I. Wainer

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Labetalol pharmacokinetics and pharmacodynamics: Evidence of stereoselective disposition

M. Bottorff, R. Lalonde, T. O'Rear, 1990, Clinical pharmacology and therapeutics.

A pilot study of plasma metabolomic patterns from patients treated with ketamine for bipolar depression: evidence for a response‐related difference in mitochondrial networks

G. Laje, C. Zarate, C. Barbas, 2014, British journal of pharmacology.

Prediction of chiral chromatographic separations using combined multivariate regression and neural networks.

I. Wainer, T. D. Booth, K. Azzaoui, 1997, Analytical chemistry.

Enantioselective induction of cyclophosphamide metabolism by phenytoin.

M. Williams, I. Wainer, M. Ducharme, 1999, Chirality.

Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss

J. Marshall, I. Wainer, P. Bhargava, 2001, British Journal of Cancer.

The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein.

I. Wainer, M. Ducharme, D. Edwards, 2002, Life sciences.

Use of a human serum albumin-based stationary phase for high-performance liquid chromatography as a tool for the rapid determination of drug-plasma protein binding.

I. Wainer, T. Noctor, M. Díaz-Pérez, 1993, Journal of pharmaceutical sciences.

Direct stereochemical resolution of aspartame stereoisomers and their degradation products by high-performance liquid chromatography on a chiral crown ether based stationary phase.

S. Motellier, I. Wainer, 1990, Journal of chromatography.

Uniformly-sized, molecularly imprinted polymers for nicotine by precipitation polymerization.

J. Haginaka, R. Moaddel, I. Wainer, 2006, Journal of chromatography. A.

Screening of tobacco smoke condensate for nicotinic acetylcholine receptor ligands using cellular membrane affinity chromatography columns and missing peak chromatography.

J. Haginaka, A. Maciuk, R. Moaddel, 2008, Journal of pharmaceutical and biomedical analysis.

Automated ligand fishing using human serum albumin-coated magnetic beads.

Qing Yang, M. Marszałł, R. Moaddel, 2007, Analytical chemistry.

The in Situ Acetylation of an Immobilized Human Serum Albumin Chiral Stationary Phase for High-Performance Liquid Chromatography in the Examination of Drug–Protein Binding Phenomena

I. Wainer, T. Noctor, 1992, Pharmaceutical Research.

Resolution of enantiomeric amides on a cellulose tribenzoate chiral stationary phase. Mobile phase modifier effects on retention and stereo-selectivity.

I. Wainer, M. Alembik, E. Smith, 1987, Journal of chromatography.

Resolution of enantiomeric aromatic alcohols on a cellulose tribenzoate high-performance liquid chromatography chiral stationary phase : A proposed chiral recognition mechanism

I. Wainer, R. Stiffin, T. Shibata, 1987 .

Enantioselective pharmacokinetics of (R)- and (S)-ketamine after a 5-day infusion in patients with complex regional pain syndrome.

R. Schwartzman, D. Mager, M. Goldberg, 2011, Chirality.

The therapeutic promise of single enantiomers: introduction

I. Wainer, 2001, Human psychopharmacology.

Liquid chromatographic method for the simultaneous determination of caffeine and fourteen caffeine metabolites in urine.

I. Wainer, N. Markoglou, E. K. Bendriss, 2000, Journal of chromatography. B, Biomedical sciences and applications.

The Impact of Stereochemistry on Drug Development and Use

H. Aboul‐Enein, I. Wainer, 1997 .

Prediction of drug binding to melanin using a melanin-based high-performance liquid chromatographic stationary phase and chemometric analysis of the chromatographic data.

I. Wainer, R. Kaliszan, A. Kaliszan, 1993, Journal of chromatography.

Pharmacodynamic profiles of ketamine (R)- and (S)- with 5-day inpatient infusion for the treatment of complex regional pain syndrome.

R. Schwartzman, D. Mager, M. Goldberg, 2010, Pain physician.

Determination of the enantiomers of ketamine and norketamine in human plasma by enantioselective liquid chromatography-mass spectrometry.

I. Wainer, M. E. Rodriguez Rosas, Sharvil Patel, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Qualitative assessment of IC50 values of inhibitors of the neuronal nicotinic acetylcholine receptor using a single chromatographic experiment and multivariate cluster analysis.

J. Collins, S. Ravichandran, R. Moaddel, 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Synthesis and chromatographic properties of an HPLC chiral stationary phase based upon human serum albumin

E. Domenici, C. Bertucci, S. Motellier, 1990 .

Stereochemical aspects of benzodiazepine binding to human serum albumin. II. Quantitative relationships between structure and enantioselective retention in high performance liquid affinity chromatography.

I. Wainer, R. Kaliszan, T. Noctor, 1992, Molecular pharmacology.

Molecular biochromatography: an approach to the liquid chromatographic determination of ligand-biopolymer interactions.

I. Wainer, T. Noctor, 1993, Advances in chromatography.

Mechanistic investigation into the enantioselective separation of mexiletine and related compounds, chromatographed on an amylose tris(3,5-dimethylphenylcarbamate) chiral stationary phase

I. Wainer, T. D. Booth, 1996 .

Heterodimerization With 5-HT2BR Is Indispensable for β2AR-Mediated Cardioprotection

Xinli Hu, Jianfeng Liu, Chanjuan Xu, 2020, Circulation research.

Stereochemical and structural effects of (2R,6R)-hydroxynorketamine on the mitochondrial metabolome in PC-12 cells.

M. Bernier, C. Barbas, S. Angulo, 2018, Biochimica et biophysica acta. General subjects.

Enantioselective interactions of dextromethorphan and levomethorphan with the α3β4-nicotinic acetylcholine receptor: comparison of chromatographic and functional data

K. Kellar, I. Wainer, K. Jóźwiak, 2003 .

The preparation and development of cellular membrane affinity chromatography columns

R. Moaddel, I. Wainer, 2009, Nature Protocols.

N‐acetylation among HIV‐positive patients and patients with AIDS: When is fast, fast and slow, slow?

B. Gilfix, C. Tsoukas, I. Wainer, 1997, Clinical pharmacology and therapeutics.

A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome.

L. Iyer, M. Goldberg, M. Torjman, 2010, Talanta.

Drug Interaction: Meperidine and Chlorpromazine, a Toxic Combination

I. Wainer, J. Stambaugh, 1981, Journal of clinical pharmacology.

The enantioselective determination of chlorpheniramine and its major metabolites in human plasma using chiral chromatography on a beta-cyclodextrin chiral stationary phase and mass spectrometric detection.

I. Wainer, K. Fried, Andrea E Young, 2002, Journal of pharmaceutical and biomedical analysis.

Selective GPR55 antagonism reduces chemoresistance in cancer cells.

M. Bernier, I. Wainer, Nagendra S. Singh, 2016, Pharmacological research.

The rapid and direct determination of ATP-ase activity by ion exchange chromatography and the application to the activity of heat shock protein-90

V. Andrisano, M. Bartolini, C. Bertucci, 2012 .

Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening.

R. Moaddel, C. Mugnaini, Kevin Spelman, 2011, Analytical biochemistry.

Genotype and phenotype of cytochrome P450 2D6 in human immunodeficiency virus-positive patients and patients with acquired immunodeficiency syndrome

B. Gilfix, C. Tsoukas, I. Wainer, 2000, European Journal of Clinical Pharmacology.

Glucuronidation and sulphation of paracetamol in HIV-positive patients and patients with AIDS.

C. Tsoukas, I. Wainer, J. Pezzullo, 1999, British journal of clinical pharmacology.

Determination and modelling of stereoselective interactions of ligands with drug transporters: A key dimension in the understanding of drug disposition

R. Moaddel, M. Koliński, I. Wainer, 2008, Xenobiotica; the fate of foreign compounds in biological systems.

Intensive therapy with growth factor support for patients with Ewing tumor metastatic at diagnosis: Pediatric Oncology Group/Children's Cancer Group Phase II Study 9457--a report from the Children's Oncology Group.

M. Link, M. Devidas, M. Gebhardt, 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Enzyme-based high-performance liquid chromatography supports as probes of enzyme activity and inhibition: the immobilization of trypsin and alpha-chymotrypsin on an immobilized artificial membrane high-performance liquid chromatography support.

W. Chui, I. Wainer, 1992, Analytical biochemistry.

The stereochemical resolution of enantiomeric free and derivatized amino acids using an HPLC chiral stationary phase based on immobilized alpha-chymotrypsin: chiral separation due to solute structure or enzyme activity.

I. Wainer, G. R. Schonbaum, P. Jadaud, 1989, Chirality.

Stereochemical recognition of enantiomeric and diastereomeric dipeptides by high-performance liquid chromatography on a chiral stationary phase based upon immobilized alpha-chymotrypsin.

I. Wainer, P. Jadaud, 1989, Journal of chromatography.

Determination of the enantiomeric composition of mexiletine and its four hydroxylated metabolites in urine by enantioselective capillary gas chromatography.

W. König, I. Wainer, B. Gehrcke, 1996, Chirality.

A population pharmacokinetic metabolism model for individualizing ciprofloxacin therapy in ophthalmology

I. Wainer, M. Ducharme, J. Chen, 1999, Therapeutic drug monitoring.

Removal of methotrexate, leucovorin, and their metabolites by combined hemodialysis and hemoperfusion

M. Relling, W. Evans, I. Wainer, 1988, Cancer.

Recent advances on endogenous Na+,K+-ATPase inhibitors: clinical investigation and purification.

G. Deray, M. Devynck, I. Wainer, 1985, Clinical and experimental hypertension. Part A, Theory and practice.

Enantioselective disposition of hydroxychloroquine after a single oral dose of the racemate to healthy subjects.

I. Wainer, M. Ducharme, S. K. Khalil, 1995, British journal of clinical pharmacology.

Interactions of racemic mefloquine and its enantiomers with P-glycoprotein in an immortalised rat brain capillary endothelial cell line, GPNT.

