David Barford

发表

Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor design.

Xinjian Yan, Bin Ye, D. Barford, 1996, Biochemistry.

Doc1 mediates the activity of the anaphase‐promoting complex by contributing to substrate recognition

J Wade Harper, D. Barford, J. Harper, 2003, The EMBO journal.

Argonaute: A scaffold for the function of short regulatory RNAs.

D. Barford, J. Parker, David Barford, 2006, Trends in biochemical sciences.

Atomic structure of the APC/C and its mechanism of protein ubiquitination

D. Barford, Ziguo Zhang, S. McLaughlin, 2015, Nature.

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera.

Ian Collins, Paul Workman, Brent Graham, 2007, Journal of molecular biology.

Crystal structure of an activated Akt/Protein Kinase B ternary complex with GSK3-peptide and AMP-PNP

Brian A. Hemmings, D. Barford, B. Hemmings, 2002, Nature Structural Biology.

Structural insights into mRNA recognition from a PIWI domain–siRNA guide complex

D. Barford, S. Roe, J. Parker, 2005, Nature.

Structural basis for the subunit assembly of the anaphase-promoting complex

Edward P. Morris, Carol V. Robinson, Florian Stengel, 2011, Nature.

Structure of TOR and its complex with KOG1.

Ernesto Arias-Palomo, Oscar Llorca, D. Barford, 2007, Molecular cell.

Eliminylation: a post-translational modification catalyzed by phosphothreonine lyases.

D. Barford, D. F. Brennan, David Barford, 2009, Trends in biochemical sciences.

Structure of the mitotic checkpoint complex

D. Barford, W. Chao, Ziguo Zhang, 2012, Nature.

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation.

D. Barford, B. Hemmings, V. Good, 2002, Molecular cell.

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

Alma L. Burlingame, Kevan M. Shokat, Arvin C. Dar, 2011, Nature.

Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2.

Haiwei Song, L. Johnson, D. Barford, 2002, Pharmacology & therapeutics.

Coactivator functions in a stoichiometric complex with anaphase‐promoting complex/cyclosome to mediate substrate recognition

D. Barford, L. Passmore, David Barford, 2005, EMBO reports.

Crystal structure and functional analysis of the eukaryotic class II release factor eRF3 from S. pombe.

Haiwei Song, Yoshikazu Nakamura, Martin A Walsh, 2004, Molecular cell.

Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity

D. Barford, S. Roe, J. Parker, 2004, The EMBO journal.

Identification of inhibitors of protein kinase B using fragment-based lead discovery.

Marcel L Verdonk, Paul G Wyatt, Michelle D Garrett, 2007, Journal of medicinal chemistry.

Structures of APC/CCdh1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor

Edward P. Morris, Anne Schreiber, D. Barford, 2010, Nature.

Regulation of A20 and other OTU deubiquitinases by reversible oxidation

David Komander, Kate S. Carroll, D. Barford, 2013, Nature Communications.

Catalysis in the crystal: synchrotron radiation studies with glycogen phosphorylase b

David I. Stuart, Paul J. McLaughlin, Janos Hajdu, 1987 .

Structure of the A20 OTU domain and mechanistic insights into deubiquitination.

David Komander, D. Barford, D. Komander, 2008, The Biochemical journal.

The Structure of the Protein Phosphatase 2A PR65/A Subunit Reveals the Conformation of Its 15 Tandemly Repeated HEAT Motifs

Brian A. Hemmings, Matthew R. Groves, D. Barford, 1999, Cell.

Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome

D. Barford, A. Heck, A. Ehrenhofer-Murray, 2019, Nature.

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

Michael P. Myers, D. Barford, M. Myers, 2003, Nature.

Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1

Philip R. Cohen, D. Barford, G. Moorhead, 1997, The EMBO journal.

The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo‐dimer interface similar to Cdc27

D. Barford, A. Thompson, Sarah Hanrahan, 2010, The EMBO journal.

Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains

David Komander, D. Barford, K. Wilkinson, 2009, EMBO reports.

The structure of the 26S proteasome subunit Rpn2 reveals its PC repeat domain as a closed toroid of two concentric α-helical rings.

D. Barford, M. Glickman, E. Morris, 2012, Structure.

Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation.

Wah Chiu, Steven J Ludtke, Christopher R Booth, 2005, Molecular cell.

The potential of cryo-electron microscopy for structure-based drug design.

D. Barford, A. Boland, Leifu Chang, 2017, Essays in biochemistry.

Molecular recognition via coupled folding and binding in a TPR domain.

D. Barford, Mark A. Williams, J. Ladbury, 2005, Journal of molecular biology.