Christopher N. Scanlan

发表

Emerging Principles for the Therapeutic Exploitation of Glycosylation

Raymond A. Dwek, Nicole Zitzmann, R. Dwek, 2014, Science.

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies

William R. Schief, Andrew B. Ward, Louise Royle, 2015, Nature Communications.

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

Yan Liu, William R. Schief, Ryan McBride, 2011, Science.

Making autoantibodies safe

D. Burton, R. Dwek, Christopher N. Scanlan, 2008, Proceedings of the National Academy of Sciences.

Impact of Immune Complex Size and Glycosylation on IgG Binding to Human FcγRs

A. Lux, F. Nimmerjahn, Christopher N. Scanlan, 2013, The Journal of Immunology.

Antibody Domain Exchange Is an Immunological Solution to Carbohydrate Cluster Recognition

Ping Zhu, Renate Kunert, Pauline M. Rudd, 2003, Science.

Travelling wave ion mobility and negative ion fragmentation for the structural determination of N‐linked glycans

C. Scarff, F. Sobott, M. Crispin, 2013, Electrophoresis.

Use of the α-mannosidase I inhibitor kifunensine allows the crystallization of apo CTLA-4 homodimer produced in long-term cultures of Chinese hamster ovary cells

D. Stuart, M. Crispin, R. Gilbert, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Application of negative ion MS/MS to the identification of N-glycans released from carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1).

D. Harvey, Christopher N. Scanlan, Kavitha Baruah, 2009, Journal of mass spectrometry : JMS.

Differentiation between isomeric triantennary N-linked glycans by negative ion tandem mass spectrometry and confirmation of glycans containing galactose attached to the bisecting (beta1-4-GlcNAc) residue in N-glycans from IgG.

M. Crispin, P. Rudd, D. Harvey, 2008, Rapid communications in mass spectrometry : RCM.

Chapter 10 - Antibody glycosylation

M. Crispin, Christopher N. Scanlan, Xiaojie Yu, 2013 .

Antibody recognition of a carbohydrate epitope: a template for HIV vaccine design.

D. Burton, R. Dwek, I. Wilson, 2005, Advances in experimental medicine and biology.

Structure and Biosynthesis of Glycoprotein Carbohydrates

M. Crispin, T. Bowden, Christopher N. Scanlan, 2011 .

A Blueprint for HIV Vaccine Discovery.

Adam Godzik, Hendrik Streeck, M Juliana McElrath, 2012, Cell host & microbe.

Reactivity-based one-pot synthesis of oligomannoses: defining antigens recognized by 2G12, a broadly neutralizing anti-HIV-1 antibody.

D. Burton, R. Dwek, I. Wilson, 2004, Angewandte Chemie.

g Glycosylation on IgG Binding to Human Fc Impact of Immune Complex Size and

Christopher N. Scanlan, Xiaojie Yu, Falk, 2022 .

Dissecting the molecular mechanism of IVIg therapy: the interaction between serum IgG and DC-SIGN is independent of antibody glycoform or Fc domain.

M. Crispin, Christopher N. Scanlan, D. Mitchell, 2013, Journal of molecular biology.

Emerging Principles for the Therapeutic Exploitation of

R. Dwek, N. Zitzmann, Christopher N. Scanlan, 2016 .

Identification of antibody glycosylation structures that predict monoclonal antibody Fc-effector function

S. Zolla-Pazner, M. Gorny, C. Bailey-Kellogg, 2014, AIDS.

Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans.

R. Dwek, M. Wormald, D. Dunlop, 2010, Glycobiology.

The Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2G12 Recognizes a Cluster of α1→2 Mannose Residues on the Outer Face of gp120

H. Katinger, D. Burton, R. Dwek, 2002, Journal of Virology.

HIV Glycomics and Glycoproteomics

K. Doores, M. Crispin, Christopher N. Scanlan, 2014 .

An endoglycosidase with alternative glycan specificity allows broadened glycoprotein remodelling.

B. G. Davis, M. Crispin, D. Harvey, 2012, Journal of the American Chemical Society.

Printed covalent glycan array for ligand profiling of diverse glycan binding proteins.

