D. Senger

发表

Osteopontin expression and distribution in human carcinomas.

E. Manseau, H. Dvorak, B. Berse, 1994, The American journal of pathology.

Specific reduction in osteopontin synthesis by antisense RNA inhibits the tumorigenicity of transformed Rat1 fibroblasts.

B. Berse, D. Senger, H. A. Gardner, 1994, Oncogene.

Transformed mammalian cells secrete specific proteins and phosphoproteins

R. Hynes, D. Wirth, D. Senger, 1979, Cell.

A secreted phosphoprotein marker for neoplastic transformation of both epithelial and fibroblastic cells

H. Dvorak, C. Perruzzi, D. Senger, 1983, Nature.

Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.

H. Dvorak, A. Dvorak, S. J. Galli, 1983, Science.

Patents And literature

D. A. Small, A. Atkinson, P. Donahoe, 1985 .

Biosynthesis, Remodeling, and Functions During Vascular Morphogenesis and Neovessel Stabilization

G. Davis, D. Senger, George E Davis, 2005 .

Collagen I Initiates Endothelial Cell Morphogenesis by Inducing Actin Polymerization through Suppression of Cyclic AMP and Protein Kinase A*

D. Senger, M. Whelan, 2003, The Journal of Biological Chemistry.

Regulation of extravascular coagulation by microvascular permeability.

H. Dvorak, A. Dvorak, J. Mcdonagh, 1985, Science.

Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels

Harold E. Dvorak, E. Manseau, H. Dvorak, 1991, The Journal of experimental medicine.

Adhesive properties of osteopontin: regulation by a naturally occurring thrombin-cleavage in close proximity to the GRGDS cell-binding domain.

L. Water, A. Papadopoulos-Sergiou, C. Perruzzi, 1994, Molecular biology of the cell.

The alpha(1)beta(1) and alpha(2)beta(1) integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis.

M. Detmar, V. Koteliansky, A. D. de Fougerolles, 2002, The American journal of pathology.

The α1β1 and α2β1 Integrins Provide Critical Support for Vascular Endothelial Growth Factor Signaling, Endothelial Cell Migration, and Tumor Angiogenesis

M. Detmar, V. Koteliansky, A. D. Fougerolles, 2002 .

Anti-inflammatory activity of Barleria lupulina: Identification of active compounds that activate the Nrf2 cell defense pathway, organize cortical actin, reduce stress fibers, and improve cell junctions in microvascular endothelial cells.

S. Cao, D. Senger, Ki Hyun Kim, 2016, Journal of ethnopharmacology.

Secreted phosphoprotein markers for neoplastic transformation of human epithelial and fibroblastic cells.

C. Perruzzi, D. Senger, 1985, Cancer research.

Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin.

C. Perruzzi, D. Senger, 1996, Biochimica et biophysica acta.

Elevated expression of secreted phosphoprotein I (osteopontin, 2ar) as a consequence of neoplastic transformation.

C. Perruzzi, D. Senger, A. Papadopoulos, 1989, Anticancer research.

Vascular Endothelial Growth Factor: Much More than an Angiogenesis Factor

D. Senger, 2010, Molecular biology of the cell.

Calcium-binding properties of osteopontin derived from non-osteogenic sources.

A. Mukherjee, P. Chang, C. W. Prince, 1993, Journal of biochemistry.

Osteopontin: its transglutaminase-catalyzed posttranslational modifications and cross-linking to fibronectin.

A. Mukherjee, S. Beninati, E. Cordella-Miele, 1994, Journal of biochemistry.

The (cid:1) 1 (cid:2) 1 and (cid:1) 2 (cid:2) 1 Integrins Provide Critical Support for Vascular Endothelial Growth Factor Signaling, Endothelial Cell Migration, and Tumor Angiogenesis

M. Detmar, V. Koteliansky, A. D. Fougerolles, 2001 .

Functional Overlap and Cooperativity Among αv and β1 Integrin Subfamilies During Skin Angiogenesis

V. Koteliansky, A. D. Fougerolles, C. Perruzzi, 2003 .

Vascular permeability factor (vascular endothelial growth factor) in guinea pig and human tumor and inflammatory effusions.

H. Dvorak, J. Nagy, S. Ledbetter, 1993, Cancer research.

Ultrastructural localization of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) to the abluminal plasma membrane and vesiculovacuolar organelles of tumor microvascular endothelium.

