H. Costantino

发表

Poly(lactide-co-glycolide) microspheres as a moldable scaffold for cartilage tissue engineering.

Lawrence J Bonassar, L. Bonassar, M. Tracy, 2005, Biomaterials.

Moisture-Induced Aggregation of Lyophilized Insulin

A. Klibanov, R. Langer, H. Costantino, 2004, Pharmaceutical Research.

The Hyperthermophilic Archaebacterium, Pyrococcus furiosus

R. Kelly, I. Blumentals, S. Brown, 1990, Annals of the New York Academy of Sciences.

Characterization of Amylolytic Enzyme Activities Associated with the Hyperthermophilic Archaebacterium Pyrococcus furiosus

Stephen H. Brown, R. Kelly, H. Costantino, 1990, Applied and environmental microbiology.

Purification and characterization of an alpha-glucosidase from a hyperthermophilic archaebacterium, Pyrococcus furiosus, exhibiting a temperature optimum of 105 to 115 degrees C

R. Kelly, S. Brown, H. Costantino, 1990, Journal of bacteriology.

Gabapentin enacarbil – clinical efficacy in restless legs syndrome

H. Costantino, A. Griffith, P. Agarwal, 2010, Neuropsychiatric disease and treatment.

In vitro formulation optimization of intranasal galantamine leading to enhanced bioavailability and reduced emetic response in vivo.

S. Quay, H. Costantino, A. Leonard, 2007, International journal of pharmaceutics.

Therapeutic utility of a novel tight junction modulating peptide for enhancing intranasal drug delivery.

S. Quay, M. Houston, H. Costantino, 2006, Journal of pharmaceutical sciences.

Determining the water sorption monolayer of lyophilized pharmaceutical proteins.

C. Hsu, H. Costantino, J. Curley, 1997, Journal of pharmaceutical sciences.

Deterioration of lyophilized pharmaceutical proteins.

A. Klibanov, R. Langer, S. Schwendeman, 1998, Biochemistry. Biokhimiia.

Effect of excipients on the stability and structure of lyophilized recombinant human growth hormone.

K. Griebenow, C. Hsu, M. Mumenthaler, 1998, Journal of pharmaceutical sciences.

Influence of calcium ions on the structure and stability of recombinant human deoxyribonuclease I in the aqueous and lyophilized states.

C. Hsu, S. Shire, H. Costantino, 1999, Journal of pharmaceutical sciences.

On the structural preservation of recombinant human growth hormone in a dried film of a synthetic biodegradable polymer.

Chung C. Hsu, K. Griebenow, C. Hsu, 1999, Journal of pharmaceutical sciences.

Preparation of excipient-free recombinant human tissue-type plasminogen activator by lyophilization from ammonium bicarbonate solution: an investigation of the two-stage sublimation phenomenon.

C. Hsu, H. Costantino, D. Brooks, 1997, Journal of pharmaceutical sciences.

The secondary structure and aggregation of lyophilized tetanus toxoid.

A. Klibanov, K. Griebenow, R. Langer, 1996, Journal of pharmaceutical sciences.

Replacing succinate with glycolate buffer improves the stability of lyophilized interferon-γ

Chung C. Hsu, H. Costantino, T. Nguyen, 1996 .

Relationship between encapsulated drug particle size and initial release of recombinant human growth hormone from biodegradable microspheres.

H. Costantino, S. Zale, O. Johnson, 2004, Journal of pharmaceutical sciences.

Discovery of tight junction modulators: significance for drug development and delivery.

H. Costantino, P. Johnson, Diane E. Frank, 2008, Drug discovery today.

Fourier-transform infrared spectroscopic investigation of protein stability in the lyophilized form.

A. Klibanov, K. Griebenow, R. Langer, 1995, Biochimica et biophysica acta.

Purification and Characterization of an cl-Glucosidase from a Hyperthermophilic Archaebacterium, Pyrococcus furiosus, Exhibiting a Temperature Optimum of 105 to 115°C

S. Brown, H. Costantino, R. M. Kelly, 2022 .

Stabilization of tetanus and diphtheria toxoids against moisture-induced aggregation.

R. Gupta, A. Klibanov, G. Siber, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Intranasal delivery: physicochemical and therapeutic aspects.

L. Illum, S. Quay, H. Costantino, 2007, International journal of pharmaceutics.

Intranasal administration of acetylcholinesterase inhibitors

S. Quay, H. Costantino, P. Johnson, 2008, BMC Neuroscience.

Development of a novel high-concentration galantamine formulation suitable for intranasal delivery.

