W W Smith

发表

Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones.

D. Matthews, C. Janson, S. Webber, 1993, Journal of medicinal chemistry.

Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis.

S. Abdel-Meguid, C. Janson, C. Silverman, 1999, The Journal of biological chemistry.

Refined structures of beta-ketoacyl-acyl carrier protein synthase III.

M. Head, C. Janson, Ward W. Smith, 2001, Journal of molecular biology.

Azepanone-based inhibitors of human and rat cathepsin K.

Y. Ru, D. Veber, K. Ward, 2001, Journal of medicinal chemistry.

Cyclic ketone inhibitors of the cysteine protease cathepsin K.

Y. Ru, D. Veber, M. Hemling, 2001, Journal of medicinal chemistry.

Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites.

R. DesJarlais, D. Veber, S. Abdel-Meguid, 1999, Journal of medicinal chemistry.

Lowering the entropic barrier for binding conformationally flexible inhibitors to enzymes.

M. James, M. Fraser, P. Bartlett, 1998, Biochemistry.

Structure of oxidized flavodoxin from Anacystis nidulans.

D Tsernoglou, G A Petsko, G. Petsko, 1983, Journal of molecular biology.

Structure-based design of cathepsin K inhibitors containing a benzyloxy-substituted benzoyl peptidomimetic.

R. DesJarlais, D. Veber, S. Abdel-Meguid, 1998, Journal of medicinal chemistry.

The structure of the oxidized form of clostridial flavodoxin at 1.9-A resolution.

R. M. Burnett, M. Lequesne, D. Kendall, 1974, The Journal of biological chemistry.

Structural studies of Rubisco from tobacco.

M S Chapman, D Eisenberg, M. S. Chapman, 1986, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Design of potent and selective human cathepsin K inhibitors that span the active site.

J G Gleason, S. Carr, R. DesJarlais, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Structure of the semiquinone form of flavodoxin from Clostridum MP. Extension of 1.8 A resolution and some comparisons with the oxidized state.

R. M. Burnett, M. Ludwig, G. D. Darling, 1978, Journal of molecular biology.

Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis.

S R Jordan, D. Matthews, C. Janson, 1992, Journal of medicinal chemistry.

Tertiary structure of plant RuBisCO: domains and their contacts.

M S Chapman, M. S. Chapman, D. Eisenberg, 1988, Science.