S. Sundseth

发表

Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway*

Timothy M. Willson, J. Lehmann, L. Moore, 1997, The Journal of Biological Chemistry.

Roadmap to Drug Development Enabled by Pharmacogenetics

I. Grossman, S. Sundseth, J. Bishop, 2015 .

Clopidogrel metaboliser status based on point-of-care CYP2C19 genetic testing in patients with coronary artery disease

S. James, D. Erlinge, C. Varenhorst, 2014, Thrombosis and Haemostasis.

Methodology to enable integration of genomic knowledge into drug development

A. Roses, I. Grossman, S. Sundseth, 2013 .

A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease

A D Roses, E M Reiman, A. Roses, 2009, The Pharmacogenomics Journal.

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Peter J. Brown, Timothy M. Willson, J. Lehmann, 1997 .

A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.

J. Lehmann, L. Moore, T. Willson, 1999, Journal of medicinal chemistry.

A phase 2, placebo-controlled study of the opioid receptor antagonist LY2196044 for the treatment of alcohol dependence.

R. Dean, K. Schuh, R. Anton, 2014, Alcoholism, clinical and experimental research.

Platinum anticancer drugs modulate P-450 mRNA levels and differentially alter hepatic drug and steroid hormone metabolism in male and female rats.

G. F. Weber, D. Waxman, G. LeBlanc, 1992, Cancer research.

Peroxisome Proliferator‐activated Receptor γ 2 and Acyl‐CoA Synthetase 5 Polymorphisms Influence Diet Response

C. Langefeld, R. McPherson, K. Adamo, 2007, Obesity.

Transferring from clopidogrel loading dose to prasugrel loading dose in acute coronary syndrome patients

M. Effron, H. Fisher, D. Angiolillo, 2014, Thrombosis and Haemostasis.

Enhanced active metabolite generation and platelet inhibition with prasugrel compared to clopidogrel regardless of genotype in thienopyridine metabolic pathways

T. Costigan, M. Effron, N. Kleiman, 2013, Thrombosis and Haemostasis.

Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemias⃞s⃞ The online version of this article (available at http://www.jlr.org) contains an additional four figures. Published, JLR Papers in Press, August 1, 2005. DOI 10.1194/j

D. S. Montgomery, S. Grundy, R. Mahley, 2005, Journal of Lipid Research.

African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles

A. Roses, M. Hauser, K. Welsh-Bohmer, 2014, Alzheimer's & Dementia.

A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study.

Silke Schmidt, Lefkos Middleton, Vincent Mooser, 2004, American journal of human genetics.

Featured Article A genetics-based biomarker risk algorithm for predicting risk of Alzheimer's disease

A. Roses, K. Welsh-Bohmer, A. Saunders, 2016 .

Impact of CYP2C19 Metabolizer Status on Patients With ACS Treated With Prasugrel Versus Clopidogrel.

Deepak L. Bhatt, D. Prabhakaran, P. Armstrong, 2016, Journal of the American College of Cardiology.

PON1 Q192R genetic variant and response to clopidogrel and prasugrel: pharmacokinetics, pharmacodynamics, and a meta-analysis of clinical outcomes

E. Antman, J. Mega, M. Price, 2015, Journal of Thrombosis and Thrombolysis.

The Effect of Cyp2c19 Gene Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Prasugrel 5-mg, Prasugrel 10-mg and Clopidogrel 75-mg in Patients with Coronary Artery Disease Gurbel Cyp2c19 Genetics in Generations and Feather

T. Lindahl, S. James, D. Erlinge, 2022 .

Gene-specific oligonucleotide probes for alpha, mu, pi, and microsomal rat glutathione S-transferases: analysis of liver transferase expression and its modulation by hepatic enzyme inducers and platinum anticancer drugs.

P. Srivastava, D. Waxman, S. Sundseth, 1992, Cancer research.

Monoclonal antibodies to resistance-related forms of cytochrome P450 in Drosophila melanogaster

S. Kennel, L. C. Waters, S. Sundseth, 1989 .

Pituitary regulation of the male-specific steroid 6 beta-hydroxylase P-450 2a (gene product IIIA2) in adult rat liver. Suppressive influence of growth hormone and thyroxine acting at a pretranslational leve;.

D. Waxman, J. Alberta, G. LeBlanc, 1990, Molecular endocrinology.

Sex-specific, growth hormone-regulated transcription of the cytochrome P450 2C11 and 2C12 genes.

D. Waxman, J. Alberta, S. Sundseth, 1992, The Journal of biological chemistry.

Isolation of insecticide resistance-related forms of cytochrome P-450 from Drosophila melanogaster.