P. Couraud, R. Farinotti, I. Wainer, 2000, Biochimica et biophysica acta.

Evidence of renal metabolism of ifosfamide to nephrotoxic metabolites.

G. Koren, S. Ito, I. Wainer, 2000, Life sciences.

Chirality in natural and applied science

W. J. Lough, I. Wainer, W. Lough, 2002 .

Enzyme-based high-performance liquid chromatography stationary phases as metabolic reactors: Immobilization of non-solubilized rat liver microsomes on an immobilized artificial membrane high-performance liquid chromatography support

I. Wainer, T. Alebić-Kolbah, 1993 .

Biochemical, Physiological and Pathological Properties of Endogenous Digitalis-Like Compounds

G. Deray, M. Devynck, I. Wainer, 1986 .

Chiral separations of cationic and anionic drugs on an α1-acid glycoprotein-bonded stationary phase (enantiopac®)

I. Wainer, G. Schill, S. Barkan, 1986 .

Chiral separations of cationic and anionic drugs on an alpha 1-acid glycoprotein-bonded stationary phase (EnantioPac). II. Influence of mobile phase additives and pH on chiral resolution and retention.

I. Wainer, G. Schill, S. Barkan, 1986, Journal of chromatography.

Stereochemical aspects of benzodiazepine binding to human serum albumin. I. Enantioselective high performance liquid affinity chromatographic examination of chiral and achiral binding interactions between 1,4-benzodiazepines and human serum albumin.

I. Wainer, R. Kaliszan, T. Noctor, 1992, Molecular pharmacology.

Influence of specific albumin ligand markers used as modifiers on the separation of benzodiazepine enantiomers by chiral liquid chromatography on a human serum albumin column.

R. Farinotti, I. Wainer, E. Chosson, 1993, Chirality.

Allosteric and competitive displacement of drugs from human serum albumin by octanoic acid, as revealed by high-performance liquid affinity chromatography, on a human serum albumin-based stationary phase.

D. S. Hage, I. Wainer, T. Noctor, 1992, Journal of chromatography.

Stereochemical resolution of enantiomeric 2-aryl propionic acid non-steroidal anti-inflammatory drugs on a human serum albumin based high-performance liquid chromatographic chiral stationary phase

I. Wainer, T. Noctor, G. Félix, 1991 .

Use of mobile phase modifiers to alter retention and stereoselectivity on a bovine serum albumin high-performance liquid chromatographic chiral stationary phase.

I. Wainer, Y. Chu, 1988, Journal of chromatography.

Efficacy and toxicity of ifosfamide stereoisomers in an in vivo rat mammary carcinoma model.

G. Batist, T. Wang, I. Wainer, 1994, Cancer research.

Role of Chiral Chromatography in Therapeutic Drug Monitoring and in Clinical and Forensic Toxicology

I. Wainer, Marion L Williams, Marion L. Williams, 2002, Therapeutic drug monitoring.

A discordance of the cytochrome P450 2C19 genotype and phenotype in patients with advanced cancer.

J. Marshall, D. Flockhart, M. Williams, 2000, British journal of clinical pharmacology.

Finding time for allosteric interactions

I. Wainer, 2004, Nature Biotechnology.

(R,R')-4'-methoxy-1-naphthylfenoterol targets GPR55-mediated ligand internalization and impairs cancer cell motility.

M. Bernier, R. Moaddel, F. Indig, 2014, Biochemical pharmacology.

Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity.

I. Wainer, J. Ducharme, S. Abdullah, 1996, Journal of chromatography. B, Biomedical applications.

Determination of the antitumor agent depsipeptide in plasma by liquid chromatography on serial octadecyl stationary phases.

J. L. Marshall, C. Chassaing, I. Wainer, 1998, Journal of chromatography. B, Biomedical sciences and applications.

Verapamil metabolites: potential P-glycoprotein-mediated multidrug resistance reversal agents.

G. Koren, G. Batist, S. Ito, 2003, Canadian journal of physiology and pharmacology.

Relevance of drug-melanin interactions to ocular pharmacology and toxicology.

I. Wainer, P. Patil, M. Salazar-Bookaman, 1994, Journal of ocular pharmacology.

High yield-purification of a urinary Na+-pump inhibitor.

U. Ruegg, I. Wainer, P. Meyer, 1985, Biochemical and biophysical research communications.

Verapamil decreases lymphocyte protein kinase C activity in humans

D. Abernethy, P. DePetrillo, I. Wainer, 1994, Clinical pharmacology and therapeutics.

Investigation of the potential of capillary electrophoresis with off-line matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for clinical analysis: examination of a glycoprotein factor associated with cancer cachexia.

I. Wainer, G. McMahon, A. Torres-Duarte, 1999, Analytical chemistry.

The Relationship Between a Urinary Cachectic Factor and Weight Loss in Advanced Cancer Patients

J. Marshall, L. Brant, M. Williams, 2004, Cancer investigation.

Direct determination of tamoxifen and its four major metabolites in plasma using coupled column high-performance liquid chromatography.

I. Wainer, K. Fried, 1994, Journal of chromatography. B, Biomedical applications.

Stereoisomers in clinical oncology: why it is important to know what the right and left hands are doing.

I. Wainer, 1993, Annals of oncology : official journal of the European Society for Medical Oncology.

Immobilized horse liver alcohol dehydrogenase as an on-line high-performance liquid chromatographic enzyme reactor for stereoselective synthesis.

D. Wahnon, D. Johnson, I. Wainer, 1999, Chirality.

(R,S)-Ketamine Metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine Increase the Mammalian Target of Rapamycin Function

M. Bernier, M. Torjman, M. Sanghvi, 2014, Anesthesiology.

Plasma protein binding study of oxybutynin by high-performance frontal analysis.

Tomoko Kimura, Yukihiro Kuroda, I. Wainer, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Breast cancer resistance protein (BCRP/ABCG2) localises to the nucleus in glioblastoma multiforme cells

M. Bernier, M. Sanghvi, R. Moaddel, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

Ketamine for Refractory Chronic Migraine: An Observational Pilot Study and Metabolite Analysis

S. Silberstein, M. Torjman, J. Lovett, 2021, Journal of clinical pharmacology.

A Population Analysis of Nebulized (R)-albuterol in Dogs Using a Novel Mixed Gut-Lung Absorption PK-PD Model

I. Wainer, M. Ducharme, T. P. Jerussi, 2000, Pharmaceutical Research.

The synthesis and characterization of a nuclear membrane affinity chromatography column for the study of human breast cancer resistant protein (BCRP) using nuclear membranes obtained from the LN-229 cells.

R. Shimmo, R. Moaddel, I. Wainer, 2013, Journal of pharmaceutical and biomedical analysis.

Influence of dose of [6RS]leucovorin on reduced folate pools and 5-fluorouracil-mediated thymidylate synthase inhibition in human colon adenocarcinoma xenografts.

P. Houghton, J. Houghton, P. Cheshire, 1990, Cancer research.

Relationship between dose rate of [6RS]Leucovorin administration, plasma concentrations of reduced folates, and pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in human colon adenocarcinoma xenografts.

P. Houghton, J. Houghton, P. Cheshire, 1990, Cancer research.

Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss

J. Marshall, I. Wainer, P. Bhargava, 2001, British Journal of Cancer.

Phase I and pharmacokinetic study of CI-980 in recurrent pediatric solid tumor cases: a Pediatric Oncology Group study.

S. Baruchel, N. Winick, M. Bernstein, 1999, Journal of pediatric hematology/oncology.

Verapamil metabolite exposure in older and younger men during steady-state oral verapamil administration.

D. Abernethy, I. Wainer, A. Anacleto, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Verapamil stereoisomers during racemic verapamil administration: Effects of aging and comparisons to administration of individual stereoisomers

J. Schwartz, I. Wainer, H. Capili, 1994, Clinical pharmacology and therapeutics.

Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment-resistant bipolar depression.

D. Luckenbaugh, C. Zarate, D. Mager, 2012, British journal of clinical pharmacology.

Characterization of a multiple endogenously expressed adenosine triphosphate-binding cassette transporters using nuclear and cellular membrane affinity chromatography columns.

R. Shimmo, R. Moaddel, I. Wainer, 2014, Journal of chromatography. A.

Effects of protein calorie malnutrition on the pharmacokinetics of ketamine in rats.

G. Gudi, D. Mager, T. Tracy, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Subchronic administration of (R,S)-ketamine induces ketamine ring hydroxylation in Wistar rats.

M. Torjman, M. Sanghvi, C. Green, 2016, Journal of pharmaceutical and biomedical analysis.

Ketamine in the Past, Present, and Future: Mechanisms, Metabolites, and Toxicity

J. Pergolizzi, E. Viscusi, M. Torjman, 2021, Current Pain and Headache Reports.

Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist

M. Scheibye-Knudsen, M. Bernier, C. Barbas, 2022, Scientific Reports.

Rapid analysis of the interactions between drugs and human serum albumin (HSA) using high-performance affinity chromatography (HPAC).

I. Wainer, Hee Seung Kim, H. Kim, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Thermodynamics and Docking of Agonists to the (cid:1) 2 -Adrenoceptor Determined Using [ 3 H]( R , R (cid:1) )-4-Methoxyfenoterol as the Marker Ligand

L. Toll, I. Wainer, Karolina Pająk, 2012 .

The synthesis and characterization of cellular membrane affinity chromatography columns for the study of human multidrug resistant proteins MRP1, MRP2 and human breast cancer resistant protein BCRP using membranes obtained from Spodoptera frugiperda (Sf9) insect cells.

R. Moaddel, I. Wainer, P. Bhatia, 2010, Talanta.

Initial synthesis and characterization of an immobilized heat shock protein 90 column for online determination of binding affinities.

