A. Stefanachi

发表

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds

F. Leonetti, M. Catto, A. Carotti, 2018, Molecules.

Enhancing the Sensitivity of Biotinylated Surfaces by Tailoring the Design of the Mixed Self-Assembled Monolayer Synthesis

L. Torsi, R. Picca, G. Scamarcio, 2020, ACS omega.

Design, Synthesis, and Biological Evaluation of 2‐Aminobenzanilide Derivatives as Potent and Selective HDAC Inhibitors

L. Altucci, A. Nebbioso, M. Jung, 2012, ChemMedChem.

Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.

C. Caccia, F. Leonetti, O. Nicolotti, 2007, Journal of medicinal chemistry.

Targeting monoamine oxidases with multipotent ligands: an emerging strategy in the search of new drugs against neurodegenerative diseases.

F. Leonetti, O. Nicolotti, M. Catto, 2011, Current medicinal chemistry.

Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors.

O. Nicolotti, M. Catto, A. Carotti, 2013, Journal of medicinal chemistry.

Computational methods for the design of potent aromatase inhibitors

Angelo D. Favia, F. Leonetti, O. Nicolotti, 2013, Expert opinion on drug discovery.

1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor.

F. Sanz, M. Loza, J. Brea, 2008, Bioorganic & medicinal chemistry.

Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor.

F. Sanz, M. Loza, E. Sotelo, 2006, Journal of medicinal chemistry.

8-Substituted-9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A2B.

M. Loza, E. Sotelo, M. Cadavid, 2004, European journal of medicinal chemistry.

Design , Synthesis , and Structure-Activity Relationships of 1-, 3-, 8-, and 9-Substituted-9-deazaxanthines at the Human A 2 B Adenosine Receptor

F. Sanz, M. Loza, E. Sotelo, 2022 .

Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design.

G. Mangiatordi, M. M. Cavalluzzi, O. Nicolotti, 2019, Drug discovery today.

Insights into the Complex Formed by Matrix Metalloproteinase-2 and Alloxan Inhibitors: Molecular Dynamics Simulations and Free Energy Calculations

G. Lattanzi, F. Leonetti, O. Nicolotti, 2011, PloS one.

3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition.

J. Åqvist, X. García‐Mera, J. Azuaje, 2020, Journal of medicinal chemistry.

Discovery of a Potent and Selective Hetero‐Bivalent AChE Inhibitor via Bioisosteric Replacement

F. Leonetti, O. Nicolotti, M. Catto, 2011, Molecular informatics.

Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to

F. Leonetti, O. Nicolotti, A. Stefanachi, 2020, Molecules.

Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein.

F. Berardi, R. Perrone, N. Colabufo, 2012, Journal of medicinal chemistry.

Negatively charged ions to probe self-assembled monolayer reorganization driven by interchain interactions

L. Torsi, R. Picca, G. Scamarcio, 2021, Journal of Materials Chemistry C.

Design, Synthesis, and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium‐like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors

F. Leonetti, O. Nicolotti, M. Catto, 2010, ChemMedChem.

Bcr-Abl Tyrosine Kinase Inhibitors in the Treatment of Pediatric CML

N. Denora, F. Leonetti, O. Nicolotti, 2020, International journal of molecular sciences.

Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.

F. Leonetti, O. Nicolotti, M. Catto, 2013, Bioorganic & medicinal chemistry.

A twenty-year journey exploring coumarin-based derivatives as bioactive molecules

F. Leonetti, O. Nicolotti, M. Catto, 2022, Frontiers in Chemistry.

Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams

F. Leonetti, O. Nicolotti, M. Catto, 2012 .

Corrigendum to “1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor” [Bioorg. Med. Chem. 16 (2008) 2852–2869]

F. Sanz, M. Loza, E. Sotelo, 2008 .

Design, synthesis, biological evaluation, NMR and DFT studies of structurally simplified trimethoxy benzamides as selective P‐glycoprotein inhibitors: the role of molecular flatness

C. Adamo, N. Colabufo, Mauro Niso, 2016, Chemical biology & drug design.

Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding.

F. Berardi, R. Perrone, N. Colabufo, 2014, Journal of medicinal chemistry.

Fine molecular tuning at position 4 of 2H-chromen-2-one derivatives in the search of potent and selective monoamine oxidase B inhibitors.

O. Nicolotti, Domenico Gadaleta, M. Catto, 2013, European journal of medicinal chemistry.

Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R).

