Z. Guan

发表

Corn baked by burning coal triggered overexpression of osteopontin in hepatocytes of rats following fluorosis

Shufeng Zhou, Jia-Qi Wang, Yixia Zhou, 2012, Toxicology and industrial health.

Fluoride induced down-regulation of IKBKG Gene expression inhibits hepatocytes senescence.

Z. Guan, C. Wu, C. Mao, 2021, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

Separation and quantitation of phospholipids and their ether analogues by high-performance liquid chromatography.

Z. Guan, J. Grünler, S. Piao, 2001, Analytical biochemistry.

Influence of chronic fluorosis on membrane lipids in rat brain.

G. Dallner, Z. Guan, P. Sindelar, 1998, Neurotoxicology and teratology.

Zoledronic acid inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways

Z. Guan, Qiang Zhou, Xiaolin Huang, 2019, International journal of molecular medicine.

Integrated transcriptomic and proteomic analysis indicated that neurotoxicity of rats with chronic fluorosis may be in mechanism involved in the changed cholinergic pathway and oxidative stress.

F. Zhang, J. Zou, Z. Guan, 2020, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

Amyloid precursor protein gene mutated at Swedish 670/671 sites in vitro induces changed expression of nicotinic acetylcholine receptors and neurotoxicity

J. Pei, Z. Guan, Zhi Tang, 2010, Neurochemistry International.

Transgenic mice overexpressing human acetylcholinesterase and the Swedish amyloid precursor protein mutation: Effect of nicotine treatment

A. Nordberg, Z. Guan, M. Svedberg, 2008, Neuroscience.

Suppressed expression of nicotinic acetylcholine receptors by nanomolar β-amyloid peptides in PC12 cells

A. Nordberg, Z. Guan, J. Tian, 2001, Journal of Neural Transmission.

Mitochondrial Changes

Z. Guan, Di-dong Lou, 2021, Coal-burning Type of Endemic Fluorosis.

The decreased expression of mitofusin-1 and increased fission-1 together with alterations in mitochondrial morphology in the kidney of rats with chronic fluorosis may involve elevated oxidative stress.

J. Pei, Z. Guan, Wen-feng Yu, 2015, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

LiCl attenuates impaired learning and memory of APP/PS1 mice, which in mechanism involves α7 nAChRs and Wnt/β‐catenin pathway

Z. Guan, Kun Cao, X. Qi, 2021, Journal of cellular and molecular medicine.

[Effect of beta-amyloid peptides on alpha-7 nicotinic receptor status in astrocytes and neurons, and its relationship to pathogenesis of Alzheimer's disease].

Z. Guan, Yan Xiao, Ke-ren Shan, 2006, Zhonghua bing li xue za zhi = Chinese journal of pathology.

Dual effects of nicotine on oxidative stress and neuroprotection in PC12 cells

A. Nordberg, Z. Guan, Wen-feng Yu, 2003, Neurochemistry International.

Cross-talk between oxidative stress and modifications of cholinergic and glutaminergic receptors in the pathogenesis of Alzheimer's disease

Z. Guan, 2008, Acta Pharmacologica Sinica.

Changes of learning and memory ability and brain nicotinic receptors of rat offspring with coal burning fluorosis.

Z. Guan, Jin-ping Li, Long-Yan Ran, 2010, Neurotoxicology and teratology.

Membrane permeability-guided identification of neuroprotective components from Polygonum cuspidatun

Cheng-Yuan Lin, Hai-tao Xiao, Z. Guan, 2014, Pharmaceutical biology.

Influence of lipid peroxidation on the nicotinic acetylcholine receptors in PC12 cells

A. Nordberg, Z. Guan, Xiao Zhang, 2000, Neuroscience Letters.

An inexpensive anaerobic chamber for the genetic manipulation of strictly anaerobic bacteria.

W. Hong, Bing Wang, Z. Guan, 2021, Anaerobe.

Rapid screening and identification of caffeic acid and its esters in Erigeron breviscapus by ultra-performance liquid chromatography/tandem mass spectrometry.