H. Dvorak, J. Nagy, A. Dvorak, 1995, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells.

H. Dvorak, D. Senger, T. Brock, 1991, The American journal of pathology.

Vascular Morphogenesis and Neovessel Stabilization Endothelial Extracellular Matrix : Biosynthesis , Remodeling , and Functions During

G. Davis, D. Senger, 2005 .

Activation of the Nrf 2 Cell Defense Pathway by Ancient Foods : Disease

Shou-Ching S. Jaminet, Dan Li, S. Cao, 2016 .

Activation of the Nrf2 Cell Defense Pathway by Ancient Foods: Disease Prevention by Important Molecules and Microbes Lost from the Modern Western Diet

Shou-Ching S. Jaminet, Dan Li, S. Cao, 2016, PloS one.

Osteopontin at the Tumor/Host Interface

L. Brown, L. Water, A. Papadopoulos-Sergiou, 1995, Annals of the New York Academy of Sciences.

Cdc42-mediated inhibition of GSK-3β improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis.

J. Nagy, D. Senger, M. Hoang, 2011, Microvascular research.

Osteopontin: Role in Cell Signalling and Adhesion

A. Chambers, D. Denhardt, W. Butler, 1995 .

Follicular Fluid-Specific Distribution of Vascular Endothelial Growth Factor Isoforms and sFlt-1 in Patients Undergoing IVF and Their Correlation With Treatment Outcomes

A. Usheva, D. Senger, S. Savchev, 2010, Reproductive Sciences.

Endogenous protein synthesis of the cell-free wheat germ system.

P. Gross, D. Senger, 1976, Developmental biology.

Complex regulation of fibronectin synthesis by cells in culture.

R. Hynes, D. Senger, A. Destree, 1983, The American journal of physiology.

C3 component of complement secreted by established cell lines

R. Hynes, D. Senger, 1978, Cell.

Glycosylation is essential for efficient secretion but not for permeability-enhancing activity of vascular permeability factor (vascular endothelial growth factor).

H. Dvorak, D. Senger, K. Yeo, 1991, Biochemical and biophysical research communications.

Macrophage procoagulants and microvascular permeability: roles in the extravascular coagulation of cellular immunity

J. M. Carr, H. Dvorak, A. Dvorak, 1985 .

Inhibition of vascular permeability factor (vascular endothelial growth factor) with antipeptide antibodies.

H. Dvorak, D. Senger, T. Brock, 1993, Archives of biochemistry and biophysics.

Vascular permeability factor, tumor angiogenesis and stroma generation.

H. Dvorak, K. Claffey, L. Brown, 1994, Invasion & metastasis.

Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1.

J. Nagy, D. Senger, M. Hoang, 2011, Blood.

Calpain inhibition improves collateral-dependent perfusion in a hypercholesterolemic swine model of chronic myocardial ischemia.

Brittany A. Potz, F. Sellke, J. Abbott, 2016, The Journal of thoracic and cardiovascular surgery.

Moderation of Calpain Activity Promotes Neovascular Integration and Lumen Formation during VEGF-Induced Pathological Angiogenesis

J. Nagy, J. Fox, D. Senger, 2010, PloS one.

VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins.

P. Bohlen, S. Hirakawa, M. Detmar, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A LARGE GLYCOPROTEIN LOST FROM THE SURFACES OF TRANSFORMED CELLS *

R. Hynes, D. Wagner, I. Ali, 1978, Annals of the New York Academy of Sciences.

Chakyunglupulins A and B, two novel 4,8,8-trimethylcyclooct-2-enone derivatives from Barleria lupulina.

J. Clardy, S. Cao, D. Senger, 2015, Tetrahedron letters.

Fibrin as a component of the tumor stroma: origins and biological significance

H. Dvorak, A. Dvorak, D. Senger, 2004, Cancer and Metastasis Reviews.

Fibrin Formation: Implications for Tumor Growth and Metastasis

H. Dvorak, A. Dvorak, D. Senger, 1984 .

VEGF‐A promotes tissue repair‐associated lymphatic vessel formation via VEGFR‐2 and the α1β1 and α2β1 integrins

P. Bohlen, S. Hirakawa, M. Detmar, 2004 .

Vascular permeability factor/vascular endothelial growth factor: an important mediator of angiogenesis in malignancy and inflammation.

