G. Chellman

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Comparison of Immune System Development in Nonclinical Species and Humans: Closing Information Gaps for Immunotoxicity Testing and Human Translatability.

G. Weinbauer, B. Enright, H. Skaggs, 2019, Reproductive toxicology.

Preclinical safety evaluations supporting pediatric drug development with biopharmaceuticals: strategy, challenges, current practices.

C. Bowman, D. Blanset, W. Halpern, 2011, Birth defects research. Part B, Developmental and reproductive toxicology.

Reproductive toxicity of denosumab in cynomolgus monkeys.

D. Branstetter, I. Pyrah, R. Boyce, 2013, Reproductive toxicology.

Developmental immunotoxicity (DIT) testing of pharmaceuticals: Current practices, state of the science, knowledge gaps, and recommendations

J. Shenton, G. Chellman, M. Collinge, 2012, Journal of immunotoxicology.

Use of Primate Pediatric Model

G. Weinbauer, G. Chellman, A. D. Rasmussen, 2012 .

Use of barusiban in a novel study design for evaluation of tocolytic agents in pregnant and neonatal monkeys, including behavioural and immunological endpoints.

M. Golub, J. Nelson, G. Chellman, 2007, Reproductive toxicology.

Inhibition of the acute toxicity of methyl chloride in male B6C3F1 mice by glutathione depletion.

J. Bus, G. Chellman, R. D. White, 1986, Toxicology and applied pharmacology.

Placental transfer of a fully human IgG2 monoclonal antibody in the cynomolgus monkey, rat, and rabbit: a comparative assessment from during organogenesis to late gestation.

M. Retter, G. Moffat, G. Chellman, 2014, Birth defects research. Part B, Developmental and reproductive toxicology.

Infant cynomolgus monkeys exposed to denosumab in utero exhibit an osteoclast-poor osteopetrotic-like skeletal phenotype at birth and in the early postnatal period.

I. Pyrah, R. Boyce, G. Chellman, 2014, Bone.

Assessment of ixekizumab, an interleukin-17A monoclonal antibody, for potential effects on reproduction and development, including immune system function, in cynomolgus monkeys.

G. Chellman, K. G. Hilbish, D. Clarke, 2015, Reproductive toxicology.

Resistance to cadmium-induced necrosis in testes of inbred mice: possible role of a metallothionein-like cadmium-binding protein.

G. Diamond, R. Baggs, G. Chellman, 1985, Toxicology and applied pharmacology.

Telemetric uterine contraction model in preterm cynomolgus monkeys.

G. Haluska, G. Chellman, D. Moddrelle, 2004, Reproductive toxicology.

Inhibition of methyl chloride toxicity in male F-344 rats by the anti-inflammatory agent BW755C.

P. Working, K. Morgan, J. Bus, 1986, Toxicology and applied pharmacology.

Investigation of maternal and fetal exposure to an IgG2 monoclonal antibody following biweekly intravaginal administration to cynomolgus monkeys throughout pregnancy.

M. Retter, R. Davies, G. Moffat, 2014, Reproductive toxicology.

Evaluation of early fetal exposure to vaginally-administered metronidazole in pregnant cynomolgus monkeys.

K. Thompson, G. Moffat, G. Chellman, 2016, Reproductive toxicology.

Developmental and reproductive toxicology studies in nonhuman primates.

G. Weinbauer, Y. Ooshima, G. Chellman, 2009, Birth defects research. Part B, Developmental and reproductive toxicology.

Role of epididymal inflammation in the induction of dominant lethal mutations in Fischer 344 rat sperm by methyl chloride.

P. Working, J. Bus, G. Chellman, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Activation of B virus (Herpesvirus simiae) in chronically immunosuppressed cynomolgus monkeys.

G. Chellman, E. Eugui, J. Hilliard, 1992, Laboratory animal science.

Decreased uptake and altered subcellular disposition of testicular cadmium as possible mechanisms of resistance to cadmium-induced testicular necrosis in inbred mice.

R. Baggs, G. Chellman, Z. Shaikh, 1984, Toxicology.

Nonclinical safety evaluation of erenumab, a CGRP receptor inhibitor for the prevention of migraine.

R. Davies, T. Monticello, H. Vargas, 2019, Regulatory toxicology and pharmacology : RTP.

Rat paw-lick/muscle irritation model for evaluating parenteral formulations for pain-on-injection and muscle damage.

G. Chellman, L. Lollini, T. McCullough, 1990, Fundamental and applied toxicology : official journal of the Society of Toxicology.

An Enhanced Pre- and Postnatal Development Study in Cynomolgus Monkeys with Tabalumab: A Human IgG4 Monoclonal Antibody.

W. Breslin, G. Chellman, K. G. Hilbish, 2015, Birth defects research. Part B, Developmental and reproductive toxicology.

Pharmaceutical toxicology: designing studies to reduce animal use, while maximizing human translation.

Stuart Creton, Henry Holzgrefe, A. Hoberman, 2013, Regulatory toxicology and pharmacology : RTP.

Hyperplastic Changes within the Leptomeninges of the Rat and Monkey in Response to Chronic Intracerebroventricular Infusion of Nerve Growth Factor

Randolph M. Johnson, G. Chellman, G. Stewart, 1997, Experimental Neurology.

Barusiban, An Effective Long-Term Treatment of Oxytocin-Induced Preterm Labor in Nonhuman Primates1

G. Chellman, T. Reinheimer, W. Bee, 2006, Biology of reproduction.

Developmental and Reproductive Toxicity Testing

C. Bowman, W. Halpern, G. Weinbauer, 2015 .

Barusiban, a new highly potent and long-acting oxytocin antagonist: pharmacokinetic and pharmacodynamic comparison with atosiban in a cynomolgus monkey model of preterm labor.

G. Haluska, G. Chellman, T. Reinheimer, 2005, The Journal of clinical endocrinology and metabolism.

Developmental and peri-postnatal study in cynomolgus monkeys with belimumab, a monoclonal antibody directed against B-lymphocyte stimulator.

T. Migone, G. Chellman, M. Devalaraja, 2009, Reproductive toxicology.

Role of testicular versus epididymal toxicity in the induction of cytotoxic damage in Fischer-344 rat sperm by methyl chloride.

P. Working, M. Hurtt, J. Bus, 1987, Reproductive toxicology.

The use of multiple endpoints to define the mechanism of action of reproductive toxicants and germ cell mutagens.

P. Working, G. Chellman, 1989, Progress in clinical and biological research.