Wen Zhou, Z. Guan, X. Qi, 2010, Rapid communications in mass spectrometry : RCM.

Heparan Sulfate Accumulation with Aβ Deposits in Alzheimer's Disease and Tg2576 Mice is Contributed by Glial Cells

B. Hyman, R. Ravid, L. Lannfelt, 2008, Brain pathology.

Berberine Ameliorates Oxygen-glucose Deprivation/Reperfusion-induced Apoptosis by Inhibiting Endoplasmic Reticulum Stress and Autophagy in PC12 Cells

Z. Guan, Wen-feng Yu, Zhenkui Ren, 2020, Current Medical Science.

Myeloperoxidase Activity and Its Corresponding mRNA Expression as well as Gene Polymorphism in the Population Living in the Coal-Burning Endemic Fluorosis Area in Guizhou of China

J. Pei, Z. Guan, Ke-ren Shan, 2013, Biological Trace Element Research.

Enhanced Oxidative Stress

Z. Guan, Long-Yan Ran, 2021, Coal-burning Type of Endemic Fluorosis.

Correlation of oxidative stress and the loss of the nicotinic receptor alpha4 subunit in the temporal cortex of patients with Alzheimer's disease

A. Nordberg, R. Ravid, Z. Guan, 2003, Neuroscience Letters.

Expression of nicotinic receptors on primary cultures of rat astrocytes and up-regulation of the α7, α4 and β2 subunits in response to nanomolar concentrations of the β-amyloid peptide1–42

A. Nordberg, Z. Guan, Jun-tian Zhang, 2005, Neurochemistry International.

Cholinesterase activity and mRNA level of nicotinic acetylcholine receptors (alpha4 and beta2 Subunits) in blood of elderly Chinese diagnosed as Alzheimer's disease.

J. Pei, Z. Guan, X. Qi, 2010, Journal of Alzheimer's disease : JAD.

Damage of Endocrine System

Z. Guan, Jie Xiang, Xiao-Xiao Zeng, 2021, Coal-burning Type of Endemic Fluorosis.

Increased level of apoptosis in rat brains and SH-SY5Y cells exposed to excessive fluoride--a mechanism connected with activating JNK phosphorylation.

J. Pei, Z. Guan, Qin Gao, 2011, Toxicology Letters.

Activation of the AGE/RAGE system in the brains of rats and in SH-SY5Y cells exposed to high level of fluoride might connect to oxidative stress.

Z. Guan, Di-dong Lou, Kai-lin Zhang, 2015, Neurotoxicology and teratology.

The influence of chronic fluorosis on mitochondrial dynamics morphology and distribution in cortical neurons of the rat brain

J. Pei, Z. Guan, Ji-gang Pan, 2013, Archives of Toxicology.

Deficit in learning and memory of rats with chronic fluorosis correlates with the decreased expressions of M1 and M3 muscarinic acetylcholine receptors

Z. Guan, Na Wei, Ya Wang, 2015, Archives of Toxicology.

Extract of Ginkgo biloba leaves attenuates neurotoxic damages in rats and SH-SY5Y cells exposed to a high level of fluoride.

Yan-Lin Ma, Z. Guan, X. Qi, 2022, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

The neurotoxicity of β-amyloid peptide toward rat brain is associated with enhanced oxidative stress, inflammation and apoptosis, all of which can be attenuated by scutellarin.

Z. Guan, Yonglin Wang, Yong Huang, 2013, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

Decreased nicotinic receptors in PC12 cells and rat brains influenced by fluoride toxicity--a mechanism relating to a damage at the level in post-transcription of the receptor genes.

A. Nordberg, Z. Guan, X. Qi, 2004, Toxicology.

Effect of long term fluoride exposure on lipid composition in rat liver.

