Y. Nakagawa

发表

Protein Kinase A Suppresses Sterol Regulatory Element-binding Protein-1C Expression via Phosphorylation of Liver X Receptor in the Liver*

Hitoshi Shimano, Takashi Matsuzaka, Hirohito Sone, 2007, Journal of Biological Chemistry.

The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice

H. Shimano, T. Matsuzaka, H. Ohno, 2018, International journal of molecular sciences.

Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages.

H. Sone, H. Shimano, N. Yamada, 2004, Biochemical and biophysical research communications.

High Mobility Group Protein-B1 Interacts with Sterol Regulatory Element-binding Proteins to Enhance Their DNA Binding*

T. Kadowaki, H. Shimano, N. Yahagi, 2005, Journal of Biological Chemistry.

TFE3 inhibits myoblast differentiation in C2C12 cells via down-regulating gene expression of myogenin.

H. Sone, H. Shimano, N. Yahagi, 2013, Biochemical and biophysical research communications.

Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood

Y. Kamei, H. Shimano, I. Hatada, 2018, Nature Communications.

Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression

H. Sone, H. Shimano, N. Yahagi, 2016, Molecular metabolism.

Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin

H. Shimano, N. Yahagi, N. Yamada, 2010, Journal of Lipid Research.

Sterol Regulatory Element–Binding Protein-1 Determines Plasma Remnant Lipoproteins and Accelerates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

H. Sone, H. Shimano, N. Yahagi, 2011, Arteriosclerosis, thrombosis, and vascular biology.

SREBP-1-independent regulation of lipogenic gene expression in adipocytes Published, JLR Papers in Press, April 24, 2007.

T. Kadowaki, H. Shimano, N. Yahagi, 2007, Journal of Lipid Research.

Elovl6 promotes nonalcoholic steatohepatitis

R. Matsumori, H. Sone, H. Shimano, 2012, Hepatology.

Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism

H. Shimano, N. Yahagi, T. Matsuzaka, 2019, Scientific Reports.

A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes

Y. Izumida, T. Kadowaki, H. Shimano, 2017, FEBS letters.

TFE3 regulates muscle metabolic gene expression, increases glycogen stores, and enhances insulin sensitivity in mice.

Kazuto Kobayashi, H. Sone, H. Shimano, 2012, American journal of physiology. Endocrinology and metabolism.

Predictive ability of current machine learning algorithms for type 2 diabetes mellitus: A meta‐analysis

C. Horikawa, K. Fujihara, Masaru Kitazawa, 2021, Journal of diabetes investigation.

SREBPs suppress IRS-2-mediated insulin signalling in the liver

A. Fukamizu, H. Sone, H. Shimano, 2004, Nature Cell Biology.

Inhibition of Ubiquitin Ligase F-box and WD Repeat Domain-containing 7α (Fbw7α) Causes Hepatosteatosis through Krüppel-like Factor 5 (KLF5)/Peroxisome Proliferator-activated Receptor γ2 (PPARγ2) Pathway but Not SREBP-1c Protein in Mice*

Satoru Takahashi, H. Sone, H. Shimano, 2011, The Journal of Biological Chemistry.

Transgenic mice overexpressing SREBP-1a under the control of the PEPCK promoter exhibit insulin resistance, but not diabetes.

H. Sone, H. Shimano, N. Yamada, 2005, Biochimica et biophysica acta.

Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice.

H. Sone, H. Shimano, N. Yahagi, 2004, Diabetes.

Positive emotion-specific changes in the gene expression profile of tickled rats.

Shigeko Sakamoto, Miyo Hori, Kazuo Murakami, 2009, Molecular medicine reports.

Lipid Synthetic Transcription Factor SREBP-1a Activates p21 WAF1/CIP1 , a Universal Cyclin-Dependent

H. Sone, H. Shimano, N. Yahagi, 2005 .

Lipid Synthetic Transcription Factor SREBP-1a Activates p21WAF1/CIP1, a Universal Cyclin-Dependent Kinase Inhibitor

H. Sone, H. Shimano, N. Yahagi, 2005, Molecular and Cellular Biology.

Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity.