M. Marszałł, M. Bernier, R. Moaddel, 2008, Analytical biochemistry.

Development and characterization of an immobilized human organic cation transporter based liquid chromatographic stationary phase.

S. Patel, C.P.S. Hsu, P. Ho, 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

On-line screening of conformationally constrained nicotines and anabasines for agonist activity at the α3β4- and α4β2-nicotinic acetylcholine receptors using immobilized receptor-based liquid chromatographic stationary phases

T. Sarkar, R. Moaddel, I. Wainer, 2004 .

Reply to: Antidepressant Actions of Ketamine Versus Hydroxynorketamine

S. Thompson, C. Zarate, T. Gould, 2017, Biological Psychiatry.

Stereoselective and regiospecific hydroxylation of ketamine and norketamine

M. Torjman, M. Sanghvi, Z. Desta, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

Ketamine infusion successful in some patients.

R. Schwartzman, M. Goldberg, M. Torjman, 2010, Pain physician.

Whole blood concentrations of mefloquine enantiomers in healthy Thai volunteers

R. Farinotti, J. Karbwang, I. Wainer, 2004, European Journal of Clinical Pharmacology.

Stereoselective pharmacokinetics of mefloquine in healthy Caucasians after multiple doses.

G. Koren, R. Farinotti, R. Pennie, 1994, Journal of pharmaceutical sciences.

Sub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors.

C. Zarate, Thao Tran, Yingxian Xiao, 2013, European journal of pharmacology.

Displacement and nonlinear chromatographic techniques in the investigation of interaction of noncompetitive inhibitors with an immobilized alpha3beta4 nicotinic acetylcholine receptor liquid chromatographic stationary phase.

J. Haginaka, R. Moaddel, I. Wainer, 2002, Analytical chemistry.

Development of an immobilized brain glutamine synthetase liquid chromatographic stationary phase for on-line biochemical studies.

I. Wainer, J. Cloix, 2001, Journal of chromatography. A.

The synthesis and initial characterization of an immobilized purinergic receptor (P2Y1) liquid chromatography stationary phase for online screening.

G. Massolini, R. Moaddel, I. Wainer, 2007, Analytical biochemistry.

Recruitment of β-Arrestin 1 and 2 to the β2-Adrenoceptor: Analysis of 65 Ligands

R. Seifert, M. Reinartz, T. Ozawa, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Recruitment of b-Arrestin 1 and 2 to the b 2-Adrenoceptor : Analysis of 65 Ligands s

R. Seifert, M. Reinartz, T. Ozawa, 2015 .

Cross-sectional analysis of plasma and CSF metabolomic markers in Huntington’s disease for participants of varying functional disability: a pilot study

J. Gaughan, J. Lovett, R. Moaddel, 2020, Scientific Reports.

Further biochemical characterization of an Na+ pump inhibitor purified from human urine.

P. Guicheney, I. Wainer, M. Grichois, 1987, European journal of biochemistry.

Relationship of Ketamine's Plasma Metabolites with Response, Diagnosis, and Side Effects in Major Depression

G. Laje, D. Luckenbaugh, C. Zarate, 2012, Biological Psychiatry.

Genotype/phenotype comparisons: a probe for the effect of disease progression on drug metabolism.

I. Wainer, Marion L Williams, 2002, Current opinion in drug discovery & development.

A validated method for the determination of paracetamol and its glucuronide and sulphate metabolites in the urine of HIV+/AIDS patients using wavelength-switching UV detection.

I. Wainer, A. di Girolamo, W. O'Neill, 1998, Journal of pharmaceutical and biomedical analysis.

Development and characterization of an immobilized enzyme reactor based on glyceraldehyde-3-phosphate dehydrogenase for on-line enzymatic studies.

V. Andrisano, M. Bartolini, I. Wainer, 2003, Journal of chromatography. A.

Quantitation of the diastereoisomers of L-buthionine-(R,S)-sulfoximine in human plasma: a validated assay by capillary electrophoresis.

G. Batist, I. Wainer, D. Lloyd, 1995, Journal of chromatography. B, Biomedical applications.

Determination of the magnitude and enantioselectivity of ligand binding to rat and rabbit serum albumins using immobilized-protein high performance liquid chromatography stationary phases.

G. Massolini, I. Wainer, A. Aubry, 1993, Biochemical pharmacology.

The distribution and clearance of (2S,6S)-hydroxynorketamine, an active ketamine metabolite, in Wistar rats

M. Sanghvi, C. Green, R. Moaddel, 2015, Pharmacology research & perspectives.

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

Xi-Ping Huang, S. Thompson, G. Elmer, 2016, Nature.

Interaction of fenoterol stereoisomers with β2-adrenoceptor-Gsα fusion proteins: antagonist and agonist competition binding

R. Seifert, M. Reinartz, I. Wainer, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Application of an in vitro system in the study of chemotherapeutic drug effects on DNA replication

M. Zannis‐Hadjopoulos, I. Wainer, G. Price, 1996, Journal of cellular biochemistry.

Chapter 7 - Immobilized enzyme reactors in liquid chromatography: On-line bioreactors for use in synthesis and drug discovery

I. Wainer, N. Markoglou, 2003 .

D-serine plasma concentration is a potential biomarker of (R,S)-ketamine antidepressant response in subjects with treatment-resistant depression

D. Luckenbaugh, C. Zarate, R. Machado-Vieira, 2014, Psychopharmacology.

The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine.

S. Yasuda, R. Woosley, I. Wainer, 2002, British journal of clinical pharmacology.

d-Serine is a potential biomarker for clinical response in treatment of post-traumatic stress disorder using (R,S)-ketamine infusion and TIMBER psychotherapy: A pilot study.

B. Pradhan, I. Wainer, L. Mitrev, 2018, Biochimica et biophysica acta. Proteins and proteomics.

Determination of reduced and oxidized homocysteine and related thiols in plasma by thiol-specific pre-column derivatization and capillary electrophoresis with laser-induced fluorescence detection.

C. Wilcox, C. Chassaing, I. Wainer, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Enantioselective liquid chromatography-mass spectrometry assay for the determination of ifosfamide and identification of the N-dechloroethylated metabolites of ifosfamide in human plasma.

C. Walko, D. Siluk, C. Lindley, 2007, Journal of pharmaceutical and biomedical analysis.

Simultaneous determination of buprenorphine, norbuprenorphine and the enantiomers of methadone and its metabolite (EDDP) in human plasma by liquid chromatography/mass spectrometry.

D. Siluk, E. Strain, I. Wainer, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Determination of total and free concentrations of the enantiomers of methadone and its metabolite (2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine) in human plasma by enantioselective liquid chromatography with mass spectrometric detection.

D. Epstein, K. Preston, E. Moolchan, 2005, Journal of chromatography. A.

The Measurement of Warfarin Enantiomers in Serum Using Coupled Achiral/Chiral, High-Performance Liquid Chromatography (HPLC)

I. Wainer, Y. Chu, 1988, Pharmaceutical Research.

Binding study of desethyloxybutynin using high-performance frontal analysis method.

Tomoko Kimura, Yukihiro Kuroda, I. Wainer, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Determination of the plasma levels of metyrapone and its enantiomeric metyrapol metabolites by direct plasma injection and multidimensional achiral-chiral chromatography.

Q. Cass, I. Wainer, N. M. Cassiano, 2002, Chirality.

Determination of metyrapone and the enantiomers of its chiral metabolite metyrapol in human plasma and urine using coupled achiral-chiral liquid chromatography.

I. Wainer, J. Chiarotto, 1995, Journal of chromatography. B, Biomedical applications.

Using chirality as a unique probe of pharmacological properties

I. Wainer, C. Granvil, J. Ducharme, 1995 .

Characterization of the protein binding of chiral drugs by high-performance affinity chromatography. Interactions of R- and S-ibuprofen with human serum albumin.

D. S. Hage, I. Wainer, T. Noctor, 1995, Journal of chromatography. A.

Coaxing a pyridine nucleus to give up its aromaticity: synthesis and pharmacological characterization of novel conformationally restricted analogues of nicotine and anabasine.

T. Sarkar, R. Moaddel, I. Wainer, 2004, Journal of medicinal chemistry.

Determination of free and protein-bound glutathione in HepG2 cells using capillary electrophoresis with laser-induced fluorescence detection.

M. Bernier, I. Wainer, Yan Wang, 2009, Journal of chromatography. A.

HPLC-electrospray mass spectrometric assay for the determination of (R,R)-fenoterol in rat plasma.

D. Siluk, I. Wainer, Hee Seung Kim, 2008, Journal of pharmaceutical and biomedical analysis.

Development and characterization of the α3β4α5 nicotinic receptor cellular membrane affinity chromatography column and its application for on line screening of plant extracts.

R. Moaddel, L. Toll, I. Wainer, 2016, Journal of chromatography. A.

Determination of p-aminosalicylic acid and its N-acetylated metabolite in human urine by capillary zone electrophoresis as a measure of in vivo N-acetyltransferase 1 activity.

E. C. Soo, I. Wainer, D. Lloyd, 1997, Journal of chromatography. B, Biomedical sciences and applications.

Determination of N-acetylator phenotype using caffeine as a probe compound: a comparison of high-performance liquid chromatography and capillary electrophoresis methods.

I. Wainer, D. Lloyd, K. Fried, 1992, Journal of chromatography.

Chromatographic Chiral Separations on Immobilised Proteins: Does High-Performance Liquid Chromatography Mirror Nature?

I. Wainer, 1991 .

Immobilized enzymes as chromatographic phases for HPLC: The chromatography of free and derivatized amino acids on immobilized trypsin

I. Wainer, P. Jadaud, S. Thelohan, 1989 .

Enzymes as HPLC stationary phases for chiral resolutions: Initial investigations withα-chymotrypsin

M. Henry, I. Wainer, P. Jadaud, 1988 .

Nonlinear accumulation of propranolol enantiomers.

