P. García-Peñarrubia

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Is TCR/pMHC Affinity a Good Estimate of the T-cell Response? An Answer Based on Predictions From 12 Phenotypic Models

J. Gálvez, J. Galvez, P. García-Peñarrubia, 2019, Front. Immunol..

Mathematical modelling and computational study of two-dimensional and three-dimensional dynamics of receptor–ligand interactions in signalling response mechanisms

J. Gálvez, J. Galvez, P. García-Peñarrubia, 2013, Journal of Mathematical Biology.

Regulatory role of PI3K‐protein kinase B on the release of interleukin‐1β in peritoneal macrophages from the ascites of cirrhotic patients

A. Tapia-Abellán, R. Francés, P. García-Peñarrubia, 2014, Clinical and experimental immunology.

MHC-I Molecules Selectively Inhibit Cell-Mediated Cytotoxicity Triggered by ITAM-Coupled Activating Receptors and 2B4

P. García-Peñarrubia, M. Martínez-Esparza, R. Corral-San Miguel, 2014, PloS one.

β1 Integrin triggering affects leukemic cell line sensitivity to natural killer cells

A. Mora, J. Gálvez, P. García-Peñarrubia, 2002, Cancer Immunology, Immunotherapy.

Determination of parameters that characterize effector-target conjugation of human NK and LAK cells by flow cytometry.

J. Gálvez, P. García-Peñarrubia, G. Rubio, 1997, Journal of immunological methods.

Model for population distributions of lymphocyte-target cell conjugates.

J. Gálvez, P. García-Peñarrubia, A. Bankhurst, 1989, Journal of theoretical biology.

Effect of conjugate size on the kinetics of cell-mediated cytotoxicity at the population level.

J. Gálvez, P. García-Peñarrubia, A. Bankhurst, 1989, Journal of theoretical biology.

Selective proliferation of natural killer cells among monocyte-depleted peripheral blood mononuclear cells as a result of stimulation with staphylococcal enterotoxin B

R. O. Kelley, P. García-Peñarrubia, A. Bankhurst, 1989, Infection and immunity.

Role of trehalose in resistance to macrophage killing: study with a tps1/tps1 trehalose-deficient mutant of Candida albicans.

J. Argüelles, T. Jouault, P. García-Peñarrubia, 2007, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Role of MAP Kinases and PI3K‐Akt on the cytokine inflammatory profile of peritoneal macrophages from the ascites of cirrhotic patients

A. Tapia-Abellán, R. Francés, P. García-Peñarrubia, 2013, Liver international : official journal of the International Association for the Study of the Liver.

The peritoneal macrophage inflammatory profile in cirrhosis depends on the alcoholic or hepatitis C viral etiology and is related to ERK phosphorylation

A. Tapia-Abellán, R. Francés, P. García-Peñarrubia, 2012, BMC Immunology.

Peritoneal macrophage priming in cirrhosis is related to ERK phosphorylation and IL‐6 secretion

P. Zapater, R. Francés, P. García-Peñarrubia, 2011, European journal of clinical investigation.

Inflammatory status in human hepatic cirrhosis 2015 Advances in Cirrhosis

P. García-Peñarrubia, Antônio, A. J. Ruiz-Alcaraz, 2015 .

TCR/pMHC Interaction: Phenotypic Model for an Unsolved Enigma

J. Gálvez, J. Galvez, P. García-Peñarrubia, 2016, Front. Immunol..

Antibacterial activity of human natural killer cells

R. O. Kelley, T. McDowell, P. García-Peñarrubia, 1989, The Journal of experimental medicine.

Analysis of the anti-inflammatory potential of Brassica bioactive compounds in a human macrophage-like cell model derived from HL-60 cells.

D. Moreno, B. Ramos-Molina, P. García-Peñarrubia, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Inhibition of non MHC-restricted cytotoxicity of human NK cells and a CD8 + αβ T cell clone by MHC class I cross-linking

P. García-Peñarrubia, E. Cayuela, A. Heredia, 2004 .

Intracellular signaling modifications involved in the anti‐inflammatory effect of 4‐alkoxy‐6,9‐dichloro[1,2,4]triazolo[4,3‐a]quinoxalines on macrophages

A. Guirado, P. García-Peñarrubia, A. J. Ruiz-Alcaraz, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Experimental and theoretical kinetics study of antibacterial killing mediated by human natural killer cells.

P. García-Peñarrubia, A. Bankhurst, F. Koster, 1989, Journal of immunology.

CD33 (Siglec-3) Inhibitory Function: Role in the NKG2D/DAP10 Activating Pathway

P. García-Peñarrubia, A. J. Ruiz-Alcaraz, T. Hernández-Caselles, 2019, Journal of immunology research.

CD33 (Siglec-3) Inhibitory Function: Role in the NKG2D/DAP10 Activating Pathway

P. García-Peñarrubia, A. J. Ruiz-Alcaraz, T. Hernández-Caselles, 2019, Journal of immunology research.

The derivation of binding parameters from effector and target conjugate frequency data using linear and non-linear data-fitting transformations. Application of such transformations to the NK-MOLT4 and NK-K562 effector-target systems.