H. Shimano, N. Yahagi, N. Yamada, 2008, Journal of lipid research.

Receptor-Type Protein Tyrosine Phosphatase ϵ (PTPϵM) is a Negative Regulator of Insulin Signaling in Primary Hepatocytes and Liver

N. Aoki, H. Shimano, N. Yamada, 2005 .

Severity of hypertension as a predictor of initiation of dialysis among study participants with and without diabetes mellitus

K. Fujihara, H. Sone, Masaru Kitazawa, 2020, Journal of Investigative Medicine.

Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance

H. Sone, Y. Higami, H. Shimano, 2018, Endocrinology.

Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome

Masaki Kobayashi, Y. Higami, H. Shimano, 2019, International journal of molecular sciences.

1 Liver – intestine CREBH regulates systemic glucose 2 and lipid metabolism 3

H. Shimano, Y. Nakagawa, 2018 .

CREBH Regulates Systemic Glucose and Lipid Metabolism

H. Shimano, Y. Nakagawa, 2018, International journal of molecular sciences.

TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis.

H. Sone, H. Shimano, N. Yahagi, 2013, Endocrinology.

Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice

H. Sone, H. Shimano, N. Yahagi, 2016, PloS one.

Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion.

H. Shimano, N. Yahagi, N. Yamada, 2009, Biochemical and biophysical research communications.

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.

H. Gomi, Satoru Takahashi, H. Sone, 2006, Cell metabolism.

Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl‐Chain Length and Hepatic Insulin Sensitivity in Mice

Satoru Takahashi, H. Sone, H. Shimano, 2020, Hepatology.

Mitochondrial intermediate peptidase is a novel regulator of sirtuin‐3 activation by caloric restriction

Masaki Kobayashi, Takumi Narita, Y. Higami, 2017, FEBS letters.

Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes—Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue

Masaki Kobayashi, Y. Higami, H. Shimano, 2020, Nutrients.

Influence of acute exercise on renalase and its regulatory mechanism

K. Takekoshi, Y. Nakagawa, H. Ohmori, 2018, Life sciences.

Glucocorticoid receptor suppresses gene expression of Rev‐erbα (Nr1d1) through interaction with the CLOCK complex

Y. Izumida, H. Shimano, N. Yahagi, 2019, FEBS letters.

Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy.

H. Sone, H. Shimano, N. Yahagi, 2015, Biochemical and biophysical research communications.

glycogen supercompensation in rats Effect of endurance exercise training on muscle

N. Yahagi, T. Matsuzaka, L. Nolte, 2015 .

CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF2.

R. Takano, H. Shimano, N. Yahagi, 2021, Biochemical and biophysical research communications.

CREBH Systemically Regulates Lipid Metabolism by Modulating and Integrating Cellular Functions

H. Shimano, Y. Nakagawa, Masaya Araki, 2021, Nutrients.

Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition

H. Sone, H. Shimano, N. Yamada, 2020, bioRxiv.

CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms

H. Sone, H. Shimano, T. Matsuzaka, 2020, iScience.

CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα

H. Sone, H. Shimano, N. Yahagi, 2016, Scientific Reports.

Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes

Masaki Kobayashi, Y. Higami, H. Shimano, 2020, Scientific Reports.

Transgenic Mice Overexpressing Nuclear SREBP-1 c in Pancreatic-Cells

H. Sone, H. Shimano, N. Yahagi, 2005 .

Transgenic Mice Overexpressing Nuclear SREBP-1c in Pancreatic β-Cells

H. Sone, H. Shimano, N. Yahagi, 2005 .

Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion.

H. Sone, H. Shimano, N. Yahagi, 2014, Biochemical and biophysical research communications.

A transcription factor of lipid synthesis, sterol regulatory element‐binding protein (SREBP)‐1a causes G1 cell‐cycle arrest after accumulation of cyclin‐dependent kinase (cdk) inhibitors

H. Shimano, N. Yahagi, N. Yamada, 2007, The FEBS journal.

Polyunsaturated Fatty Acids Selectively Suppress Sterol Regulatory Element-binding Protein-1 through Proteolytic Processing and Autoloop Regulatory Circuit*

K. Kataoka, Y. Izumida, T. Kadowaki, 2010, The Journal of Biological Chemistry.

In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression.

Masayuki Yamamoto, T. Kadowaki, H. Shimano, 2007, Biochemical and biophysical research communications.

