H. Shiba

发表

Dentin sialophosphoprotein is a potentially latent bioactive protein in dentin.

Shigeki Suzuki, J. Nakanishi, Kazuma Yoshida, 2016, Journal of oral biosciences.

Susceptibility of periodontopathogenic and cariogenic bacteria to defensins and potential therapeutic use of defensins in oral diseases.

T. Kawai, M. Sugai, H. Shiba, 2007, Current pharmaceutical design.

Promotion of functioning of human periodontal ligament cells and human endothelial cells by nerve growth factor.

Y. Kato, H. Shiba, K. Tsuji, 2006, Journal of periodontology.

Irsogladine maleate inhibits Porphyromonas gingivalis-mediated expression of toll-like receptor 2 and interleukin-8 in human gingival epithelial cells.

T. Fujita, H. Shiba, K. Ouhara, 2015, Journal of periodontal research.

The antimicrobial peptide LL37 promotes bone regeneration in a rat calvarial bone defect

T. Iwata, T. Fujita, H. Shiba, 2013, Peptides.

Human autologous serum obtained using a completely closed bag system as a substitute for foetal calf serum in human mesenchymal stem cell cultures

H. Shiba, H. Kurihara, N. Mizuno, 2006, Cell biology international.

Expression of Osteoprotegerin (Osteoclastogenesis Inhibitory Factor) in Cultures of Human Dental Mesenchymal Cells and Epithelial Cells

M. Sugai, T. Fujita, H. Shiba, 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Cellular immuno-competence of infected root canal contents in pathogenesis of periapical lesions.

H. Yoshino, H. Shiba, H. Kawaguchi, 1997, Journal of endodontics.

Brain-derived neurotrophic factor prevents the endothelial barrier dysfunction induced by interleukin-1β and tumor necrosis factor-α.

T. Fujita, H. Shiba, H. Kurihara, 2015, Journal of periodontal research.

The differential expression of mgl mRNA by Porphyromonas gingivalis affects the production of methyl mercaptan.

T. Shintani, T. Fujita, H. Shiba, 2015, Oral diseases.

miR-584 expressed in human gingival epithelial cells is induced by Porphyromonas gingivalis stimulation and regulates interleukin-8 production via lactoferrin receptor.

T. Iwata, T. Fujita, H. Shiba, 2014, Journal of periodontology.

Azithromycin recovers reductions in barrier function in human gingival epithelial cells stimulated with tumor necrosis factor-α.

T. Fujita, H. Shiba, K. Ouhara, 2016, Archives of oral biology.

Interleukin-8 induces DNA synthesis, migration and down-regulation of cleaved caspase-3 in cultured human gingival epithelial cells.

T. Iwata, T. Fujita, H. Shiba, 2015, Journal of periodontal research.

Brain-derived Neurotrophic Factor Stimulates Bone/Cementum-related Protein Gene Expression in Cementoblasts*

T. Takata, T. Fujita, H. Shiba, 2008, Journal of Biological Chemistry.

Aggressive periodontitis and NOD2 variants

T. Iwata, H. Kawakami, H. Morino, 2020, Journal of Human Genetics.

Glycyrrhizic acid suppresses inflammation and reduces the increased glucose levels induced by the combination of Porphyromonas gulae and ligature placement in diabetic model mice

T. Fujita, H. Shiba, K. Ouhara, 2019, International immunopharmacology.

Distinction Between Cell Proliferation and Apoptosis Signals Regulated by Brain‐Derived Neurotrophic Factor in Human Periodontal Ligament Cells and Gingival Epithelial Cells

T. Takata, T. Fujita, H. Shiba, 2016, Journal of cellular biochemistry.

BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade.

T. Takata, T. Fujita, H. Shiba, 2014, International immunopharmacology.

Proteome analysis of proteins related to aggressive periodontitis combined with neutrophil chemotaxis dysfunction.

T. Iwata, H. Shiba, H. Kurihara, 2011, Journal of clinical periodontology.

Differential effects of various growth factors and cytokines on the syntheses of DNA, type I collagen, laminin, fibronectin, osteonectin/secreted protein, acidic and rich in cysteine (SPARC), and alkaline phosphatase by human pulp cells in culture

T. Kawamoto, M. Noshiro, Y. Kato, 1998, Journal of cellular physiology.

Syntheses of Prostaglandin E2 and E-Cadherin and Gene Expression of β-defensin-2 by Human Gingival Epithelial Cells in Response to Actinobacillus actinomycetemcomitans

M. Sugai, H. Shiba, H. Komatsuzawa, 2003, Inflammation.

Expression of endothelins and their receptors in cells from human periodontal tissues.