H. Dvorak, M. Detmar, J. Nagy, 1995, International archives of allergy and immunology.

Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins.

M. Detmar, K. Claffey, J. Benes, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Expression and distribution of osteopontin in human tissues: widespread association with luminal epithelial surfaces.

E. Manseau, H. Dvorak, B. Berse, 1992, Molecular biology of the cell.

Purification of a human milk protein closely similar to tumor-secreted phosphoproteins and osteopontin.

D. Tenen, C. Perruzzi, D. Senger, 1989, Biochimica et biophysica acta.

Iridoid glycosides from Barleria lupulina.

J. Clardy, K. Chung, M. Yip, 2015, Journal of natural products.

Extracellular matrix mediates a molecular balance between vascular morphogenesis and regression

G. Davis, D. Senger, 2008, Current opinion in hematology.

Ultrastructural immunogold localization of osteopontin in human gallbladder epithelial cells.

H. Dvorak, A. Dvorak, L. Brown, 1994, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Iridoid and phenylethanoid glycosides from the aerial part of Barleria lupulina

J. Clardy, Ki-Hyun Kim, S. Cao, 2016 .

Vascular permeability factor mRNA and protein expression in human kidney.

E. Manseau, H. Dvorak, B. Berse, 1992, Kidney international.

Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing

H. Dvorak, B. Berse, L. Brown, 1992, The Journal of experimental medicine.

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract.

E. Manseau, H. Dvorak, R. Jackman, 1993, Cancer research.

Macromolecule synthesis and determination in sea urchin blastomeres at the sixteen-cell stage.

P. Gross, D. Senger, 1978, Developmental biology.

The programmed switch in lysine-rich histone synthesis at gastrulation

R. Arceci, P. Gross, D. Senger, 1976, Cell.

Pathogenesis of tumor stroma generation: a critical role for leaky blood vessels and fibrin deposition.

H. Dvorak, J. Nagy, A. Dvorak, 1989, Biochimica et biophysica acta.

Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas.

E. Manseau, H. Dvorak, R. Jackman, 1993, The American journal of pathology.

VEGF-A, cytoskeletal dynamics, and the pathological vascular phenotype.

J. Nagy, D. Senger, 2006, Experimental cell research.

Matrix‐specific activation of Src and Rho initiates capillary morphogenesis of endothelial cells

D. Senger, Yanqiu Liu, Yanqiu Liu, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Molecular framework for angiogenesis: a complex web of interactions between extravasated plasma proteins and endothelial cell proteins induced by angiogenic cytokines.

D. Senger, 1996, The American journal of pathology.

Angiogenesis as a potential biomarker in prostate cancer chemoprevention trials.

I. Ali, D. Senger, L. E. Smith, 2001, Urology.

Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors.

H. Dvorak, B. Berse, L. Brown, 1992, Molecular biology of the cell.

A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines.

H. Dvorak, J. Feder, C. Perruzzi, 1986, Cancer research.

Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue

N. Olsen, H. Dvorak, R. Jackman, 1994, The Journal of experimental medicine.

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer.

Anthony J. Guidi, S. Schnitt, J. Connolly, 1995, Human pathology.

Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: Direct correlation with clinical retinopathy of prematurity

Lois E. H. Smith, D. Leroith, B. Carlsson, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor

Lois E. H. Smith, Samuel E. Driver, S. Soker, 1999, Nature Medicine.

Expression of vascular permeability factor/vascular endothelial growth factor by human granulosa and theca lutein cells. Role in corpus luteum development.

E. Manseau, H. Dvorak, L. Brown, 1995, American Journal of Pathology.

Secreted phosphoproteins associated with neoplastic transformation: close homology with plasma proteins cleaved during blood coagulation.

D. Tenen, C. Perruzzi, D. Senger, 1988, Cancer research.

Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor.

D. Connolly, H. Dvorak, J. Feder, 1990, Cancer research.

Vascular Permeability Factor, Fibrin, and the Pathogenesis of Tumor Stroma Formation a

H. Dvorak, J. Nagy, A. Dvorak, 1992, Annals of the New York Academy of Sciences.

Transformation-specific secreted phosphoproteins

R. Hynes, D. Wirth, D. Senger, 1980, Nature.

Molecular profiling of angiogenesis markers.

