Malkit Sami

发表

Structural and kinetic basis for heightened immunogenicity of T cell vaccines

Andrew Sewell, Robert M. Esnouf, Bent K. Jakobsen, 2005, The Journal of experimental medicine.

Human TCR-Binding Affinity is Governed by MHC Class Restriction1

Andrew K. Sewell, George F. Gao, David A. Price, 2007, The Journal of Immunology.

Monoclonal TCR-redirected tumor cell killing

Yvonne McGrath, Yi Li, Bent K Jakobsen, 2012, Nature Medicine.

Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA.

T. Blicher, B. Jakobsen, M. W. van der Kamp, 2020, The Journal of clinical investigation.

TCR‐induced alteration of primary MHC peptide anchor residue

S. Wells, A. Sewell, B. Jakobsen, 2019, European journal of immunology.

T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding.

A. Sewell, J. Boulter, B. Jakobsen, 2008, Molecular immunology.

Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex.

G. Gao, J. Bell, T. Georgiou, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystal structure of HLA‐A*2402 complexed with a telomerase peptide

G. Gao, J. Bell, J. Boulter, 2006, European journal of immunology.

Crystallization and preliminary X-ray structural studies of a high-affinity CD8alphaalpha co-receptor to pMHC.

G. Gao, M. Glick, J. Bell, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Complex Interactions Overrides Affinity-enhancing TCR-Major T-cell Receptor ( TCR )-Peptide Specificity Immunology :

Schauenburg, A. Sewell, P. Rizkallah, 2013 .

T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions*

A. Sewell, B. Jakobsen, P. Rizkallah, 2013, The Journal of Biological Chemistry.

Stable, soluble T-cell receptor molecules for crystallization and therapeutics.

Meir Glick, Bent K Jakobsen, M. Glick, 2003, Protein engineering.

T-cell Receptor Specificity Maintained by Altered Thermodynamics*

Yi Li, Andrew K. Sewell, John J. Miles, 2013, The Journal of Biological Chemistry.

Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry.

J. Boulter, B. Jakobsen, P. Rizkallah, 2007, Protein engineering, design & selection : PEDS.

Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy

Bent K. Jakobsen, B. Jakobsen, J. Dukes, 2016, Scientific Reports.

Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide‐MHC without increasing apparent cross‐reactivity

Yi Li, Feng Gao, Ruth Moysey, 2006, Protein science : a publication of the Protein Society.

Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors

M. Kalos, C. June, B. Jakobsen, 2012, Cancer Immunology, Immunotherapy.

Governed by MHC Class Restriction Human TCR-Binding Affinity is

G. Gao, J. Bell, A. Sewell, 2010 .

Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode

J. Boulter, B. Jakobsen, B. Baker, 2013, Front. Immunol..

High affinity soluble ILT2 receptor: a potent inhibitor of CD8+ T cell activation

J. E. Brewer, B. Jakobsen, R. Ashfield, 2010, Protein & Cell.

Abstract 2900: IMCgp100: A novel bi-specific biologic for the treatment of malignant melanoma

G. Linette, M. Kalos, C. June, 2014 .

Computational design and crystal structure of an enhanced affinity mutant human CD8 αα coreceptor

G. Gao, M. Glick, J. Bell, 2007 .

Monoclonal TCR-redirected tumor cell killing

M. Kalos, C. June, A. Sewell, 2012, Nature Medicine.