I. Vlodavsky

T. Weinstein, T. Chajek-Shaul, I. Vlodavsky, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Heparanase expression in Langerhans cell histiocytosis

R. Elhasid, R. Dvir, I. Vlodavsky, 2014, Pediatric blood & cancer.

Synthesis, cytotoxic and heparanase inhibition studies of 5-oxo-1-arylpyrrolidine-3-carboxamides of hydrazides and 4-amino-5-aryl-4H-1,2,4-triazole-3-thiol.

Basappa, G. Sethi, T. R. Swaroop, 2020, Current organic synthesis.

Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds

Basappa, V. Gupta, S. Rangappa, 2019, iScience.

Significance of host heparanase in promoting tumor growth and metastasis.

Y. Shaked, Gan‐Lin Zhang, Xiao-Min Wang, 2020, Matrix biology : journal of the International Society for Matrix Biology.

Post‐transcriptional regulation of heparanase gene expression by a 3’ AU‐rich element

O. Nativ, I. Vlodavsky, N. Ilan, 2010 .

Post-transcriptional regulation of heparanase gene expression by a 3' AU-rich element.

O. Nativ, I. Vlodavsky, N. Ilan, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Halofuginone inhibits NF‐κB and p38 MAPK in activated T cells

A. Nagler, M. Leiba, L. Cahalon, 2006 .

Extracellular matrix-based cancer targeting.

N. Karamanos, M. Götte, A. Passi, 2021, Trends in molecular medicine.

Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior.

S. Varambally, A. Purushothaman, R. Sanderson, 2017, Matrix biology : journal of the International Society for Matrix Biology.

Clinical Significance of Heparanase Splice Variant (T5) in Renal Cell Carcinoma: Evaluation by a Novel T5-Specific Monoclonal Antibody

O. Nativ, I. Doweck, I. Vlodavsky, 2012, PloS one.

Heparanase-The Message Comes in Different Flavors.

U. Bhattacharya, I. Vlodavsky, N. Ilan, 2020, Advances in experimental medicine and biology.

Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis

R. Sanderson, I. Vlodavsky, N. Ilan, 2010, The FEBS journal.

Molecular and Cellular Aspects of Heparanase

I. Vlodavsky, M. Elkin, N. Ilan, 2008 .

Characterization of Mechanisms Involved in Secretion of Active Heparanase*

I. Vlodavsky, N. Ilan, I. Shafat, 2006, Journal of Biological Chemistry.

Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice

T. V. van Kuppevelt, C. Pisano, M. Garsen, 2011, Diabetes.

Endothelial dysfunction and its critical role in COVID‐19‐associated coagulopathy: Defibrotide as an endothelium‐protective, targeted therapy

P. Richardson, C. Carlo-Stella, M. Iacobelli, 2021, EJHaem.

Macrophage Activation by Heparanase Is Mediated by TLR-2 and TLR-4 and Associates With Plaque Progression

G. Nussbaum, D. Aronson, E. Sabo, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Heparanase is overexpressed in lung cancer and correlates inversely with patient survival

I. Doweck, I. Vlodavsky, O. Ben‐Izhak, 2008, Cancer.

Inhibition of Heparanase in Pediatric Brain Tumor Cells Attenuates their Proliferation, Invasive Capacity, and In Vivo Tumor Growth

A. Spyrou, T. Olofsson, K. Forsberg-Nilsson, 2017, Molecular Cancer Therapeutics.

Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis.

T. Peretz, I. Vlodavsky, M. Elkin, 2004, Journal of the National Cancer Institute.

Heparanase: From basic research to therapeutic applications in cancer and inflammation.

Preeti Singh, R. Sanderson, I. Vlodavsky, 2016, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Growth characteristics of human first trimester decidual cells cultured in serum-free medium: production of prolactin, prostaglandins and fibronectin.

Z. Fuks, A. Eldor, I. Vlodavsky, 1984, Biology of reproduction.

Heparanase expression correlates with poor survival in metastatic ovarian carcinoma.

B. Davidson, C. Tropé, B. Risberg, 2007, Gynecologic oncology.

Molecular Structure of Heparan Sulfate from Spalax

E. Nevo, A. Avivi, I. Vlodavsky, 2009, Journal of Biological Chemistry.

Heparanase expression in periapical granulomas and radicular cysts

S. Elad, I. Vlodavsky, R. Or, 2011, Odontology.

Pro-Angiogenic Effects of Latent Heparanase and Thrombin Receptor-Mediated Pathways—Do They Share a Common Ground in Melanoma Cells?

E. Kostenis, G. Bendas, I. Vlodavsky, 2018, Thrombosis and Haemostasis.

The Impact of Heparanese and Heparin on Cancer Metastasis and Angiogenesis

R. Sasisekharan, I. Vlodavsky, B. Casu, 2006, Pathophysiology of Haemostasis and Thrombosis.

Characterization of an extracellular matrix-degrading protease derived from a highly metastatic tumor cell line.

Z. Fuks, M. Kramer, V. Schirrmacher, 1985, European journal of cancer & clinical oncology.

Role of contact inhibition in the regulation of receptor-mediated uptake of low density lipoprotein in cultured vascular endothelial cells.

D. Gospodarowicz, C. Fielding, P. Fielding, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Human heparanase nuclear localization and enzymatic activity

I. Vlodavsky, O. Ben‐Izhak, S. Schubert, 2004, Laboratory Investigation.

Novel N-acetyl-Glycol-split heparin biotin-conjugates endowed with anti-heparanase activity.

G. Giannini, G. Roscilli, I. Vlodavsky, 2019, European journal of medicinal chemistry.

Heparanase induces tissue factor expression in vascular endothelial and cancer cells

B. Brenner, I. Vlodavsky, N. Ilan, 2006, Journal of thrombosis and haemostasis : JTH.

Biology of the Heparanase–Heparan Sulfate Axis and Its Role in Disease Pathogenesis

Hien M. Nguyen, Shiming Yang, I. Vlodavsky, 2021, Seminars in Thrombosis and Hemostasis.

Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation

E. Meyron-Holtz, P. Arosio, M. Poli, 2016, PloS one.

Reduction of anionic sites in the glomerular basement membrane by heparanase does not lead to proteinuria.

L. P. Van den Heuvel, L. Heuvel, T. V. van Kuppevelt, 2008, Kidney international.

Heparanase in glomerular diseases.

A. Rops, J. Berden, J. van der Vlag, 2007, Kidney international.

Heparanase Uptake Is Mediated by Cell Membrane Heparan Sulfate Proteoglycans*

M. Flugelman, I. Vlodavsky, N. Ilan, 2004, Journal of Biological Chemistry.

Pre-clinical and clinical significance of heparanase in Ewing’s sarcoma

F. Zunino, C. Lanzi, G. Cassinelli, 2011, Journal of cellular and molecular medicine.

Growth of human mammary carcinoma cells from biopsy specimens in serum‐free medium on extracellular matrix

Z. Fuks, I. Vlodavsky, A. Horowitz, 1986, International journal of cancer.

Decreased expression of heparanase in glioblastoma multiforme.

Y. Ueno, K. Ohshima, T. Fukushima, 2005, Journal of neurosurgery.

Sequential degradation of heparan sulfate in the subendothelial extracellular matrix by highly metastatic lymphoma cells

Z. Fuks, M. Kramer, V. Schirrmacher, 1985, International journal of cancer.

Interaction of Metastatic and Non-Metastatic Tumor Lines with Aortic Endothelial Cell Monolayer and Their Underlying Basal Lamina

V. Schirrmacher, I. Vlodavsky, 1983 .

Identification of strong intron enhancer in the heparanase gene: effect of functional rs4693608 variant on HPSE enhancer activity in hematological and solid malignancies

A. Nagler, A. Shimoni, K. Beider, 2018, Oncogenesis.

Variations in the size and sulfation of heparin modulate the effect of heparin on the binding of VEGF165 to its receptors.

S. Soker, G. Neufeld, B. Levi, 1994, Biochemical and biophysical research communications.

Cellular and Molecular Life Sciences Processing of Heparanase Is Mediated by Syndecan‑1 Cytoplasmic Domain and Involves Syntenin and Α‑actinin

A. Shteingauz, I. Vlodavsky, N. Ilan, 2022 .

Alternatively spliced Spalax heparanase inhibits extracellular matrix degradation, tumor growth, and metastasis

E. Nevo, A. Avivi, I. Vlodavsky, 2009, Proceedings of the National Academy of Sciences.

Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival.

I. Doweck, E. Sabo, I. Vlodavsky, 2006, Neoplasia.

An ELISA method for the detection and quantification of human heparanase.

F. Nakhoul, I. Vlodavsky, N. Ilan, 2006, Biochemical and biophysical research communications.

Molecular Properties and Involvement of Heparanase in Cancer Progression and Mammary Gland Morphogenesis

T. Peretz, O. Pappo, I. Pecker, 2001, Journal of Mammary Gland Biology and Neoplasia.

Inhibition of tumor metastasis by heparanase inhibiting species of heparin.

T. Peretz, O. Lider, I. Vlodavsky, 1994, Invasion & metastasis.

Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis

R. Abramovitch, E. Mitrani, V. Schirrmacher, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Cloning of two splice variants of Spalax heparanase encoding for truncated proteins

E. Nevo, A. Avivi, I. Vlodavsky, 2020, Anti-cancer drugs.

A two‐domain mechanism for group A streptococcal adherence through protein F to the extracellular matrix.

K. Yamada, E. Hanski, S. Akiyama, 1996, The EMBO journal.

Degranulating mast cells secrete an endoglycosidase that degrades heparan sulfate in subendothelial extracellular matrix.

E. Razin, A. Eldor, I. Vlodavsky, 1990, Blood.

Functional Domains in Thrombin Outside the Catalytic Site

M. Benezra, E. Dejana, R. Bar-Shavit, 1992 .

An Arg-Gly-Asp sequence within thrombin promotes endothelial cell adhesion

M. Lampugnani, E. Dejana, R. Bar-Shavit, 1991, The Journal of cell biology.

The potential of heparanase as a therapeutic target in cancer.

F. Zunino, C. Pisano, I. Vlodavsky, 2014, Biochemical pharmacology.

Heparanase Loosens E-Cadherin-Mediated Cell-Cell Contact via Activation of Src

I. Vlodavsky, N. Ilan, Victoria Cohen-Kaplan, 2020, Frontiers in Oncology.

Nephroprotective Effect of Heparanase in Experimental Nephrotic Syndrome

E. Sabo, Z. Abassi, I. Vlodavsky, 2015, PloS one.

Inhibition of glomerular mesangial cell proliferation and extracellular matrix deposition by halofuginone.

M. Pines, A. Nagler, O. Genina, 1997, Kidney international.

Accelerated Resolution of AA Amyloid in Heparanase Knockout Mice Is Associated with Matrix Metalloproteases

Ying-xia Tan, Andreas Digre, I. Vlodavsky, 2012, PloS one.

Control of Cell Proliferation by Heparan Sulfate and Heparin-Binding Growth Factors

S. Ben‐Sasson, T. Peretz, R. Bar-Shavit, 1995, Thrombosis and Haemostasis.

Function of Heparanase in Prostate Tumorigenesis: Potential for Therapy

E. Pikarsky, T. Peretz, I. Lerner, 2008, Clinical Cancer Research.

Specific involvement of glypican in thrombin adhesive properties

R. Bar-Shavit, I. Vlodavsky, M. Maoz, 1996, Journal of cellular biochemistry.

Binding of thrombin to subendothelial extracellular matrix. Protection and expression of functional properties.