M. Loza, J. Brea, N. Colabufo, 2020, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase.

Angelo Carotti, Francesco Leonetti, Orazio Nicolotti, 2011, Journal of medicinal chemistry.

Fast and highly efficient one-pot synthesis of 9-deazaxanthines

F. Leonetti, Anna Cappa, A. Carotti, 2003 .

Synthesis of 1-substituted-6-methyluracils.

E. Sotelo, Alberto Coelho, R. Nieto, 2003, Chemical & pharmaceutical bulletin.

Galloyl benzamide‐based compounds modulating tumour necrosis factor α‐stimulated c‐Jun N‐terminal kinase and p38 mitogen‐activated protein kinase signalling pathways

F. Leonetti, A. Carotti, A. Stefanachi, 2015, The Journal of pharmacy and pharmacology.

Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9.

Angelo Carotti, Saverio Cellamare, Fulvio Loiodice, 2012, European journal of medicinal chemistry.

Synthesis and biological evaluation of N-biphenyl-nicotinic based moiety compounds: A new class of antimitotic agents for the treatment of Hodgkin Lymphoma.

A. Guarini, A. Azzariti, L. Porcelli, 2019, Cancer letters.

Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides

M. de Candia, N. Denora, A. Boccarelli, 2017, ChemMedChem.

Mind the Gap! A Journey towards Computational Toxicology

Angelo Carotti, Saverio Cellamare, Daniela Trisciuzzi, 2016, Molecular informatics.

Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase.

M. Loza, J. Brea, E. Sotelo, 2022, Journal of medicinal chemistry.

Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration.

Mauro Niso, F. Intranuovo, G. Mangiatordi, 2020, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Abeta1-40 aggregation in vitro.

E. Sotelo, P. Acquafredda, M. Catto, 2008, Bioorganic & medicinal chemistry.

N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R).

M. Loza, E. Sotelo, J. Brea, 2023, European journal of medicinal chemistry.

Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists

X. García‐Mera, Cristina Val, M. Loza, 2022, Journal of medicinal chemistry.

Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.

F. Leonetti, Anna Cappa, O. Nicolotti, 2008, Bioorganic & medicinal chemistry.

Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques

E. Sotelo, Mauro Niso, C. Riganti, 2023, Journal of medicinal chemistry.

Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase.

R. Hartmann, F. Leonetti, O. Nicolotti, 2015, European journal of medicinal chemistry.

Strategies of multi-objective optimization in drug discovery and development

Angelo Carotti, Ilenia Giangreco, Francesco Leonetti, 2011, Expert opinion on drug discovery.

Solid phase synthesis of a molecular library of pyrimidines, pyrazoles, and isoxazoles with biological potential

Angelo Carotti, Francesco Leonetti, Orazio Nicolotti, 2010 .

Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs

E. Sotelo, A. Ligresti, F. Leonetti, 2023, International journal of molecular sciences.

Controlling the Binding Efficiency of Surface Confined Antibodies through the Design of Mixed Self‐Assembled Monolayers

L. Torsi, R. Picca, G. Scamarcio, 2023, Advanced Materials Interfaces.

1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships.

M. Loza, J. Brea, F. Leonetti, 2008, Bioorganic & medicinal chemistry.

Surface composition of mixed self-assembled monolayers on Au by infrared attenuated total reflection spectroscopy

L. Torsi, G. Scamarcio, D. Blasi, 2021 .

BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile.

F. Leonetti, O. Nicolotti, M. Catto, 2011, Current medicinal chemistry.

Galloyl benzamide‐based compounds modulating tumour necrosis factor α‐stimulated c‐Jun N‐terminal kinase and p38 mitogen‐activated protein kinase signalling pathways

F. Leonetti, A. Carotti, A. Stefanachi, 2015, The Journal of pharmacy and pharmacology.

Strategies of multi-objective optimization in drug discovery and development

F. Leonetti, O. Nicolotti, A. Carotti, 2011, Expert opinion on drug discovery.

1,3-dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships.

X. García‐Mera, J. Brea, O. Nicolotti, 2009, Bioorganic & medicinal chemistry.

Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides

M. de Candia, N. Denora, A. Boccarelli, 2017, ChemMedChem.

New strategies in the chemotherapy of leukemia: eradicating cancer stem cells in chronic myeloid leukemia.

F. Leonetti, O. Nicolotti, M. Catto, 2012, Current cancer drug targets.