Chi-Huey Wong, James C Paulson, Ian A Wilson, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Exploiting the defensive sugars of HIV-1 for drug and vaccine design

R. Dwek, N. Zitzmann, Christopher N. Scanlan, 2007, Nature.

A peptide inhibitor of HIV‐1 neutralizing antibody 2G12 is not a structural mimic of the natural carbohydrate epitope on gp120

H. Katinger, D. Burton, I. Wilson, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A Glycoconjugate Antigen Based on the Recognition Motif of a Broadly Neutralizing Human Immunodeficiency Virus Antibody, 2G12, Is Immunogenic but Elicits Antibodies Unable To Bind to the Self Glycans of gp120

D. Burton, R. Dwek, I. Wilson, 2008, Journal of Virology.

Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity.

C. Bailey-Kellogg, G. Alter, M. Crispin, 2013, The Journal of clinical investigation.

The Glycan Shield of HIV Is Predominantly Oligomannose Independently of Production System or Viral Clade

D. Burton, R. Dwek, D. Dunlop, 2011, PloS one.

Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens

Dennis R Burton, Raymond A Dwek, David J Harvey, 2010, Proceedings of the National Academy of Sciences.

The Cambrian Conundrum: Early Divergence and Later Ecological Success in the Early History of Animals

John P. Moore, D. Burton, Chi‐Huey Wong, 2011 .

THE HIV VACCINE PROBLEM : WHY HAVE PAST APPROACHES TO DEVELOP AN HIV VACCINE FAILED ?

Walker, A. Godzik, B. Walker, 2022 .

Expression-system-dependent modulation of HIV-1 envelope glycoprotein antigenicity and immunogenicity.

Q. Sattentau, P. Kwong, L. Kong, 2010, Journal of molecular biology.

Toward a carbohydrate-based HIV-1 vaccine

D. Burton, R. Dwek, I. Wilson, 2006 .

Selective Deactivation of Serum IgG: A General Strategy for the Enhancement of Monoclonal Antibody Receptor Interactions

R. Dwek, M. Crispin, T. Bowden, 2012, Journal of molecular biology.

Engineering Hydrophobic Protein–Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies

M. Crispin, T. Bowden, D. Alonzi, 2013, Journal of the American Chemical Society.

Chemical and Structural Analysis of an Antibody Folding Intermediate Trapped during Glycan Biosynthesis

D. Stuart, E. Jones, M. Crispin, 2012, Journal of the American Chemical Society.

Ion Mobility Mass Spectrometry for Extracting Spectra of N-Glycans Directly from Incubation Mixtures Following Glycan Release: Application to Glycans from Engineered Glycoforms of Intact, Folded HIV gp120

C. Scarff, F. Sobott, M. Crispin, 2011, Journal of the American Society for Mass Spectrometry.

Redirecting adenoviruses to tumour cells using therapeutic antibodies: Generation of a versatile human bispecific adaptor.

M. Crispin, M. Dalziel, E. Beale, 2015, Molecular immunology.

Traitement à base de liposomes des infections virales

P. Rudd, N. Zitzmann, S. Petrescu, 2007 .

A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity

D. Burton, I. Wilson, M. Wormald, 2010, Proceedings of the National Academy of Sciences.

Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.

D. Burton, R. Dwek, M. Wormald, 2007, Journal of molecular biology.

MALDI-MS/MS with Traveling Wave Ion Mobility for the Structural Analysis of N-Linked Glycans

C. Scarff, M. Crispin, D. Harvey, 2012, Journal of The American Society for Mass Spectrometry.

The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12.

H. Katinger, D. Burton, R. Dwek, 2003, Advances in experimental medicine and biology.

The therapeutic phase I trial of the recombinant native HIV-1 Tat protein

D. Burton, R. Dwek, D. Dunlop, 2008, AIDS.

Fragments of Bacterial Endoglycosidase S and Immunoglobulin G Reveal Subdomains of Each That Contribute to Deglycosylation

J. Schnell, M. Crispin, N. Zitzmann, 2014, The Journal of Biological Chemistry.

Erwin Success in the Early History of Animals The Cambrian Conundrum : Early Divergence and Later Ecological

John P. Moore, D. Burton, Chi‐Huey Wong, 2011 .