L. Pisani

发表

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds

F. Leonetti, M. Catto, A. Carotti, 2018, Molecules.

Multitarget‐Directed Tricyclic Pyridazinones as G Protein‐Coupled Receptor Ligands and Cholinesterase Inhibitors

M. Loza, J. Brea, G. Pinna, 2015, ChemMedChem.

In silico design of novel 2H-chromen-2-one derivatives as potent and selective MAO-B inhibitors.

Angelo Carotti, Orazio Nicolotti, Domenico Gadaleta, 2015, European journal of medicinal chemistry.

Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones

M. de Candia, M. Catto, L. Pisani, 2019, Molecules.

A rational approach to elucidate human monoamine oxidase molecular selectivity

G. Lattanzi, D. Alberga, G. Mangiatordi, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

8‐Aminomethyl‐7‐hydroxy‐4‐methylcoumarins as Multitarget Leads for Alzheimer's Disease

F. Sussman, J. Brea, M. Catto, 2016 .

Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.

P. Carrupt, Alessandra Nurisso, N. Denora, 2015, Journal of medicinal chemistry.

Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.

C. Caccia, F. Leonetti, O. Nicolotti, 2007, Journal of medicinal chemistry.

Targeting monoamine oxidases with multipotent ligands: an emerging strategy in the search of new drugs against neurodegenerative diseases.

F. Leonetti, O. Nicolotti, M. Catto, 2011, Current medicinal chemistry.

Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors.

O. Nicolotti, M. Catto, A. Carotti, 2013, Journal of medicinal chemistry.

5-aroyl-3,4-dihydropyrimidin-2-one library generation via automated sequential and parallel microwave-assisted synthesis techniques.

J. Kremsner, C. Kappe, H. Prokopcová, 2007, Journal of combinatorial chemistry.

Rational Redesign of Monoamine Oxidase A into a Dehydrogenase to Probe ROS in Cardiac Aging

A. Mattevi, J. Mialet-Perez, A. Parini, 2020, ACS chemical biology.

Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors

R. Iacobazzi, N. Denora, D. Alberga, 2018, Chemical biology & drug design.

Evaluation of Water‐Soluble Mannich Base Prodrugs of 2,3,4,5‐Tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as Multitarget‐Directed Agents for Alzheimer's Disease

N. Denora, M. Catto, L. Pisani, 2020, ChemMedChem.

Scouting around 1,2,3,4‐Tetrahydrochromeno[3,2‐c]pyridin‐10‐ones for Single‐ and Multitarget Ligands Directed towards Relevant Alzheimer's Targets

M. Catto, L. Pisani, C. Altomare, 2020, ChemMedChem.

Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease.

M. de Candia, M. Catto, L. Pisani, 2019, European journal of medicinal chemistry.

Discovery of a Potent and Selective Hetero‐Bivalent AChE Inhibitor via Bioisosteric Replacement

F. Leonetti, O. Nicolotti, M. Catto, 2011, Molecular informatics.

Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer’s Disease Potential

R. Borisov, M. de Candia, O. Nicolotti, 2021, Molecules.

3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance.

A. V. Varlamov, N. Colabufo, Mauro Niso, 2019, Future medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium‐like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors

F. Leonetti, O. Nicolotti, M. Catto, 2010, ChemMedChem.

Mannich base approach to 5‐methoxyisatin 3‐(4‐isopropylphenyl)hydrazone: A water‐soluble prodrug for a multitarget inhibition of cholinesterases, beta‐amyloid fibrillization and oligomer‐induced cytotoxicity

O. Nicolotti, M. Catto, L. Pisani, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer’s Disease

R. Sabaté, A. Espargaró, M. de Candia, 2020, Molecules.

Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.

F. Leonetti, O. Nicolotti, M. Catto, 2013, Bioorganic & medicinal chemistry.

A twenty-year journey exploring coumarin-based derivatives as bioactive molecules

F. Leonetti, O. Nicolotti, M. Catto, 2022, Frontiers in Chemistry.

Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams

F. Leonetti, O. Nicolotti, M. Catto, 2012 .

1,2,3,4-Tetrahydroisoquinoline/2 H -chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1

N. Colabufo, Mauro Niso, L. Pisani, 2022 .

Fine molecular tuning at position 4 of 2H-chromen-2-one derivatives in the search of potent and selective monoamine oxidase B inhibitors.

O. Nicolotti, Domenico Gadaleta, M. Catto, 2013, European journal of medicinal chemistry.

Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.