Lois E. H. Smith, K. Desai, I. Ali, 2002, The American journal of pathology.

Rho activity critically and selectively regulates endothelial cell organization during angiogenesis

D. Senger, M. Whelan, M. Hoang, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Expression of Vascular Permeability Factor! Vascular Endothelial Growth Factor by Human Granulosa and Theca Lutein Cells Role in Corpus Luteum Development

E. Manseau, H. Dvorak, L. Brown, 2007 .

Vascular permeability factor (VPF, VEGF) in tumor biology

Brygida Berse, Janice A. Nagy, Ann M. Dvorak, 1993, Cancer and Metastasis Reviews.

Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin.

M. Detmar, K. Claffey, S. Ledbetter, 1996, The American journal of pathology.

Structural requirements for dimerization, glycosylation, secretion, and biological function of VPF/VEGF.

B. Spiegelman, K. Claffey, D. Senger, 1995, Biochimica et biophysica acta.

VEGF expression by epithelial and stromal cell compartments: resolving a controversy.

L. Water, D. Senger, L. Van De Water, 2000, The American journal of pathology.

Development ofTime-Resolved Immunofluorometric Assayof VascularPermeability Factor

D. Senger, K. Yeo, T. Yeo, 1992 .

In vivo and in vitro models of Mammalian angiogenesis.

D. Senger, M. Hoang, 2005, Methods in molecular biology.

Moderate GSK-3β inhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy

Lois E. H. Smith, D. Senger, M. Hoang, 2010, Angiogenesis.

Transformation-specific secreted proteins.

R. Hynes, D. Wirth, D. Senger, 1980, Cold Spring Harbor symposia on quantitative biology.

The Journal of Experimental Medicine CORRESPONDENCE

E. Manseau, H. Dvorak, J. Nagy, 2005 .

Orphan nuclear receptor TR 3 / Nur 77 regulates VEGF-A – induced angiogenesis through its transcriptional activity

E. Manseau, H. Dvorak, J. Nagy, 2006 .

Calpain inhibitors reduce retinal hypoxia in ischemic retinopathy by improving neovascular architecture and functional perfusion.

Lois E. H. Smith, D. Senger, M. Hoang, 2011, Biochimica et biophysica acta.

Technical Advance Molecular Profiling of Angiogenesis Markers

Lois E. H. Smith, K. Desai, I. Ali, 2002 .

T24 human bladder carcinoma cells with activated Ha-ras protooncogene: nontumorigenic cells susceptible to malignant transformation with carcinogen.

I. Ali, C. Perruzzi, D. Senger, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Development of time-resolved immunofluorometric assay of vascular permeability factor.

D. Senger, K. Yeo, T. Yeo, 1992, Clinical chemistry.

Functional overlap and cooperativity among alphav and beta1 integrin subfamilies during skin angiogenesis.

V. Koteliansky, A. D. de Fougerolles, C. Perruzzi, 2003, The Journal of investigative dermatology.

Histones of sea urchin embryos. Transients in transcription, translation, and the composition of chromatin.

R. Arceci, P. Gross, D. Senger, 1978, Developmental biology.

Extracellular matrix mediates a molecular balance between vascular morphogenesis and regression

G. Davis, D. Senger, 2008, Current opinion in hematology.

Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors.

B. Berse, L. Brown, L. Water, 1992, Molecular biology of the cell.

Expression and distribution of osteopontin in human tissues: widespread association with luminal epithelial surfaces.

E. Manseau, H. Dvorak, B. Berse, 1992, Molecular biology of the cell.

Vascular permeability factor (vascular endothelial growth factor) in guinea pig and human tumor and inflammatory effusions.

H. Dvorak, J. Nagy, S. Ledbetter, 1993, Cancer research.

Diabetic Wound Healing and Activation of Nrf2 by Herbal Medicine.

D. Senger, Shugeng Cao, 2016, Journal of nature and science.

Vascular Permeability Factor/endothelial Growth Factor (vpf/vegf): Accumulation and Expression in Human Synovial Fluids and Rheumatoid Synovial Tissue

B. Berse, L. Brown, D. Senger, 1994 .

Orphan nuclear receptor TR3/Nur77 regulates VEGF-A–induced angiogenesis through its transcriptional activity

E. Manseau, H. Dvorak, J. Nagy, 2006, The Journal of experimental medicine.