT NUCLEOTIDES.

P. D. Lawley, P. Brookes, 1963, The Biochemical journal.

DNA as a target of alkylating carcinogens.

P. D. Lawley, 1980, British medical bulletin.

DNA adducts from chemotherapeutic agents.

D. Phillips, P. D. Lawley, 1996, Mutation research.

Mutagens as carcinogens: development of current concepts.

P. D. Lawley, 1989, Mutation research.

Effects of alkylating agents on the induced synthesis of beta-galactosidase by Escherichia coli Bs-1.

S. Venitt, P. D. Lawley, P. Brookes, 1968, Biochimica et biophysica acta.

Molecular Mechanism of the Cytotoxic Action of Difunctional Alkylating Agents and of Resistance to this Action

P. D. Lawley, P. Brookes, P. D. LAWLEY, 1965, Nature.

Cytotoxicity of alkylating agents towards sensitive and resistant strains of Escherichia coli in relation to extent and mode of alkylation of cellular macromolecules and repair of alkylation lesions in deoxyribonucleic acids.

P. D. Lawley, P. Brookes, 1968, The Biochemical journal.

Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure liquid chromatography.

W. Warren, P. D. Lawley, D. Swenson, 1978, The Biochemical journal.

Removal of minor methylation products 7-methyladenine and 3-methylguanine from DNA of Escherichia coli treated with dimethyl sulphate.

W. Warren, P. D. Lawley, 1976, Chemico-biological interactions.

Methylation of DNA in various organs of C57B1 mice by a carcinogenic dose of N-methyl-N-nitrosourea and stabiltty of some methylation products up to 18 hours.

P. D. Lawley, J. Frei, 1975, Chemico-biological interactions.

Specific excision of methylation products from DNA of Escherichia coli treated with N-methyl-N'-nitro-N-nitrosoguanidine.

P. D. Lawley, D. J. Orr, 1970, Chemico-biological interactions.

Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N'-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation.

P. D. Lawley, C. J. Thatcher, Carolyn J. Thatcher, 1970, The Biochemical journal.

Historical origins of current concepts of carcinogenesis.

P. D. Lawley, 1994, Advances in cancer research.

Mechanism of Action of Alkylating Agents: Comparisons with other Cytotoxic, Mutagenic and Carcinogenic Agents

P. D. Lawley, 1966 .

Alkylation of DNA by melphalan with special reference to adenine derivatives and adenine-guanine cross-linking.

P. D. Lawley, M. Osborne, 1993, Chemico-biological interactions.

The relative reactivities of deoxyribonucleotides and of the bases of DNA towards alkylating agents.

P. D. Lawley, 1957, Biochimica et biophysica acta.

Methylation of adenine in deoxyadenylic acid or deoxyribonucleic acid at N-7.

P. D. Lawley, P. Brookes, 1964, The Biochemical journal.

112. The methylation of adenosine and adenylic acid

P. D. Lawley, P. Brookes, 1960 .

Time course of O6-methylguanine removal from DNA of N-methyl-N-nitrosourea-treatedhuman fibroblasts

A. Medcalf, P. D. Lawley, A. S. C. Medcalf, 1981, Nature.

Theory of tumour initiation by chemical carcinogens: dependence of activity on structure of ultimate carcinogen.

A. Dipple, P. D. Lawley, P. Brookes, 1968, European journal of cancer.

Interstrand cross-linking of DNA by difunctional alkylating agents.

P. D. Lawley, P. Brookes, 1967, Journal of molecular biology.

254. The methylation of cystosine and cytidine

P. D. Lawley, P. Brookes, 1962 .

Evidence for the Binding of Polynuclear Aromatic Hydrocarbons to the Nucleic Acids of Mouse Skin : Relation between Carcinogenic Power of Hydrocarbons and their Binding to Deoxyribonucleic Acid

P. D. Lawley, P. Brookes, 1964, Nature.

Increased urinary excretion of labelled deoxyribonucleosides in rats with stable pre-labelled DNA treated with methyl methanesulphonate or nitrogen mustard.

B. Chu, P. D. Lawley, 1975, Chemico-biological interactions.

Increased urinary excretion of pyrimidine and nicotinamide derivatives in rats treated with methyl methane-sulphonate

B. Chu, P. D. Lawley, 1974 .

Methylation of nucleic acids by 2,2-dichlorovinyl dimethyl phosphate (dichlorvos, DDVP).

P. D. Lawley, S. A. Shah, D. J. Orr, 1974, Chemico-biological interactions.

The action of mono- and di-functional sulphur mustards on the ribonucleic acid-containing bacteriophage mu2.

P. D. Lawley, P. Edwards, K. V. Shooter, 1971, The Biochemical journal.

REACTION OF SOME MUTAGENIC AND CARCINOGENIC COMPOUNDS WITH NUCLEIC ACIDS.

P. D. Lawley, P. Brookes, 1964, Journal of cellular and comparative physiology.

EVIDENCE FOR THE ACTION OF ALKYLATING AGENTS ON DEOXYRIBONUCLEIC ACID.