SREBP-1 Interacts with Hepatocyte Nuclear Factor-4α and Interferes with PGC-1 Recruitment to Suppress Hepatic Gluconeogenic Genes*

H. Sone, H. Shimano, N. Yahagi, 2004, Journal of Biological Chemistry.

WWP1 knockout in mice exacerbates obesity‐related phenotypes in white adipose tissue but improves whole‐body glucose metabolism

Masaki Kobayashi, Y. Higami, H. Kawabe, 2020, FEBS open bio.

Corrigendum: Glycogen shortage during fasting triggers liver–brain–adipose neurocircuitry to facilitate fat utilization

K. Kataoka, Y. Izumida, T. Kadowaki, 2013, Nature Communications.

Glycogen shortage during fasting triggers liver–brain–adipose neurocircuitry to facilitate fat utilization

K. Kataoka, Y. Izumida, T. Kadowaki, 2013, Nature Communications.

Protein tyrosine phosphatase PTPepsilonM negatively regulates PDGF beta-receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells.

N. Aoki, H. Miyazaki, Y. Nakagawa, 2010, American journal of physiology. Cell physiology.

Protein tyrosine phosphatase PTP ε M negatively regulates PDGF (cid:1) -receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells

N. Aoki, H. Miyazaki, Y. Nakagawa, 2010 .

Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice.

H. Sone, N. Yahagi, T. Matsuzaka, 2022, Biochimica et biophysica acta. Molecular basis of disease.

High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding.

T. Kadowaki, H. Shimano, N. Yahagi, 2005, The Journal of biological chemistry.

Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice

H. Shimano, N. Yamada, T. Matsuzaka, 2016, PloS one.

expression in human skeletal muscle Effects of exercise on GLUT-4 and glycogenin gene

M. Huss, M. Lindholm, S. Kjellqvist, 2015 .

Tickling stimulation causes the up-regulation of the kallikrein family in the submandibular gland of the rat

T. Shiga, Shigeko Sakamoto, Miyo Hori, 2013, Behavioural Brain Research.

Tyrosine phosphatase epsilonM stimulates migration and survival of porcine aortic endothelial cells by activating c-Src.

M. Shiota, H. Miyazaki, Y. Nakagawa, 2004, Biochemical and biophysical research communications.

IRE1 α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death during endoplasmic reticulum stress

Simon, P. Greengard, A. Trusina, 2014 .

Weaning-induced expression of a milk-fat globule protein, MFG-E8, in mouse mammary glands, as demonstrated by the analyses of its mRNA, protein and phosphatidylserine-binding activity.

N. Aoki, K. Oshima, C. Sato, 2006, The Biochemical journal.

Expression of Bovine asl-casein CDNAin Escherichia coli

M. Nagao, R. Sasaki, Tanaka, 2006 .

Cyclin-dependent Kinase Inhibitor, p21 WAF1/CIP1 , Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to

H. Shimano, N. Yahagi, N. Yamada, 2008 .

Cyclin-dependent Kinase Inhibitor , p 21 WAF 1 / CIP 1 , Is Involved in Adipocyte Differentiation and Hypertrophy , Linking to Obesity , and Insulin Resistance *

H. Shimano, N. Yahagi, N. Yamada, 2008 .

Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells.

H. Sone, H. Shimano, N. Yahagi, 2005, Diabetes.

Macrophage Elovl6 Deficiency Ameliorates Foam Cell Formation and Reduces Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

R. Matsumori, H. Sone, H. Shimano, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4–FGF21 Signaling in Mouse Hepatocyte AML12 Cells

H. Sone, H. Shimano, T. Matsuzaka, 2022, Nutrients.

p53 Activation in Adipocytes of Obese Mice*

H. Shimano, N. Yahagi, N. Yamada, 2003, Journal of Biological Chemistry.

TGF-β activates Akt kinase via a microRNA-dependent amplifying circuit targeting PTEN

J. Rossi, Mitsuo Kato, Hang Yuan, 2009, Nature Cell Biology.

p53 Involvement in the Pathogenesis of Fatty Liver Disease*

T. Kadowaki, H. Shimano, N. Yahagi, 2004, Journal of Biological Chemistry.

Ligand-Activated PPARα-Dependent DNA Demethylation Regulates the Fatty Acid β-Oxidation Genes in the Postnatal Liver

Y. Kamei, H. Shimano, I. Hatada, 2014, Diabetes.

Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis.