R. Bar-Shavit, A. Eldor, I. Vlodavsky, 1989, The Journal of clinical investigation.

Binding, Internalization, and Degradation of Insulin in Vascular Endothelial Cells

Z. Fuks, E. Cerasi, N. Kaiser, 1982, Diabetes.

Differential structural requirements of heparin and heparan sulfate proteoglycans that promote binding of basic fibroblast growth factor to its receptor.

A. Yayon, D. Aviezer, M. Safran, 1994, The Journal of biological chemistry.

Reversal of basic fibroblast growth factor-mediated autocrine cell transformation by aromatic anionic compounds.

M. Benezra, S. Ben‐Sasson, R. Bar-Shavit, 1992, Cancer research.

Proteases and glycosidases on the surface of exosomes: Newly discovered mechanisms for extracellular remodeling.

R. Sanderson, I. Vlodavsky, Shyam Bandari, 2017, Matrix biology : journal of the International Society for Matrix Biology.

High‐density lipoprotein and extracellular matrix promotes growth and plating efficiency of normal human mammary epithelial cells in serum‐free medium

Z. Fuks, I. Vlodavsky, A. Horowitz, 1983, International journal of cancer.

Expression of basic fibroblast growth factor in normal human tissues.

C. Cordon-Cardo, A. Haimovitz-Friedman, Z. Fuks, 1990, Laboratory investigation; a journal of technical methods and pathology.

Protection and Expression of Functional Properties

R. Bar-Shavit, A. Eldor, I. Vlodavsky, 1989 .

Role of Heparanase on Hepatic Uptake of Intestinal Derived Lipoprotein and Fatty Streak Formation in Mice

I. Vlodavsky, D. Planer, S. Metzger, 2011, PloS one.

Inhibition of heparanase-mediated degradation of extracellular matrix heparan sulfate by non-anticoagulant heparin species.

I. Cohen, Z. Fuks, A. Eldor, 1987, Blood.

A comparison of the binding of epidermal growth factor to cultured granulosa and luteal cells.

D. Gospodarowicz, I. Vlodavsky, K. Brown, 1978, The Journal of biological chemistry.

Dichotomic role of heparanase in a murine model of metabolic syndrome

T. Rabelink, F. Carlotti, I. Vlodavsky, 2020, Cellular and Molecular Life Sciences.

Identification of Glypican as a Dual Modulator of the Biological Activity of Fibroblast Growth Factors*

A. Admon, D. Carey, D. Ron, 1997, The Journal of Biological Chemistry.

Heparanase up‐regulation in tongue cancer

R. Nagler, S. Akrish, I. Vlodavsky, 2007, Cancer.

Heparanase expression in malignant salivary gland tumors inversely correlates with long-term survival.

R. Nagler, I. Vlodavsky, O. Ben‐Izhak, 2006, Neoplasia.

Identification and Characterization of Heparin/Heparan Sulfate Binding Domains of the Endoglycosidase Heparanase*

I. Vlodavsky, D. Beccati, N. Ilan, 2005, Journal of Biological Chemistry.

Laminarin sulfate mimics the effects of heparin on smooth muscle cell proliferation and basic fibroblast growth factor‐receptor binding and mitogenic activity

T. Peretz, I. Vlodavsky, H. Miao, 1995, Journal of Cellular Physiology.

Insulin binding and degradation in vascular endothelial cells: modulation by cell growth and culture organization.

Z. Fuks, E. Cerasi, N. Kaiser, 1983, Endocrinology.

Endothelial Heparanase Regulates Heart Metabolism by Stimulating Lipoprotein Lipase Secretion From Cardiomyocytes

Ying Wang, B. Rodrigues, I. Vlodavsky, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Targeting heparanase to the mammary epithelium enhances mammary gland development and promotes tumor growth and metastasis.

I. Vlodavsky, N. Ilan, U. Barash, 2017, Matrix biology : journal of the International Society for Matrix Biology.

HEPARANASE PRETREATMENT ATTENUATES ENDOTOXIN-INDUCED ACUTE LUNG INJURY IN RATS

M. Krausz, I. Vlodavsky, N. Ilan, 2007, Shock.

Heparanase Interacts with Resistin and Augments Its Activity

I. Vlodavsky, D. Novick, N. Ilan, 2014, PloS one.

Heparanase 2 expression inversely correlates with bladder carcinoma grade and stage

O. Nativ, I. Vlodavsky, N. Ilan, 2016, Oncotarget.

Synthesis and heparin-like biological activity of amino acid-based polymers

A. Domb, I. Vlodavsky, A. Bentolila, 2000 .

The extracellular matrix and the control of proliferation of vascular endothelial and vascular smooth muscle cells.

D. Gospodarowicz, N. Savion, I. Vlodavsky, 1980, Journal of supramolecular structure.

The role of fibroblast growth factor and the extracellular matrix in the control of proliferation and differentiation of corneal endothelial cells

D. Gospodarowicz, N. Savion, I. Vlodavsky, 1981, Vision Research.

Structural and functional alterations in the surface of vascular endothelial cells associated with the formation of a confluent cell monolayer and with the withdrawal of fibroblast growth factor.

D. Gospodarowicz, I. Vlodavsky, 1979, Journal of supramolecular structure.

The interaction of the high-density lipoprotein with cultured cells of bovine vascular endothelium.

D. Gospodarowicz, J. Tauber, I. Vlodavsky, 1981, European journal of biochemistry.

Inhibition of low density lipoprotein uptake in confluent endothelial cell monolayers correlates with a restricted surface receptor redistribution

D. Gospodarowicz, P. Fielding, I. Vlodavsky, 1979, Journal of cellular physiology.

Contact inhibition and the regulation of endocytosis in the corneal endothelium: correlation with a restricted surface receptor lateral mobility and the appearance of a fibronectin meshwork.

D. Gospodarowicz, I. Vlodavsky, D. Goldminz, 1979, Experimental eye research.

Antiproliferative activity to glomerular mesangial cells and receptor binding of a heparin-mimicking polyaromatic anionic compound.

M. Benezra, S. Ben‐Sasson, M. Davies, 1997, Journal of the American Society of Nephrology : JASN.

The effect of flow on the interaction of isolated megakaryocytes with subendothelial extracellular matrix.

R. Stromberg, A. Eldor, I. Vlodavsky, 1991, Blood cells.

Heparanase induces Akt phosphorylation via a lipid raft receptor.

I. Vlodavsky, N. Ilan, Svetlana Gingis-Velitski, 2007, Biochemical and biophysical research communications.

Heparanase Enhances Syndecan-1 Shedding

F. Zhan, J. Shaughnessy, R. Sanderson, 2007, Journal of Biological Chemistry.

Adult rat oligodendrocytes grown in vitro upon an extracellular matrix have the ability to proliferate

H. Ovadia, O. Abramsky, I. Vlodavsky, 1984, Brain Research.

Differential structural requirements for the induction of cell attachment, proliferation and differentiation by the extracellular matrix.

Z. Fuks, H. Ovadia, I. Vlodavsky, 1985, Experimental cell research.

Cell interaction with the extracellular matrices produced by endothelial cells and fibroblasts.

Z. Fuks, I. Vlodavsky, R. Fridman, 1985, Experimental Cell Research.

Heparanase Expression Propagates Liver Damage in CCL4-Induced Mouse Model

Tianji Zhang, Jin-ping Li, I. Vlodavsky, 2022, Cells.

Dendrimer Heparan Sulfate Glycomimetics: Potent Heparanase Inhibitors for Anticancer Therapy.

Yassir A. Ahmed, P. Tyler, J. Miller, 2018, ACS chemical biology.

Increased expression of heparanase in overt diabetic nephropathy.

R. Goldschmeding, A. Rops, J. Berden, 2006, Kidney international.

Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy

R. Sanderson, A. Rapraeger, I. Vlodavsky, 2017, The FEBS journal.

Heparanase upregulation by colonic epithelium in inflammatory bowel disease

R. Eliakim, G. Groisman, M. Waterman, 2007, Modern Pathology.

New Heparanase-Inhibiting Triazolo-Thiadiazoles Attenuate Primary Tumor Growth and Metastasis

S. Rangappa, K. Rangappa, C. D. Mohan, 2021, Cancers.

Epidermal growth factor and expression of specific genes: effects on cultured rat pituitary cells are dissociable from the mitogenic response.

D. Gospodarowicz, J. Baxter, I. Vlodavsky, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Heparanase is highly expressed and regulates proliferation in GH-secreting pituitary tumor cells.

D. Nass, I. Shimon, H. Rubinfeld, 2011, Endocrinology.

Production of heparanase by normal and neoplastic murine B‐lymphocytes

E. Yefenof, R. Laskov, I. Vlodavsky, 1991, International journal of cancer.

Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis

R. Reijmers, Andreas Digre, M. Åbrink, 2017 .

Role of the degradation process in the mitogenic effect of epidermal growth factor.

D. Gospodarowicz, N. Savion, I. Vlodavsky, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Effects of the heparin-mimicking compound RG-13577 on lipoprotein lipase and on lipase mediated binding of LDL to cells.

G. Olivecrona, I. Vlodavsky, E. Makoveichuk, 2001, Atherosclerosis.

Different Effects of Aspirin, Dipyridamole and UD-CG 115 on Platelet Activation in a Model of Vascular Injury: Studies with Extracellular Matrix Covered with Endothelial Cells

Z. Fuks, A. Eldor, I. Vlodavsky, 1986, Thrombosis and Haemostasis.

Endothelial Cell Heparanase Taken Up by Cardiomyocytes Regulates Lipoprotein Lipase Transfer to the Coronary Lumen After Diabetes

Ying Wang, B. Rodrigues, George Liu, 2014, Diabetes.

Endothelial Cell Heparanase Taken Up by Cardiomyocytes Regulates Lipoprotein Lipase Transfer to the Coronary Lumen following Diabetes

Ying Wang, B. Rodrigues, George Liu, 2014 .

An improved method of endothelial seeding on small caliber prosthetic vascular grafts coated with natural extracellular matrix.

I. Vlodavsky, G. Uretzky, A. Schneider, 1993, Clinical materials.

An improved method for endothelial cell seeding on polytetrafluoroethylene small caliber vascular grafts.

M. Karck, R. Melmed, I. Vlodavsky, 1992, Journal of vascular surgery.

Transgenic over-expression of mammalian heparanase delays prion disease onset and progression.

Y. Tal, A. Taraboulos, I. Vlodavsky, 2015, Biochemical and biophysical research communications.

The Role of Heparanase in the Pathogenesis of Acute Pancreatitis: A Potential Therapeutic Target

Preeti Singh, E. Sabo, I. Gralnek, 2017, Scientific Reports.

Lung ICAM‐1 and ICAM‐2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin‐inflamed lungs

B. Engelhardt, R. Alon, I. Vlodavsky, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Systemic LPS-induced Aβ-solubilization and clearance in AβPP-transgenic mice is diminished by heparanase overexpression

Andreas Digre, L. Nilsson, I. Vlodavsky, 2019, Scientific Reports.

Translocation of Active Heparanase to Cell Surface Regulates Degradation of Extracellular Matrix Heparan Sulfate upon Transmigration of Mature Monocyte-Derived Dendritic Cells1

D. Mevorach, T. Peretz, S. Benhamron, 2006, The Journal of Immunology.

Dendritic Cells Monocyte-Derived Transmigration of Mature Extracellular Matrix Heparan Sulfate upon Surface Regulates Degradation of Translocation of Active Heparanase to Cell

D. Mevorach, T. Peretz, S. Benhamron, 2006 .

Response to Maccio et al, “Multifactorial pathogenesis of COVID‐19‐related coagulopathy: Can defibrotide have a role in the early phases of coagulation disorders?”