D. Fujioka, H. Yoshino, H. Shiba, 2003, Journal of periodontal research.

Osteoprotegerin levels increased by interleukin-1beta in human periodontal ligament cells are suppressed through prostaglandin E(2) synthesized de novo.

T. Fujita, H. Yoshino, H. Shiba, 2002, Cytokine.

EFFECTS OF TRANSFORMING GROWTH FACTOR‐β1 AND FIBRONECTIN ON SPARC EXPRESSION IN CULTURES OF HUMAN PERIODONTAL LIGAMENT CELLS

T. Fujita, H. Shiba, H. Kurihara, 2002 .

Expression of IL-1 beta and IL-8 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans.

M. Sugai, T. Fujita, H. Shiba, 2001, Cytokine.

Effects of ageing on proliferative ability, and the expressions of secreted protein, acidic and rich in cysteine (SPARC) and osteoprotegerin (osteoclastogenesis inhibitory factor) in cultures of human periodontal ligament cells

T. Fujita, H. Shiba, H. Kurihara, 2000, Mechanisms of Ageing and Development.

A small nuclear acidic protein (MTI-II, Zn2+-binding protein, parathymosin) attenuates TNF-α inhibition of BMP-induced osteogenesis by enhancing accessibility of the Smad4-NF-κB p65 complex to Smad binding element

E. Jimi, C. Kitamura, Shigeki Suzuki, 2020, Molecular and Cellular Biochemistry.

Irsogladine maleate regulates epithelial barrier function in tumor necrosis factor-α-stimulated human gingival epithelial cells.

S. Murakami, T. Fujita, H. Shiba, 2012, Journal of periodontal research.

Irsogladine maleate regulates gingival epithelial barrier function and intercellular communication in gingival epithelial cells

T. Fujita, H. Shiba, H. Kurihara, 2012 .

The expressions of claudin-1 and E-cadherin in junctional epithelium.

T. Fujita, H. Shiba, H. Kurihara, 2010, Journal of periodontal research.

Brain-derived neurotrophic factor enhances periodontal tissue regeneration.

H. Yoshino, H. Shiba, H. Kurihara, 2005, Tissue engineering.

Neurotrophins in cultured cells from periodontal tissues.

H. Yoshino, H. Shiba, H. Kurihara, 2003, Journal of periodontology.

Effect of neurotrophins on differentiation, calcification and proliferation in cultures of human pulp cells

T. Fujita, H. Shiba, H. Kurihara, 2007, Cell biology international.

Brain‐derived neurotrophic factor protects cementoblasts from serum starvation‐induced cell death

T. Takata, T. Fujita, H. Shiba, 2009, Journal of cellular physiology.

Dental pulp cell-derived powerful inducer of TNF-α comprises PKR containing stress granule rich microvesicles

T. Fukuda, F. Nishimura, Shigeki Suzuki, 2019, Scientific Reports.

Sequential process in brain-derived neurotrophic factor-induced functional periodontal tissue regeneration.

T. Fujita, H. Shiba, H. Kurihara, 2016, European journal of oral sciences.

Characteristics of high-molecular-weight hyaluronic acid as a brain-derived neurotrophic factor scaffold in periodontal tissue regeneration.

T. Iwata, T. Fujita, H. Shiba, 2011, Tissue engineering. Part A.

Brain‐derived neurotrophic factor protects cementoblasts from serum starvation‐induced cell death

T. Takata, T. Fujita, H. Shiba, 2009, Journal of cellular physiology.

Expression levels of novel cytokine IL-32 in periodontitis and its role in the suppression of IL-8 production by human gingival fibroblasts stimulated with Porphyromonas gingivalis

T. Kawai, T. Fujita, N. Karimbux, 2012, Journal of oral microbiology.

Actinobacillus actinomycetemcomitans Outer Membrane Protein 100 Triggers Innate Immunity and Production of β-Defensin and the 18-Kilodalton Cationic Antimicrobial Protein through the Fibronectin-Integrin Pathway in Human Gingival Epithelial Cells

K. Sayama, K. Hashimoto, T. Kawai, 2006, Infection and Immunity.

Heparin-LL37 complexes are less cytotoxic for human dental pulp cells and have undiminished antimicrobial and LPS-neutralizing abilities.

K. Yoshida, J. Nakanishi, H. Shiba, 2019, International endodontic journal.

LL37 induces VEGF expression in dental pulp cells through ERK signalling.