H. Sone, N. Yahagi, T. Matsuzaka, 2023, BBA advances.

TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes

H. Sone, H. Shimano, N. Yahagi, 2006, Nature Medicine.

Critical role of CREBH‐mediated induction of transforming growth factor β2 by hepatitis C virus infection in fibrogenic responses in hepatic stellate cells

Masahiro Yamamoto, H. Shimano, T. Matsuura, 2017, Hepatology.

Expression of Bovine αs1-casein cDNA in Escherichia coli

M. Nagao, R. Sasaki, A. Ishii, 1988 .

Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry.

Y. Izumida, T. Kadowaki, H. Shimano, 2017, Biochemical and biophysical research communications.

Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP-1c in Pancreatic Islets

H. Sone, H. Shimano, N. Yahagi, 2008, Diabetes.

A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C‐FOS in hepatocytes

Y. Izumida, H. Shimano, N. Yahagi, 2018, FEBS letters.

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

Hitoshi Shimano, Mayumi Ishikawa, Takashi Matsuzaka, 2007, Nature Medicine.

Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity

Hui Zhao, H. Sone, H. Shimano, 2017, Diabetes.

Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr−/− mouse model

T. Fujimura, R. Matsumori, H. Sone, 2015, Scientific Reports.

Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.

H. Sone, H. Shimano, N. Yahagi, 2014, Endocrinology.

National Cholesterol Awareness Month Article Macrophage Elovl 6 Deficiency Ameliorates Foam Cell Formation and Reduces Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

R. Matsumori, H. Sone, H. Shimano, 2011 .

Identification of human ELOVL5 enhancer regions controlled by SREBP.

Y. Izumida, H. Shimano, N. Yahagi, 2015, Biochemical and biophysical research communications.

Cyclin-dependent Kinase Inhibitor, p21WAF1/CIP1, Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to Obesity, and Insulin Resistance*

Hitoshi Shimano, Mayumi Ishikawa, Takashi Matsuzaka, 2008, Journal of Biological Chemistry.

Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells.

H. Shimano, N. Yahagi, N. Yamada, 2012, Biochemical and biophysical research communications.

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

P. Greengard, N. Heintz, A. Trusina, 2012, Cell metabolism.

Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes

Masaki Kobayashi, Y. Higami, H. Shimano, 2020, Scientific Reports.

Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice

J. Gustafsson, J. Yanagisawa, A. Murayama, 2014, Hepatology.

ER ligands ameliorate fatty liver through a non-classical ER / LXR pathway

A. Murayama, H. Shimano, K. Steffensen, 2013 .

The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice.

N. Aoki, H. Shimano, N. Yahagi, 2009, Biochemical and biophysical research communications.

Adipocyte-derived microvesicles are associated with multiple angiogenic factors and induce angiogenesis in vivo and in vitro.

Koichi Hattori, N. Aoki, B. Heissig, 2010, Endocrinology.

IRE 1 α induces thioredoxin-interacting protein to activate the NLRP 3 inflammasome and promote programmed cell death during endoplasmic reticulum stress

Simon, P. Greengard, N. Heintz, 2014 .

Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα.

V. Sládek, Y. Shigeta, H. Shimano, 2018, Biochemical and biophysical research communications.

Identification of Neutral Cholesterol Ester Hydrolase, a Key Enzyme Removing Cholesterol from Macrophages*

T. Kadowaki, N. Yahagi, R. Nagai, 2008, Journal of Biological Chemistry.

Identification and characterization of microvesicles secreted by 3T3-L1 adipocytes: redox- and hormone-dependent induction of milk fat globule-epidermal growth factor 8-associated microvesicles.

N. Aoki, N. Tamura, T. Matsuda, 2007, Endocrinology.

Protein tyrosine phosphatase PTP20 induces actin cytoskeleton reorganization by dephosphorylating p190 RhoGAP in rat ovarian granulosa cells stimulated with follicle-stimulating hormone.

A. Ullrich, K. Miyazaki, N. Ishida, 2003, Molecular endocrinology.

Studies of Kshara, an Ayurvedic medicine (2).

Katsuya Yamamoto, Y. Nakagawa, M. Mikage, 2005 .

Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation.

N. Aoki, Kazuto Sugimura, K. Okumura, 2010, Biochemical and biophysical research communications.

Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice.

H. Shimano, T. Matsuzaka, Y. Nakagawa, 2017, Journal of pharmacological sciences.

ER proteostasis regulators cell-non-autonomously control sleep.

