Manthena V Varma

发表

Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.

Jing Chen, David B Duignan, Robert Aiello, 2012, Journal of medicinal chemistry.

pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery.

Li Di, Hui Zhang, Iain Gardner, 2012, Molecular pharmaceutics.

Clearance mechanism assignment and total clearance prediction in human based upon in silico models.

Franco Lombardo, R Scott Obach, Giuliano Berellini, 2014, Journal of medicinal chemistry.

Development of a new permeability assay using low-efflux MDCKII cells.

Li Di, Bo Feng, Hui Zhang, 2011, Journal of pharmaceutical sciences.

Simultaneous Assessment of Transporter-Mediated Drug–Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey

A. D. Rodrigues, Chester Costales, Sweta Modi, 2018, Drug Metabolism and Disposition.

Dealing with the complex drug-drug interactions: towards mechanistic models.

Ping Zhao, Nina Isoherranen, P. Zhao, 2015, Biopharmaceutics & drug disposition.

Model-based approaches to predict drug–drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond

Hugh A Barton, Jian Lin, Hannah M Jones, 2013, Expert opinion on drug metabolism & toxicology.

Quantitative prediction of renal transporter-mediated clinical drug-drug interactions.

Bo Feng, Brian Corrigan, Ayman El-Kattan, 2013, Molecular pharmaceutics.

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance().

Yizhong Zhang, Matthew P Jacobson, Spiros Liras, 2012, MedChemComm.

Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach

Bo Feng, B. Feng, M. Varma, 2017, Drug Metabolism and Disposition.