G. Dallner, Z. Guan, K. Xiao, 2000, Toxicology.

Decreased Protein Levels of Nicotinic Receptor Subunits in the Hippocampus and Temporal Cortex of Patients with Alzheimer’s Disease

A. Nordberg, R. Ravid, Z. Guan, 2000, Journal of neurochemistry.

Changed cellular membrane lipid composition and lipid peroxidation of kidney in rats with chronic fluorosis

Z. Guan, K. Xiao, Yi-guo Long, 2000, Archives of Toxicology.

[Study on association between HLA-DP gene polymorphism and susceptibility to hepatitis B virus infection in minority population in Guizhou province].

Z. Guan, Wenfeng Yu, Ting Zhang, 2016, Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi.

Expression of nicotinic acetylcholine receptors in human and rat adrenal medulla.

A. Nordberg, E. Hellström‐Lindahl, Z. Guan, 2001, Life sciences.

Protein and mRNA levels of nicotinic receptors in brain of tobacco using controls and patients with Alzheimer's disease

A. Nordberg, R. Ravid, A. Nordberg, 2003, Neuroscience.

Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation

Z. Guan, Kun Cao, Long-Yan Ran, 2019, Alzheimer's Research & Therapy.

High selective expression of α7 nicotinic receptors on astrocytes in the brains of patients with sporadic Alzheimer's disease and patients carrying Swedish APP 670/671 mutation: a possible association with neuritic plaques

A. Nordberg, N. Bogdanovic, Z. Guan, 2005, Experimental Neurology.

Expression of nicotinic receptors on primary cultures of rat astrocytes and up-regulation of the alpha7, alpha4 and beta2 subunits in response to nanomolar concentrations of the beta-amyloid peptide(1-42).

A. Nordberg, Z. Guan, Jin Xiu, 2005, Neurochemistry international.

Alterations of nAChRs and ERK1/2 in the brains of rats with chronic fluorosis and their connections with the decreased capacity of learning and memory.

Z. Guan, Qin Gao, Yan-jie Liu, 2010, Toxicology letters.

Inhibiting gene expression of α3 nicotinic receptor in SH-SY5Y cells with the effects on APP metabolism and antioxidation in Alzheimer's disease

Z. Guan, Zhi Tang, X. Qi, 2008, Neurochemistry International.

[Effect of endemic fluoride poisoning caused by coal burning on the oxidative stress in rat testis].

J. Gu, Z. Guan, Yan-ni Yu, 2011, Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.

Changes of Receptors

Z. Guan, Yangting Dong, 2021, Coal-burning Type of Endemic Fluorosis.

Long‐lasting acetylcholinesterase splice variations in anticholinesterase‐treated Alzheimer's disease patients

A. Nordberg, A. Nordberg, H. Soreq, 2004, Journal of neurochemistry.

Original Research: Influence of okadaic acid on hyperphosphorylation of tau and nicotinic acetylcholine receptors in primary neurons

J. Pei, Liang Zhao, Z. Guan, 2016, Experimental biology and medicine.

The neuroprotective effects of SIRT1 in mice carrying the APP/PS1 double-transgenic mutation and in SH-SY5Y cells over-expressing human APP670/671 may involve elevated levels of α7 nicotinic acetylcholine receptors

Z. Guan, Hui Song, Kun Cao, 2020, Aging.

Protections against toxicity in the brains of rat with chronic fluorosis and primary neurons exposed to fluoride by resveratrol involves nicotinic acetylcholine receptors.

Dan Chen, Z. Guan, Kun Cao, 2020, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

Selective changes in the levels of nicotinic acetylcholine receptor protein and of corresponding mRNA species in the brains of patients with Parkinson’s disease

A. Nordberg, J. Rinne, E. Hellström‐Lindahl, 2002, Brain Research.

Decrease and structural modifications of phosphatidylethanolamine plasmalogen in the brain with Alzheimer disease.

P. Lantos, N. Cairns, G. Dallner, 1999, Journal of neuropathology and experimental neurology.

The protective role of plasmalogens in iron-induced lipid peroxidation.