R. Straka, M. Bottorff, R. Lalonde, 1988, British journal of clinical pharmacology.

Proposal for the classification of high-performance liquid chromatographic chiral stationary phases: How to choose the right column

I. Wainer, 1987 .

The direct enantiomeric determination of (-)- and (+)-propranolol in human serum by high-performance liquid chromatography on a chiral stationary phase.

J. Powell, I. Wainer, K. Donn, 1984, Journal of chromatography.

Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol.

D. Abernethy, C. Bertucci, I. Wainer, 2006, Chirality.

A novel class of allosteric modulators of AMPA/Kainate receptors.

M. Baraldi, G. Puia, G. Cannazza, 2009, Bioorganic & medicinal chemistry letters.

Drug stereochemistry : analytical methods and pharmacology

I. Wainer, 1993 .

Stereochemical and conformational study on fenoterol by ECD spectroscopy and TD-DFT calculations.

C. Bertucci, I. Wainer, R. Zanasi, 2014, Journal of pharmaceutical and biomedical analysis.

Stereoselective binding of 2,3-substituted 3-hydroxypropionic acids on an immobilised human serum albumin chiral stationary phase: stereochemical characterisation and quantitative structure-retention relationship study.

A. Cavalli, V. Andrisano, V. Cavrini, 2000, Journal of chromatography. A.

Chiral resolution of some antimalarial agents by sub‐ and supercritical fluid chromatography on an (S)‐naphthylurea stationary phase

R. Farinotti, G. Peytavin, A. Baillet, 1993 .

Resolution of enantiomeric amides on a Pirkle-type chiral stationary phase. A comparison of subcritical fluid and liquid chromatographic approaches.

R. Rosset, P. Macaudiere, A. Tambuté, 1986, Journal of chromatography.

High-performance liquid chromatographic chiral stationary phase separation with filament-on thermospray mass spectrometric identification of the enantiomer contaminant (S)-(+)-methamphetamine.

J. Henion, C. Brunner, J. Gal, 1986, Analytical chemistry.

Electronic substituent effects during the liver alcohol dehydrogenase catalyzed reduction of aromatic aldehydes.

C. Ham, J. McFarland, I. Wainer, 1974, Biochemistry.

Determination of the enantiomers of albuterol in human and canine plasma by enantioselective high-performance liquid chromatography on a teicoplanin-based chiral stationary phase.

I. Wainer, P. Koch, K. Fried, 1998, Chirality.

On-line synthesis utilizing immobilized enzyme reactors based upon immobilized dopamine beta-hydroxylase.

I. Wainer, N. Markoglou, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Synthesis and characterization of immobilized dopamine beta-hydroxylase in membrane-bound and solubilized formats.

I. Wainer, N. Markoglou, 2001, Journal of biochemical and biophysical methods.

Biosynthesis in an on-line immobilized-enzyme reactor containing phenylethanolamine N-methyltransferase in single-enzyme and coupled-enzyme formats.

I. Wainer, N. Markoglou, 2002, Journal of chromatography. A.

Simultaneous chiral separation of leucovorin and its major metabolite 5-methyl-tetrahydrofolate by capillary electrophoresis using cyclodextrins as chiral selectors: Estimation of the formation constant and mobility of the solute-cyclodextrin complexes

I. Wainer, D. Lloyd, A. Shibukawa, 1993 .

Drug Analysis using High-Performance Liquid Chromatographic (HPLC) Chiral Stationary Phases: Where to Begin and Which to Use

I. Wainer, R. Stiffin, Y. Chu, 1988 .

Liquid chromatographic chiral stationary phases in pharmaceutical analysis: determination of trace amounts of the (-)-enantiomer in (+)-amphetamine.

I. Wainer, W. Adams, T. D. Doyle, 1984, Journal of pharmaceutical sciences.

Immobilized serum albumin: rapid HPLC probe of stereoselective protein-binding interactions.

P Salvadori, E. Domenici, C. Bertucci, 1990, Chirality.

The Application of HPLC Chiral Stationary Phases to Pharmaceutical Analysis: The Resolution of Some Tropic Acid Derivatives

I. Wainer, C. Breder, T. D. Doyle, 1984 .

Investigation of the enantioselective separations of α-alkylarylcarboxylic acids on an amylose tris(3,5-dimethylphenylcarbamate) chiral stationary phase using quantitative structure-enantioselective retention relationships Identification of a conformationally driven chiral recognition mechanism

I. Wainer, T. D. Booth, 1996 .

Drug Stereochemistry : Analytical Methods and Pharmacology, Third Edition

W. J. Lough, I. Wainer, K. Jóźwiak, 2012 .

Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor.

D. Abernethy, I. Wainer, R. Xiao, 2007, Journal of medicinal chemistry.

High Performance Liquid Chromatography

W. J. Lough, I. Wainer, 1996 .

High performance liquid chromatography: fundamental principles and practice

W. J. Lough, Irving W. Wainer, I. Wainer, 1995 .

Use of Centrifugal Partition Chromatography and Proteins in The Preparative Separation of Amino Acid Enantiomers

D. Armstrong, I. Wainer, R. A. Menges, 1990 .

Antitumor activity of (R,R’)-4-methoxy-1-naphthylfenoterol in a rat C6 glioma xenograft model in the mouse

M. Bernier, R. Moaddel, J. Cloix, 2013, Pharmacology research & perspectives.

β2-Adrenergic Receptor Agonists Inhibit the Proliferation of 1321N1 Astrocytoma Cells

M. Bernier, L. Toll, I. Wainer, 2011, Journal of Pharmacology and Experimental Therapeutics.

A new direction for the Journal of Chromatography B: Biomedical Sciences and Applications

W. Lindner, I. Wainer, D. Lloyd, 2000 .

An in vitro study of the stereoselective dissolution of (rac)-verapamil from two sustained release formulations

I. Wainer, A. Aubry, 1993 .

Development of a chromatographic bioreactor based on immobilized beta-glucuronidase on monolithic support for the determination of dextromethorphan and dextrorphan in human urine.

G. Massolini, S. Furlanetto, G. Marrubini, 2004, Journal of pharmaceutical and biomedical analysis.

Activation of β2-adrenergic receptor by (R,R')-4'-methoxy-1-naphthylfenoterol inhibits proliferation and motility of melanoma cells.

A. Boguszewska-Czubara, M. Bernier, L. Toll, 2015, Cellular signalling.

On-line determination of lipase activity and enantioselectivity using an immobilized enzyme reactor coupled to a chiral stationary phase

I. Wainer, Zhang Xiao-ming, 1993 .

Is chiral recognition a three‐point process?

D. Wahnon, I. Wainer, T. D. Booth, 1997 .

Application of high-performance liquid chromatographic chiral stationary phases to pharmaceutical analysis structural and conformational effects in the direct enantiomeric resolution of α-methylarylacetic acid antiinflammatory agents

I. Wainer, T. D. Doyle, 1984 .

I. Wainer, D. Lloyd, A. Shibukawa, 1993 .

Determination of cytosine-β-d-arabinoside in plasma using capillary electrophoresis

A. Cypess, I. Wainer, D. Lloyd, 1991 .

Approaches to quantitative structure-enantioselectivity relationship modeling of chiral separations using capillary electrophoresis.

I. Wainer, I W Wainer, D K Lloyd, 2001, Journal of chromatography. A.

Enantioselective high-performance liquid affinity chromatography as a probe of ligand-biopolymer interactions: an overview of a different use for high-performance liquid chromatographic chiral stationary phases

Irving W. Wainer, I. Wainer, 1994 .

Integrated approach to the multidimensional analysis of complex biological samples by microseparation techniques. Analysis of glycoprotein factor associated with cancer cachexia.

I. Wainer, A. Torres-Duarte, G. Rozing, 1999, Journal of chromatography. A.

The direct determination of the enantiomers of ketorolac and parahydroxyketorolac in plasma and urine using enantioselective liquid chromatography on a human serum albumin-based chiral stationary phase

I. Wainer, A. Aubry, John C. Chen, 1994 .

The effect of alcoholic mobile phase modifiers on retention and stereoselectivity on a commercially available cellulose-based HPLC chiral stationary phase: An unexpected reversal in enantiometric elution order

I. Wainer, R. Stiffin, M. Gaffney, 1989 .

Conformational mobility of immobilized proteins.

R. Moaddel, I. Wainer, 2007, Journal of pharmaceutical and biomedical analysis.

High-performance liquid chromatographic separation of the diastereoisomers of propoxyphene Determination of microquantities of β-dl-propoxyphene in comercial preparations of α-d-propoxyphene

I. Wainer, S. Barkan, 1982 .

The effects of racemic ketamine on painful stimulation of skin and viscera in human subjects

M. Bushnell, G. Duncan, I. Strigo, 2005, Pain.

The on-line determination of the enantiomeric purity of enzymatically produced chiral compounds

I. Wainer, T. Alebić-Kolbah, G. Félix, 1993 .

The effects of pH and alcoholic organic modifiers on the direct separation of some acidic, basic and neutral compounds on a commercially available ovomucoid column

I. Wainer, A. Aubry, J. Iredale, 1991 .

Simultaneous analysis of liposomal doxorubicin and doxorubicin using capillary electrophoresis and laser induced fluorescence.

I. Wainer, H. Kim, 2010, Journal of pharmaceutical and biomedical analysis.

HPLC-atmospheric pressure chemical ionization mass spectrometric method for enantioselective determination of R,S-propranolol and R,S-hyoscyamine in human plasma.

N. Gronich, D. Mager, D. Abernethy, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Detection of a mixed-backbone oligonucleotide (GEM 231) in liver and tumor tissues by capillary electrophoresis.