M. Díaz-Ricart, C. Carlo-Stella, G. Yanik, 2020, Journal of Thrombosis and Haemostasis.

Macrophages Upregulate Estrogen Receptor Expression in the Model of Obesity-Associated Breast Carcinoma

A. Popovtzer, T. Peretz, I. Vlodavsky, 2022, Cells.

Increased expression of heparanase in overt diabetic

R. Goldschmeding, I. Vlodavsky, J. Aten, 2006 .

Connective tissue activating peptide III expression disappears progressively with increased dysplasia in human cervical epithelium.

D. Grisaru, A. Eldor, J. Lessing, 2000, Gynecologic oncology.

The antiproliferative effect of interferon and the mitogenic activity of growth factors are independent cell cycle events. Studies with vascular smooth muscle cells and endothelial cells.

N. Kaiser, A. Eldor, A. Panet, 1985, Experimental cell research.

Effects of extracellular matrix on the response of endothelial cells to radiation in vitro.

M. Andreeff, A. Haimovitz-Friedman, Z. Fuks, 1992, European journal of cancer.

Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo

Z. Armstrong, I. Vlodavsky, H. Overkleeft, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Heparanase of murine effector lymphocytes and neutrophils is not required for their diapedesis into sites of inflammation

R. Alon, G. Shakhar, Irina Gurevich, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Heparanase and basic fibroblast growth factor are co-expressed in malignant mesothelioma

A. Berner, B. Davidson, S. Nielsen, 2004, Clinical & Experimental Metastasis.

Studies on atherogenesis and corneal transplantation using cultured vascular and corneal endothelia.

D. Gospodarowicz, J. Alvarado, I. Vlodavsky, 1979, Recent progress in hormone research.

Interferon enhances prostacyclin production by cultured vascular endothelial cells.

Z. Fuks, A. Eldor, A. Panet, 1984, The Journal of clinical investigation.

Anti-inflammatory effects of heparin and its derivatives: inhibition of complement and of lymphocyte migration.

I. Cohen, Y. Naparstek, O. Lider, 1992, Advances in experimental medicine and biology.

Heparanase 2 (Hpa2) attenuates the growth of human sarcoma.

I. Vlodavsky, N. Ilan, Yifat Yanku, 2022, Matrix biology : journal of the International Society for Matrix Biology.

Synthesis and distribution of cytoskeletal elements in endothelial cells as a function of cell growth and organization

D. Gospodarowicz, N. Savion, I. Vlodavsky, 1982, Journal of cellular physiology.

Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy

B. Tang, Min Yang, I. Vlodavsky, 2022, Oncogenesis.

The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression1

Preeti Singh, E. Hammond, E. Half, 2017, Neoplasia.

High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature.

B. Rodrigues, I. Vlodavsky, Amy P Chiu, 2016, Cardiovascular research.

Heparanase procoagulant activity is elevated and predicts survival in non-small cell lung cancer patients.

R. Hoffman, B. Brenner, I. Vlodavsky, 2014, Thrombosis research.

Novel peptides that inhibit heparanase activation of the coagulation system

B. Brenner, B. Brenner, I. Vlodavsky, 2014, Thrombosis and Haemostasis.

Involvement of heparanase in atherosclerosis and other vessel wall pathologies.

R. Sanderson, I. Vlodavsky, Jin-ping Li, 2013, Matrix biology : journal of the International Society for Matrix Biology.

Heparanase: multiple functions in inflammation, diabetes and atherosclerosis.

R. Iozzo, R. Sanderson, I. Vlodavsky, 2013, Matrix biology : journal of the International Society for Matrix Biology.

Heparanase Levels Are Elevated in the Urine and Plasma of Type 2 Diabetes Patients and Associate with Blood Glucose Levels

F. Nakhoul, I. Vlodavsky, N. Ilan, 2011, PloS one.

Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII

B. Brenner, I. Vlodavsky, Y. Nadir, 2010, Haematologica.

Involvement of Heparanase in early pregnancy losses.

B. Brenner, I. Vlodavsky, I. Henig, 2010, Thrombosis research.

Heparanase: busy at the cell surface.

R. Sanderson, I. Vlodavsky, N. Ilan, 2009, Trends in biochemical sciences.

Heparanase expression by Barrett's epithelium and during esophageal carcinoma progression

R. Brun, G. Groisman, M. Waterman, 2009, Modern Pathology.

Newly Generated Heparanase Knock-Out Mice Unravel Co-Regulation of Heparanase and Matrix Metalloproteinases

T. Peretz, I. Vlodavsky, U. Lindahl, 2009, PloS one.

Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression.

I. Doweck, I. Vlodavsky, N. Ilan, 2008, Cancer research.

Heparanase induces VEGF C and facilitates tumor lymphangiogenesis

I. Doweck, I. Vlodavsky, N. Ilan, 2008, International journal of cancer.

Heparanase induces tissue factor pathway inhibitor expression and extracellular accumulation in endothelial and tumor cells

B. Brenner, I. Vlodavsky, N. Ilan, 2008, Thrombosis and Haemostasis.

Heparanase levels are elevated in the plasma of pediatric cancer patients and correlate with response to anticancer treatment.

S. Postovsky, R. Elhasid, I. Vlodavsky, 2007, Neoplasia.

Processing and activation of latent heparanase occurs in lysosomes

M. Flugelman, I. Vlodavsky, S. Schubert, 2004, Journal of Cell Science.

Heparanase affects adhesive and tumorigenic potential of human glioma cells.

I. Vlodavsky, H. Miao, N. Ilan, 2003, Cancer research.

Heterodimer formation is essential for heparanase enzymatic activity.

R. Heinrikson, I. Vlodavsky, H. Miao, 2003, Biochemical and biophysical research communications.

Expression Pattern and Secretion of Human and Chicken Heparanase Are Determined by Their Signal Peptide Sequence*

E. Mitrani, I. Pecker, I. Vlodavsky, 2001, The Journal of Biological Chemistry.

Heparanase expression in primary and metastatic pancreatic cancer.

H. Friess, J. Kleeff, M. Büchler, 2001, Cancer research.

Expression of heparanase by platelets and circulating cells of the immune system: possible involvement in diapedesis and extravasation.

I. Cohen, A. Haimovitz-Friedman, Z. Fuks, 1992, Invasion & metastasis.

Heparanase: One Molecule with Multiple Functions in Cancer Progression

I. Vlodavsky, M. Elkin, N. Ilan, 2008, Connective tissue research.

Reprints and Subscriptions Permissions

I. Vlodavsky, H. Miao, N. Ilan, 2003 .

Antitumor properties of a new non-anticoagulant heparin analog from the mollusk Nodipecten nodosus: Effect on P-selectin, heparanase, metastasis and cellular recruitment.

L. Borsig, A. Gomes, I. Vlodavsky, 2015, Glycobiology.

Envelope glycoprotein of avian hemangioma retrovirus induces a thrombogenic surface on human and bovine endothelial cells

M. Kotler, M. Blajchman, A. Eldor, 1990, Journal of virology.

Thrombin as a multifunctional protein: induction of cell adhesion and proliferation.

M. Benezra, W. Bode, R. Bar-Shavit, 1992, American journal of respiratory cell and molecular biology.

Enhanced growth and morphological differentiation of isolated adult rat oligodendrocytes in vitro: use of a naturally produced extracellular matrix

Z. Fuks, H. Ovadia, O. Abramsky, 1983, Brain Research.

Leukomogenic factors downregulate heparanase expression in acute myeloid leukemia cells.

O. Vainas, S. Minucci, R. Eshel, 2005, Biochemical and biophysical research communications.

The mechanism of human bladder tumor implantation in an in vitro model.

D. Pode, I. Vlodavsky, A. Horowitz, 1986, The Journal of urology.

Morphological appearance, growth behavior and migratory activity of human tumor cells maintained on extracellular matrix versus plastic

D. Gospodarowicz, G. Lui, I. Vlodavsky, 1980, Cell.

Eosinophil major basic protein: first identified natural heparanase-inhibiting protein.

F. Levi-Schaffer, G. Gleich, I. Puxeddu, 2004, The Journal of allergy and clinical immunology.

Heparanase Promotes Engraftment and Prevents Graft versus Host Disease in Stem Cell Transplantation

A. Nagler, M. Zeira, I. Vlodavsky, 2010, PloS one.

Reduced amyloid burden in AβPP/heparanase double-transgenic mice

L. Nilsson, I. Vlodavsky, Jin-ping Li, 2014 .

Heparanase 2 Attenuates Head and Neck Tumor Vascularity and Growth.

G. Neufeld, I. Doweck, I. Vlodavsky, 2016, Cancer research.

Heparanase prevents the development of type 1 diabetes in non‐obese diabetic mice by regulating T‐cell activation and cytokines production

O. Pappo, M. Zeira, I. Vlodavsky, 2008, Diabetes/metabolism research and reviews.

Regulation of adhesion of CD4+ T lymphocytes to intact or heparinase-treated subendothelial extracellular matrix by diffusible or anchored RANTES and MIP-1 beta.

R. Hershkoviz, D. Gilat, O. Lider, 1994, Journal of immunology.

Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis.

A. Nagler, M. Zeira, I. Vlodavsky, 2010, Molecular immunology.

Heparanase regulates retention and proliferation of primitive Sca-1+/c-Kit+/Lin- cells via modulation of the bone marrow microenvironment.

A. Nagler, K. Golan, Y. Vagima, 2008, Blood.

Heparanase regulates retention and proliferation of primitive Sca-1 (cid:1) /c-Kit (cid:1) /Lin (cid:2) cells via modulation of the bone marrow microenvironment

A. Nagler, K. Golan, Y. Vagima, 2008 .

Heparanase: A Potential New Factor Involved in the Renal Epithelial Mesenchymal Transition (EMT) Induced by Ischemia/Reperfusion (I/R) Injury

G. Gambaro, A. Lupo, G. Zaza, 2016, PloS one.

Local Retention Versus Systemic Release of Soluble VEGF Receptor-1 Are Mediated by Heparin-Binding and Regulated by Heparanase

S. Yagel, E. Keshet, I. Vlodavsky, 2011, Circulation research.

Characteristics of chylomicron binding and lipid uptake by endothelial cells in culture.

D. Gospodarowicz, C. Fielding, P. Fielding, 1979, The Journal of biological chemistry.

Heparanase Enhances Tumor Growth and Chemoresistance by Promoting Autophagy.

A. Shteingauz, I. Doweck, M. Gruber, 2015, Cancer research.

Halofuginone: From veterinary use to human therapy

A. Nagler, M. Pines, I. Vlodavsky, 2000 .

Cathepsin L Is Responsible for Processing and Activation of Proheparanase through Multiple Cleavages of a Linker Segment*

T. Peretz, J. Joyce, C. Palermo, 2008, Journal of Biological Chemistry.

Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival

Evan J. Kyzar, C. Patil, P. Finn, 2020, bioRxiv.

Heparanase-enhanced Shedding of Syndecan-1 and Its Role in Driving Disease Pathogenesis and Progression

R. Sanderson, I. Vlodavsky, K. Tripathi, 2020, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis

F. Zunino, R. Sanderson, C. Pisano, 2011, Clinical Cancer Research.

Mammalian heparanase as mediator of tumor metastasis and angiogenesis.

