Donald S. Backos

发表

NMDA Receptor-Dependent Activation of the Small GTPase Rab5 Drives the Removal of Synaptic AMPA Receptors during Hippocampal LTD

J. Esteban, D. Backos, Tyler C. Brown, 2005, Neuron.

Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase.

H. Forman, T. Kavanagh, C. White, 2009, Molecular aspects of medicine.

SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.

J. Capra, J. Thompson, Brett S. Peterson, 2017, Cell metabolism.

Strategies and Approaches of Targeting STAT3 for Cancer Treatment.

D. Backos, Donald S. Backos, P. Reigan, 2016, ACS chemical biology.

Motor protein–dependent transport of AMPA receptors into spines during long-term potentiation

M. Passafaro, A. El-Husseini, J. Esteban, 2008, Nature Neuroscience.

Substituted pteridinones as p90 ribosomal S6 protein kinase (RSK) inhibitors: A structure-activity study.

Donald S. Backos, P. Reigan, Christopher J. Matheson, 2020, Bioorganic & medicinal chemistry.

Selective Targeting of RSK Isoforms in Cancer.

D. Backos, Donald S. Backos, P. Reigan, 2017, Trends in cancer.

Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane

J. Esteban, M. Spaller, D. Backos, 2006, The EMBO journal.

Identification and characterization of novel mutations implicated in congenital fibrinogen disorders

C. Thornburg, L. Noetzli, J. Di Paola, 2018, Research and practice in thrombosis and haemostasis.

Targeting WEE1 Kinase in Cancer.

D. Backos, Donald S. Backos, P. Reigan, 2016, Trends in pharmacological sciences.

Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH*

Peter Fristrup, Jonas S. Laursen, C. Olsen, 2016, The Journal of Biological Chemistry.

Maneb adducts human peroxiredoxin 3 through thiol interactions

James R. Roede, John O. Marentette, D. Backos, 2021, Advances in Redox Research.

Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo.

D. Simberg, S. Moghimi, Guankui Wang, 2017, Nature nanotechnology.

Evaluation of quantitative assays for the identification of direct signal transducer and activator of transcription 3 (STAT3) inhibitors

D. Backos, Donald S. Backos, P. Reigan, 2016, Oncotarget.

Investigating the Sensitivity of NAD (cid:2) -dependent Sirtuin Deacylation Activities to NADH * □ S

Jonas S. Laursen, C. Olsen, C. Andersen, 2020 .

A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.

Laura G. Dubois, J. Thompson, T. M. O’Connell, 2017, Cell metabolism.

Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors.

C. Jordan, D. Backos, Donald S. Backos, 2020, European journal of medicinal chemistry.

Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation

James R. Roede, D. Orlicky, M. Hirschey, 2017, Alcoholism, clinical and experimental research.

Structure-Based Screen Identification of a Mammalian Ste20-like Kinase 4 (MST4) Inhibitor with Therapeutic Potential for Pituitary Tumors

Mei Xu, D. Backos, Donald S. Backos, 2015, Molecular Cancer Therapeutics.

Local Control of AMPA Receptor Trafficking at the Postsynaptic Terminal by a Small GTPase of the Rab Family*

J. Esteban, D. Backos, Donald S. Backos, 2004, Journal of Biological Chemistry.

The Nurr1 Ligand,1,1-bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism

Pranav U. Damale, Edwin K. P. Chong, D. Backos, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Molecular docking of substituted pteridinones and pyrimidines to the ATP-binding site of the N-terminal domain of RSK2 and associated MM/GBSA and molecular field datasets

D. Backos, Donald S. Backos, P. Reigan, 2020, Data in brief.

Allosteric Inhibitors of the Eya2 Phosphatase Are Selective and Inhibit Eya2-mediated Cell Migration*

M. Ferrer, H. Ford, E. Eisenmesser, 2014, The Journal of Biological Chemistry.

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.

Yingming Zhao, Brett S. Peterson, O. Ilkayeva, 2014, Cell metabolism.

Iloprost requires the Frizzled-9 receptor to prevent lung cancer

Alex J. Smith, L. Dwyer-Nield, M. Tennis, 2022, iScience.

The Lateral Metalation of Isoxazolo[3,4-d]pyridazinones towards Hit-to-Lead Development of Selective Positive Modulators of Metabotropic Glutamate Receptors

Donald S. Backos, P. Reigan, N. R. Natale, 2023, Molecules.

Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4.

D. Backos, Donald S. Backos, P. Reigan, 2018, Bioorganic & medicinal chemistry.

The Role of Glutathione and the Glutathione-Linked Enzyme Systems in Brain Tumor Drug Resistance

D. Backos, Donald S. Backos, P. Reigan, 2014 .

Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55.

E. Groman, V. M. Holers, D. Simberg, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Posttranslational modification and regulation of glutamate-cysteine ligase by the α,β-unsaturated aldehyde 4-hydroxy-2-nonenal.

