Zhenyu Li

发表

Recent advances in the discovery and development of novel HIV-1 NNRTI platforms: 2006-2008 update.

Peng Zhan, P. Zhan, Xinyong Liu, 2009, Current medicinal chemistry.

Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Peng Zhan, Jing Zhang, Christophe Pannecouque, 2011, Bioorganic & medicinal chemistry.

Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach.

Peng Zhan, Erik De Clercq, Ye Tian, 2012, Bioorganic & medicinal chemistry.

Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs.

Peng Zhan, Ye Tian, Xuwang Chen, 2012, Bioorganic & medicinal chemistry letters.

Sulfanyltriazole/tetrazoles: a promising class of HIV-1 NNRTIs.

Peng Zhan, E. De Clercq, P. Zhan, 2009, Mini reviews in medicinal chemistry.

Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX*

Ernst Schönbrunn, Baozong Li, W. Guida, 2009, The Journal of Biological Chemistry.

Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles.

Peng Zhan, Xiao Ding, Dongwei Kang, 2016, Journal of medicinal chemistry.

Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies.

Qiang Zhang, Qiang Zhang, Feihu Wang, 2010, Colloids and surfaces. B, Biointerfaces.

Design strategies of novel NNRTIs to overcome drug resistance.

Peng Zhan, Christophe Pannecouque, E. De Clercq, 2009, Current medicinal chemistry.

Discovery of novel pyridazinylthioacetamides as potent HIV-1 NNRTIs using a structure-based bioisosterism approach

Peng Zhan, Erik De Clercq, Ye Tian, 2013 .

Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs.

Peng Zhan, Jan Balzarini, Xuwang Chen, 2014, Bioorganic & medicinal chemistry.

Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking.

Shen-Shu Sung, Michael J Zaworotko, W. Guida, 2009, Bioorganic & medicinal chemistry letters.

ATM activates p 53 by regulating MDM 2 oligomerization and E 3 processivity

William Lane, William Arbuthnot Sir Lane, Lihong Chen, 2009 .

ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

William Arbuthnot Sir Lane, Jiandong Chen, Lihong Chen, 2009, The EMBO journal.

Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles.

Peng Zhan, F. J. Luque, Ye Tian, 2019, Journal of medicinal chemistry.

Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition.

Michael M. Madden, Qing Lin, Jiandong Chen, 2011, Bioorganic & medicinal chemistry letters.

Discovery of nitropyridine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors via a structure-based core refining approach.

Peng Zhan, Christophe Pannecouque, E. De Clercq, 2014, European journal of medicinal chemistry.