R. Iacobazzi, N. Denora, M. Catto, 2019, European journal of medicinal chemistry.

Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity

M. de Candia, F. De Santis, M. Catto, 2018, Molecules.

Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies.

A. Linusson, M. de Candia, T. Latronico, 2022, Journal of medicinal chemistry.

Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs.

Angelo Carotti, Leonardo Pisani, Andrea Mattevi, 2007, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase.

Angelo Carotti, Francesco Leonetti, Orazio Nicolotti, 2011, Journal of medicinal chemistry.

Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B i

C. Caccia, F. Leonetti, O. Nicolotti, 2009, Journal of medicinal chemistry.

Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif

N. Denora, G. Mangiatordi, O. Nicolotti, 2016, Molecules.

Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.

A. Sparatore, O. Nicolotti, F. Novelli, 2011, European journal of medicinal chemistry.

1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1.

N. Colabufo, Mauro Niso, L. Pisani, 2019, European journal of medicinal chemistry.

Synthesis of 5-Aroyldihydropyrimidinones via Liebeskind-Srogl Thiol Ester-Boronic Acid Cross-Couplings

C. Kappe, H. Prokopcová, L. Pisani, 2007 .

4-Hydroxycoumarins as Michael donors in asymmetric routes to polycyclic coumarins (microreview)

L. Pisani, Mariagrazia Rullo, 2018, Chemistry of Heterocyclic Compounds.

Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.

M. Bartolini, J. Sussman, M. Naldi, 2019, European journal of medicinal chemistry.

A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE)

A. Laghezza, M. Catto, F. Loiodice, 2022, Molecules.

Structure-property relationship study of the HPLC enantioselective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase.

M. de Candia, M. Catto, L. Pisani, 2018, Journal of separation science.

Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs.

P. Koutentis, I. Eberini, M. Catto, 2017, Biochemical pharmacology.

Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures

F. Ekström, M. Catto, L. Pisani, 2022, ACS medicinal chemistry letters.

A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease

M. de Candia, M. Catto, L. Pisani, 2019, Molecules.

Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity.

J. Campos, A. Conejo-García, F. Leonetti, 2011, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9.

Angelo Carotti, Saverio Cellamare, Fulvio Loiodice, 2012, European journal of medicinal chemistry.

Mind the Gap! A Journey towards Computational Toxicology

Angelo Carotti, Saverio Cellamare, Daniela Trisciuzzi, 2016, Molecular informatics.

Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease.

J. D. del Río, E. Laurini, S. Pricl, 2023, European journal of medicinal chemistry.

First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease

M. de Candia, O. Nicolotti, M. Catto, 2021, Molecules.

Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.

F. Leonetti, Anna Cappa, O. Nicolotti, 2008, Bioorganic & medicinal chemistry.

Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi‐ and Tricyclic Systems as Dual Inhibitors of Cholinesterases and β‐Amyloid (Aβ) Aggregation

A. Sparatore, N. Denora, F. Novelli, 2015, ChemMedChem.

Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase.

R. Hartmann, F. Leonetti, O. Nicolotti, 2015, European journal of medicinal chemistry.

Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model

Angelo Carotti, Ilenia Giangreco, Francesco Leonetti, 2010, J. Comput. Aided Mol. Des..

Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors.

A. Linusson, G. Mangiatordi, T. Latronico, 2023, European journal of medicinal chemistry.

Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo‐ and Heterodimerization of Coumarin‐Based Moieties

M. Catto, L. Pisani, R. Farina, 2017, ChemMedChem.

Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.

Lydia Siragusa, R. Iacobazzi, N. Denora, 2016, Journal of medicinal chemistry.

Solid phase synthesis of a molecular library of pyrimidines, pyrazoles, and isoxazoles with biological potential

Angelo Carotti, Francesco Leonetti, Orazio Nicolotti, 2010 .

BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile.

F. Leonetti, O. Nicolotti, M. Catto, 2011, Current medicinal chemistry.

Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents.

N. Denora, O. Nicolotti, M. Catto, 2021, ACS chemical neuroscience.

Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor.

I. Silman, E. de la Mora, J. Colletier, 2020, ACS medicinal chemistry letters.

Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.

M. Bartolini, J. Sussman, M. Naldi, 2019, European journal of medicinal chemistry.

A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics

M. de Candia, M. Catto, L. Pisani, 2024, Antioxidants.

Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity.

G. M. Liuzzi, M. Catto, L. Pisani, 2024, European journal of medicinal chemistry.

New strategies in the chemotherapy of leukemia: eradicating cancer stem cells in chronic myeloid leukemia.

F. Leonetti, O. Nicolotti, M. Catto, 2012, Current cancer drug targets.