M. Helfrich

P. W. Johnston, S. Ralston, L. Ho, 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Explorer A Class III Semaphorin ( Sema 3 e ) Inhibits Mouse Osteoblast Migration and Decreases Osteoclast Formation In Vitro

A. Hughes, S. Ralston, M. Rogers, 2017 .

A Class III Semaphorin (Sema3e) Inhibits Mouse Osteoblast Migration and Decreases Osteoclast Formation In Vitro

A. Hughes, S. Ralston, M. Rogers, 2012, Calcified Tissue International.

Autophagy: A new player in skeletal maintenance?

L. Hocking, M. Helfrich, C. Whitehouse, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Osteoclast formation in vitro from progenitor cells present in the adult mouse circulation

R. Mieremet, M. Helfrich, C. Wil Thesingh, 1989, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Modulation of vitronectin receptor‐mediated osteoclast adhesion by Arg‐Gly‐Asp peptide analogs: A structure‐function analysis

M. Horton, S. Nesbitt, M. Helfrich, 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Chapter 6 – Early Onset Pagetic Disorders: Implications for Late-Onset Paget’s Disease of Bone

J. Crockett, M. Helfrich, 2016 .

Early Onset Pagetic Disorders

J. Crockett, M. Helfrich, 2016 .

A New Heterozygous Mutation (R714C) of the Osteopetrosis Gene, Pleckstrin Homolog Domain Containing Family M (With Run Domain) Member 1 (PLEKHM1), Impairs Vesicular Acidification and Increases TRACP Secretion in Osteoclasts

J. Timmermans, A. Teti, S. Migliaccio, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Osteoclast heterogeneity: lessons from osteopetrosis and inflammatory conditions.

V. Everts, M. Helfrich, T. D. de Vries, 2009, Biochimica et biophysica acta.

Pamidronate causes apoptosis of plasma cells in vivo in patients with multiple myeloma

S. Ralston, M. Greaves, M. Rogers, 2002, British journal of haematology.

Rat osteoclasts adhere to a wide range of rgd (arg‐gly‐asp) peptide‐containing proteins, including the bone sialoproteins and fibronectin, via a β3 integrin

S. Nesbitt, M. Helfrich, E. Dorey, 1992 .

Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase.

S. Ralston, N. Benjamin, P. Grabowski, 1994, Endocrinology.

CHAPTER 8 – Integrins and Other Adhesion Molecules

M. Horton, M. Helfrich, 2006 .

The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor

M. Horton, R. Philp, N. Totty, 1989, The Journal of cell biology.

Identification of a Novel Phosphonocarboxylate Inhibitor of Rab Geranylgeranyl Transferase That Specifically Prevents Rab Prenylation in Osteoclasts and Macrophages*

M. Horton, S. Nesbitt, B. Larijani, 2001, The Journal of Biological Chemistry.

RANK-Dependent Autosomal Recessive Osteopetrosis: Characterization of Five New Cases With Novel Mutations

A. Fischer, A. Schulz, A. Durandy, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

An Unbalanced Rearrangement of Chromosomes 4:20 is Associated with Childhood Osteoporosis and Reduced Caspase-3 Levels

S. Ahmed, M. McMillan, E. Kinning, 2016, Journal of Pediatric Genetics.

Multicenter Blinded Analysis of RT‐PCR Detection Methods for Paramyxoviruses in Relation to Paget's Disease of Bone

S. Ralston, W. Fraser, B. Rima, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Glycan degradation promotes macroautophagy

J. Pratt, K. Ryan, J. O'prey, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Does Paget's Disease Really Have a Viral Aetiology? Letter to the Editor: Maybe Not

S. Ralston, R. Hobson, T. Pennington, 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Biochemical characterization of human osteoclast integrins. Osteoclasts express alpha v beta 3, alpha 2 beta 1, and alpha v beta 1 integrins.

M. Horton, S. Nesbitt, A. Nesbit, 1993, The Journal of biological chemistry.

Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL

N. Bishop, A. Teti, A. Villa, 2007, Nature Genetics.

Fibrinogen mediates platelet-polymorphonuclear leukocyte cooperation during immune-complex glomerulonephritis in rats.

M. Horton, J. Lefkowith, L. Feigen, 1994, The Journal of clinical investigation.

Osteoclast diseases and dental abnormalities.

M. Helfrich, 2005, Archives of oral biology.

A study using confocal laser scanning microscopy

M. Horton, M. Helfrich, H. Väänänen, 1993 .

An assessment of the ability of human bone marrow cultures to generate osteoclasts.

M. Horton, T. Martin, A. Flanagan, 1992, International journal of experimental pathology.

A morphologic study of osteoclasts isolated from osteopetrotic microphthalmic (mi/mi) mouse and human fetal long bones using an instrument permitting combination of light and scanning electron microscopy.