O. Pappo, I. Pecker, I. Vlodavsky, 2000, The Israel Medical Association journal : IMAJ.

Localization of heparanase in normal and pathological human placenta.

S. Yagel, E. Anteby, D. Prus, 2002, Molecular human reproduction.

Heparanase expression: a potential ancillary diagnostic tool for distinguishing between malignant cells and reactive mesothelium in body cavity effusions

V. Doviner, I. Vlodavsky, Y. Sherman, 2007, Cytopathology : official journal of the British Society for Clinical Cytology.

Heparanase expression in human leukemias is restricted to acute myeloid leukemias.

A. Nagler, A. Polliack, I. Pecker, 2002, Experimental hematology.

Inhibition of bladder carcinoma angiogenesis, stromal support, and tumor growth by halofuginone.

A. Hochberg, M. Pines, I. Ariel, 1999, Cancer research.

Opposing Functions of Heparanase-1 and Heparanase-2 in Cancer Progression.

R. Sanderson, I. Vlodavsky, N. Ilan, 2018, Trends in biochemical sciences.

Heparanase processing by lysosomal/endosomal protein preparation

I. Vlodavsky, N. Ilan, R. Atzmon, 2005, FEBS letters.

Inhibition of T lymphocyte heparanase by heparin prevents T cell migration and T cell‐mediated immunity

I. Cohen, Y. Naparstek, O. Lider, 1990, European journal of immunology.

Soluble antigen induces T lymphocytes to secrete an endoglycosidase that degrades the heparan sulfate moiety of subendothelial extracellular matrix

I. Cohen, Z. Fuks, Y. Naparstek, 1987, Journal of cellular physiology.

Induction of cell attachment and morphological differentiation in a pheochromocytoma cell line and embryonal sensory cells by the extracellular matrix.

I. Lax, J. Schlessinger, Z. Fuks, 1982, Developmental biology.

A synthetic heparin-mimicking polyanionic compound inhibits central nervous system inflammation

S. Ben‐Sasson, I. Vlodavsky, M. Irony-Tur-Sinai, 2003, Journal of the Neurological Sciences.

Accumulation of Ym1 and formation of intracellular crystalline bodies in alveolar macrophages lacking heparanase.

I. Vlodavsky, G. Pejler, Jin-ping Li, 2010, Molecular immunology.

Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545

A. Lupo, Preeti Singh, G. Zaza, 2017, Oncotarget.

Megakaryocyte maturation is associated with expression of the CXC chemokine connective tissue‐activating peptide CTAP III

A. Eldor, V. Deutsch, I. Vlodavsky, 2000, British journal of haematology.

Poly(N-acryl amino acids): a new class of biologically active polyanions.

A. Domb, I. Vlodavsky, A. Bentolila, 2000, Journal of medicinal chemistry.

Mammalian Heparanase: Molecular Properties, Inhibition and Involvement in Tumor Metastasis and Angiogenesis

O. Pappo, M. Hulett, C. Parish, 2002 .

Interaction of T lymphocytes and macrophages with cultured vascular endothelial cells: Attachment, invasion, and subsequent degradation of the subendothelial extracellular matrix

Z. Fuks, N. Savion, I. Vlodavsky, 1984, Journal of cellular physiology.

Cell attachment, growth characteristics and surface morphology of human upper‐respiratory tract epithelium cultured on extracellular matrix

I. Vlodavsky, H. Ben-bassat, I. Gay, 1983, European journal of clinical investigation.

The HPSE Gene Insulator—A Novel Regulatory Element That Affects Heparanase Expression, Stem Cell Mobilization, and the Risk of Acute Graft versus Host Disease

A. Nagler, A. Shimoni, K. Beider, 2021, Cells.

Mechanism of HPSE Gene SNPs Function: From Normal Processes to Inflammation, Cancerogenesis and Tumor Progression.

A. Nagler, O. Ostrovsky, I. Vlodavsky, 2020, Advances in experimental medicine and biology.

Modification of heparanase gene expression in response to conditioning and LPS treatment: strong correlation to rs4693608 SNP

A. Shteingauz, A. Nagler, A. Shimoni, 2014, Journal of leukocyte biology.

Genetic variations in the heparanase gene (HPSE) associate with increased risk of GVHD following allogeneic stem cell transplantation: effect of discrepancy between recipients and donors.

A. Nagler, A. Shimoni, O. Ostrovsky, 2010, Blood.

Heparin–Superparamagnetic Iron Oxide Nanoparticles for Theranostic Applications

L. Fiandra, M. Colombo, G. Torri, 2022, Molecules.

Heparanase enhances early hepatocyte inclusion in the recipient liver after transplantation in partially hepatectomized rats.

Y. Baruch, G. Shoshany, I. Vlodavsky, 2008, Tissue engineering. Part A.

Heparanase Enhances Early Hepatocyte Inclusion in the Recipient Liver after Transplantation in Partially Hepatectomized Rats

Y. Baruch, G. Shoshany, I. Vlodavsky, 2007 .

Megakaryocyte interaction with subendothelial extracellular matrix is associated with adhesion, platelet-like shape change, and thromboxane A2 production

Z. Fuks, A. Eldor, I. Vlodavsky, 1985 .

Spatiotemporal Expression of Heparanase During Human and Rodent Ovarian Folliculogenesis1

S. Yagel, E. Anteby, J. Orly, 2005, Biology of reproduction.

Title. Spatiotemporal Expression of Heparanase During Human and Rodent Ovarian Folliculogenesis Short title. Heparanase expression in the ovarian follicle Key words. basic fibroblast growth factor, corpus luteum, follicle, heparanase, ovary

S. Yagel, E. Anteby, J. Orly, 2005 .

Difference in the calcium regulation of concanavalin A agglutinability and surface microvilli in normal and transformed cells. Relationship to membrane--cytoskeleton interaction.

L. Sachs, I. Vlodavsky, 1977, Experimental cell research.

Culture of human granulosa cells from an in vitro fertilization program: effects of extracellular matrix on morphology and cyclic adenosine 3',5' monophosphate production.

S. Rotmensch, I. Vlodavsky, J. Dor, 1986, Fertility and sterility.

The molecular and cellular basis of exostosis formation in hereditary multiple exostoses

H. Werner, D. Chan, K. Cheah, 2008, International journal of experimental pathology (Print).

Cultured endothelial cells increase their capacity to synthesize prostacyclin following the formation of a contact inhibited cell monolayer

Z. Fuks, B. Weksler, A. Eldor, 1983, Journal of cellular physiology.

In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis.

I. Vlodavsky, R. Kisilevsky, U. Lindahl, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes*♦

A. Purushothaman, R. Sanderson, I. Vlodavsky, 2013, The Journal of Biological Chemistry.

Hyaluronan, CD44 and its variant exons in human trophoblast invasion and placental angiogenesis.

A. Hochberg, N. de Groot, R. Stern, 1996, Molecular human reproduction.

Respective roles of laminin and fibronectin in adhesion of human carcinoma and sarcoma cells

D. Gospodarowicz, I. Vlodavsky, 1981, Nature.

The identification and localization of fibronectin in cultured corneal endothelial cells: cell surface polarity and physiological implications.

D. Gospodarowicz, J. Alvarado, I. Vlodavsky, 1979, Experimental eye research.

Heparanase Increases Podocyte Survival and Autophagic Flux after Adriamycin-Induced Injury

Z. Abassi, I. Vlodavsky, S. Assady, 2022, International journal of molecular sciences.

A new targeting approach for breast cancer gene therapy using the heparanase promoter.

D. Curiel, P. Reynolds, T. Schöndorf, 2006, Cancer letters.

Heparanase promotes growth, angiogenesis and survival of primary breast tumors

T. Peretz, R. Bar-Shavit, R. Hazan, 2006, International journal of cancer.

Purification and characterization of placental heparanase and its expression by cultured cytotrophoblasts.

A. Hochberg, N. de Groot, R. Goshen, 1996, Molecular human reproduction.

Importance of size and sulfation of heparin in release of basic fibroblast growth factor from the vascular endothelium and extracellular matrix.

I. Vlodavsky, C. Svahn, M. Weber, 1992, Biochemistry.

Heparanase neutralizes the anticoagulation properties of heparin and low‐molecular‐weight heparin

B. Brenner, E. Nevo, I. Vlodavsky, 2006, Journal of thrombosis and haemostasis : JTH.

Storage of Heparin-Binding Endothelial Cell Growth Factors in the Cornea: a New Mechanism for Corneal Neovascularization

J. Folkman, M. Klagsbrun, I. Vlodavsky, 1987 .

Involvement of both heparanase and plasminogen activator in lymphoma cell‐mediated degradation of heparan sulfate in the subendothelial extracellular matrix

V. Schirrmacher, I. Vlodavsky, M. Mayer, 1986, Journal of cellular physiology.

Heparanase 2 (Hpa2) attenuates the growth of pancreatic carcinoma.

Preeti Singh, I. Vlodavsky, N. Ilan, 2021, Matrix biology : journal of the International Society for Matrix Biology.

The heparanase inhibitor PG545 is a potent anti-lymphoma drug: Mode of action.

U. Bhattacharya, E. Hammond, I. Vlodavsky, 2019, Matrix biology : journal of the International Society for Matrix Biology.

Heparan Sulfate Mimicking Glycopolymer Prevents Pancreatic β Cell Destruction and Suppresses Inflammatory Cytokine Expression in Islets under the Challenge of Upregulated Heparanase.

Kezhong Zhang, I. Vlodavsky, Ravi S. Loka, 2022, ACS chemical biology.

Is host heparanase required for the rapid spread of heparan sulfate binding viruses?

C. Parish, I. Vlodavsky, C. Ranasinghe, 2019, Virology.

Expression of heparanase in soft tissue sarcomas of adults

G. Bar-Sela, I. Vlodavsky, N. Ilan, 2014, Journal of experimental & clinical cancer research : CR.

Nuclear accumulation of epidermal growth factor in cultured bovine corneal endothelial and granulosa cells.

D. Gospodarowicz, N. Savion, I. Vlodavsky, 1981, The Journal of biological chemistry.

Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies

M. Leiba, M. Korostishevsky, O. Ostrovsky, 2007, Leukemia.

Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis.

T. Rabelink, T. V. van Kuppevelt, H. Dijkman, 2016, The American journal of pathology.

Dissociation between Mature Phenotype and Impaired Transmigration in Dendritic Cells from Heparanase-Deficient Mice

D. Mevorach, S. Benhamron, I. Vlodavsky, 2012, PloS one.

Modulating Heparanase Activity: Tuning Sulfation Pattern and Glycosidic Linkage of Oligosaccharides.

Hien M. Nguyen, Kezhong Zhang, I. Vlodavsky, 2020, Journal of medicinal chemistry.

Heparan sulfate proteoglycans

I. Vlodavsky, Y. Friedmann, 2001 .

Processing of Macromolecular Heparin by Heparanase*

P. Jemth, I. Vlodavsky, U. Lindahl, 2003, Journal of Biological Chemistry.

Human heparanase is localized within lysosomes in a stable form.

E. Zamir, B. Geiger, N. Feinstein, 2002, Experimental cell research.

Induction of heparanase 2 (Hpa2) expression by stress is mediated by ATF3.

Preeti Singh, A. Aronheim, R. Sanderson, 2021, Matrix Biology.

