Jeffrey J Kovacs

发表

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor.

Minoru Yoshida, June-Tai Wu, C. Nicchitta, 2005, Molecular cell.

Vascular Endothelial Growth Factor Receptor 3 Regulates Endothelial Function Through &bgr;-Arrestin 1

C. Piantadosi, C. Badea, S. Rajagopal, 2019, Circulation.

Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties.

C. Rudin, Jason P. Burke, C. Bristow, 2020, Journal of medicinal chemistry.

Shared Nearest Neighbors Approach and Interactive Browser for Network Analysis of a Comprehensive Non-Small-Cell Lung Cancer Data Set.

Jing Wang, I. Wistuba, J. Heymach, 2022, JCO clinical cancer informatics.

Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor.

P. Mandal, Jason P. Burke, F. Mseeh, 2021, Journal of medicinal chemistry.

β-Arrestin2 mediates the initiation and progression of myeloid leukemia

R. Lefkowitz, Takahiro Ito, T. Reya, 2012, Proceedings of the National Academy of Sciences.

β-Arrestin Regulation of Myosin Light Chain Phosphorylation Promotes AT1aR-mediated Cell Contraction and Migration

R. Lefkowitz, W. Miller, Jihee Kim, 2013, PloS one.

The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress

J. Vance, T. Yao, A. Ito, 2003, Cell.

Androgen receptor activity promotes resistance to BRAF-targeted melanoma therapy

Jeffrey E. Lee, M. Ross, J. McQuade, 2020 .

Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib

Justin K. Huang, P. Mandal, Jason P. Burke, 2020, Cancer Research.

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy

P. A. Futreal, L. Donehower, Tajhal Dayaram, 2018, Cell stem cell.

Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy

M. Ross, J. McQuade, B. Helmink, 2022, Nature.

Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy.

P. A. Futreal, M. Ross, J. McQuade, 2022, Journal of Clinical Oncology.

β-Arrestin Deficiency Protects Against Pulmonary Fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix

W. M. Foster, R. Lefkowitz, A. Lovgren, 2011, Science Translational Medicine.

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

A. Maitra, K. Do, B. Vangamudi, 2021, Nature Communications.

MDM2–HDAC1‐mediated deacetylation of p53 is required for its degradation

Yoshiharu Kawaguchi, Ettore Appella, E. Appella, 2002, The EMBO journal.

Discovery of IACS-9439, a potent, exquisitely selective and orally bioavailable inhibitor of CSF1R.

P. Mandal, Jason P. Burke, F. Mseeh, 2020, Journal of medicinal chemistry.

Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways.

R. Lefkowitz, Jihee Kim, Makoto R. Hara, 2009, Developmental cell.

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1

Kunhong Xiao, Sudarshan Rajagopal, Wayne Grant, 2011, Nature.

ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer

C. Creighton, B. Raught, Fengju Chen, 2019, Nature Communications.

Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin.

S. Li, S. Tzeng, T. Yao, 2007, Journal of molecular biology.

β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium

R. Lefkowitz, K. Xiao, Jihee Kim, 2008, Science.

Dual Inhibition of MEK and AXL Targets Tumor Cell Heterogeneity and Prevents Resistant Outgrowth Mediated by the Epithelial-to-Mesenchymal Transition in NSCLC

Jing Wang, J. Konen, L. Byers, 2021, Cancer Research.

beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.

J. Violin, R. Lefkowitz, E. Whalen, 2009, The Journal of clinical investigation.

Targeted Disruption of β-Arrestin 2-Mediated Signaling Pathways by Aptamer Chimeras Leads to Inhibition of Leukemic Cell Growth

B. Sullenger, Margie Li, M. Fereshteh, 2014, PloS one.

Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR)

S. Gygi, J. Villén, Shan Zhao, 2010, Proceedings of the National Academy of Sciences.

Regulation of the Dynamics of hsp90 Action on the Glucocorticoid Receptor by Acetylation/Deacetylation of the Chaperone*

T. Yao, W. Pratt, Jeffrey J. Kovacs, 2005, Journal of Biological Chemistry.

Dysregulation and Epigenetic Reprogramming of NRF2 Signaling Axis Promote Acquisition of Cisplatin Resistance and Metastasis in Head and Neck Squamous Cell Carcinoma

W. Symmans, K. Tomczak, Wencai Ma, 2023, Clinical cancer research : an official journal of the American Association for Cancer Research.

Chaperoning steroid hormone signaling via reversible acetylation

T. Yao, Jeffrey J Kovacs, T. Cohen, 2005, Nuclear receptor signaling.

Ntrk1 Promotes Resistance to PD-1 Checkpoint Blockade in Mesenchymal Kras/p53 Mutant Lung Cancer

J. Konen, C. Bristow, D. Gibbons, 2019, Cancers.

β-Arrestin2 mediates the initiation and progression of myeloid leukemia

R. Lefkowitz, Takahiro Ito, T. Reya, 2012, Proceedings of the National Academy of Sciences.

Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy

M. Ross, J. McQuade, B. Helmink, 2022, Nature.

Regulation of EGF Receptor Signaling by Histone Deacetylase 6 (HDAC6)-Mediated Reversible Acetylation

Jeffrey J. Kovacs, Jeffrey J Kovacs, 2005 .

ArticleHDAC 6 Regulates Hsp 90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor

C. Nicchitta, Xuan Zhao, T. Yao, 2005 .