G. Dallner, L. Ernster, Z. Guan, 1999, Free radical biology & medicine.

Preventing Expression of the Nicotinic Receptor Subunit α7 in SH-SY5Y Cells with Interference RNA Indicates that this Receptor may Protect Against the Neurotoxicity of Aβ

Z. Guan, X. Qi, Jia-mou Ren, 2013, Neurochemical Research.

Mangiferin prevents the impairment of mitochondrial dynamics and an increase in oxidative stress caused by excessive fluoride in SH‐SY5Y cells

Jun Luo, Z. Guan, Zhi Tang, 2021, Journal of biochemical and molecular toxicology.

Scutellarin protects against Aβ-induced learning and memory deficits in rats: involvement of nicotinic acetylcholine receptors and cholinesterase

Z. Guan, Yonglin Wang, Li-li Guo, 2011, Acta Pharmacologica Sinica.

Expression levels of the α7 nicotinic acetylcholine receptor in the brains of patients with Alzheimer's disease and their effect on synaptic proteins in SH-SY5Y cells

Z. Guan, X. Qi, Jia-mou Ren, 2020, Molecular medicine reports.

Stimulation of SIRT1 Attenuates the Level of Oxidative Stress in the Brains of APP/PS1 Double Transgenic Mice and in Primary Neurons Exposed to Oligomers of the Amyloid-β Peptide.

Z. Guan, Kun Cao, X. Qi, 2018, Journal of Alzheimer's disease : JAD.

Decreased protein level of nicotinic receptor alpha7 subunit in the frontal cortex from schizophrenic brain.

K. Blennow, A. Nordberg, Z. Guan, 1999, Neuroreport.

Effects of statins on α7 nicotinic receptor, cholinesterase and α-form of secreted amyloid precursor peptide in SH-SY5Y cells

J. Roensch, A. Nordberg, M. Crisby, 2007, Neurochemistry International.

Effects of statins on alpha7 nicotinic receptor, cholinesterase and alpha-form of secreted amyloid precursor peptide in SH-SY5Y cells.

J. Roensch, A. Nordberg, M. Crisby, 2007, Neurochemistry international.

Lovastatin stimulates up‐regulation of α7 nicotinic receptors in cultured neurons without cholesterol dependency, a mechanism involving production of the α‐form of secreted amyloid precursor protein

A. Nordberg, Z. Guan, M. Mousavi, 2005, Journal of neuroscience research.

Oxidative stress might be a mechanism connected with the decreased alpha 7 nicotinic receptor influenced by high-concentration of fluoride in SH-SY5Y neuroblastoma cells.

Z. Guan, Qin Gao, Yan-jie Liu, 2008, Toxicology in vitro : an international journal published in association with BIBRA.

Decreased nicotinic receptors and cognitive deficit in rats intracerebroventricularly injected with beta‐amyloid peptide(1‐42) and fed a high‐cholesterol diet

J. Pei, Z. Guan, X. Qi, 2008, Journal of neuroscience research.

Influence of cholesterol and lovastatin on α-form of secreted amyloid precursor protein and expression of α7 nicotinic receptor on astrocytes

A. Nordberg, Z. Guan, X. Qi, 2006, Neurochemistry International.

Protection against the Neurotoxic Effects of β-Amyloid Peptide on Cultured Neuronal Cells by Lovastatin Involves Elevated Expression of α7 Nicotinic Acetylcholine Receptors and Activating Phosphorylation of Protein Kinases.

Liang Zhao, Z. Guan, Yan Xiao, 2018, The American journal of pathology.

[An experimental study of blood biochemical diagnostic indices for chronic fluorosis].

Z. Guan, 1991, Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine].

SIRT1 attenuates the neurotoxicity associated with Alzheimer's disease, via a mechanism which may involve regulation of peroxisome proliferator-activated receptor γ coactivator 1-α.