Role of heparanase 2 (Hpa2) in gastric cancer

I. Vlodavsky, Tangya Li, Wang Sumin, 2021, Neoplasia.

Elucidating the Consequences of Heparan Sulfate Binding by Heparanase 2

I. Vlodavsky, N. Ilan, S. Feld, 2021, Frontiers in Oncology.

The prognostic significance of heparanase expression in metastatic melanoma

G. Bar-Sela, I. Vlodavsky, O. Ben‐Izhak, 2016, Oncotarget.

Heparanase expression upregulates platelet adhesion activity and thrombogenicity

U. Hedin, Ying-xia Tan, I. Vlodavsky, 2016, Oncotarget.

Mammary Branching Morphogenesis Requires Reciprocal Signaling by Heparanase and MMP‐14

M. Bissell, J. Mott, R. Bhat, 2015, Journal of cellular biochemistry.

Characterization of Heparanase-induced Phosphatidylinositol 3-Kinase-AKT Activation and Its Integrin Dependence*

S. Johansson, I. Vlodavsky, Jin-ping Li, 2013, The Journal of Biological Chemistry.

Heparanase affects secretory granule homeostasis of murine mast cells through degrading heparin.

I. Vlodavsky, G. Pejler, Jin-ping Li, 2011, The Journal of allergy and clinical immunology.

Heparanase modulates heparinoids anticoagulant activities via non-enzymatic mechanisms

L. Muhl, Y. Herishanu, I. Vlodavsky, 2007, Thrombosis and Haemostasis.

Modulation of the Heparanase-inhibiting Activity of Heparin through Selective Desulfation, Graded N-Acetylation, and Glycol Splitting*

G. Giannini, C. Pisano, G. Torri, 2005, Journal of Biological Chemistry.

Murine ocular heparanase expression before and during infection with Pseudomonas aeruginosa.

S. Alousi, R. Berk, Z. Dong, 2004, Investigative ophthalmology & visual science.

Overexpression of heparanase attenuated TGF‐β‐stimulated signaling in tumor cells

A. Moustakas, T. Batool, I. Vlodavsky, 2017, FEBS open bio.

Properties and function of heparanase in cancer metastasis and angiogenesis.

I. Vlodavsky, O. Goldshmidt, 2001, Haemostasis.

Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides

C. Stein, I. Vlodavsky, H. Miao, 1999, International journal of cancer.

Heparan sulfate primed on β‐D‐xylosides restores binding of basic fibroblast growth factor

T. A. Fritz, J. Esko, A. Yayon, 1995, Journal of cellular biochemistry.

Implications of Heparanase on Heparin Synthesis and Metabolism in Mast Cells

I. Vlodavsky, Jin-ping Li, M. Maccarana, 2022, International journal of molecular sciences.

Heparanase and cancer progression: New directions, new promises

I. Vlodavsky, N. Ilan, Gil Arvatz, 2016, Human vaccines & immunotherapeutics.

Heparanase expression in periapical granulomas and radicular cysts

S. Elad, I. Vlodavsky, R. Or, 2011, Odontology.

Suppression of experimental autoimmune diseases and prolongation of allograft survival by treatment of animals with low doses of heparins.

I. Cohen, Y. Naparstek, O. Lider, 1989, The Journal of clinical investigation.

CMV Seropositive Status Increases Heparanase SNPs Regulatory Activity, Risk of Acute GVHD and Yield of CD34+ Cell Mobilization

A. Nagler, A. Shimoni, K. Beider, 2021, Cells.

Heparanase: From Basic Research to Clinical Applications

R. Sanderson, I. Vlodavsky, Jin-ping Li, 2020 .

Cancer Therapy : Preclinical SST 0001 , a Chemically Modified Heparin , Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase / Syndecan-1 Axis

F. Zunino, R. Sanderson, C. Pisano, 2011 .

Flow‐Induced Secretion of Endothelial Heparanase Regulates Cardiac Lipoprotein Lipase and Changes Following Diabetes

James D. Johnson, B. Rodrigues, H. Cen, 2022, Journal of the American Heart Association.

Platelet interaction with subendothelial extracellular matrix: platelet-fibrinogen interactions are essential for platelet aggregation but not for the matrix-induced release reaction.

Z. Fuks, A. Eldor, I. Vlodavsky, 1985, Blood.

Platelet interaction with the extracellular matrix produced by cultured endothelial cells: a model to study the thrombogenicity of isolated subendothelial basal lamina.

Z. Fuks, A. Eldor, I. Vlodavsky, 1982, Thrombosis research.

2 Megakaryocyte function and dysfunction

A. Eldor, V. Deutsch, I. Vlodavsky, 1989 .

Measurement of platelet and megakaryocyte interaction with the subendothelial extracellular matrix.

Z. Fuks, A. Eldor, I. Vlodavsky, 1989, Methods in enzymology.

Adhesion, spreading and fragmentation of human megakaryocytes exposed to subendothelial extracellular matrix: a scanning electron microscopy study.

A. Polliack, M. Hersh, A. Eldor, 1986, Scanning electron microscopy.

Megakaryocyte interaction with subendothelial extracellular matrix is associated with adhesion, platelet-like shape change, and thromboxane A2 production.

Z. Fuks, A. Eldor, I. Vlodavsky, 1985, Blood.

Subcellular localization of heparanase in human neutrophils

A. Tauber, Y. Matzner, I. Vlodavsky, 1992, Journal of leukocyte biology.

Selective inhibition of neutrophil activation by the subendothelial extracellular matrix: possible role in protection of the vessel wall during diapedesis.

A. Eldor, Y. Matzner, I. Vlodavsky, 1990, Experimental cell research.

Differentiating human leukemia cells express heparanase that degrades heparan sulfate in subendothelial extracellular matrix.

Z. Fuks, E. Fibach, J. Yahalom, 1988, Leukemia research.

Platelet-tumor cell interaction with the subendothelial extracellular matrix: relationship to cancer metastasis.

Z. Fuks, A. Eldor, J. Yahalom, 1985, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

by Human Platelet Heparitinase

Z. Fuks, A. Eldor, J. Yahalom, 1984 .

Vascular endothelial cells maintained in the absence of fibroblast growth factor undergo structural and functional alterations that are incompatible with their in vivo differentiated properties

D. Gospodarowicz, I. Vlodavsky, L. Johnson, 1979, The Journal of cell biology.

Heparanase regulates thrombosis in vascular injury and stent-induced flow disturbance.

E. Edelman, A. Baker, V. Kolachalama, 2012, Journal of the American College of Cardiology.

Permissive effect of the extracellular matrix on cell proliferation in vitro.

D. Gospodarowicz, I. Vlodavsky, D. Delgado, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Basic fibroblast growth factor is an extracellular matrix component required for supporting the proliferation of vascular endothelial cells and the differentiation of PC12 cells

M. Klagsbrun, Z. Fuks, S. Rogelj, 1989, The Journal of cell biology.

Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity

Basappa, Julian E. Fuchs, A. Bender, 2017, BMC Cancer.

Inhibition of matrix metalloproteinase-2 expression and bladder carcinoma metastasis by halofuginone.

A. Hochberg, A. Nagler, M. Pines, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.

I. Vlodavsky, I Vlodavsky, Y. Friedmann, 2001, The Journal of clinical investigation.

Substrate Specificity of Heparanases from Human Hepatoma and Platelets*

I. Vlodavsky, U. Lindahl, Jin-ping Li, 1998, The Journal of Biological Chemistry.

In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides

A. Ciechanover, J. M. Rogers, D. Fushman, 2020, RSC chemical biology.

Antitumor efficacy of the heparanase inhibitor SST0001 alone and in combination with antiangiogenic agents in the treatment of human pediatric sarcoma models.

N. Zaffaroni, F. Zunino, E. Favini, 2013, Biochemical pharmacology.

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

J. Folkman, M. Klagsbrun, R Fridman, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Cytocidal effect caused by the envelope glycoprotein of a newly isolated avian hemangioma-inducing retrovirus

M. Kotler, A. Eldor, A. Panet, 1989, Journal of virology.

Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules.

J. Folkman, M. Klagsbrun, S. Doctrow, 1989, Biochemistry.

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.

D. Ingber, J. Folkman, M. Klagsbrun, 1988, The American journal of pathology.

Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models

R. Sarid, R. Abramovitch, I. Vlodavsky, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis

O. Pappo, I. Pecker, I. Vlodavsky, 1999, Nature Medicine.

Production and characterization of interferon from endothelial cells

Z. Fuks, S. Einhorn, A. Eldor, 1985, Journal of cellular physiology.

The heparanase system and tumor metastasis: is heparanase the seed and soil?

I. Vlodavsky, N. Ilan, I. Shafat, 2011, Cancer and Metastasis Reviews.

Focus on molecules: heparanase.

G. Laurie, K. Bower, I. Vlodavsky, 2010, Experimental eye research.

Heparanase 2 Interacts with Heparan Sulfate with High Affinity and Inhibits Heparanase Activity*

A. Shteingauz, I. Doweck, I. Vlodavsky, 2010, The Journal of Biological Chemistry.

Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis.

Michael Elkin, Israel Vlodavsky, I. Vlodavsky, 2006, The international journal of biochemistry & cell biology.

Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis

Michael Elkin, Israel Vlodavsky, M. Hoffman, 2007, Development.

Anti‐heparanase monoclonal antibody enhances heparanase enzymatic activity and facilitates wound healing

I. Vlodavsky, N. Ilan, R. Ishai‐Michaeli, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Involvement of heparan sulfate and related molecules in sequestration and growth promoting activity of fibroblast growth factor

D. Ron, B. Medalion, I. Vlodavsky, 1996, Cancer Metastasis Review.

Specific Inhibition of Heparanase by a Glycopolymer with Well-Defined Sulfation Pattern Prevents Breast Cancer Metastasis in Mice.

Hien M. Nguyen, I. Vlodavsky, Ravi S. Loka, 2018, ACS applied materials & interfaces.

Fibronectin production by human mammary cells.

J. Riggs, F. Becker, H. Smith, 1981, Journal of the National Cancer Institute.

Lymphoma cell-mediated degradation of sulfated proteoglycans in the subendothelial extracellular matrix: relationship to tumor cell metastasis.

Z. Fuks, V. Schirrmacher, I. Vlodavsky, 1983, Cancer research.

Membrane changes and adenosine triphosphate content in normal and malignant transformed cells.

L. Sachs, I. Vlodavsky, M. Inbar, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Charge‐dependent binding of granzyme A (MTSP‐1) to basement membranes

R. Bar-Shavit, M. Kramer, I. Vlodavsky, 1993, European journal of immunology.

Availability of L-fucose-like sites on the surface membrane of normal and transformed mammalian cells.

L. Sachs, I. Vlodavsky, M. Inbar, 1972, Biochimica et biophysica acta.

Synergistic effect of human chorionic gonadotropin and extracellular matrix on in vitro differentiation of human granulosa cells: progesterone production and gap junction formation.

S. Rotmensch, I. Vlodavsky, I Vlodavsky, 1989, Endocrinology.

Phospholipase‐C from Bacillus cereus: Production, purification, and properties

J. Shiloach, Z. Selinger, I. Vlodavsky, 1973, Biotechnology and bioengineering.

Temperature-sensitive agglutinability of human erythrocytes by lectins.

L. Sachs, I. Vlodavsky, M. Inbar, 1972, Biochimica et biophysica acta.

Activation of platelet heparitinase by tumor cell-derived factors.

A. Haimovitz-Friedman, Z. Fuks, V. Schirrmacher, 1991, Blood.

Mechanism of Transendothelial Cell Passage and Matrix Degradation by Metastatic Tumor Cells

V. Schirrmacher, I. Vlodavsky, G. Brunner, 1987 .

Lymphoma cell interaction with cultured vascular endothelial cells and with the subendothelial basal lamina: attachment, invasion and morphological appearance.