J. Gálvez, P. García-Peñarrubia, F. Lajarin, 1995, Journal of immunological methods.

Binding units (BU) and the area under binding isotherms (AUI). New indices of effector-target conjugation.

J. Gálvez, P. García-Peñarrubia, F. Lajarin, 1994, Journal of immunological methods.

Effector-target interactions: saturability, affinity and binding isotherms. A study of such interactions in the human NK cell-K562 tumour cell system.

R. Alvarez, J. Gálvez, P. García-Peñarrubia, 1992, Journal of immunological methods.

Implication of CpG-ODN and reactive oxygen species in the inhibition of intracellular growth of Salmonella typhimurium in hepatocytes.

P. García-Peñarrubia, A. Torío, P. Gámiz, 2004, Microbes and infection.

Glycoconjugate expression on the cell wall of tps1/tps1 trehalose-deficient Candida albicans strain and implications for its interaction with macrophages.

J. Argüelles, A. Tapia-Abellán, D. Poulain, 2011, Glycobiology.

Potential of Sulforaphane and Broccoli Membrane Vesicles as Regulators of M1/M2 Human Macrophage Activity

M. Carvajal, D. Moreno, P. García-Peñarrubia, 2022, International journal of molecular sciences.

Implication of reactive oxygen species in the antibacterial activity against Salmonella typhimurium of hepatocyte cell lines.

P. García-Peñarrubia, P. Gámiz, T. Hernández-Caselles, 1999, Free radical biology & medicine.

Norfloxacin modulates the inflammatory response and directly affects neutrophils in patients with decompensated cirrhosis.

P. Zapater, R. Francés, P. García-Peñarrubia, 2009, Gastroenterology.

Acquisition of MDR phenotype by leukemic cells is associated with increased caspase‐3 activity and a collateral sensitivity to cold stress

M. Cánovas, P. García-Peñarrubia, J. Ferragut, 2012, Journal of cellular biochemistry.

Mathematical modelling and computational study of two-dimensional and three-dimensional dynamics of receptor–ligand interactions in signalling response mechanisms

J. Gálvez, J. Galvez, P. García-Peñarrubia, 2013, Journal of Mathematical Biology.

Therapeutic potential of pteridine derivatives: A comprehensive review

A. Guirado, P. García-Peñarrubia, A. J. Ruiz-Alcaraz, 2018, Medicinal research reviews.

Anti-leukemia activity of 4-amino-2-aryl-6,9-dichlorobenzo[g]pteridines

A. Guirado, P. García-Peñarrubia, A. J. Ruiz-Alcaraz, 2018, Naunyn-Schmiedeberg's Archives of Pharmacology.

The Role of Peritoneal Macrophages in Endometriosis

P. García-Peñarrubia, A. J. Ruiz-Alcaraz, M. Martínez-Esparza, 2021, International journal of molecular sciences.

A study of CD33 (SIGLEC‐3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing

A. B. Pérez-Oliva, P. García-Peñarrubia, A. García-Alonso, 2006, Journal of leukocyte biology.

First synthesis and biological evaluation of 4-amino-2-aryl-6,9-dichlorobenzo[g]pteridines as inhibitors of TNF-α and IL-6.

A. Guirado, P. García-Peñarrubia, D. Bautista, 2013, European journal of medicinal chemistry.

Brassica Bioactives Could Ameliorate the Chronic Inflammatory Condition of Endometriosis

M. Carvajal, D. Moreno, P. García-Peñarrubia, 2020, International journal of molecular sciences.

Effect of different treatments of the endotoxin-induced modifications in serum iron levels.

P. García-Peñarrubia, A. Cremades, F. García, 1986, General pharmacology.

Role of trehalose-6P phosphatase (TPS2) in stress tolerance and resistance to macrophage killing in Candida albicans.

J. Argüelles, J. Ros, P. García-Peñarrubia, 2009, International journal of medical microbiology : IJMM.

Attenuated JNK signaling in multidrug-resistant leukemic cells. Dual role of MAPK in cell survival.

M. Cánovas, P. García-Peñarrubia, A. J. Ruiz-Alcaraz, 2017, Cellular signalling.

Hypothetical roadmap towards endometriosis: prenatal endocrine-disrupting chemical pollutant exposure, anogenital distance, gut-genital microbiota and subclinical infections.

P. García-Peñarrubia, A. J. Ruiz-Alcaraz, M. Martínez-Esparza, 2020, Human reproduction update.

Prostaglandins from human T suppressor/cytotoxic cells modulate natural killer antibacterial activity

P. García-Peñarrubia, A. Bankhurst, F. Koster, 1989, The Journal of experimental medicine.

Inflammatory status in human hepatic cirrhosis.