J. L. Marshall, R. I. Glazer, I. Wainer, 2001, Journal of chromatography. B, Biomedical sciences and applications.

Determination of the stereoisomers of hydroxychloroquine and its major metabolites in plasma and urine following a single oral administration of racemic hydroxychloroquine.

I. Wainer, H. Fieger, J. Iredale, 1993, Seminars in arthritis and rheumatism.

Pharmaceutical and Biomedical Applications of Liquid Chromatography

J. Lough, C. Riley, I. Wainer, 1994 .

Influence of Dose of [6/?5]Leucovorin on Reduced Folate Pools and 5-Fluorouracil-mediated Thymidylate Synthase Inhibition in Human Colon Adenocarcinoma Xenografts1

P. Houghton, J. Houghton, P. Cheshire, 2006 .

Column-switching techniques in the biomedical analysis of stereoisomeric drugs: why, how and when.

I. Wainer, K. Fried, 1997, Journal of chromatography. B, Biomedical sciences and applications.

The impact of new liquid chromatography chiral stationary phase technology on the study of stereoselective pharmacokinetics

I. Wainer, 1993 .

Simultaneous direct determination of the enantiomers of verapamil and norverapamil in plasma using a derivatized amylose high-performance liquid chromatographic chiral stationary phase.

I. Wainer, A. Shibukawa, 1992, Journal of chromatography.

Comparative molecular field analysis of fenoterol derivatives interacting with an agonist-stabilized form of the β₂-adrenergic receptor.

Ewelina Rutkowska, L. Toll, I. Wainer, 2014, Bioorganic & medicinal chemistry.

Gas phase electron ionization fragmentation of dextromethorphan and related quaternary ammonium salts

M. Ohashi, I. Wainer, R. Barron, 1984 .

Determination of dextro- and levomethorphan mixtures using chiral lanthanide NMR shift reagents.

M. Tischler, I. Wainer, E. Sheinin, 1980, Journal of pharmaceutical sciences.

In vivo comparison of putative probes of CYP3A4/5 activity: erythromycin, dextromethorphan, and verapamil

J. Schwartz, I. Wainer, M. E. Krecic‐Shepard, 1999, Clinical pharmacology and therapeutics.

Effect of protein-calorie malnutrition on cytochromes P450 and glutathione S-transferase

T. Tracy, I. Wainer, W. Zhang, 1999, European Journal of Drug Metabolism and Pharmacokinetics.

On-line deconjugation of chloramphenicol-β-d-glucuronide on an immobilized β-glucuronidase column: Application to the direct analysis of urine samples

I. Wainer, M. Ducharme, G. Félix, 1998 .

Immobilized receptor- and transporter-based liquid chromatographic phases for on-line pharmacological and biochemical studies: a mini-review.

R. Moaddel, I. Wainer, M. Baynham, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Competitive and allosteric interactions in ligand binding to P-glycoprotein as observed on an immobilized P-glycoprotein liquid chromatographic stationary phase.

F. Leonessa, I. Wainer, R. Clarke, 2001, Molecular pharmacology.

Development of an immobilized P-glycoprotein stationary phase for on-line liquid chromatographic determination of drug-binding affinities.

F. Leonessa, I. Wainer, R. Clarke, 2000, Journal of chromatography. B, Biomedical sciences and applications.

Drug Interactions I: Meperidine and Combination Oral Contraceptives

I. Wainer, J. Stambaugh, JOHN E. STAMBAUGH, 1975 .

A phase I trial of depsipeptide (FR901228) in patients with advanced cancer.

J. Marshall, N. Rizvi, W. Figg, 2002, Journal of experimental therapeutics & oncology.

Tamoxifen metabolic patterns within a glioma patient population treated with high-dose tamoxifen.

B. Leyland-Jones, G. Shenouda, I. Wainer, 2003, British journal of clinical pharmacology.

Ketamine: An Update for Its Use in Complex Regional Pain Syndrome and Major Depressive Disorder

W. Bentley, M. Goldberg, I. Wainer, 2015 .

Multidimensional on-line screening for ligands to the alpha3beta4 neuronal nicotinic acetylcholine receptor using an immobilized nicotinic receptor liquid chromatographic stationary phase.

R. Moaddel, I. Wainer, Sharvil Patel, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Development of immobilized membrane-based affinity columns for use in the online characterization of membrane bound proteins and for targeted affinity isolations.

R. Moaddel, I. Wainer, 2006, Analytica chimica acta.

Immobilized nicotinic receptor stationary phases: going with the flow in high-throughput screening and pharmacological studies.

R. Moaddel, I. Wainer, Ruin Moaddel, 2003, Journal of pharmaceutical and biomedical analysis.

Immobilized nicotinic receptor stationary phase for on-line liquid chromatographic determination of drug-receptor affinities.

K. Kellar, I. Wainer, Y. Zhang, 1998, Analytical biochemistry.

Advances in Translational Neuropathic Research: Example of Enantioselective Pharmacokinetic–Pharmacodynamic Modeling of Ketamine-induced Pain Relief in Complex Regional Pain Syndrome

M. Goldberg, R. Domsky, R. Hirsh, 2011, Current pain and headache reports.

New Insights into the Pharmacokinetics and Metabolism of (R,S)-Ifosfamide in Cancer Patients Using a Population Pharmacokinetic-Metabolism Model

G. Batist, I. Wainer, M. Ducharme, 2000, Pharmaceutical Research.

The Clinical Pharmacology of Meperidine—Comparison of Routes of Administration

I. Wainer, J. Stambaugh, John K. Sanstead, 1976, Journal of clinical pharmacology.

Enantioselective binding to the human organic cation transporter-1 (hOCT1) determined using an immobilized hOCT1 liquid chromatographic stationary phase.

S. Patel, P. Ho, R. Moaddel, 2005, Chirality.

The development of mitochondrial membrane affinity chromatography columns for the study of mitochondrial transmembrane proteins.

R. Shimmo, R. Moaddel, F. Indig, 2015, Analytical biochemistry.

Synthesis and characterization of a cellular membrane affinity chromatography column containing histamine 1 and P2Y(1) receptors: a multiple G-protein coupled receptor column.

Harrison K. Musyimi, M. Sanghvi, R. Moaddel, 2010, Journal of pharmaceutical and biomedical analysis.

Characterization of a multiple ligand-gated ion channel cellular membrane affinity chromatography column and identification of endogenously expressed receptors in astrocytoma cell lines.

M. Gandhari, M. Bernier, R. Moaddel, 2008, Analytical chemistry.

Initial synthesis and characterization of an alpha7 nicotinic receptor cellular membrane affinity chromatography column: effect of receptor subtype and cell type.

Tomoko Kimura, M. Bernier, M. Juhaszova, 2008, Analytical chemistry.

Interaction of noncompetitive inhibitors with the alpha3beta2 nicotinic acetylcholine receptor investigated by affinity chromatography and molecular docking.

J. Collins, S. Ravichandran, R. Moaddel, 2007, Journal of medicinal chemistry.

Allosteric modifiers of neuronal nicotinic acetylcholine receptors: New methods, new opportunities

R. Moaddel, I. Wainer, K. Jóźwiak, 2007, Medicinal research reviews.

Identification of P-glycoprotein substrates using open tubular chromatography on an immobilized P-glycoprotein column: Comparison of chromatographic results with Caco-2 permeability.

R. Hamid, R. Moaddel, P. Bullock, 2006, Analytica chimica acta.

Non-Competitive Inhibitory Activities of Morphinan and Morphine Derivatives at the α3β4 Neuronal Nicotinic Acetylcholine Receptor Determined Using Nonlinear Chromatography and Chemometric Techniques

A. Maciuk, R. Moaddel, I. Wainer, 2006, Pharmaceutical Research.

Direct chromatographic determination of dissociation rate constants of ligand-receptor complexes: assessment of the interaction of noncompetitive inhibitors with an immobilized nicotinic acetylcholine receptor-based liquid chromatography stationary phase.

R. Moaddel, I. Wainer, K. Jóźwiak, 2005, Analytical chemistry.

Conformational mobility of immobilized alpha3beta2, alpha3beta4, alpha4beta2, and alpha4beta4 nicotinic acetylcholine receptors.

R. Moaddel, I. Wainer, K. Jóźwiak, 2005, Analytical chemistry.

G-Protein-Coupled Receptor Chromatographic Stationary Phases. 2. Ligand-Induced Conformational Mobility in an Immobilized β2-Adrenergic Receptor

I. Wainer, R. Xiao, F. Beigi, 2004 .

Interaction of noncompetitive inhibitors with an immobilized alpha3beta4 nicotinic acetylcholine receptor investigated by affinity chromatography, quantitative-structure activity relationship analysis, and molecular docking.

Jack R Collins, J. Collins, S. Ravichandran, 2004, Journal of medicinal chemistry.

Development and characterization of an open tubular column containing immobilized P-glycoprotein for rapid on-line screening for P-glycoprotein substrates.

R. Moaddel, P. Bullock, I. Wainer, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Multiple Receptor Liquid Chromatographic Stationary Phases: The Co-Immobilization of Nicotinic Receptors, γ-Amino-Butyric Acid Receptors, and N-Methyl D-Aspartate Receptors

G. Ertem, R. Moaddel, J. Cloix, 2004, Pharmaceutical Research.

Syntheses of immobilized G protein-coupled receptor chromatographic stationary phases: characterization of immobilized mu and kappa opioid receptors.

I. Wainer, F. Beigi, 2003, Analytical chemistry.

Enantioselective interactions of dextromethorphan and levomethorphan with the alpha 3 beta 4-nicotinic acetylcholine receptor: comparison of chromatographic and functional data.

K. Kellar, I. Wainer, K. Jóźwiak, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Liquid chromatographic studies with immobilized neuronal nicotinic acetylcholine receptor stationary phases: effects of receptor subtypes, pH and ionic strength on drug-receptor interactions.

K. Kellar, I. Wainer, Y. Xiao, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Interaction of bupropion with muscle-type nicotinic acetylcholine receptors in different conformational states.