R. Mieremet, M. Helfrich, 1988, Bone.

Spatial organization of microfilaments and vitronectin receptor , v 3 , in osteoclasts A study using confocal laser scanning microscopy

M. Horton, M. Helfrich, H. Väänänen, 2022 .

Integrins on rat osteoclasts: Characterization of two monoclonal antibodies (F4 and F11) to rat β3

S. Nesbitt, M. Helfrich, M. Horton, 1992 .

Beta 1 integrins and osteoclast function: involvement in collagen recognition and bone resorption.

M. Horton, S. Nesbitt, D. Mendrick, 1996, Bone.

Interaction of Osteopontin with Osteoclast Integrins a

M. Horton, M. Nesbit, M. Helfrich, 1995, Annals of the New York Academy of Sciences.

Integrin expression in human melanoma cell lines: Heterogeneity of vitronectin receptor composition and function

M. Horton, S. Nesbitt, I. Hart, 1991, International journal of cancer.

A new familial sclerosing bone dysplasia

E. Chouery, A. Mégarbané, G. Lefranc, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Autosomal recessive osteopetrosis: variability of findings at diagnosis and during the natural course.

A. Fischer, C. Griscelli, J. Hermans, 1994, Pediatrics.

Osteoclast generation from human fetal bone marrow in cocultures with murine fetal long bones

R. Mieremet, M. Helfrich, C. Thesingh, 1987, Cell and Tissue Research.

Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans.

J. Timmermans, A. Teti, A. Villa, 2007, The Journal of clinical investigation.

Recognition of cryptic sites in human and mouse laminins by rat osteoclasts is mediated by beta 3 and beta 1 integrins.

S. Bodary, M. Helfrich, M. Horton, 1994, Bone.

Morphologic features of bone in human osteopetrosis.

R. Mieremet, C. G. Groot, J. P. Scherft, 1991, Bone.

Are paramyxoviruses involved in Paget's disease? A negative view.

S. Ralston, M. Helfrich, 1999, Bone.

The synthesis and evaluation of o-phenylenediamine derivatives as fluorescent probes for nitric oxide detection

S. Ralston, M. Plater, Stuart H. Ralston, 2001 .

Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations.

David Mellis, Evelina Mazzolari, Paolo Vezzoni, 2008, American journal of human genetics.

The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway.

P. Croucher, M. Rogers, R. Russell, 1998, Cancer research.

ER Stress-Mediated Apoptosis in a New Mouse Model of Osteogenesis imperfecta

Gerhard K. H. Przemeck, H. Fuchs, E. Wolf, 2007, PLoS genetics.

Osteopetrosis: genetics, treatment and new insights into osteoclast function

A. Schulz, A. Villa, C. Sobacchi, 2013, Nature Reviews Endocrinology.

Genetics and aetiology of Pagetic disorders of bone.

L. Hocking, M. Helfrich, 2008, Archives of biochemistry and biophysics.

Bone Research Protocols

S. Ralston, Stuart H. Ralston, M. Helfrich, 2003, Methods in Molecular Biology.

Expression of Nitric Oxide Synthase Isoforms in Bone and Bone Cell Cultures

J. Pollock, S. Ralston, H. Ohshima, 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma: A novel mechanism of oncogene de-regulation

S. Ralston, F. Paulin, A. Willis, 2000, Oncogene.

Osteoclast diseases

M. Helfrich, 2003, Microscopy research and technique.

PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection.

B. Maček, D. Bumann, A. Frangakis, 2015, Cell host & microbe.

The pathogenesis of osteoclast diseases: Some knowns, but still many unknowns

L. Hocking, J. Crockett, F. Coxon, 2007 .

Abstracts Presented at the Bone Research Society Meeting, Jointly with the British Society for Matrix Biology

J. Gregory, M. Ahasan, C. Buckley, 2009, Calcified Tissue International.

The skeleton: a multi-functional complex organ: the role of key signalling pathways in osteoclast differentiation and in bone resorption.

J. Crockett, M. Helfrich, Miep H Helfrich, 2011, The Journal of endocrinology.

A mutation affecting the latency-associated peptide of TGFbeta1 in Camurati-Engelmann disease enhances osteoclast formation in vitro.

S. Ralston, K. Janssens, W. Fraser, 2003, The Journal of clinical endocrinology and metabolism.

Protein Geranylgeranylation Is Required for Osteoclast Formation, Function, and Survival: Inhibition by Bisphosphonates and GGTI‐298

S. Ralston, S. Sebti, M. Rogers, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts

Therese G. Kellgren, A. Ameur, G. Hallmans, 2017, Scientific Reports.