P. García-Peñarrubia, A. J. Ruiz-Alcaraz, M. Martínez-Esparza, 2015, World journal of gastroenterology.

Acquisition of multidrug resistance by L1210 leukemia cells decreases their tumorigenicity and enhances their susceptibility to the host immune response

A. Ferrer-Montiel, P. García-Peñarrubia, J. Ferragut, 2005, Cancer Immunology, Immunotherapy.

Cross‐linking of MHC class I molecules on human NK cells inhibits NK cell function, segregates MHC I from the NK cell synapse, and induces intracellular phosphotyrosines

Gonzalo Rubio, J. Gálvez, P. García-Peñarrubia, 2004, Journal of leukocyte biology.

Membrane Vesicles for Nanoencapsulated Sulforaphane Increased Their Anti-Inflammatory Role on an In Vitro Human Macrophage Model

M. Carvajal, P. García-Peñarrubia, J. Teruel, 2022, International journal of molecular sciences.

Characterization of human peritoneal monocyte/macrophage subsets in homeostasis: Phenotype, GATA6, phagocytic/oxidative activities and cytokines expression

P. García-Peñarrubia, A. J. Ruiz-Alcaraz, M. Martínez-Esparza, 2018, Scientific Reports.

Epitope mapping, expression and post-translational modifications of two isoforms of CD33 (CD33M and CD33m) on lymphoid and myeloid human cells.

A. B. Pérez-Oliva, P. García-Peñarrubia, M. Martínez-Esparza, 2011, Glycobiology.

Quantitation of effector-target affinity in the human NK cell and K562 tumor cell system.

P. García-Peñarrubia, A. Bankhurst, Pilar García-Peñarrubia, 1989, Journal of immunological methods.

The maximum conjugate frequency (αmax) characterizes killer cell populations

P. García-Peñarrubia, A. Bankhurst, F. Koster, 1989 .

Study of the physical meaning of the binding parameters involved in effector-target conjugation using monoclonal antibodies against adhesion molecules and cholera toxin.

J. Gálvez, P. García-Peñarrubia, Adolfo Campos, 2002, Cellular immunology.

Kinetic analysis of effector cell recycling and effector-target binding capacity in a model of cell-mediated cytotoxicity.

P. García-Peñarrubia, A. Bankhurst, 1989, Journal of immunology.

Recent insights into the characteristics and role of peritoneal macrophages from ascites of cirrhotic patients

P. García-Peñarrubia, A. J. Ruiz-Alcaraz, M. Martínez-Esparza, 2021, World journal of gastroenterology.

Collateral sensitivity to cold stress and differential BCL-2 family expression in new daunomycin-resistant lymphoblastoid cell lines.

M. Cánovas, P. García-Peñarrubia, E. Martín-Orozco, 2015, Experimental cell research.

Isolation of functional mature peritoneal macrophages from healthy humans

H. Martínez-Banaclocha, A. Tapia-Abellán, P. Pelegrín, 2019, Immunology and cell biology.

Expression of LAIR-1 (CD305) on Human Blood Monocytes as a Marker of Hepatic Cirrhosis Progression

P. García-Peñarrubia, A. J. Ruiz-Alcaraz, G. Antón, 2019, Journal of immunology research.

A novel CD14(high) CD16(high) subset of peritoneal macrophages from cirrhotic patients is associated to an increased response to LPS.

A. Tapia-Abellán, P. García-Peñarrubia, A. J. Ruiz-Alcaraz, 2016, Molecular immunology.

Conjugation between cloned human NK cells (H7.8) and K562/MOLT4 tumor cell systems: saturability, binding parameters, and population distribution of conjugates.

J. Gálvez, P. García-Peñarrubia, P. Aparicio, 1996, Cellular immunology.

Penetration of host cell lines by bacteria. Characteristics of the process of intracellular bacterial infection

J. Gálvez, P. García-Peñarrubia, F. Lajarin, 1997 .

Spatio-Temporal Dependence of the Signaling Response in Immune-Receptor Trafficking Networks Regulated by Cell Density: A Theoretical Model

J. Gálvez, J. Galvez, P. García-Peñarrubia, 2011, PloS one.

Synthetic oligodeoxynucleotides induce MAP kinases activation in murine TIB-73 hepatocytes.

P. García-Peñarrubia, A. J. Ruiz-Alcaraz, M. Martínez-Esparza, 2010, Histology and histopathology.

Characterization of human peritoneal monocyte/macrophage subsets in homeostasis: Phenotype, GATA6, phagocytic/oxidative activities and cytokines expression

P. García-Peñarrubia, A. J. Ruiz-Alcaraz, M. Martínez-Esparza, 2018, Scientific Reports.

Regulatory role of PI 3 K-Akt on the release of IL-1 β in peritoneal macrophages from the ascites of cirrhotic patients 1 Short title : Signaling for IL-1 in Peritoneal Macrophages

R. Francés, P. García-Peñarrubia, J. Such, 2014 .

Synthetic oligodeoxynucleotides induce MAP kinases activation in murine TIB-73 hepatocytes.

P. García-Peñarrubia, A. J. Ruiz-Alcaraz, M. Martínez-Esparza, 2010, Histology and Histopathology.

Mathematical modeling of adhesion of bacteria to host cell lines.

J. Gálvez, P. García-Peñarrubia, F. Lajarin, 1997, Bulletin of mathematical biology.