H. Arias, C. Bouzat, R. Moaddel, 2009, Biochemistry.

Quantitative determination of the enantiomers of methadone and its metabolite (EDDP) in human saliva by enantioselective liquid chromatography with mass spectrometric detection.

D. Epstein, K. Preston, E. Moolchan, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Pharmacokinetics of (R)- and (S)-cyclophosphamide and their dechloroethylated metabolites in cancer patients.

M. Bernstein, M. Williams, I. Wainer, 1999, Chirality.

Analytical and preparative high-performance liquid chromatographic separation of the enantiomers of ifosfamide, cyclophosphamide and trofosfamide and their determination in plasma.

I. Wainer, D. Masurel, 1989, Journal of chromatography.

Application of high-performance liquid chromatographic chiral stationary phases to pharmaceutical analysis : Direct enantiomeric resolution of amide derivatives of 1-phenyl-2-aminopropane

I. Wainer, T. D. Doyle, 1983 .

A validated liquid chromatography method for the simultaneous determination of vitamins A and E in human plasma.

L. Ferrucci, S. Ling, Â. Bós, 2007, Journal of pharmaceutical and biomedical analysis.

The Effect of Phenobarbital on the Metabolism of Meperidine in Normal Volunteers

I. Wainer, J. Stambaugh, JOHN E. STAMBAUGH, 1978, Journal of clinical pharmacology.

Comparison of the conversion of 5-formyltetrahydrofolate and 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolates and tetrahydrofolates in human colon tumors.

P. Houghton, J. Houghton, P. Cheshire, 1989, Cancer communications.

Concurrent activation of β2-adrenergic receptor and blockage of GPR55 disrupts pro-oncogenic signaling in glioma cells.

R. Wersto, M. Bernier, F. Indig, 2017, Cellular signalling.

Receptor independent effects on DNA replication by steroids

M. Zannis‐Hadjopoulos, I. Wainer, G. Price, 1998, Journal of cellular biochemistry.

Requirements for initial assay validation and publication in J. Chromatography B.

W. Lindner, I. Wainer, 1998, Journal of chromatography. B, Biomedical sciences and applications.

Course of Improvement in Depressive Symptoms to a Single Intravenous Infusion of Ketamine vs Add-on Riluzole: Results from a 4-Week, Double-Blind, Placebo-Controlled Study

D. Luckenbaugh, H. Manji, C. Zarate, 2012, Neuropsychopharmacology.

Trauma Interventions using Mindfulness Based Extinction and Reconsolidation (TIMBER) psychotherapy prolong the therapeutic effects of single ketamine infusion on post-traumatic stress disorder and comorbid depression: a pilot randomized, placebo-controlled, crossover clinical trial

M. Torjman, R. Moaddel, B. Pradhan, 2017 .

Ifosfamide stereoselective dichloroethylation and neurotoxicity

B. Leyland-Jones, I. Wainer, C. Granvil, 1994, The Lancet.

Determination of 4-hydroxyifosfamide concomitantly with ifosfamide and its dechloroethylated metabolites using gas chromatography and a nitrogen phosphorus-selective detector.

I. Wainer, B. Gourmel, B. Bousquet, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Synthesis of an immobilized Bombyx mori pheromone-binding protein liquid chromatography stationary phase.

J. R. Aldrich, R. Moaddel, Jennifer M. Tsuruda, 2006, Talanta.

The development of an immobilized enzyme reactor containing glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi: the effect of species' specific differences on the immobilization.

G. Oliva, A. Andricopulo, R. Guido, 2008, The Analyst.

Determination of the anticancer agent CI-980 in plasma by achiral liquid chromatography on a Pirkle-type stationary phase.

I. Wainer, N. Markoglou, 1997, Journal of chromatography. B, Biomedical sciences and applications.

Interaction of ibogaine with human α3β4-nicotinic acetylcholine receptors in different conformational states

H. Arias, R. Moaddel, Katarzyna M Targowska-Duda, 2010 .

Immobilized proteins as HPLC chiral stationary phases

I. Wainer, 1989 .

Development and validation of a sensitive LC-MS/MS method for the determination of fenoterol in human plasma and urine samples.

J. Strait, M. Sanghvi, R. Moaddel, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Rapid large-scale isolation of biologically active molecules using reversed-phase "flash" chromatography: initial purification of endogenous Na+, K+-ATPase inhibitors from human urine.

I. Wainer, M. Crabos, J. Cloix, 1985, Journal of chromatography.

High-performance liquid chromatography assay for simultaneous determination of dextromethorphan and its main metabolites in urine and in microsomal preparations.

I. Wainer, N. Markoglou, E. K. Bendriss, 2001, Journal of chromatography. B, Biomedical sciences and applications.

The Effect of Co‐administered Drugs on Oxaprozin Binding to Human Serum Albumin

J. Longstreth, I. Wainer, N. Markoglou, 1995, The Journal of pharmacy and pharmacology.

COMPARATIVE PHARMACOKINETICS OF d‐ AND l‐ALPHAMETHYLDOPA IN PLASMA, AQUEOUS HUMOR, AND CEREBROSPINAL FLUID IN RABBITS

D. Laude, E. Auclair, F. Chaouloff, 1988, Fundamental & clinical pharmacology.

Determination of the enantiomers of verapamil and norverapamil in serum using coupled achiral-chiral high-performance liquid chromatography.

I. Wainer, Y. Chu, 1989, Journal of chromatography.

Determination of dextromethorphan and dextrorphan in urine by capillary zone electrophoresis: Application to the determination of debrisoquin-oxidation metabolic phenotype

I. Wainer, S. Li, D. Lloyd, 1993 .

A unique reversal of elution order during direct enantiomeric resolution of amide derivatives of 1‐phenyl‐2‐aminopropane by high performance liquid chromatography on chiral stationary phases

I. Wainer, T. D. Doyle, 1984 .

Achiral and chiral high-performance liquid chromatography of verapamil and its metabolites in serum samples.

I. Wainer, E. Brandšteterová, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Determination of the enantiomers of mefloquine in plasma and whole blood using a coupled achiral-chiral high-performance liquid chromatographic system.

R. Farinotti, A. Thuillier, I. Wainer, 1990, Journal of chromatography.

Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil.

K. Korzekwa, F. Gonzalez, T. Tracy, 1999, British journal of clinical pharmacology.

Human Colon Adenocarcinoma Xenografts inand 5-Fluorouracil-mediated Thymidylate Synthase Inhibition ] Leucovorin on Reduced Folate Pools RS Influence of Dose of [ 6 Updated

P. Houghton, P. Cheshire, I. Wainer, 2006 .

Evaluation of a chiral stationary phase based on mixed immobilized proteins

I. Wainer, N. Markoglou, A. Aubry, 1994 .

Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the β2-adrenoceptor

R. Seifert, M. Reinartz, T. Ozawa, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

Discovery of β-arrestin-biased β2-adrenoceptor agonists from 2-amino-2-phenylethanol derivatives

M. Cheng, I. Wainer, R. Xiao, 2019, Acta Pharmacologica Sinica.

Stereochemistry of an Agonist Determines Coupling Preference of β2-Adrenoceptor to Different G Proteins in Cardiomyocytes

Darrell R. Abernethy, Irving W. Wainer, D. Abernethy, 2009, Molecular Pharmacology.

Tyrosine 308 Is Necessary for Ligand-directed Gs Protein-biased Signaling of β2-Adrenoceptor*

Michel Bernier, Lawrence Toll, Anita Plazinska, 2014, The Journal of Biological Chemistry.

Interaction of fenoterol stereoisomers with β2-adrenoceptor-Gsα fusion proteins: antagonist and agonist competition binding

R. Seifert, M. Reinartz, I. Wainer, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Comparative molecular field analysis of fenoterol derivatives: A platform towards highly selective and effective beta(2)-adrenergic receptor agonists.

L. Toll, I. Wainer, R. Xiao, 2010, Bioorganic & medicinal chemistry.

Conformational Mobility of Immobilized ¿3ß32, ¿3ß34, ¿4ß12, and ¿4ß4 Nicotinic Acetylcholine Receptors

R. Moaddel, I. Wainer, K. Whittington, 2005 .

Capillary electrophoresis-laser-induced fluorescence (CE-LIF) assay for measurement of intracellular D-serine and serine racemase activity.

M. Bernier, R. Moaddel, I. Wainer, 2012, Analytical biochemistry.

Gabapentin and (S)-pregabalin decrease intracellular d-serine concentrations in PC-12 cells

M. Torjman, I. Wainer, Nagendra S. Singh, 2013, Neuroscience Letters.

Steric and electronic effects in the resolution of enantiomeric amides on a commercially available Pirkle-type high-performance liquid chromatographic chiral stationary phase.

I. Wainer, M. Alembik, 1986, Journal of chromatography.

Chiral recognition model for the resolution of ephedrine and related α,β-aminoalcohols as enantiomeric oxazolidine derivatives

F. Fry, I. Wainer, Z. Hamidzadeh, 1986 .

Interaction of 18-Methoxycoronaridine with Nicotinic Acetylcholine Receptors in Different Conformational States

S. D. Glick, H. Arias, R. Moaddel, 2011 .

Interaction of 18-methoxycoronaridine with nicotinic acetylcholine receptors in different conformational states.

S. D. Glick, H. Arias, R. Maciejewski, 2010, Biochimica et biophysica acta.

Immobilized enzyme reactors based upon the flavoenzymes monoamine oxidase A and B.

I. Wainer, N. Markoglou, Ruth Hsuesh, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

The determination of the enantiomers of halofantrine and monodesbutylhalofantrine in plasma and whole blood using sequential achiral/chiral high-performance liquid chromatography.

R. Farinotti, I. Wainer, A. Aubry, 1992, Journal of pharmaceutical and biomedical analysis.

Improved column-switching liquid chromatographic method for the determination of the enantiomers of mefloquine.