P. D. Lawley, P. Brookes, 1963, Experimental cell research.

Reaction of alkylating mutagens and carcinogens with nucleic acids: detection and estimation of a small extent of methylation at O-6 of guanine in DNA by methyl methanesulphonate in vitro.

P. D. Lawley, S. A. Shah, 1972, Chemico-biological interactions.

Tissue distribution and mode of DNA methylation in mice by methyl methanesulphonate and N-methyl-N′-nitro-N-nitrosoguanidine: Lack of thymic lymphoma induction and low extent of methylation of target tissue DNA at O-6 of guanine

P. D. Lawley, J. Frei, 1976 .

Methylation of DNA by 3H-14C-methyl-labelled N-methyl-N-nitrosourea--evidence for transfer of the intact methyl group.

P. D. Lawley, S. A. Shah, 1973, Chemico-biological interactions.

EFFECTS OF ALKYLATING AGENTS ON T2 AND T4 BACTERIOPHAGES.

P. D. Lawley, P. Brookes, 1963, The Biochemical journal.

Inactivation of bacteriophage T7 by mono- and difunctional sulphur mustards in relation to cross-linking and depurination of bacteriophage DNA.

P. D. Lawley, P. Edwards, K. V. Shooter, 1969, Journal of molecular biology.

Specific excision of ethylated purines from DNA of Escherichia coli treated with N-ethyl-N-nitrosourea.

W. Warren, P. D. Lawley, 1975, Chemico-biological interactions.

Isolation and identification of products from alkylation of nucleic acids: ethyl- and isopropyl-purines.

M. Jarman, P. D. Lawley, D. J. Orr, 1975, The Biochemical journal.

Repair of chemical carcinogen-induced damage in DNA of human lymphocytes and lymphoid cell lines--studies of the kinetics of removal of O6-methylguanine and 3-methyladenine.

I. Roitt, P. Lydyard, E. Phillips, 1986, Chemico-biological interactions.

Reaction products from N-methyl-N-nitrosourea and deoxyribonucleic acid containing thymidine residues. Synthesis and identification of a new methylation product, O4-methylthymidine.

P. Farmer, M. Jarman, P. D. Lawley, 1973, The Biochemical journal.

Alkylation by propylene oxide of deoxyribonucleic acid, adenine, guanosine and deoxyguanylic acid.

M. Jarman, P. D. Lawley, 1972, The Biochemical journal.

Alkylation of DNA and its aftermath.

P. D. Lawley, 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

Concepts of carcinogenesis

P. D. Lawley, 1987 .

N-Nitroso Compounds

P. D. Lawley, 1990 .

Reaction of N-methyl-N-nitrosourea (MNUA) with 32P-labelled DNA: evidence for formation of phosphotriesters.

P. D. Lawley, 1973, Chemico-biological interactions.

Reaction of alkylating mutagens and carcinogens with nucleic acids: N-3 of guanine as a site of alkylation by N-methyl-N-nitrosourea and dimethyl sulphate.

P. D. Lawley, S. A. Shah, D. J. Orr, 1972, Chemico-biological interactions.

The preparation and properties of some benzylated nucleosides.

A. Dipple, P. D. Lawley, P. Brookes, 1968, Journal of the Chemical Society. Perkin transactions 1.

Increased sensitivity of lymphocytes from patients with systemic autoimmune diseases to DNA alkylation by the methylating carcinogen N-methyl-N-nitrosourea.

I. Hill, A. Denman, P. D. Lawley, 1988, Annals of the rheumatic diseases.

Deficient repair of O6-methylguanine in lymphocytes from rheumatoid arthritis families may be an acquired defect.

I. Roitt, P. Lydyard, P. D. Lawley, 1988, Clinical and experimental immunology.

DEFECTIVE REPAIR OF 06-METHYLGUANINE IN AUTOIMMUNE DISEASES

A. Denman, P. D. Lawley, W. Hylton, 1982, The Lancet.

Acidic Dissociation of 7 : 9-Dialkylguanines and its Possible Relation to Mutagenic Properties of Alkylating Agents

P. D. Lawley, P. Brookes, 1961, Nature.

Interaction studies with DNA. I. The binding of rosaniline at low ratio of concentrations rosaniline: DNA, and competitive effect of sodium and other metal cations.

P. D. Lawley, 1956, Biochimica et biophysica acta.

Biomethylation of deoxyribonucleic acid in cultured human tumour cells (HeLa). Methylated bases other than 5-methylcytosine not detected.

P. D. Lawley, S. A. Shah, A. R. Crathorn, 1972, The Biochemical journal.

Differences in the patterns of methylation in rat liver ribosomal ribonucleic acid after reaction in vivo with methyl methanesulphonate and NN-dimethylnitrosamine.

A. Craig, P. O'connor, P. D. Lawley, 1972, The Biochemical journal.

The removal of alkylation products from the DNA of Escherichia coli cells treated with the carcinogens N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea: influence of growth conditions and DNA repair defects.