T. Fujita, H. Shiba, H. Komatsuzawa, 2015, International endodontic journal.

Macrophage inflammatory protein-3α and β-defensin-2 stimulate dentin sialophosphoprotein gene expression in human pulp cells

M. Sugai, D. Kinane, H. Shiba, 2003 .

Aggregatibacter actinomycetemcomitans outer membrane protein 29 (Omp29) induces TGF‐β‐regulated apoptosis signal in human gingival epithelial cells via fibronectin/integrinβ1/FAK cascade

T. Fujita, H. Shiba, H. Komatsuzawa, 2016, Cellular microbiology.

Optineurin regulates osteoblastogenesis through STAT1.

T. Iwata, Y. Sotomaru, H. Kawakami, 2020, Biochemical and biophysical research communications.

Oxytocin suppresses CXCL10 production in TNF‐α‐stimulated human dental pulp stem cells

H. Shiba, K. Takeda, Satoru Shindo, 2022, Cell biology international.

Antimicrobial peptide LL37 promotes vascular endothelial growth factor-A expression in human periodontal ligament cells.

T. Fujita, H. Shiba, K. Kanbara, 2013, Journal of periodontal research.

Dentin phosphoprotein inhibits lipopolysaccharide-induced macrophage activation independent of its serine/aspartic acid-rich repeats.

N. Haruyama, Shigeki Suzuki, J. Nakanishi, 2019, Archives of oral biology.

Oxidative stress impairs the calcification ability of human dental pulp cells

J. Nakanishi, H. Shiba, K. Takeda, 2022, BMC Oral Health.

Irsogladine maleate regulates barrier function and neutrophil accumulation in the gingival epithelium

T. Fujita, H. Shiba, H. Kurihara, 2012 .

Irsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans.

Y. Abiko, T. Fujita, H. Shiba, 2010, Biochemical pharmacology.

Irsogladine maleate counters the interleukin-1 beta-induced suppression in gap-junctional intercellular communication but does not affect the interleukin-1 beta-induced zonula occludens protein-1 levels in human gingival epithelial cells.

C. Hirono, T. Fujita, H. Shiba, 2007, Journal of periodontal research.

Involvement of smad2 and Erk/Akt cascade in TGF-β1-induced apoptosis in human gingival epithelial cells.

T. Fujita, H. Shiba, K. Ouhara, 2015, Cytokine.

Parotid secretory protein is expressed and inducible in human gingival keratinocytes.

S. Gorr, S. G. Venkatesh, D. Kinane, 2005, Journal of periodontal research.

Regulation of IL-8 by Irsogladine maleate is involved in abolishment of Actinobacillus actinomycetemcomitans-induced reduction of gap-junctional intercellular communication.

T. Iwata, C. Hirono, T. Fujita, 2006, Cytokine.

Effect of neurotrophin-4/5 on bone/cementum-related protein expressions and DNA synthesis in cultures of human periodontal ligament cells.

H. Shiba, H. Kurihara, N. Mizuno, 2008, Journal of periodontology.

Macrophage inflammatory protein-3alpha and beta-defensin-2 stimulate dentin sialophosphoprotein gene expression in human pulp cells.

M. Sugai, D. Kinane, H. Shiba, 2003, Biochemical and biophysical research communications.

Houttuynia cordata suppresses the Aggregatibacter actinomycetemcomitans- induced increase of inflammatory-related genes in cultured human gingival epithelial cells

T. Fujita, H. Shiba, K. Ouhara, 2015 .

Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans.

T. Iwata, Y. Abiko, T. Fujita, 2013, International immunopharmacology.

Introduction of a mixture of β-tricalcium phosphate into a complex of bone marrow mesenchymal stem cells and type I collagen can augment the volume of alveolar bone without impairing cementum regeneration.

T. Iwata, T. Fujita, H. Shiba, 2015, Journal of periodontology.

Effect of bone morphogenetic proteins‐4, '5 and '6 on DNA synthesis and expression of bone‐related proteins in cultured human periodontal ligament cells

H. Shiba, H. Kurihara, Wan-peng Xu, 2004, Cell biology international.

Enhancement of alkaline phosphatase synthesis in pulp cells co‐cultured with epithelial cells derived from lower rabbit incisors

Y. Kato, M. Sugai, H. Shiba, 2003, Cell biology international.

Semaphorin3A released from human dental pulp cells inhibits the increase in interleukin‐6 and CXC chemokine ligand 10 production induced by tumor necrosis factor‐α through suppression of nuclear factor‐κB activation

H. Shiba, K. Takeda, Satomi Shirawachi, 2020, Cell biology international.

Development of the Prophylaxis of Periodontitis by Regulating Gingival Epithelial Cell Functions

T. Fujita, H. Shiba, H. Kurihara, 2013 .

Relationship between length variations in Ser/Asp-rich repeats in phosphophoryn and in vitro precipitation of calcium phosphate.