Z. Fuks, V. Schirrmacher, I. Vlodavsky, 1983, Invasion & metastasis.

Tumor cell attachment to the vascular endothelium and subsequent degradation of the subendothelial extracellular matrix.

Z. Fuks, I. Vlodavsky, R. Atzmon, 1982, Experimental cell research.

Heparanase activity in cultured endothelial cells

Z. Fuks, B. Weksler, A. Eldor, 1991, Journal of cellular physiology.

Maintenance on extracellular matrix and expression of heparanase activity by human ovarian carcinoma cells from biopsy specimens

Z. Fuks, T. Peretz, U. Beller, 1990, International journal of cancer.

Degradation of heparan sulfate in the subendothelial extracellular matrix by a readily released heparanase from human neutrophils. Possible role in invasion through basement membranes.

Z. Fuks, J. Yahalom, Y. Matzner, 1985, The Journal of clinical investigation.

Arachidonic metabolism and radiation toxicity in cultures of vascular endothelial cells.

Z. Fuks, A. Eldor, Y. Matzner, 1989, Prostaglandins, leukotrienes, and essential fatty acids.

The effect of radiation on prostacycliln (PG2) productnio by cultured endothelial cells

Z. Fuks, A. Eldor, I. Vlodavsky, 1983 .

Difference in the cellular cholesterol to phospholipid ratio in normal lymphocytes and lymphocytic leukaemic cells

L. Sachs, I. Vlodavsky, 1974, Nature.

Effect of contact inhibition on the regulation of cholesterol metabolism in cultured vascular endothelial cells.

D. Gospodarowicz, C. Fielding, P. Fielding, 1979, The Journal of biological chemistry.

Phosphorothioate Oligodeoxynucleotides Bind to Basic Fibroblast Growth Factor, Inhibit Its Binding to Cell Surface Receptors, and Remove It from Low Affinity Binding Sites on Extracellular Matrix (*)

C. Stein, J. Tonkinson, I. Vlodavsky, 1995, The Journal of Biological Chemistry.

Heparanase Promotes Glioma Progression and Is Inversely Correlated with Patient Survival

Voichita D. Marinescu, M. Essand, A. Smits, 2016, Molecular Cancer Research.

Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3

V. Miller, Y. Shaked, R. Satchi‐Fainaro, 2016, Cell reports.

Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors

Laura H. Tang, D. Klimstra, J. Joyce, 2014, Oncogene.

A mouse model of urofacial syndrome with dysfunctional urination.

S. Kaneko, Xiaokun Li, Xue Li, 2015, Human molecular genetics.

Heparanase cooperates with Ras to drive breast and skin tumorigenesis.

E. Hammond, I. Vlodavsky, Jin-ping Li, 2014, Cancer research.

Heparanase co-operates with Ras 1 Heparanase co-operates with Ras to drive breast and skin tumorigenesis

E. Hammond, I. Vlodavsky, Jin-ping Li, 2014 .

Heparanase regulates murine hair growth.

H. Kleinman, D. Philp, I. Vlodavsky, 2005, The American journal of pathology.

Induction of Ad4BP/SF-1, steroidogenic acute regulatory protein, and cytochrome P450scc enzyme system expression in newly established human granulosa cell lines.

I. Vlodavsky, Y. Yoshida, F. Kotsuji, 1998, Endocrinology.

The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules.

S. Soker, G. Neufeld, I. Vlodavsky, 1992, The Journal of biological chemistry.

Radiation Damage in Endothelial Cells Autocrine Effects of Fibroblast Growth Factor in Repair of Updated

A. Haimovitz-Friedman, Z. Fuks, I. Vlodavsky, 2006 .

Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration

B. Tang, Yuanyuan Lei, Shengjie Huang, 2021, Microbiome.

Significance of Heparanase in Cancer and Inflammation

C. Pisano, I. Vlodavsky, M. Elkin, 2012, Cancer Microenvironment.

Modulation of Mdm2 expression and p53-induced apoptosis in immortalized human ovarian granulosa cells.

E. Shaulian, M. Oren, I. Vlodavsky, 1998, Endocrinology.

Fibroblast Growth Factors in Tumor Progression and Angiogenesis

G. Christofori, I. Vlodavsky, 1999 .

Effects of irradiation on the release of growth factors from cultured bovine, porcine, and human endothelial cells.

A. Haimovitz-Friedman, Z. Fuks, D. Goodman, 1989, Cancer research.

Syndecan-1 deficiency promotes tumor growth in a murine model of colitis-induced colon carcinoma

M. Götte, G. Nussbaum, I. Vlodavsky, 2017, PloS one.

Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass

R. Müller, Y. Gabet, I. Bab, 2006, Journal of cellular physiology.

Helicobacter pylori-Induced Heparanase Promotes H. pylori Colonization and Gastritis

B. Tang, Yuanyuan Lei, Min Yang, 2021, Frontiers in Immunology.

Differential effect of components of the extracellular matrix on differentiation and apoptosis

I. Meiri, I. Vlodavsky, A. Amsterdam, 1997, Current Biology.

Megakaryocyte interaction with the subendothelial extracellular matrix.

A. Eldor, I. Vlodavsky, R. Levine, 1986, Progress in clinical and biological research.

Halofuginone: a potent inhibitor of critical steps in angiogenesis progression

A. Nagler, M. Pines, I. Hemo, 2000, The FASEB Journal.

Prognostic value of heparanase expression and cellular localization in oral cancer

S. Akrish, E. Sabo, I. Vlodavsky, 2011, Head & neck.

Thrombin receptor overexpression in malignant and physiological invasion processes

Reuven Reich, Israel Vlodavsky, R. Bar-Shavit, 1998, Nature Medicine.

Halofuginone inhibits angiogenesis and growth in implanted metastatic rat brain tumor model--an MRI study.

A. Nagler, T. Siegal, R. Abramovitch, 2004, Neoplasia.

VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix*

G. Neufeld, E. Keshet, T. Cohen, 1997, The Journal of Biological Chemistry.

Heparanase Affects Food Intake and Regulates Energy Balance in Mice

J. Jansson, Ying-xia Tan, S. Dickson, 2012, PloS one.

The Potential of Low Molecular Weight Heparin to Mitigate Cytokine Storm in Severe COVID‐19 Patients: A Retrospective Cohort Study

I. Vlodavsky, Chao Yang, Jin-ping Li, 2020, Clinical and translational science.

Heparan sulfate degradation in tumor cell invasion and angiogenesis.

I. Cohen, M. Klagsbrun, A. Eldor, 1988, Advances in experimental medicine and biology.

Functional MR imaging during hypercapnia and hyperoxia: noninvasive tool for monitoring changes in liver perfusion and hemodynamics in a rat model.

Yifat Edrei, Rinat Abramovitch, Galia Tsarfaty, 2007, Radiology.

Restriction of receptor mobility and the agglutination of cells by concanavalin A.

L. Sachs, I. Vlodavsky, Leo Sachs, 1975, Experimental cell research.

COVID‐19‐induced endotheliitis: emerging evidence and possible therapeutic strategies

P. Richardson, R. Soiffer, C. Carlo-Stella, 2021, British journal of haematology.

Lectin receptors on the cell surface membrane and the kinetics of lectin-induced cell agglutination.

L. Sachs, I. Vlodavsky, 1975, Experimental cell research.

Overexpression of heparanase in mice promoted megakaryopoiesis

F. Gong, Ying-xia Tan, I. Vlodavsky, 2018, Glycobiology.

Role of endothelial heparanase in delayed-type hypersensitivity.

T. Peretz, I. Vlodavsky, M. Elkin, 2006, Blood.

Impact of Heparanase and the Tumor Microenvironment on Cancer Metastasis and Angiogenesis: Basic Aspects and Clinical Applications

I. Vlodavsky, M. Elkin, N. Ilan, 2011, Rambam Maimonides medical journal.

Tumorigenic and adhesive properties of heparanase.

I. Vlodavsky, N. Ilan, F. Levy-Adam, 2010, Seminars in cancer biology.

Conditioned medium from endothelial cell cultures can restore the normal phenotypic expression of vascular endothelium maintained in vitro in the absence of fibroblast growth factor

J. Foidart, D. Gospodarowicz, I. Vlodavsky, 1980, Journal of cellular physiology.

Latent Heparanase Facilitates VLA-4–Mediated Melanoma Cell Binding and Emerges As a Relevant Target of Heparin in the Interference with Metastatic Progression

A. Shteingauz, R. Blaheta, G. Bendas, 2015, Seminars in Thrombosis & Hemostasis.

A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics

O. Nativ, R. Shemesh, I. Vlodavsky, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The effect of radiation on prostacyclin (PGI2) production by cultured endothelial cells.

Z. Fuks, A. Eldor, I. Vlodavsky, 1983, Prostaglandins.

Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate.

D. Spillmann, T. V. van Kuppevelt, I. Vlodavsky, 2007, Nature chemical biology.

The FASEB Journal express article 10.1096/fj.00-0895fje. Published online May 29, 2001.

I. Pecker, I. Vlodavsky, M. Elkin, 2022 .

Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain

L. Lannfelt, L. Nilsson, I. Vlodavsky, 2012, Acta Neuropathologica.

Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma.

M. Koch, J. Weitz, Y. Ge, 2009, The Journal of clinical investigation.

Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice.

T. Peretz, V. Doviner, I. Vlodavsky, 2011, The Journal of clinical investigation.

Tumor suppressor p53 regulates heparanase gene expression

Y. Haupt, T. Peretz, I. Vlodavsky, 2006, Oncogene.

FOXP3+ regulatory T cells use heparanase to access IL-2 bound to ECM in inflamed tissues

L. Steinman, T. Palmer, Sai-Wen Tang, 2023, bioRxiv.

A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils.

C. Rolny, N. Ausmees, M. Phillipson, 2010, Blood.

Heparin, heparan sulfate and heparanase in inflammatory reactions

I. Vlodavsky, Jin-ping Li, 2009, Thrombosis and Haemostasis.

Heparanase mediates cell adhesion independent of its enzymatic activity

B. Geiger, Miriam Cohen, I. Vlodavsky, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Differential effects of polysulfated polysaccharide on experimental encephalomyelitis, proliferation of autoimmune T cells, and inhibition of heparanase activity.

R. Hershkoviz, O. Lider, F. Mor, 1995, Journal of autoimmunity.

Molecular behavior adapts to context: heparanase functions as an extracellular matrix-degrading enzyme or as a T cell adhesion molecule, depending on the local pH

R. Hershkoviz, L. Cahalon, D. Gilat, 1995, The Journal of experimental medicine.

Perturbation of Endothelial Functions by Ionizing Irradiation: Effects on Prostaglandins, Chemoattractants and Mitogens

Z. Fuks, A. Eldor, Y. Matzner, 1989, Seminars in thrombosis and hemostasis.

A synthetic heparin‐mimicking polyanionic compound binds to the LDL receptor‐related protein and inhibits vascular smooth muscle cell proliferation

M. Benezra, S. Ben‐Sasson, A. Panet, 2001, Journal of cellular biochemistry.

Forty Years of Basic and Translational Heparanase Research

R. Sanderson, I. Vlodavsky, N. Ilan, 2020, Advances in experimental medicine and biology.

Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate.

Benito Casu, Annamaria Naggi, Israel Vlodavsky, 2007, Current pharmaceutical design.