R. Farinotti, I. Wainer, F. Gimenez, 1993, Journal of chromatography.

Development and characterization of an immobilized enzyme reactor (IMER) based on human glyceraldehyde-3-phosphate dehydrogenase for on-line enzymatic studies.

G. Oliva, A. Andricopulo, R. Moaddel, 2006, Journal of chromatography. A.

Development and characterization of an immobilized enzyme reactor based on glyceraldehyde-3-phosphate dehydrogenase for on-line enzymatic studies

Vincenza Andrisano, Irving W. Wainer, V. Andrisano, 2003 .

The development and characterization of protein-based stationary phases for studying drug-protein and protein-protein interactions.

M. Sanghvi, R. Moaddel, I. Wainer, 2011, Journal of chromatography. A.

Chiral Separation of Cationic Drugs on an α1-Acid Glycoprotein Bonded Stationary Phase

I. Wainer, G. Schill, S. Barkan, 1986 .

Identification and characterization of estrogen receptor-related receptor alpha and gamma in human glioma and astrocytoma cells

M. Gandhari, M. Bernier, J. Cloix, 2010, Molecular and Cellular Endocrinology.

Effects of Ketamine and Ketamine Metabolites on Evoked Striatal Dopamine Release, Dopamine Receptors, and Monoamine Transporters

D. Frost, Xi-Ping Huang, T. Gould, 2016, The Journal of Pharmacology and Experimental Therapeutics.

The covalent immobilization of microsomal uridine diphospho-glucuronosyltransferase (UDPGT): initial synthesis and characterization of an UDPGT immobilized enzyme reactor for the on-line study of glucuronidation.

I. Wainer, H. Kim, 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Microsomal immobilized-enzyme-reactor for on-line production of glucuronides in a HPLC column

I. Wainer, T. Alebić-Kolbah, 1993 .

Capillary electrophoretic and high-performance liquid chromatographic studies of the enantioselective separation of alpha1-adrenoreceptor antagonists.

R. Gotti, V. Andrisano, V. Cavrini, 1998, Journal of chromatography. A.

Enantioselective separation of chiral arylcarboxylic acids on an immobilized human serum albumin chiral stationary phase.

V. Andrisano, V. Cavrini, I. Wainer, 1997, Chirality.

Properties of a stationary phase based on immobilised chicken liver basic fatty acid-binding protein.

G. Massolini, M. Perduca, H. Monaco, 2001, Journal of chromatography. B, Biomedical sciences and applications.

Quantitative structure-enationselective retention relationships for the chromatography of 1,4-benzodiazepines on a human serum albumin based HPLC chiral stationary phase: An approach to the computational prediction of retention and enantioselectivity

Roman Kaliszan, Irving W. Wainer, I. Wainer, 1992 .

Use of a human serum albumin-based high-performance liquid chromatography chiral stationary phase for the investigation of protein binding: detection of the allosteric interaction between warfarin and benzodiazepine binding sites.

P Salvadori, E. Domenici, C. Bertucci, 1991, Journal of pharmaceutical sciences.

Improved chromatographic performance of a modified human albumin based stationary phase.

C. Bertucci, I. Wainer, 1997, Chirality.

The Use of Displacement Chromatography to Alter Retention and Enantioselectivity on a Human Serum Albumin-Based HPLC Chiral Stationary Phase: A Mini-Review

I. Wainer, T. Noctor, 1993 .

Deactivated hydrocarbonaceous silica and immobilized artificial membrane stationary phases in high-performance liquid chromatographic determination of hydrophobicities of organic bases: relationship to log P and CLOGP.

I. Wainer, R Kaliszan, R. Kaliszan, 1993, Journal of pharmaceutical and biomedical analysis.

Synthesis and characterization of an immobilized phenylethanolamine N-methyltransferase liquid chromatographic stationary phase.

I. Wainer, N. Markoglou, 2001, Analytical biochemistry.

GPR55 receptor antagonist decreases glycolytic activity in PANC‐1 pancreatic cancer cell line and tumor xenografts

R. Powers, A. Boguszewska-Czubara, M. Bernier, 2017, International journal of cancer.

Synthesis and Characterization of Liquid Chromatographic Columns Containing the Immobilized Ligand Binding Domain of the Estrogen Related Receptor α and Estrogen Related Receptor

R. Moaddel, I. Wainer, C. Frazier, 2011 .

Synthesis and characterization of liquid chromatographic columns containing the immobilized ligand binding domain of the estrogen related receptor alpha and estrogen related receptor gamma.

M. Sanghvi, R. Moaddel, I. Wainer, 2010, Journal of pharmaceutical and biomedical analysis.

What is hydroxynorketamine and what can it bring to neurotherapeutics?

C. Zarate, M. Bernier, R. Moaddel, 2014, Expert review of neurotherapeutics.

Direct analysis of the enantiomers of mexiletine and its metabolites in plasma and urine using an HPLC-CSP.

I. Wainer, H. Fieger, 1993, Journal of pharmaceutical and biomedical analysis.

Pharmacophore modelling of stereoselective binding to the human organic cation transporter (hOCT1)

S. Ravichandran, R. Moaddel, I. Wainer, 2007, British journal of pharmacology.

Crown ether-catalyzed synthesis of diastereoisomeric esters

I. Wainer, 1980 .

D-serine plasma concentration is a potential biomarker of (R,S)-ketamine antidepressant response in subjects with treatment-resistant depression

D. Luckenbaugh, C. Zarate, R. Machado-Vieira, 2014, Psychopharmacology.

Stereochemistry: definitions and a note on nomenclature

John Caldwell, Irving W. Wainer, J. Caldwell, 2001, Human psychopharmacology.

Validated assays in the journal of chromatography B: an initial editorial position

W. Lindner, I. Wainer, 1996 .

Enantioselective inhibition of d‐serine transport by (S)‐ketamine

M. Mattson, M. Bernier, R. Moaddel, 2015, British journal of pharmacology.

Stereoselective binding of chiral ligands to single nucleotide polymorphisms of the human organic cation transporter-1 determined using cellular membrane affinity chromatography.

S. Patel, S. Ravichandran, R. Moaddel, 2010, Analytical biochemistry.

Cannabinoid Receptor Activation Correlates with the Proapoptotic Action of the β2-Adrenergic Agonist (R,R′)-4-Methoxy-1-Naphthylfenoterol in HepG2 Hepatocarcinoma Cells

R. Wersto, M. Bernier, L. Toll, 2012, Journal of Pharmacology and Experimental Therapeutics.

Tricyclic antidepressants and mecamylamine bind to different sites in the human alpha4beta2 nicotinic receptor ion channel.

H. Arias, R. Moaddel, Katarzyna M Targowska-Duda, 2010, The international journal of biochemistry & cell biology.

Enantioselective chromatography of the antimalarial agents chloroquine, mefloquine, and enpiroline on a α1-acid glycoprotein chiral stationary phase : evidence for a multiple-site chiral recognition mechanism

R. Farinotti, I. Wainer, A. Aubry, 1992 .

Resolution of enantiomeric amides on a cellulose-based chiral stationary phase. Steric and electronic effects.

I. Wainer, M. Alembik, 1986, Journal of chromatography.

Chiral Recognition on Biopolymer-Based High-Pressure Liquid Chromatographic Chiral Stationary Phases: A Case for Multiple Interaction Sites

E. Domenici, I. Wainer, T. Noctor, 1991 .

Enantioselective determination of hydroxychloroquine and its major metabolites in urine and the observation of a reversal in the (+)/(-)-hydroxychloroquine ratio.

I. Wainer, H. Fieger, J. Iredale, 1993, Chirality.

Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes.

A. Parkinson, I. Wainer, C. Granvil, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Determination of the enantiomers of ifosfamide and its 2- and 3-N-dechloroethylated metabolites in plasma and urine using enantioselective gas chromatography with mass spectrometric detection.

W. König, I. Wainer, B. Gehrcke, 1993, Journal of chromatography.

Efficacy, toxicity, pharmacokinetics, and in vitro metabolism of the enantiomers of ifosfamide in mice.

P. Houghton, I. Wainer, C. L. Young, 1990, Cancer research.

Stereoselective pharmacokinetics of ifosfamide and its 2- and 3-N-dechloroethylated metabolites in female cancer patients

B. Leyland-Jones, I. Wainer, C. Granvil, 2009, Cancer Chemotherapy and Pharmacology.

The N-dechloroethylation of ifosfamide: using stereochemistry to obtain an accurate picture of a clinically relevant metabolic pathway

I. Wainer, C. Granvil, J. Ducharme, 1996, Cancer Chemotherapy and Pharmacology.

The determination of (-)-(S)- and (+)-(R)-ifosfamide in plasma using enantioselective gas chromatography: a validated assay for pharmacokinetic and clinical studies.

I. Wainer, H. Frank, C. L. Young, 1989, Chirality.

Cyclophosphamide versus ifosfamide: to use ifosfamide or not to use, that is the three-dimensional question.

M. Williams, I. Wainer, 1999, Current pharmaceutical design.

ROLE OF CYP 2 B 6 AND CYP 3 A 4 IN THE IN VITRO N-DECHLOROETHYLATION OF ( R )-AND ( S )-IFOSFAMIDE IN HUMAN LIVER MICROSOMES

A. Parkinson, I. Wainer, C. Granvil, 1999 .

Efficacy and Toxicity of Ifosfamide Stereoisomers in an in Vivo Rat Mammary Carcinoma Model 1

G. Batist, T. Wang, I. Wainer, 2006 .

Influence of phenobarbital induction on the enantioselective N-dechloroethylation of ifosfamide enantiomers in the rat.