F. Nishimura, N. Haruyama, Shigeki Suzuki, 2015, Archives of oral biology.

Neodymium-doped yttrium-aluminium-garnet laser irradiation abolishes the increase in interleukin-6 levels caused by peptidoglycan through the p38 mitogen-activated protein kinase pathway in human pulp cells.

H. Tsuda, T. Fujita, H. Shiba, 2009, Journal of endodontics.

Irsogladine maleate abolishes the increase in interleukin-8 levels caused by outer membrane protein 29 from Aggregatibacter (Actinobacillus) actinomycetemcomitans through the ERK pathway in human gingival epithelial cells.

T. Fujita, H. Shiba, H. Komatsuzawa, 2008, Journal of periodontal research.

Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone‐related and enamel proteins

H. Shiba, H. Kurihara, Wan-peng Xu, 2005, Cell biology international.

Differential effects of growth factors and cytokines on the synthesis of SPARC, DNA, fibronectin and alkaline phosphatase activity in human periodontal ligament cells

T. Fujita, H. Shiba, H. Kurihara, 2004, Cell biology international.

Differential gene expression of bone‐related proteins in epithelial and fibroblastic cells derived from human periodontal ligament

H. Shiba, H. Kurihara, N. Mizuno, 2003, Cell biology international.

The effect of extracellular calcium ion on gene expression of bone-related proteins in human pulp cells.

T. Fujita, H. Shiba, H. Kurihara, 2003, Journal of endodontics.

Transforming Growth Factor-β1 and Basic Fibroblast Growth Factor Modulate Osteocalcin and Osteonectin/SPARC Syntheses in Vitamin-D-activated Pulp Cells

T. Fujita, H. Shiba, H. Kurihara, 2001, Journal of dentistry research.

Characteristics of periodontal ligament subpopulations obtained by sequential enzymatic digestion of rat molar periodontal ligament.

T. Takata, H. Shiba, M. Miyauchi, 2006, Bone.

Enhancement of periodontal tissue regeneration by transplantation of bone marrow mesenchymal stem cells.

Takashi Takata, Hidemi Kurihara, T. Iwata, 2004, Journal of periodontology.

Combined endodontic and periodontal management of a class 3 invasive cervical resorption in a mandibular first molar

T. Iwata, H. Shiba, H. Kurihara, 2018, Clinical case reports.

Surgical Sealing of Laterally Localized Accessory Root Canal with Resin Containing S-PRG Filler in Combination with Non-Surgical Endodontic Treatment: A Case Report

N. Kakimoto, T. Nakamoto, Shigeki Suzuki, 2020, Dentistry journal.

Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, {beta}-defensins and LL37, produced by human epithelial cells.

K. Sayama, K. Hashimoto, M. Sugai, 2005, The Journal of antimicrobial chemotherapy.

Outer membrane protein 100, a versatile virulence factor of Actinobacillus actinomycetemcomitans

T. Kawai, M. Sugai, R. Gonçalves, 2003, Molecular microbiology.

Involvement of Rac1 in macrophage activation by brain-derived neurotrophic factor

H. Shiba, K. Ouhara, H. Kurihara, 2021, Molecular Biology Reports.

A novel gingival overgrowth mouse model induced by the combination of CsA and ligature-induced inflammation.

T. Fujita, H. Shiba, H. Kurihara, 2017, Journal of immunological methods.

SPARC stimulates the synthesis of OPG/OCIF, MMP-2 and DNA in human periodontal ligament cells.

T. Fujita, H. Shiba, H. Kurihara, 2002, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

Proliferative ability and alkaline phosphatase activity with in vivo cellular aging in human pulp cells.

H. Shiba, H. Kurihara, N. Mizuno, 2003, Journal of endodontics.

The genetic basis of periodontitis.

T. Hart, D. Kinane, H. Shiba, 2005, Periodontology 2000.

DMP-1 promoter-associated antisense strand non-coding RNA, panRNA-DMP-1, physically associates with EGFR to repress EGF-induced squamous cell carcinoma migration

E. Nemoto, Shigeki Suzuki, Kazuma Yoshida, 2021, Molecular and Cellular Biochemistry.

Genome-wide identification of chromatin-enriched RNA reveals that unspliced dentin matrix protein-1 mRNA regulates cell proliferation in squamous cell carcinoma.

F. Nishimura, N. Haruyama, Shigeki Suzuki, 2018, Biochemical and biophysical research communications.

Brain‐derived neurotrophic factor induces migration of endothelial cells through a TrkB–ERK–integrin αVβ3–FAK cascade

T. Fujita, H. Shiba, H. Kurihara, 2012, Journal of cellular physiology.

Loss of IκBζ Drives Dentin Formation via Altered H3K4me3 Status

E. Nemoto, H. Shiba, K. Yamasaki, 2022, Journal of dental research.