Z. Guan, Kun Cao, L. Shan, 2020, The American journal of pathology.

Loss of nicotinic receptors induced by beta‐amyloid peptides in PC12 cells: Possible mechanism involving lipid peroxidation

A. Nordberg, Z. Guan, J. Olsson, 2003, Journal of neuroscience research.

Changed expressions of N-methyl-d-aspartate receptors in the brains of rats and primary neurons exposed to high level of fluoride.

Z. Guan, X. Qi, Na Wei, 2018, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

Deficit in learning and memory of rats with chronic fluorosis correlates with the decreased expressions of M1 and M3 muscarinic acetylcholine receptors

Z. Guan, Na Wei, Ya Wang, 2014, Archives of Toxicology.

Correlations between polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A and C-C motif chemokine receptor 5 genes and infection with the hepatitis B virus in three ethnic groups in China

Z. Guan, Kui Tan, Ke-ren Shan, 2017, The Journal of international medical research.

Sustained cholinesterase inhibition in AD patients receiving rivastigmine for 12 months

A. Nordberg, A. Nordberg, O. Almkvist, 2002, Neurology.

Inhibited Expression of α4β2 Nicotinic Acetylcholine Receptor in Blood Leukocytes of Chinese Patients with Vascular Dementia and in Blood Leukocytes as Well as the Hippocampus of Brain from Ischemic Rats

Liang Zhao, Z. Guan, Yan Xiao, 2016, Cellular and Molecular Neurobiology.

The influence of NQO2 on the dysfunctional autophagy and oxidative stress induced in the hippocampus of rats and in SH‐SY5Y cells by fluoride

Z. Guan, X. Qi, Long-Yan Ran, 2023, CNS neuroscience & therapeutics.

Content and fatty acid composition of cardiolipin in the brain of patients with alzheimer's disease

Z. Guan, P. Sindelar, C. Edlund, 1994, Neurochemistry International.

Postnatal upregulation of α4 and α3 nicotinic receptor subunits in the brain of α7 nicotinic receptor-deficient mice

A. Nordberg, Z. Guan, W.-F. Yu, 2007, Neuroscience.

The influence of inhibiting or stimulating the expression of the α3 subunit of the nicotinic receptor in SH-SY5Y cells on levels of amyloid-β peptide and β-secretase

Z. Guan, X. Qi, Ke-ren Shan, 2013, Neurochemistry International.

Correlations Between Cholinesterase Activity and Cognitive Scores in Post-Ischemic Rats and Patients with Vascular Dementia

J. Pei, Z. Guan, Yan Xiao, 2012, Cellular and Molecular Neurobiology.

Elevations in the Levels of NF-κB and Inflammatory Chemotactic Factors in the Brains with Alzheimer's Disease - One Mechanism May Involve α3 Nicotinic Acetylcholine Receptor.

B. Winblad, R. Ravid, J. Pei, 2016, Current Alzheimer research.

Oxidative stress induced by beta-amyloid peptide1–42 is involved in the altered composition of cellular membrane lipids and the decreased expression of nicotinic receptors in human SH-SY5Y neuroblastoma cells

Z. Guan, X. Qi, R. Gu, 2005, Neurochemistry International.

Activation of α7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway

Z. Guan, X. Qi, Fan Wang, 2020, Aging.

Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 Pathway

Z. Guan, Kun Cao, Jie Xiang, 2021, Medical science monitor : international medical journal of experimental and clinical research.

Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 Pathway

Z. Guan, Jie Xiang, Yangting Dong, 2021, Medical Science Monitor : International Medical Journal of Experimental and Clinical Research.

Changed clathrin regulatory proteins in the brains of Alzheimer's disease patients and animal models.