T. Kawano, Y. Nakagawa, H. Fujita, 2023, Cell reports.

Studies of Kshara, an Ayurvedic medicine (2).1) Preparation of alternative Kshara Sutra in Japan

Katsuya Yamamoto, Y. Nakagawa, M. Mikage, 2005 .

Elucidation of Molecular Mechanism of a Selective PPARα Modulator, Pemafibrate, through Combinational Approaches of X-ray Crystallography, Thermodynamic Analysis, and First-Principle Calculations

S. Nakano, H. Shimano, H. Tokiwa, 2020, International journal of molecular sciences.

KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting.

K. Kataoka, Y. Izumida, T. Kadowaki, 2016, Cell reports.

Increased angiotensin II coupled with decreased Adra1a expression enhances cardiac hypertrophy in pregnancy-associated hypertensive mice

A. Fukamizu, Y. Nakagawa, Jun-Dal Kim, 2023, The Journal of biological chemistry.

A Novel Type II Restriction Endonuclease from Leuconostoc mesenteroides in the Ariake Sea

Y. Tashiro, G. Kobayashi, F. Kato, 2008 .

Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1.

H. Shimano, N. Yahagi, T. Matsuzaka, 2019, Biochemical and biophysical research communications.

Selective peroxisome proliferator‐activated receptor‐α modulator K‐877 efficiently activates the peroxisome proliferator‐activated receptor‐α pathway and improves lipid metabolism in mice

H. Shimano, N. Yahagi, N. Yamada, 2017, Journal of diabetes investigation.

Exercise training reduces ventricular arrhythmias through restoring calcium handling and sympathetic tone in myocardial infarction mice

K. Aonuma, A. Nogami, H. Shimano, 2019, Physiological reports.

Starvation‐induced transcription factor CREBH negatively governs body growth by controlling GH signaling

Satoru Takahashi, H. Sone, H. Shimano, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at ER monitoring and regulating fatty acids

H. Sone, H. Shimano, N. Yahagi, 2021, bioRxiv.

Antitumor-promoting activity of eperisone.

Y. Yamaoka, H. Nishino, Y. Nakagawa, 1989, Oncology.

Network meta-analysis of glucose-lowering drug treatment regimens with the potential risk of hypoglycemia in patients with type 2 diabetes mellitus in terms of glycemic control and severe hypoglycemia

K. Fujihara, H. Sone, Masaru Kitazawa, 2023, Journal of investigative medicine : the official publication of the American Federation for Clinical Research.

Carrot Consumption Frequency Associated with Reduced BMI and Obesity through the SNP Intermediary rs4445711

Yasunaga Takeda, C. Horikawa, K. Fujihara, 2021, Nutrients.

Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle

Masaki Kobayashi, Y. Higami, H. Shimano, 2021, Experimental Gerontology.

The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha.

H. Shimano, N. Yamada, T. Matsuzaka, 2010, Biochemical and biophysical research communications.

Altered microbiota by a high-fat diet accelerates lethal myeloid hematopoiesis associated with systemic SOCS3 deficiency

Shujiro Okuda, W. Alexander, H. Hirai, 2021, iScience.

Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice

A. Nawaz, S. Softic, Y. Nagai, 2023, bioRxiv.

Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system

Satoru Takahashi, H. Sone, H. Shimano, 2016, Scientific Reports.

Industrial Application of Microbial Sensors for Bioprocess Control

T. Tosa, Y. Nakagawa, Tomoaki Morimoto, 1992 .

Multi-omics analysis of right ventricles in rat models of pulmonary arterial hypertension: Consideration of mitochondrial biogenesis by chrysin

Y. Kasuya, A. Naito, Asako Yanagisawa, 2022, International journal of molecular medicine.

Receptor-type protein tyrosine phosphatase epsilon (PTPepsilonM) is a negative regulator of insulin signaling in primary hepatocytes and liver.

N. Aoki, H. Shimano, N. Yamada, 2005, Zoological science.

Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion.

H. Shimano, N. Yahagi, N. Yamada, 2009, Biochemical and biophysical research communications.

Protein tyrosine phosphatase PTP ε M negatively regulates PDGF (cid:1) -receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells

N. Aoki, H. Miyazaki, Y. Nakagawa, 2010 .

Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis.

H. Sone, N. Yahagi, T. Matsuzaka, 2023, BBA advances.