L. C. Waters, S. Sundseth, C. E. Nix, 1990, The Biochemical journal.

The characterization of PPARα ligand drug action in an in vivo model by comprehensive differential gene expression profiling

J. Rothberg, S. Sundseth, D. Winegar, 2001, Functional & Integrative Genomics.

Metabolism in Male and Female Rats Differentially Alter Hepatic Drug and Steroid Hormone Platinum Anticancer Drugs Modulate P-450 mRNA Levels and Updated

G. F. Weber, D. Waxman, G. LeBlanc, 2006 .

Ileal bile acid transporter inhibition, CYP7A1 induction, and antilipemic action of 264W94 DOI 10.1194/jlr.M200121-JLR200

Chari D Smith, C. Root, S. Sundseth, 2002, Journal of Lipid Research.

Hepatic P-450 cholesterol 7 alpha-hydroxylase. Regulation in vivo at the protein and mRNA level in response to mevalonate, diurnal rhythm, and bile acid feedback.

D. Waxman, S. Sundseth, 1990, The Journal of biological chemistry.

Effects of cyclosporin on cholesterol 27-hydroxylation and LDL receptor activity in HepG2 cells.

S. Sundseth, D. Winegar, R. Hawke, 1996, Journal of lipid research.

The characterization of PPAR alpha ligand drug action in an in vivo model by comprehensive differential gene expression profiling.

J. Rothberg, S. Sundseth, D. Winegar, 2001, Functional & integrative genomics.

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.

J. Lehmann, T. Willson, S. Kliewer, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Comprehensive Messenger Ribonucleic Acid Profiling Reveals That Peroxisome Proliferator-Activated Receptor γ Activation Has Coordinate Effects on Gene Expression in Multiple Insulin-Sensitive Tissues.

T. Willson, S. Kliewer, T. Mansfield, 2001, Endocrinology.

Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease

Michael Lutz, Scott Sundseth, A. Roses, 2016, Alzheimer's & Dementia.

Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score—the CoLaus Study

L. T. Middleton, P. M. Matthews, A. D. Roses, 2009, Diabetologia.

Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues.

T. Willson, S. Kliewer, T. Mansfield, 2001, Endocrinology.

Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone.

D. Waxman, S. Sundseth, 1992, The Journal of biological chemistry.

Applications of Pharmacogenetics in Pharmaceutical Research and Development

D. Burns, S. Sundseth, 2012 .

The RXR agonist LG100268 causes hepatomegaly, improves glycaemic control and decreases cardiovascular risk and cachexia in diabetic mice suffering from pancreatic beta-cell dysfunction

R. M. Lightfoot, J. Weiel, J. Lenhard, 1999, Diabetologia.

The TOMMORROW study: Design of an Alzheimer's disease delay-of-onset clinical trial

L. Schneider, C. Lyketsos, A. Monsch, 2019, Alzheimer's & dementia.

A genetics-based biomarker risk algorithm for predicting risk of Alzheimer's disease

A. Roses, K. Welsh-Bohmer, A. Saunders, 2016, Alzheimer's & dementia.

The Genetics of Generalized Osteoarthritis (GOGO) study: study design and evaluation of osteoarthritis phenotypes.

R. Moskowitz, M. Hochberg, J. Jordan, 2007, Osteoarthritis and cartilage.

Articular hypermobility is a protective factor for hand osteoarthritis.

J B Renner, Scott Sundseth, R. Moskowitz, 2004, Arthritis and rheumatism.

Structural variants can be more informative for disease diagnostics, prognostics and translation than current SNP mapping and exon sequencing

Michael W. Lutz, A. D. Roses, Daniel K. Burns, 2016, Expert opinion on drug metabolism & toxicology.

Relation between atherogenic dyslipidemia and the Adult Treatment Program-III definition of metabolic syndrome (Genetic Epidemiology of Metabolic Syndrome Project).

Jonathan C. Cohen, S. Grundy, R. Mahley, 2005, The American journal of cardiology.

Regulation of P450-dependent hepatic steroid hydroxylation by growth hormone and thyroxine

D. Waxman, J. Alberta, S. Sundseth, 1992 .

The effect of CYP2C19 gene polymorphisms on the pharmacokinetics and pharmacodynamics of prasugrel 5-mg, prasugrel 10-mg and clopidogrel 75-mg in patients with coronary artery disease

T. Lindahl, S. James, D. Erlinge, 2014, Thrombosis and Haemostasis.