Vitronectin receptor has a role in bone resorption but does not mediate tight sealing zone attachment of osteoclasts to the bone surface

M. Horton, M. Helfrich, H. Väänänen, 1991, The Journal of cell biology.

The Pro and Con of Measles Virus in Paget's Disease: Con

S. Ralston, B. Rima, M. Helfrich, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

New knowledge on critical osteoclast formation and activation pathways from study of rare genetic diseases of osteoclasts: focus on the RANK/RANKL axis

J. Crockett, M. Helfrich, David J Mellis, 2010, Osteoporosis International.

Signal peptide mutations in RANK prevent downstream activation of NF-κB

S. Ralston, M. Rogers, J. Crockett, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Adhesive properties of isolated chick osteocytes in vitro.

M. Horton, A. van der Plas, P. Nijweide, 1996, Bone.

Arg-Gly-Asp (RGD) peptides and the anti-vitronectin receptor antibody 23C6 inhibit dentine resorption and cell spreading by osteoclasts.

M. Horton, T. Arnett, M. Helfrich, 1991, Experimental cell research.

Regulation of bone mass and bone turnover by neuronal nitric oxide synthase.

S. Ralston, H. Libouban, M. Helfrich, 2004, Endocrinology.

Bone Research Society, Annual Meeting 2017 Proceedings

P. Tsai, T. Spector, J. Bell, 2018, Journal of musculoskeletal & neuronal interactions.

Hydrogen peroxide, but not superoxide, stimulates bone resorption in mouse calvariae.

J H Fraser, S. Ralston, H. Wallace, 1996, Bone.

Endothelial Nitric Oxide Synthase is Not Essential for Nitric Oxide Production by Osteoblasts Subjected to Fluid Shear Stress In Vitro

Jenneke Klein-Nulend, Richard M. Aspden, R. Aspden, 2012, Calcified Tissue International.

Immunolocalization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis.

S. Ralston, P. K. Wright, H. Ohshima, 1997, British journal of rheumatology.

End stage renal disease‐induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived‐matrix vesicles

M. Dweck, D. Newby, C. Farquharson, 2017, Journal of cellular physiology.

Scanning electron microscopy of bone.

R. Aspden, M. Helfrich, D. Marshall, 2003, Methods in molecular medicine.

Functional interaction between sequestosome-1/p62 and autophagy-linked FYVE-containing protein WDFY3 in human osteoclasts.

L. Hocking, M. Rogers, M. Helfrich, 2010, Biochemical and biophysical research communications.

Nitric oxide response to shear stress by human bone cell cultures is endothelial nitric oxide synthase dependent.

E H Burger, J. Klein-Nulend, E. Burger, 1998, Biochemical and biophysical research communications.

D. Reid, S. Ralston, A. Gödecke, 2000 .

Supplemental Information PLEKHM 1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC 3 / GABARAP Proteins

Doris Popovic, C. Behrends, David G. McEwan, 2014 .

Endothelial Nitric Oxide Synthase is Not Essential for Nitric Oxide Production by Osteoblasts Subjected to Fluid Shear Stress In Vitro

R. Aspden, A. Hughes, J. Klein-Nulend, 2013, Calcified Tissue International.

Biochemical Characterization of Human Osteoclast Integrins

M. Horton, A. Nesbit, M. Helfrich, 2001 .

Defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase.

D. Reid, S. Ralston, A. Gödecke, 2001, Endocrinology.

Cytokine-activated endothelium recruits osteoclast precursors.

S. Ralston, M. Helfrich, H. Macpherson, 2001, Endocrinology.

Parallel-plate fluid flow systems for bone cell stimulation.

Richard M Aspden, R. Aspden, M. Helfrich, 2010, Journal of biomechanics.

A Negative Search for a Paramyxoviral Etiology of Paget's Disease of Bone: Molecular, Immunological, and Ultrastructural Studies in U.K. Patients

W. Fraser, R. Hobson, G. Dickson, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection.

B. Maček, D. Bumann, A. Frangakis, 2015, Cell Host and Microbe.

Guidelines for the use and interpretation of assays for monitoring autophage

T. P. Neufeld, Thomas J. Begley, H. Coller, 2012 .

Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans.

J. Timmermans, A. Teti, A. Villa, 2007, The Journal of clinical investigation.

An Unbalanced Rearrangement of Chromosomes 4:20 is Associated with Childhood Osteoporosis and Reduced Caspase-3 Levels

M. McMillan, E. Kinning, M. Helfrich, 2016, Journal of Pediatric Genetics.

Defective Bone Formation and Anabolic Response to Exogenous Estrogen in Mice with Targeted Disruption of Endothelial Nitric Oxide Synthase**This study was supported by grants from the Arthritis Research Campaign (UK) and the Medical Research Council (UK).

M. Helfrich, K. E. Armour, K. Armour, 2001, Endocrinology.