James R. Roede, D. Petersen, D. Backos, 2011, Free radical biology & medicine.

Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes

K. J. Lawrence, R. Harris, L. Snell, 2017, Scientific Reports.

Deacetylation by SIRT3 Relieves Inhibition of Mitochondrial Protein Function

Brett S. Peterson, M. Hirschey, K. A. Anderson, 2016 .

Development of Potent Pyrazolopyrimidinone‐Based WEE1 Inhibitors with Limited Single‐Agent Cytotoxicity for Cancer Therapy

D. Backos, Donald S. Backos, P. Reigan, 2018, ChemMedChem.

A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells.

M. Wempe, V. Amani, R. Vibhakar, 2016, ACS chemical biology.

ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein-protein interactions with HPRT1.

Brian C. Jackson, Vindhya Koppaka, Ying Chen, 2013, Chemico-biological interactions.

Characterization and Optimization of the Novel Transient Receptor Potential Melastatin 2 Antagonist tatM2NX

P. Herson, D. Backos, Donald S. Backos, 2019, Molecular Pharmacology.

Compensatory Expression of Nur77 and Nurr1 Regulates NF-κB–Dependent Inflammatory Signaling in Astrocytes

J. Moreno, D. Backos, Donald S. Backos, 2018, Molecular Pharmacology.

Manipulation of cellular GSH biosynthetic capacity via TAT-mediated protein transduction of wild-type or a dominant-negative mutant of glutamate cysteine ligase alters cell sensitivity to oxidant-induced cytotoxicity.

C. Brocker, D. Backos, Donald S. Backos, 2010, Toxicology and applied pharmacology.

Computational Modeling of NLRP3 Identifies Enhanced ATP Binding and Multimerization in Cryopyrin-Associated Periodic Syndromes

J. Domenico, D. Backos, J. Samson, 2020, Frontiers in Immunology.

Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells.

S. Safe, Qiao Wu, D. Backos, 2014, Molecular endocrinology.

AIMing towards improved antitumor efficacy.

Matthew J. Weaver, Chun Xing Li, Donald S. Backos, 2015, Bioorganic & medicinal chemistry letters.

Redox modulation of NQO1

R. de Cabo, D. Ross, D. Siegel, 2018, PloS one.

Brain-derived Neurotrophic Factor Regulates the Expression and Synaptic Delivery ofα-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor Subunits in Hippocampal Neurons*

C. V. Melo, C. Duarte, R. Carvalho, 2007, Journal of Biological Chemistry.

The role of glutathione in brain tumor drug resistance.

D. Backos, Donald S. Backos, P. Reigan, 2012, Biochemical pharmacology.

ROCK and Rho: Promising therapeutic targets to ameliorate pulmonary fibrosis.

D. Riches, D. Backos, E. Redente, 2015, The American journal of pathology.

Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.

J. Galligan, D. Petersen, D. Backos, 2014, Free radical biology & medicine.

Characterizing Sirtuin 3 Deacetylase Affinity for Aldehyde Dehydrogenase 2.

D. Backos, Donald S. Backos, K. Fritz, 2017, Chemical research in toxicology.

Identification of 5′ AMP-activated Kinase as a Target of Reactive Aldehydes during Chronic Ingestion of High Concentrations of Ethanol*

D. Petersen, D. Orlicky, D. Backos, 2014, The Journal of Biological Chemistry.

Ethanol Chronic Ingestion of High Concentrations as a Target of Reactive Aldehydes during AMP-activated Kinase ′ Identification of 5 Lipids :

D. Petersen, D. Orlicky, D. Backos, 2014 .

Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease

J. Galligan, D. Petersen, D. Orlicky, 2012, Journal of toxicology.

Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis.

D. Petersen, D. Orlicky, D. Backos, 2013, Free radical biology & medicine.

Novel chromobox 2 inhibitory peptide decreases tumor progression

Benjamin G. Bitler, R. Iwanaga, V. Nguyen, 2023, Expert opinion on therapeutic targets.

Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2.

Brian C. Jackson, B. Jackson, D. Thompson, 2013, Chemico-biological interactions.

Statin therapy inhibits fatty acid synthase via dynamic protein modifications

Scott B. Crown, J. Thompson, O. Ilkayeva, 2021, Nature Communications.

4‐Hydroxy‐2‐nonenal attenuates 8‐oxoguanine DNA glycosylase 1 activity

Nicholas J. Carruthers, S. Palaniyandi, P. Stemmer, 2020, Journal of cellular biochemistry.

Glycation of Glutamate Cysteine Ligase by 2-Deoxy-d-Ribose and its Potential Impact on Chemoresistance in Glioblastoma

J. Kepa, D. Petersen, A. Donson, 2013, Neurochemical Research.

Persistent, Progressive Pulmonary Fibrosis and Epithelial Remodeling in Mice.

Ali N. Bahadur, D. Lynch, S. Humphries, 2021, American journal of respiratory cell and molecular biology.