G. Batist, I. Wainer, C. Granvil, 1994, Drug metabolism and disposition: the biological fate of chemicals.

Mechanism of retention of benzodiazepines in affinity, reversed-phase and adsorption high-performance liquid chromatography in view of quantitative structure retention relationships

W. P. Purcell, R. Kaliszan, I. Wainer, 1992 .

Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor.

G. Massolini, M. Trincavelli, C. Martini, 2010, Journal of medicinal chemistry.

Molecular interactions between fenoterol stereoisomers and derivatives and the β2-adrenergic receptor binding site studied by docking and molecular dynamics simulations

M. Koliński, I. Wainer, A. Płazińska, 2013, Journal of Molecular Modeling.

Ligand and protein fishing with heat shock protein 90 coated magnetic beads.

M. Marszałł, M. Gandhari, M. Bernier, 2008, Analytical chemistry.

Ketamine Metabolites Enantioselectively Decrease Intracellular D-Serine Concentrations in PC-12 Cells

M. Bernier, Ewelina Rutkowska, R. Moaddel, 2016, PloS one.

The effect of stereochemistry on the thermodynamic characteristics of the binding of fenoterol stereoisomers to the beta(2)-adrenoceptor.

L. Toll, I. Wainer, R. Xiao, 2010, Biochemical pharmacology.

Measurement of endogenous Na+,K+‐ATPase inhibitors in human plasma and urine using high‐performance liquid chromatography

I. Wainer, M. Crabos, J. Cloix, 1984, FEBS letters.

Controlled trials of very high dose folic acid, vitamins B12 and B6, intravenous folinic acid and serine for treatment of hyperhomocysteinemia in ESRD.

R. Gonin, C. Chassaing, C. Wilcox, 2003, Journal of nephrology.

Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells.

M. Bernier, M. Torjman, R. Moaddel, 2013, Cellular signalling.

Direct resolution of enantiomers via thin-layer chromatography using a chiral adsorbent

C. Brunner, I. Wainer, T. D. Doyle, 1983 .

The Application of HPLC Chiral Stationary Phases to Stereochemical Problems of Pharmaceutical Interest: A General Method for the Resolution of Enantiomeric Amines as β-Naphthylcarbamate Derivatives

F. Fry, I. Wainer, W. Adams, 1986 .

Enantioselective separation of enantiomeric amides on three amylose‐based chiral stationary phases: Effects of backbone and carbamate side chain chiralities

W. J. Lough, I. Wainer, T. D. Booth, 1997 .

Separation of testosterone metabolites in microsomal incubates using a new capillary electrophoresis assay.

I. Wainer, D. Lloyd, G. Egginger, 1996, Journal of chromatography. B, Biomedical applications.

Direct resolution of the stereoisomers of leucovorin and 5-methyltetrahydrofolate using a bovine serum albumin high-performance liquid chromatographic chiral stationary phase coupled to an achiral phenyl column.

I. Wainer, R. Stiffin, 1988, Journal of Chromatography A.

Selectivity of CF and 5-fluorouracil: critical role of polyglutamylation.

P. Houghton, J. Houghton, J. Rodman, 1988, Advances in experimental medicine and biology.

The Study of Chiral Cardiovascular Drugs: Analytical Approaches and Some Pharmacological Consequences

M. Bottorff, R. Lalonde, I. Wainer, 1988 .

Stereoselective verapamil disposition and dynamics in aging during racemic verapamil administration.

D. Abernethy, J. Longstreth, I. Wainer, 1993, The Journal of pharmacology and experimental therapeutics.

Applicability of HPLC Chiral Stationary Phases to Pharmacokinetic and Disposition Studies on Enantiomeric Drugs

I. Wainer, 1986 .

Application of high-performance liquid chromatographic chiral stationary phases to pharmaceutical analysis. Resolution of enantiomeric barbiturates, succinimides and related molecules on four commercially available chiral stationary phases.

J. D. Weber, C. Brunner, I. Wainer, 1985, Journal of chromatography.

Resolution of norephedrine as its 2-oxazolidone derivative: enantiomeric separation on a chiral high-performance liquid chromatographic stationary phase and preparative regeneration of the resolved isomers

I. Wainer, M. Aldridge, Z. Hamidzadeh, 1983 .

Application of high-performance liquid chromatographic chiral stationary phases to pharmaceutical analysis: resolution of ephedrine

I. Wainer, M. Aldridge, Z. Hamidzadeh, 1983 .

Plasma concentrations of the enantiomers of halofantrine and its main metabolite in malaria patients

J. Bras, I. Wainer, O. Bouchaud, 2004, European Journal of Clinical Pharmacology.

The determination of (R)- and (S)-glutethimide and the corresponding 4-hydroxyglutethimide metabolises in human serum and urine using a Pirkle-type HPLC chiral stationary phase.

L. J. Fischer, I. Wainer, M. Alembik, 1987, Journal of pharmaceutical and biomedical analysis.

Development of an automatic solid phase extraction and liquid chromatography mass spectrometry method by using a monolithic column for the analysis of Cyclosporin A in human plasma.

Covadonga Álvarez, I. Wainer, 2009, Talanta.

The Enantioselective Binding of Mefloquine Enantiomers to P-glycoprotein Determined Using An Immobilized P-glycoprotein Liquid Chromatographic Stationary Phase

R. Clarke, F. Leonessa, I. Wainer, 2001, Pharmaceutical Research.

The rapid and direct determination of ATPase activity by ion exchange chromatography and the application to the activity of heat shock protein-90.

V. Andrisano, M. Bartolini, C. Bertucci, 2013, Journal of pharmaceutical and biomedical analysis.

The stereoselective sulfate conjugation of 4'-methoxyfenoterol stereoisomers by sulfotransferase enzymes.

L. Iyer, Ewelina Rutkowska, C. Green, 2012, Chirality.

The application of achiral/chiral coupled-column high-performance liquid chromatography to biomedical analysis.

I. Wainer, 1989, Journal of pharmaceutical and biomedical analysis.

The Bioavailability of Meperidine Using Urine Assays for Meperidine and Normeperidine

I. Wainer, J. Stambaugh, 1975, Journal of clinical pharmacology.

GLC determination of meperidinic and normeperidinic acids in urine.

I. Wainer, J. Stambaugh, 1978, Journal of pharmaceutical sciences.

STEREOCHEMICAL TERMS AND CONCEPTS: AN OVERVIEW*

I. Wainer, Alice A. Marcotte, 2001 .

Chromatographic Studies of Molecular Recognition and Solute Binding to Enzymes and Plasma Proteins

W. J. Lough, I. Wainer, Sharvil Patel, 2005 .

Affinity-Based Chiral Stationary Phases

W. J. Lough, I. Wainer, Sharvil Patel, 2005 .

On-line drug metabolism in capillary electrophoresis. 1. Glucuronidation using rat liver microsomes.

I. Wainer, H. Kim, 2006, Analytical chemistry.

A POTENTIALLY TOXIC DRUG INTERACTION BETWEEN PETHIDINE (MEPERIDINE) AND PHENOBARBITONE

I. Wainer, J. Stambaugh, I. Schwartz, 1977, The Lancet.

The Bioavailability of Meperidine

I. Wainer, J. Stambaugh, 1974, Journal of clinical pharmacology.

Determination of hydroxychloroquine and its major metabolites in plasma using sequential achiral-chiral high-performance liquid chromatography.

I. Wainer, J. Iredale, 1992, Journal of chromatography.

Distribution of the enantiomers of hydroxychloroquine and its metabolites in ocular tissues of the rabbit after oral administration of racemic-hydroxychloroquine.

I. Wainer, J. Ducharme, J. C. Chen, 1994, Chirality.

Stereoselective distribution of hydroxychloroquine in the rabbit following single and multiple oral doses of the racemate and the separate enantiomers.

J. Rodman, I. Wainer, J. Ducharme, 1994, Chirality.

Thermodynamics and Docking of Agonists to the β2-Adrenoceptor Determined Using [3H](R,R′)-4-Methoxyfenoterol as the Marker Ligand

L. Toll, I. Wainer, Karolina Pająk, 2012, Molecular Pharmacology.

JPET # 195206 1 Cannabinoid receptor activation correlates with the pro-apoptotic action of the β 2-adrenergic agonist , ( R , R ’ )-4-methoxy-1-naphthylfenoterol , in HepG 2 hepatocarcinoma cells

R. Wersto, M. Bernier, L. Toll, 2012 .

Direct stereochemical resolution of enantiomeric amides via thin-layer chromatography on a covalently bonded chiral stationary phase.

C. Brunner, I. Wainer, 1989, Journal of chromatography.

Activation of β2-adrenergic receptor by (R,R')-4'-methoxy-1-naphthylfenoterol inhibits proliferation and motility of melanoma cells.

A. Boguszewska-Czubara, M. Bernier, L. Toll, 2015, Cellular signalling.

Selective GPR55 antagonism reduces chemoresistance in cancer cells.

M. Bernier, I. Wainer, Nagendra S. Singh, 2016, Pharmacological research.

Development and characterization of the α3β4α5 nicotinic receptor cellular membrane affinity chromatography column and its application for on line screening of plant extracts.

R. Moaddel, I. Wainer, K. Dossou, 2016, Journal of chromatography. A.

Exploring enantiospecific ligand-protein interactions using cellular membrane affinity chromatography: chiral recognition as a dynamic process.

S. Ravichandran, R. Moaddel, I. Wainer, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Are basal D-serine plasma levels a predictive biomarker for the rapid antidepressant effects of ketamineand ketamine metabolites?

I. Wainer, 2014, Psychopharmacology.

Gabapentin and (S)-pregabalin decrease intracellular d-serine concentrations in PC-12 cells

M. Torjman, I. Wainer, Nagendra S. Singh, 2013, Neuroscience Letters.

Stereoselective and regiospecific hydroxylation of ketamine and norketamine

M. Torjman, M. Sanghvi, Z. Desta, 2012, Xenobiotica; the fate of foreign compounds in biological systems.