R. Ravid, Z. Guan, Yan Xiao, 2010, Journal of Alzheimer's disease : JAD.

Reduced expression of SIRT1 and SOD-1 and the correlation between these levels in various regions of the brains of patients with Alzheimer's disease

Z. Guan, Hui Song, Kun Cao, 2018, Journal of Clinical Pathology.

Resveratrol Attenuates the Disruption of Lipid Metabolism Observed in Amyloid Precursor Protein/Presenilin 1 Mouse Brains and Cultured Primary Neurons Exposed to Aβ

Yan He, Z. Guan, Kun Cao, 2023, Neuroscience.

Reduced expression of neuronal nicotinic acetylcholine receptors during the early stages of damage by oxidative stress in PC12 cells

A. Nordberg, Z. Guan, M. Mousavi, 2001, Journal of neuroscience research.

Pretreatment of SH‐SY5Y cells with dicaffeoylquinic acids attenuates the reduced expression of nicotinic receptors, elevated level of oxidative stress and enhanced apoptosis caused by β‐amyloid peptide

Z. Guan, X. Qi, Yonglin Wang, 2013, The Journal of pharmacy and pharmacology.

Lithium chloride reduced the level of oxidative stress in brains and serums of APP/PS1 double transgenic mice via the regulation of GSK3β/Nrf2/HO-1 pathway

Z. Guan, Hui Song, Kun Cao, 2020, The International journal of neuroscience.

Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation

Z. Guan, Kun Cao, Long-Yan Ran, 2019, Alzheimer's Research & Therapy.

Postnatal upregulation of alpha4 and alpha3 nicotinic receptor subunits in the brain of alpha7 nicotinic receptor-deficient mice.

A. Nordberg, Z. Guan, W.-F. Yu, 2007, Neuroscience.

Myeloperoxidase Activity and Its Corresponding mRNA Expression as well as Gene Polymorphism in the Population Living in the Coal-Burning Endemic Fluorosis Area in Guizhou of China

J. Pei, Z. Guan, Ke-ren Shan, 2013, Biological Trace Element Research.

Changes of DNA repair gene methylation in blood of chronic fluorosis patients and rats.

Yi-Heng Wang, Z. Guan, X. Qi, 2018, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

Changes in Gene Expression

Z. Guan, Jie Deng, 2021, Coal-burning Type of Endemic Fluorosis.

Selective decreases of nicotinic acetylcholine receptors in PC12 cells exposed to fluoride.

A. Nordberg, Z. Guan, Ke-ren Shan, 2003, Toxicology.

Modification of Digestive System

Z. Guan, Jian Zou, 2021, Coal-burning Type of Endemic Fluorosis.

Characterization of polymorphisms in the mitochondrial DNA of twelve ethnic groups in the Guizhou province of China

Z. Guan, Ke-ren Shan, Ting Zhang, 2016, Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis.

Chronic fluoride toxicity decreases the number of nicotinic acetylcholine receptors in rat brain.

A. Nordberg, Z. Guan, Yi-guo Long, 2002, Neurotoxicology and teratology.

A case of hemolytic disease of the newborn caused by anti-Hro and anti-e.

Z. Guan, Y. Wang, N. Song, 1990, Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao.

ALTERATIONS OF APOPTOSIS AND EXPRESSIONS OF Bax AND Bcl-2 IN THE CEREBRAL CORTICES OF RATS WITH CHRONIC FLUOROSIS

Z. Guan, Di-dong Lou, J. Peić, 2014 .

Preventing Expression of the Nicotinic Receptor Subunit α7 in SH-SY5Y Cells with Interference RNA Indicates that this Receptor may Protect Against the Neurotoxicity of Aβ

Z. Guan, X. Qi, Jia-mou Ren, 2013, Neurochemical Research.

Correlations Between Cholinesterase Activity and Cognitive Scores in Post-Ischemic Rats and Patients with Vascular Dementia

J. Pei, Z. Guan, Yan Xiao, 2011, Cellular and Molecular Neurobiology.

Lowered levels of nicotinic acetylcholine receptors and elevated apoptosis in the hippocampus of brains from patients with type 2 diabetes mellitus and db/db mice

Z. Guan, Kun Cao, X. Qi, 2020, Aging.