E. Bennett

发表

AB‐Bind: Antibody binding mutational database for computational affinity predictions

James R. Apgar, Sarah Sirin, A. Keating, 2016, Protein science : a publication of the Protein Society.

Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues.

Y. Sham, G. Magni, M. Di Stefano, 2009, Bioorganic & medicinal chemistry.

Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design

James R. Apgar, Han Yang, X. Zhong, 2020, PloS one.

Morpholine derivatives greatly enhance the selectivity of mammalian target of rapamycin (mTOR) inhibitors.

N. Brooijmans, L. Toral-Barza, K. Curran, 2009, Journal of medicinal chemistry.

Synthesis of 4-phenoxybenzamide adenine dinucleotide as NAD analogue with inhibitory activity against enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis.

P. Tonge, Taesoo Kim, L. Bonnac, 2007, Bioorganic & medicinal chemistry letters.

PF-06804103, A Site-specific Anti-HER2 Antibody–Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers

F. Loganzo, C. J. O’Donnell, J. Lucas, 2020, Molecular Cancer Therapeutics.

Identification of pyrimidine derivatives as hSMG-1 inhibitors.

A. Gopalsamy, J. Bard, Wei-guo Zhang, 2012, Bioorganic & medicinal chemistry letters.

Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor.

L. Bonnac, Daniel J. Wilson, E. Bennett, 2007, Bioorganic & medicinal chemistry letters.

Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domain.

C. Aldrich, C. Barry, H. Boshoff, 2006, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of beta-ketosulfonamide adenylation inhibitors as potential antitubercular agents.

C. Aldrich, C. Barry, H. Boshoff, 2006, Organic letters.

Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis.

C. Aldrich, C. Barry, H. Boshoff, 2006, Journal of medicinal chemistry.

Nicotinamide adenine dinucleotide based therapeutics.

L. Bonnac, R. Petrelli, G. Gao, 2008, Current medicinal chemistry.

4-Amino-5-hydroxymethyl-2-methylpyrimidine Phosphate Kinase from Salmonella typhimurium

T. Begley, S. Ealick, E. Bennett, 2002 .

Rationally designed dual inhibitors of HIV reverse transcriptase and integrase.

C. Salomon, Daniel J. Wilson, Zhengqiang Wang, 2007, Journal of medicinal chemistry.

Structural Basis for Substrate Specificity of Escherichia coli Purine Nucleoside Phosphorylase*

S. Ealick, W. Parker, E. Bennett, 2003, Journal of Biological Chemistry.

Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine.

C. Aldrich, C. Barry, H. Boshoff, 2008, Journal of medicinal chemistry.

Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution.

Tadhg P Begley, Gong Cheng, T. Begley, 2002, Structure.

A mechanism-based aryl carrier protein/thiolation domain affinity probe.

Courtney C Aldrich, C. Aldrich, Chunhua Qiao, 2007, Journal of the American Chemical Society.

Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.

R. Anand, D. Levasseur, Jeong S. Hong, 2003, Chemistry & biology.

A model for the Bacillus subtilis formylglycinamide ribonucleotide amidotransferase multiprotein complex.

M. Sintchak, R. Anand, J. Stubbe, 2004, Biochemistry.

Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates

F. Loganzo, C. J. O’Donnell, E. Graziani, 2017, The AAPS Journal.

Low-data interpretable deep learning prediction of antibody viscosity using a biophysically meaningful representation

James R. Apgar, B. Rai, E. Bennett, 2023, Scientific Reports.

5'-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: an adenylation enzyme required for siderophore biosynthesis of the mycobactins.

C. Aldrich, C. Barry, H. Boshoff, 2007, Journal of medicinal chemistry.

Mechanism of human S-adenosylmethionine decarboxylase proenzyme processing as revealed by the structure of the S68A mutant.

W. Tolbert, A. Pegg, S. Ealick, 2003, Biochemistry.

Reduction of therapeutic antibody self-association using yeast-display selections and machine learning

Yulei Zhang, Amendra Fernando, E. Bennett, 2022, mAbs.

Quantitative three dimensional structure linear interaction energy model of 5'-O-[N-(salicyl)sulfamoyl]adenosine and the aryl acid adenylating enzyme MbtA.

D. Ferguson, C. Aldrich, E. Bennett, 2008, Journal of medicinal chemistry.

Identification and optimization of indolo[2,3-c]quinoline inhibitors of IRAK4.

D. Boschelli, V. Rao, E. A. Murphy, 2014, Bioorganic & medicinal chemistry letters.

Three-dimensional Structure of YaaE from Bacillus subtilis, a Glutaminase Implicated in Pyridoxal-5′-phosphate Biosynthesis*

Tadhg P Begley, J. A. Bauer, T. Begley, 2004, Journal of Biological Chemistry.

Combining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibody

James R. Apgar, Joe DeBartolo, E. Bennett, 2021, mAbs.

Monomeric S-adenosylmethionine decarboxylase from plants provides an alternative to putrescine stimulation.

A. Pegg, S. Ealick, E. Bennett, 2002, Biochemistry.

Probing binding requirements of NAD kinase with modified substrate (NAD) analogues.

Qian Ming, Steven E Patterson, G. Magni, 2007, Bioorganic & medicinal chemistry letters.