W. Warren, P. D. Lawley, 1980, Carcinogenesis.

Molecular mechanisms in alkylation mutagenesis. Induced reversion of bacteriophage T4rII AP72 by ethyl methanesulphonate in relation to extent and mode of ethylation of purines in bacteriophage deoxyribonucleic acid.

P. D. Lawley, C. N. Martin, 1975, The Biochemical journal.

Cellular reactions of O6-methylguanine, a product of some alkylating carcinogens.

C. T. Miller, P. D. Lawley, S. A. Shah, 1973, The Biochemical journal.

The molecular basis for biological inactivation of nucleic acids. The action of methylating agents on the ribonucleic acid-containing bacteriophage R17.

P. D. Lawley, S. A. Shah, K. V. Shooter, 1974, The Biochemical journal.

Methylated bases in liver nucleic acids from rats treated with dimethylnitrosamine

P. Magee, P. D. Lawley, P. Swann, 1968 .

Induction of thymomas by N-methyl-N-nitrosourea in AKR mice: interaction between the chemical carcinogen and endogenous murine leukaemia viruses.

C. Cooper, W. Warren, P. D. Lawley, 1987, Carcinogenesis.

Thymomas induced by simple alkylating agents in C57BL/Cbi mice: kinetics of the dose response.

P. D. Lawley, J. Frei, 1980, Journal of the National Cancer Institute.

The susceptibility of inbred mice to the production of malignant thymoma by N-methyl-N-nitrosourea.

P. D. Lawley, G. Harris, 1994, Carcinogenesis.

Autoimmune haemolytic disease in mice after exposure to a methylating carcinogen.

P. D. Lawley, P. Chandler, M. Jones, 1983, Immunology.

Reaction of hydroxylamine at high concentration with deoxycytidine or with polycytidylic acid: Evidence that substitution of amino groups in cytosine residues by hydroxylamino is a primary reaction, and the possible relevance to hydroxylamine mutagenesis

P. D. Lawley, 1967 .

Products from alkylation of DNA in cells by melphalan: human soft tissue sarcoma cell line RD and Escherichia coli WP2.

W. Warren, P. D. Lawley, M. Osborne, 1995, Chemico-biological interactions.

Direct assay for O6-methylguanine-DNA methyltransferase and comparison of detection methods for the methylated enzyme in polyacrylamide gels and electroblots.

E. Gardner, G. Major, P. D. Lawley, 1991, The Biochemical journal.

Purification to homogeneity and partial amino acid sequence of a fragment which includes the methyl acceptor site of the human DNA repair protein for O6-methylguanine.

E. Gardner, G. Major, P. D. Lawley, 1990, Nucleic acids research.

"Excision" of bases from DNA methylated by carcinogens in vivo and its possible significance in mutagenesis and carcinogenesis.

P. D. Lawley, 1975, Basic life sciences.

Increased urinary excretion of pyrimidine and nicotinamide derivatives in rats treated with methyl methanesulphonate.

B. Chu, P. D. Lawley, 1974, Chemico-biological interactions.

THE ACTION OF ALKYLATING AGENTS ON DEOXYRIBONUCLEIC ACID IN RELATION TO BIOLOGICAL EFFECTS OF THE ALKYLATING AGENTS.

P. D. Lawley, P. Brookes, 1963, Experimental cell research.

Chemical induction of thymomas in AKR mice: Interaction of chemical carcinogens and endogenous murine leukemia viruses. Comparison of N‐methyl‐N‐nitrosourea and methyl methanesulphonate

C. Cooper, W. Warren, Jeremy Clark, 1990, Molecular carcinogenesis.

Alkylation of DNA by melphalan in relation to immunoassay of melphalan-DNA adducts: characterization of mono-alkylated and cross-linked products from reaction of melphalan with dGMP and GMP.

M. Tilby, P. Farmer, P. D. Lawley, 1990, Chemico-biological interactions.

Chemical Mutagens

J. Drake, R. Mortimer, T. Manney, 1971, Springer US.

Interaction studies with DNA. IV. The binding of 5-aminoacridine studied fluorimetrically, and its comparison with the binding of rosaniline.

P. D. Lawley, 1956, Biochimica et biophysica acta.

Interaction studies with DNA. II. The binding of dimeric and polymeric rosaniline by sodium thymonucleate and the metachromatic effect.

P. D. Lawley, 1956, Biochimica et biophysica acta.

The action of alkylating agents on deoxyribonucleic acid

P. D. Lawley, 1961 .

Chemical Mutagens

J. Drake, J. Crow, R. Mortimer, 1971, Springer US.

Methylation of Cellular DNA by the Carcinogen N-Methyl-N-Nitrosourea and Removal of Methylpurines — Comparisons of Escherichia coli, Mouse and Human Cells

P. D. Lawley, 1981 .

A monofunctional derivative of melphalan: preparation, DNA alkylation products, and determination of the specificity of monoclonal antibodies that recognize melphalan-DNA adducts.

A. Hall, K. Gould, M. Tilby, 1998, Chemical research in toxicology.