S. Quay, H. Costantino, A. Leonard, 2005, Journal of pharmaceutical sciences.

Protein Spray-Freeze Drying. Effect of Atomization Conditions on Particle Size and Stability

Kai Griebenow, K. Griebenow, M. Tracy, 2000, Pharmaceutical Research.

Protein spray freeze drying. 2. Effect of formulation variables on particle size and stability.

K. Griebenow, M. Tracy, H. Costantino, 2002, Journal of pharmaceutical sciences.

Solid-phase aggregation of proteins under pharmaceutically relevant conditions.

A. Klibanov, R. Langer, H. Costantino, 1994, Journal of pharmaceutical sciences.

Investigation of protein/carbohydrate interactions in the dried state. 1. Calorimetric studies.

P. Souillac, J. H. Rytting, H. Costantino, 2002, Journal of pharmaceutical sciences.

Statistical Modeling of protein spray drying at the lab scale

M. Tracy, H. Costantino, Kristin B. Prinn, 2002, AAPS PharmSciTech.

The effect of operating and formulation variables on the morphology of spray-dried protein particles.

Y. Maa, C. Hsu, P. Nguyen, 1997, Pharmaceutical development and technology.

Recent trends in stabilizing protein structure upon encapsulation and release from bioerodible polymers

K. Griebenow, Wasfi A Al-Azzam, H. Costantino, 2002, The Journal of pharmacy and pharmacology.

Intranasal insulin: PK profile designed specifically for prandial treatment of Type 2 Diabetes

S. Quay, H. Costantino, A. Sileno, 2008 .

Water sorption behavior of lyophilized protein–sugar systems and implications for solid-state interactions

Chung C. Hsu, H. Costantino, S. Wu, 1998 .

Stability of solid pharmaceutical proteins

H. Costantino, H. R. Costantino, 1995 .

The Effect of Formulation Excipients on Protein Stability and Aerosol Performance of Spray-Dried Powders of a Recombinant Humanized Anti-IgE Monoclonal Antibody1

Steven J. Shire, Chung C. Hsu, Y. Maa, 1999, Pharmaceutical Research.

Effect of mannitol crystallization on the stability and aerosol performance of a spray-dried pharmaceutical protein, recombinant humanized anti-IgE monoclonal antibody.

Chung C. Hsu, Y. Maa, C. Hsu, 1998, Journal of pharmaceutical sciences.

Heterogeneity of serum albumin samples with respect to solid-state aggregation via thiol-disulfide interchange : Implications for sustained release from polymers

R. Langer, A. Klibanov, H. Costantino, 1997 .

Fourier‐transform Infrared Spectroscopic Analysis of the Secondary Structure of Recombinant Humanized Immunoglobulin G

Chung C. Hsu, S. Shire, H. Costantino, 1997 .

Fourier‐transform Infrared Spectroscopic Investigation of the Secondary Structure of Aqueous and Dried Recombinant Human Deoxyribonuclease I

Chung C. Hsu, K. Griebenow, S. Shire, 1998 .

Inhibition of moisture-induced aggregation of tetanus toxoid by protecting thiol groups

G. Siber, R. Langer, S. Schwendeman, 1994 .

Aggregation of a Lyophilized Pharmaceutical Protein, Recombinant Human Albumin: Effect of Moisture and Stabilization by Excipients

A. Klibanov, R. Langer, H. Costantino, 1995, Bio/Technology.

Non-aqueous encapsulation of excipient-stabilized spray-freeze dried BSA into poly(lactide-co-glycolide) microspheres results in release of native protein.

K. Griebenow, H. Costantino, K. Carrasquillo, 2001, Journal of controlled release : official journal of the Controlled Release Society.

A Novel Injectable Approach for Cartilage Formation in Vivo Using PLG Microspheres

L. Bonassar, M. Tracy, Nichole R. Mercier, 2004, Annals of Biomedical Engineering.

On the pH memory of lyophilized compounds containing protein functional groups.

A. Klibanov, K. Griebenow, R. Langer, 1997, Biotechnology and bioengineering.

Fourier‐transform Infrared Spectroscopy Demonstrates that Lyophilization Alters the Secondary Structure of Recombinant Human Growth Hormone

Chung C. Hsu, H. Costantino, T. Nguyen, 1996 .