Generation of lipid neutrophil chemoattractant by irradiated bovine aortic endothelial cells.

Z. Fuks, E. Razin, A. Eldor, 1988, Journal of immunology.

Molecular properties and involvement of heparanase in cancer progression and normal development.

I. Vlodavsky, I Vlodavsky, S Metzger, 2001, Biochimie.

Hyperglycemia-Induced Secretion of Endothelial Heparanase Stimulates a Vascular Endothelial Growth Factor Autocrine Network in Cardiomyocytes That Promotes Recruitment of Lipoprotein Lipase

James D. Johnson, Ying Wang, B. Rodrigues, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development.

T. Peretz, I. Vlodavsky, M. Elkin, 2002, Seminars in cancer biology.

Expression of heparanase, Mdm2, and erbB2 in ovarian cancer.

I. Vlodavsky, M. Glezerman, A. Amsterdam, 2001, International journal of oncology.

Heparanase Induces Endothelial Cell Migration via Protein Kinase B/Akt Activation*

M. Flugelman, I. Vlodavsky, N. Ilan, 2004, Journal of Biological Chemistry.

Role of promoter methylation in regulation of the mammalian heparanase gene

T. Peretz, Y. Ashhab, I. Vlodavsky, 2003, Oncogene.

Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation.

I. Vlodavsky, N. Ilan, A. Zetser, 2006, Cancer research.

Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis

Z. Fuks, R. Bar-Shavit, I. Vlodavsky, 1990, Cancer and Metastasis Reviews.

Extracellular matrix‐resident basic fibroblast growth factor: Implication for the control of angiogenesis

M. Klagsbrun, Z. Fuks, R. Bar-Shavit, 1991, Journal of cellular biochemistry.

Stimulation of human amniotic fluid cell proliferation and colony formation by cell plating on a naturally produced extracellular matrix

Z. Fuks, I. Vlodavsky, S. Yarkoni, 1982 .

Thrombin-induced release of active basic fibroblast growth factor-heparan sulfate complexes from subendothelial extracellular matrix.

M. Benezra, G. Neufeld, R. Bar-Shavit, 1993, Blood.

In vitro Studies on Tumor Cell Interaction with the Vascular Endothelium and the Subendothelial Basal Lamina: Relationship to Tumor Cell Metastasis

Z. Fuks, V. Schirrmacher, I. Vlodavsky, 1983 .

Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.

Y. Ma, A. Yayon, I. Vlodavsky, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Prevention of human bladder tumor cell implantation in an in vitro assay.

D. Pode, I. Vlodavsky, A. Horowitz, 1987, The Journal of urology.

Effects of Dipyrone on Prostaglandin Production by Human Platelets and Cultured Bovine Aortic Endothelial Cells

A. Eldor, I. Vlodavsky, M. Levy, 1983, Thrombosis and Haemostasis.

Extracellular matrix induces tumour necrosis factor-alpha secretion by an interaction between resting rat CD4+ T cells and macrophages.

I. Cohen, S. Miron, D. Wallach, 1993, Immunology.

Heparanase Deficiency Is Associated with Disruption, Detachment, and Folding of the Retinal Pigment Epithelium

Alan W. Stitt, J. Feyen, I. Vlodavsky, 2020, Current eye research.

Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis.

J. Michaeli, A. Haimovitz-Friedman, Z. Fuks, 1994, Cancer research.

Inhibition of matrix metalloproteinase-2 by halofuginone is mediated by the Egr1 transcription factor

A. Nagler, T. Peretz, A. Shimoni, 2012, Anti-cancer drugs.

Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence

V. Doviner, I. Vlodavsky, N. Ilan, 2006, Modern Pathology.

Are primed polymorphonuclear leukocytes contributors to the high heparanase levels in hemodialysis patients?

S. Sela, B. Kristal, A. Rops, 2008, American journal of physiology. Heart and circulatory physiology.

Cellular Heparan Sulfate Participates in the Metabolism of Prions*

J. Esko, Y. Tal, A. Taraboulos, 2003, Journal of Biological Chemistry.

Heparan Sulfate Is a Cellular Receptor for Purified Infectious Prions*

Y. Yedidia, D. Papy-Garcia, A. Taraboulos, 2005, Journal of Biological Chemistry.

Nuclear accumulation of epidermal growth factor in cultured rat pituitary cells

D. Gospodarowicz, J. Baxter, I. Vlodavsky, 1980, Nature.

Striated muscle fibers differentiate in primary cultures of adult anterior pituitary cells.

R. Bar-Shavit, I. Vlodavsky, J. Gross, 1988, Endocrinology.

Heparanase and chemotherapy synergize to drive macrophage activation and enhance tumor growth.

Y. Shaked, R. Sanderson, Shiming Yang, 2019, Cancer research.

Heparanase promotes glioma progression via enhancing CD24 expression

Xiaojun Yang, A. Spyrou, K. Forsberg-Nilsson, 2019, International journal of cancer.

Patient derived xenografts (PDX) predict an effective heparanase-based therapy for lung cancer

E. Hammond, I. Vlodavsky, R. Kremer, 2018, Oncotarget.

Prognostic significance of heparanase expression in primary and metastatic breast carcinoma

G. Bar-Sela, I. Vlodavsky, N. Ilan, 2017, Oncotarget.

Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype.

M. Ng, R. Sanderson, I. Vlodavsky, 2016, Matrix biology : journal of the International Society for Matrix Biology.

The heparanase/syndecan‐1 axis in cancer: mechanisms and therapies

A. Purushothaman, R. Sanderson, J. Au, 2013, The FEBS journal.

The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy.

B. Barlogie, J. Shaughnessy, L. Suva, 2007, Blood.

Functional magnetic resonance imaging monitoring of pathological changes in rodent livers during hyperoxia and hypercapnia

Yifat Edrei, Rinat Abramovitch, Idit Matot, 2008, Hepatology.

Systemic LPS-induced Aβ-solubilization and clearance in AβPP-transgenic mice is diminished by heparanase overexpression

Andreas Digre, L. Nilsson, I. Vlodavsky, 2019, Scientific Reports.

Overexpression of Heparanase Lowers the Amyloid Burden in Amyloid-β Precursor Protein Transgenic Mice*

L. Nilsson, I. Vlodavsky, Jin-ping Li, 2014, The Journal of Biological Chemistry.

Adaptive evolution of heparanase in hypoxia-tolerant Spalax: gene cloning and identification of a unique splice variant.

E. Nevo, A. Avivi, I. Vlodavsky, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Heparanase improves mouse embryo implantation.

A. Revel, A. Shushan, I. Vlodavsky, 2005, Fertility and sterility.

Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer’s disease

Xiaomin Wang, L. Lannfelt, Ying-xia Tan, 2021, Acta Neuropathologica Communications.

Endogenous basic fibroblast growth factor displaced by heparin from the lumenal surface of human blood vessels is preferentially sequestered by injured regions of the vessel wall.

A. Nagler, B. Medalion, A. Elami, 1997, Circulation.

The role of heparanase in lymph node metastatic dissemination: dynamic contrast-enhanced MRI of Eb lymphoma in mice.

M. Neeman, A. Harmelin, N. Nevo, 2005, Neoplasia.

Cloning, expression, and characterization of an alternatively spliced variant of human heparanase.

E. Nevo, A. Avivi, I. Vlodavsky, 2007, Biochemical and biophysical research communications.

Role of Heparanase in Platelet and Tumor Cell Interactions with the Subendothelial Extracellular Matrix

Z. Fuks, A. Eldor, J. Yahalom, 1987, Seminars in thrombosis and hemostasis.

Tail Vein Assay of Cancer Metastasis

I. Vlodavsky, M. Elkin, 2001, Current protocols in cell biology.

Interaction of lipoprotein lipase with subendothelial extracellular matrix.

R. Bar-Shavit, G. Bengtsson-Olivecrona, I. Vlodavsky, 1990, Biochimica et biophysica acta.

P‐selectin‐ and heparanase‐dependent antimetastatic activity of non‐anticoagulant heparins

L. Borsig, G. Torri, I. Vlodavsky, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Non-Anticoagulant Heparins and Inhibition of Cancer

R. Sanderson, I. Vlodavsky, B. Casu, 2007, Pathophysiology of Haemostasis and Thrombosis.

Heparanase, heparin and the coagulation system in cancer progression.

R. Sasisekharan, G. Torri, B. Brenner, 2007, Thrombosis research.

O-sulfated bacterial polysaccharides with low anticoagulant activity inhibit metastasis.

L. Nissinen, A. Wärri, M. Borgenström, 2007, Seminars in thrombosis and hemostasis.

Title: Role of endothelial heparanase in delayed-type hypersensitivity Condensed title: Role of Heparanase in DTH

T. Peretz, I. Vlodavsky, M. Elkin, 2005 .

Heparanase Induces Signal Transducer and Activator of Transcription (STAT) Protein Phosphorylation

I. Doweck, Y. Yanir, I. Vlodavsky, 2011, The Journal of Biological Chemistry.

Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling.

I. Vlodavsky, N. Ilan, S. Feld, 2009, Cancer research.

Sulfate Moieties in the Subendothelial Extracellular Matrix Are Involved in Basic Fibroblast Growth Factor Sequestration, Dimerization, and Stimulation of Cell Proliferation (*)

T. Peretz, I. Vlodavsky, H. Miao, 1996, The Journal of Biological Chemistry.

The Role of Heparanase in the Pathogenesis of Acute Pancreatitis: A Potential Therapeutic Target

Preeti Singh, E. Sabo, I. Gralnek, 2017, Scientific Reports.

Heparanase Facilitates Cell Adhesion and Spreading by Clustering of Cell Surface Heparan Sulfate Proteoglycans

Israel Vlodavsky, I. Vlodavsky, E. Suss-Toby, 2008, PloS one.

Elevated Urine Heparanase Levels Are Associated with Proteinuria and Decreased Renal Allograft Function

M. Boaz, D. Schwartz, T. Weinstein, 2012, PloS one.

A cellulose-binding domain-fused recombinant human T cell connective tissue-activating peptide-III manifests heparanase activity.

I. Cohen, O. Shoseyov, L. Cahalon, 1999, Biochemical and biophysical research communications.

Indication of selective growth of human endometrial epithelial cells on extracellular matrix

Y. Ezra, I. Vlodavsky, D. Navot, 1988, In Vitro Cellular & Developmental Biology.

Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and α-actinin

A. Shteingauz, I. Vlodavsky, N. Ilan, 2014, Cellular and Molecular Life Sciences.

PADMA-28, a traditional Tibetan herbal preparation, blocks cellular responses to bFGF and IGF-I

I. Ginsburg, P. Brodt, R. Mechoulam, 2004, InflammoPharmacology.

Heparanase expression increases throughout the endometrial hyperplasia–cancer sequence

D. Grisaru, I. Vlodavsky, J. Canaani, 2008, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

Regulation of heparanase gene expression by estrogen in breast cancer.

H. Kleinman, T. Peretz, I. Vlodavsky, 2003, Cancer research.

Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity

Basappa, Julian E. Fuchs, A. Bender, 2017, BMC Cancer.

Heparin-like synthetic polymers, named RGTAs, mimic biological effects of heparin in vitro.

A. Meddahi-Pellé, I. Vlodavsky, H. Miao, 2006, Journal of biomedical materials research. Part A.

Heparanase protects the heart against chemical or ischemia/reperfusion injury.

