William MacNee

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Characterisation of COPD heterogeneity in the ECLIPSE cohort

Edwin K Silverman, Bartolome Celli, Ruth Tal-Singer, 2010, Respiratory research.

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

Harry J de Koning, Edwin K Silverman, Matthijs Oudkerk, 2017, Nature Genetics.

The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study.

Courtney Crim, Asger Dirksen, Nestor L. Müller, 2013, The Lancet. Respiratory medicine.

Identification of five chronic obstructive pulmonary disease subgroups with different prognoses in the ECLIPSE cohort using cluster analysis.

Courtney Crim, Edwin K Silverman, Ruth Tal-Singer, 2015, Annals of the American Thoracic Society.

The COPD control panel: towards personalised medicine in COPD

Alvar Agusti, A. Agustí, W. MacNee, 2012, Thorax.

PM10-exposed macrophages stimulate a proinflammatory response in lung epithelial cells via TNF-α

Irfan Rahman, Ken Donaldson, W. MacNee, 2002 .

Determinants of exercise-induced oxygen desaturation including pulmonary emphysema in COPD: Results from the ECLIPSE study.

Per S Bakke, Ruth Tal-Singer, Martijn A Spruit, 2016, Respiratory medicine.

Pulmonary Function is Associated with Distal Aortic Calcium, Not Proximal Aortic Distensibility. MESA Lung Study

Daniel Duprez, Eric A Hoffman, Rui Jiang, 2011, COPD.

Update in chronic obstructive pulmonary disease 2007.

W. MacNee, William MacNee, W. Macnee, 2008, American journal of respiratory and critical care medicine.

Efficacy of Simple Short-Term in Vitro Assays for Predicting the Potential of Metal Oxide Nanoparticles to Cause Pulmonary Inflammation

Vicki Stone, Craig Poland, Craig A. Poland, 2008, Environmental health perspectives.

The pulmonary toxicology of ultrafine particles.

David Brown, Lang Tran, Vicki Stone, 2002, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

An official American Thoracic Society/European Respiratory Society statement: research questions in COPD

Thierry Troosters, Marc Decramer, George R. Washko, 2015, European Respiratory Review.

Diesel Exhaust Inhalation Causes Vascular Dysfunction and Impaired Endogenous Fibrinolysis

David E. Newby, Ken Donaldson, Kareen Darnley, 2005 .

High-dose acetylcysteine in idiopathic pulmonary fibrosis.

Johny Verschakelen, Frédérique Capron, Michiel Thomeer, 2005, The New England journal of medicine.

Home monitoring of breathing rate in people with chronic obstructive pulmonary disease: observational study of feasibility, acceptability, and change after exacerbation

Christopher J Weir, Brian McKinstry, Richard A. Parker, 2017, International journal of chronic obstructive pulmonary disease.

Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10).

Vicki Stone, David M. Brown, Roel P F Schins, 2003, Free radical biology & medicine.

Pulmonary and systemic effects of short-term inhalation exposure to ultrafine carbon black particles.

J. Heyder, W. MacNee, E. Karg, 2004, Toxicology and applied pharmacology.

Ultrafine carbon black particles inhibit human lung fibroblast-mediated collagen gel contraction.

D. Romberger, W. MacNee, S. Rennard, 2003, American journal of respiratory cell and molecular biology.

Should we view chronic obstructive pulmonary disease differently after ECLIPSE? A clinical perspective from the study team.

Courtney Crim, Edwin K Silverman, Bartolome Celli, 2014, American journal of respiratory and critical care medicine.

Chest CT measures of muscle and adipose tissue in COPD: gender-based differences in content and in relationships with blood biomarkers.

Raúl San José Estépar, Linfu Zhou, Rola Harmouche, 2014, Academic radiology.

Education: Ultrafine Particles

Ken Donaldson, W. MacNee, K. Donaldson, 2001 .

Validity of physical activity monitors during daily life in patients with COPD

Thierry Troosters, Roberto A. Rabinovich, Klaas R. Westerterp, 2013, European Respiratory Journal.

Soluble transition metals cause the pro-inflammatory effects of welding fumes in vitro.

Ken Donaldson, I. Beverland, M. Heal, 2004, Toxicology and applied pharmacology.

New paradigms in the pathogenesis of chronic obstructive pulmonary disease I.

W. MacNee, R. Tuder, Rubin M Tuder, 2009, Proceedings of the American Thoracic Society.

Combination of erythromycin and dexamethasone improves corticosteroid sensitivity induced by CSE through inhibiting PI3K-δ/Akt pathway and increasing GR expression.

Yang Zhang, Zhi-Yi He, Yang Zhang, 2015, American journal of physiology. Lung cellular and molecular physiology.

Reconfiguring Care for Chronic Disease with Home Monitoring: A Pilot Study Report on Telemetry-Supported Care for COPD Patients in the Lothian Region

Aziz Sheikh, Claudia Pagliari, Brian McKinstry, 2009 .

Graphene-based nanoplatelets: a new risk to the respiratory system as a consequence of their unusual aerodynamic properties.

Ken Donaldson, W. MacNee, K. Donaldson, 2012, ACS nano.

Diesel Exhaust Inhalation Causes Vascular Dysfunction and Impaired Endogenous Fibrinolysis

David E Newby, Ken Donaldson, Kareen Darnley, 2005, Circulation.

Socioeconomic deprivation increases the effect of winter on admissions to hospital with COPD: retrospective analysis of 10 years of national hospitalisation data

C. Fischbacher, S. Wild, W. MacNee, 2013, Primary care respiratory journal : journal of the General Practice Airways Group.

Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

Mark Bradley, Jayoung Jeong, Ken Donaldson, 2013, Particle and Fibre Toxicology.

Fast Facts: Chronic Obstructive Pulmonary Disease

W. MacNee, William MacNee, M. Drummond, 2009 .

Potential role of IL‐8, platelet‐activating factor and TNF‐α in the sequestration of neutrophils in the lung: effects on neutrophil deformability, adhesion receptor expression, and chemotaxis

W. MacNee, E. Drost, William MacNee, 2002, European journal of immunology.

Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype

Courtney Crim, Edwin K. Silverman, David A. Lomas, 2012, PloS one.

Aging, inflammation, and emphysema.

W. MacNee, William MacNee, W. Macnee, 2011, American journal of respiratory and critical care medicine.

The Importance of Surface Area and Specific Reactivity in the Acute Pulmonary Inflammatory Response to Particles

David M. Brown, Ken Donaldson, C. L. Tran, 2002 .

Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD).

W. MacNee, William MacNee, W. Macnee, 2009, Biochemical Society transactions.

Metal Oxide Nanoparticles Induce Unique Inflammatory Footprints in the Lung: Important Implications for Nanoparticle Testing

Mark Bradley, Craig A. Poland, Ken Donaldson, 2010, Environmental health perspectives.

CHARACTERISTICS, STABILITY AND OUTCOMES OF THE GOLD 2011 COPD GROUPS IN THE ECLIPSE COHORT

Courtney Crim, Steve, David A. Lomas, 2013 .