C. Nislow, S. Flibotte, T. Pulinilkunnil, 2019, Journal of molecular and cellular cardiology.

Heparanase Alters Arterial Structure, Mechanics, and Repair Following Endovascular Stenting in Mice

E. Edelman, T. Shazly, A. Baker, 2009, Circulation research.

Clinical significance of urine heparanase in bladder cancer progression.

D. Pode, T. Peretz, I. Vlodavsky, 2008, Neoplasia.

Heparanase is expressed in adult human osteoarthritic cartilage and drives catabolic responses in primary chondrocytes.

A. Sharabi, N. Snir, G. Gibor, 2018, Osteoarthritis and cartilage.

Effect of HPSE and HPSE2 SNPs on the Risk of Developing Primary Paraskeletal Multiple Myeloma

A. Nagler, M. Leiba, R. Sanderson, 2023, Cells.

Control of normal differentiation of myeloid leukemic cells. X. Glucose utilization, cellular ATP and associated membrane changes in D+ and D− cells

L. Sachs, E. Fibach, I. Vlodavsky, 1976, Journal of cellular physiology.

Function from within: Autophagy induction by HPSE/heparanase—new possibilities for intervention

A. Shteingauz, I. Vlodavsky, N. Ilan, 2015, Autophagy.

Enzymatically Quiescent Heparanase Augments T Cell Interactions with VCAM-1 and Extracellular Matrix Components under Versatile Dynamic Contexts1

R. Alon, R. Hershkoviz, L. Cahalon, 2004, The Journal of Immunology.

Heparanase expression during normal liver development and following partial hepatectomy

O. Pappo, I. Vlodavsky, N. Ilan, 2004, The Journal of pathology.

Recovery of prostacyclin capacity of irradiated endothelial cells and the protective effect of vitamin C.

Z. Fuks, A. Eldor, E. Riklis, 1987, Prostaglandins.

Site-directed Mutagenesis, Proteolytic Cleavage, and Activation of Human Proheparanase*

T. Peretz, I. Vlodavsky, H. Aingorn, 2005, Journal of Biological Chemistry.

Epidermal growth factor induced membrane changes in 3T3 cells

H. Herschman, I. Vlodavsky, R. Pruss, 1978, Journal of cellular physiology.

Heparanase expression in nasopharyngeal carcinoma inversely correlates with patient survival

G. Bar-Sela, I. Vlodavsky, O. Ben‐Izhak, 2006, Histopathology.

Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice

I. Vlodavsky, A. Rubinstein, M. Elkin, 2014, Cellular and Molecular Life Sciences.

Heparanase 2 (Hpa2) attenuates tumor growth by inducing Sox2 expression.

G. Neufeld, O. Kessler, I. Vlodavsky, 2021, Matrix biology : journal of the International Society for Matrix Biology.

A Pro-Tumorigenic Effect of Heparanase 2 (Hpa2) in Thyroid Carcinoma Involves Its Localization to the Nuclear Membrane

I. Doweck, I. Vlodavsky, N. Ilan, 2021, Frontiers in Oncology.

Inhibition of collagen synthesis, smooth muscle cell proliferation, and injury-induced intimal hyperplasia by halofuginone.

M. Pines, A. Nagler, O. Genina, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Involvement of human heparanase in the pathogenesis of diabetic nephropathy.

M. Davies, I. Vlodavsky, D. Darmon, 2002, The Israel Medical Association journal : IMAJ.

Heparanase-neutralizing antibodies attenuate lymphoma tumor growth and metastasis

E. Nevo, M. Ng, E. Hammond, 2016, Proceedings of the National Academy of Sciences.

Structure–activity relationships of heparin‐mimicking compounds in induction of bFGF release from extracellular matrix and inhibition of smooth muscle cell proliferation and heparanase activity

M. Benezra, S. Ben‐Sasson, I. Vlodavsky, 2002, Journal of cellular physiology.

Protein Kinase C Mediates Basic Fibroblast Growth Factor Protection of Endothelial Cells against Radiation-induced Apoptosis 1

J. Michaeli, A. Haimovitz-Friedman, Z. Fuks, 2006 .

Induction of a hypertrophic growth status of coronary smooth muscle cells is associated with an overexpression of TGF-beta.

A. Schmidt, I. Vlodavsky, E. Buddecke, 2002, European journal of cell biology.

Differentiation of coronary smooth muscle cells to a cell cycle-arrested hypertrophic growth status by a synthetic non-toxic heparin-mimicking compound.

A. Schmidt, I. Vlodavsky, E. Buddecke, 1999, Atherosclerosis.

Interferon enhances phospholipase A2 activity in bovine aortic endothelial cells.

S. Yedgar, A. Eldor, A. Panet, 1990, Eicosanoids.

Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells

M. Götte, B. Greve, P. Pelucchi, 2020, Frontiers in Oncology.

Coordinate secretion and functional synergism of T cell‐associated serine proteinase‐1 (MTSP‐1) and endoglycosidase(s) of activated T cells

R. Bar-Shavit, M. Kramer, M. Simon, 1991, European journal of immunology.

Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically Induced Diabetes

James D. Johnson, C. Nislow, S. Flibotte, 2016, Diabetes.

Heparanase Modulates Chromatin Accessibility

Xingqi Chen, I. Vlodavsky, Jin-ping Li, 2023, Cells.

Heparanase—A single protein with multiple enzymatic and nonenzymatic functions

R. Sanderson, I. Vlodavsky, N. Ilan, 2023, Proteoglycan research.

Regulation of cap formation by concanavalin A and differentiation of myeloid leukemic cells. Relationship to free and anchored surface receptors.

J. Lotem, L. Sachs, I. Vlodavsky, 1976, Experimental cell research.

Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation

A. Nagler, M. Korostishevsky, O. Ostrovsky, 2009, Journal of leukocyte biology.

Heparanase 2 (Hpa2)- a new player essential for pancreatic acinar cell differentiation

I. Vlodavsky, N. Ilan, U. Barash, 2023, Cell death & disease.

Entactin/nidogen: synthesis by bovine corneal endothelial cells and distribution in the human cornea.

J. Pe’er, I. Vlodavsky, A. Fish, 1994, Investigative ophthalmology & visual science.

Authors' Reply

H. Werner, D. Chan, K. Cheah, 2009 .

Characterization of HPSE Gene Single Nucleotide Polymorphisms in Jewish Populations of Israel

A. Nagler, M. Leiba, M. Korostishevsky, 2006, Acta Haematologica.

Megakaryocyte maturation is associated with expression of the cxc chemokine connective tissue activating peptide ctap III

A. Eldor, V. Deutsch, I. Vlodavsky, 2000 .

Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis

R. Reijmers, Andreas Digre, I. Vlodavsky, 2017, Scientific reports.

Appearance in confluent vascular endothelial cell monolayers of a specific cell surface protein (CSP-60) not detected in actively growing endothelial cells or in cell types growing in multiple layers.

D. Gospodarowicz, I. Vlodavsky, L. Johnson, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Defibrotide: potential for treating endothelial dysfunction related to viral and post-infectious syndromes

P. Richardson, M. Díaz-Ricart, C. Carlo-Stella, 2021, Expert opinion on therapeutic targets.

Prothrombin Conversion to Thrombin by Plasminogen Activator Residing in the Subendothelial Extracellular Matrix

M. Benezra, R. Bar-Shavit, I. Vlodavsky, 1993, Seminars in thrombosis and hemostasis.

Involvement of Heparanase in Tumor Progression and Normal Differentiation

S. Minucci, C. Pisano, R. Eshel, 2003, Pathophysiology of Haemostasis and Thrombosis.

Biosynthesis and storage of basic fibroblast growth factor (bFGF) by endothelial cells: implication for the mechanism of action of angiogenesis.

M. Klagsbrun, I. Vlodavsky, 1988, Progress in clinical and biological research.

Heparan Sulfate Primed on p-D-Xylosides Restores

Timothy, A. Yayon, I. Vlodavsky, 2003 .

Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma.

M. Koch, J. Weitz, Y. Ge, 2009, The Journal of clinical investigation.

Inhibition of Heparanase in Pediatric Brain Tumor Cells Attenuates their Proliferation, Invasive Capacity, and In Vivo Tumor Growth

A. Spyrou, T. Olofsson, K. Forsberg-Nilsson, 2017, Molecular Cancer Therapeutics.

The impact of heparanase on cancer progression

C. Pisano, B. Brenner, I. Vlodavsky, 2009 .

Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.

I. Vlodavsky, Y. Friedmann, 2001, The Journal of clinical investigation.

Chemoenzymatic Synthesis of D‐Glucaro‐δ‐lactam Containing Oligosaccharides as Putative Heparanase Inhibitors

Jian Liu, M. Petitou, I. Vlodavsky, 2021, ChemistrySelect.

Endothelial Heparanase Regulates Heart Metabolism by Stimulating Lipoprotein Lipase Secretion From Cardiomyocytes

Ying Wang, B. Rodrigues, I. Vlodavsky, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Heparanase inhibitors restrain mesothelioma

H. Pass, M. Lapidot, I. Vlodavsky, 2018, OncoTarget.

Heparanase Activation of the Coagulation System in a Mice Sepsis Model

B. Brenner, I. Vlodavsky, I. Henig, 2011 .

Non-Anticoagulant Heparins and Inhibition of Cancer

R. Sanderson, I. Vlodavsky, B. Casu*, 2007, Pathophysiology of Haemostasis and Thrombosis.

Radiation Damage in Endothelial Cells Autocrine Effects of Fibroblast Growth Factor in Repair of Updated

A. Haimovitz-Friedman, Z. Fuks, I. Vlodavsky, 2006 .

Binding of Hormonal Steroids to Isolated Oligodendroglia and Astroglia Grown In Vitro on a Naturally Produced Extracellular Matrix

H. Ovadia, O. Abramsky, I. Vlodavsky, 1984, Clinical neuropharmacology.

The Potential of Low Molecular Weight Heparin to Mitigate Cytokine Storm in Severe COVID‐19 Patients: A Retrospective Cohort Study

I. Vlodavsky, Chao Yang, Jin-ping Li, 2020, Clinical and translational science.

Involvement of Heparanase in Empyema: Implication for Novel Therapeutic Approaches.

M. Lapidot, Y. Geffen, I. Vlodavsky, 2015, Journal of clinical & cellular immunology.

Inhibition of Heparanase Activity by Heparin and Nonanticoagulant Heparins Potential Use in Prevention of Extravasation and Dissemination of Blood‐Borne Cells a

Z. Fuks, A. Eldor, Y. Matzner, 1989 .

Expression of heparanase in soft tissue sarcomas of adults

G. Bar-Sela, I. Vlodavsky, N. Ilan, 2014, Journal of experimental & clinical cancer research : CR.

Low and high affinity receptors mediate cellular uptake of heparanase.

R. Maya, I. Vlodavsky, N. Ilan, 2008, The international journal of biochemistry & cell biology.

Role of endothelial heparanase in delayed-type hypersensitivity.

T. Peretz, I. Vlodavsky, M. Elkin, 2006, Blood.

Cardiomyocyte VEGF Regulates Endothelial Cell GPIHBP1 to Relocate Lipoprotein Lipase to the Coronary Lumen During Diabetes Mellitus

B. Rodrigues, I. Vlodavsky, Amy P Chiu, 2016, Arteriosclerosis, thrombosis, and vascular biology.

A synthetic heparin‐mimicking polyanionic compound binds to the LDL receptor‐related protein and inhibits vascular smooth muscle cell proliferation

M. Benezra, S. Ben‐Sasson, A. Panet, 2001, Journal of cellular biochemistry.