Hiroaki Suzuki

发表

Protein Kinase A Suppresses Sterol Regulatory Element-binding Protein-1C Expression via Phosphorylation of Liver X Receptor in the Liver*

Hitoshi Shimano, Takashi Matsuzaka, Hirohito Sone, 2007, Journal of Biological Chemistry.

Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages.

H. Sone, H. Shimano, N. Yamada, 2004, Biochemical and biophysical research communications.

The lack of long-range negative correlations in glucose dynamics is associated with worse glucose control in patients with diabetes mellitus.

Z. Struzik, Yoshiharu Yamamoto, N. Yamada, 2012, Metabolism: clinical and experimental.

Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue.

H. Shimano, N. Yamada, H. Toyoshima, 2007, Journal of atherosclerosis and thrombosis.

TFE3 inhibits myoblast differentiation in C2C12 cells via down-regulating gene expression of myogenin.

H. Sone, H. Shimano, N. Yahagi, 2013, Biochemical and biophysical research communications.

Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression

H. Sone, H. Shimano, N. Yahagi, 2016, Molecular metabolism.

Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin

H. Shimano, N. Yahagi, N. Yamada, 2010, Journal of Lipid Research.

Sterol Regulatory Element–Binding Protein-1 Determines Plasma Remnant Lipoproteins and Accelerates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

H. Sone, H. Shimano, N. Yahagi, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Elovl6 promotes nonalcoholic steatohepatitis

R. Matsumori, H. Sone, H. Shimano, 2012, Hepatology.

Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism

H. Shimano, N. Yahagi, T. Matsuzaka, 2019, Scientific Reports.

Management of type IIb dyslipidemia.

S. Yamashita, H. Sone, H. Arai, 2012, Journal of atherosclerosis and thrombosis.

TFE3 regulates muscle metabolic gene expression, increases glycogen stores, and enhances insulin sensitivity in mice.

Kazuto Kobayashi, H. Sone, H. Shimano, 2012, American journal of physiology. Endocrinology and metabolism.

SREBPs suppress IRS-2-mediated insulin signalling in the liver

A. Fukamizu, H. Sone, H. Shimano, 2004, Nature Cell Biology.

Inhibition of Ubiquitin Ligase F-box and WD Repeat Domain-containing 7α (Fbw7α) Causes Hepatosteatosis through Krüppel-like Factor 5 (KLF5)/Peroxisome Proliferator-activated Receptor γ2 (PPARγ2) Pathway but Not SREBP-1c Protein in Mice*

Satoru Takahashi, H. Sone, H. Shimano, 2011, The Journal of Biological Chemistry.

Transgenic mice overexpressing SREBP-1a under the control of the PEPCK promoter exhibit insulin resistance, but not diabetes.

H. Sone, H. Shimano, N. Yamada, 2005, Biochimica et biophysica acta.

Diagnosis and management of type I and type V hyperlipoproteinemia.

S. Yamashita, H. Sone, H. Arai, 2012, Journal of atherosclerosis and thrombosis.

Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes

A. Sato, K. Fujihara, H. Sone, 2015, Journal of diabetes research.

Carotid artery plaque and LDL-to-HDL cholesterol ratio predict atherosclerotic status in coronary arteries in asymptomatic patients with type 2 diabetes mellitus.

A. Sato, K. Fujihara, H. Sone, 2013, Journal of atherosclerosis and thrombosis.

Malondialdehyde-modified LDL-related variables are associated with diabetic kidney disease in type 2 diabetes.

K. Fujihara, H. Shimano, N. Yahagi, 2018, Diabetes research and clinical practice.

Lipid Synthetic Transcription Factor SREBP-1a Activates p21 WAF1/CIP1 , a Universal Cyclin-Dependent

H. Sone, H. Shimano, N. Yahagi, 2005 .

Lipid Synthetic Transcription Factor SREBP-1a Activates p21WAF1/CIP1, a Universal Cyclin-Dependent Kinase Inhibitor

H. Sone, H. Shimano, N. Yahagi, 2005, Molecular and Cellular Biology.

Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance

H. Sone, Y. Higami, H. Shimano, 2018, Endocrinology.

TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis.

H. Sone, H. Shimano, N. Yahagi, 2013, Endocrinology.

Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice

H. Sone, H. Shimano, N. Yahagi, 2016, PloS one.

Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status.

A. Iwama, H. Sone, H. Shimano, 2002, American journal of physiology. Endocrinology and metabolism.

Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion.

H. Shimano, N. Yahagi, N. Yamada, 2009, Biochemical and biophysical research communications.

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.

H. Gomi, Satoru Takahashi, H. Sone, 2006, Cell metabolism.

Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl‐Chain Length and Hepatic Insulin Sensitivity in Mice

Satoru Takahashi, H. Sone, H. Shimano, 2020, Hepatology.

Glucocorticoid receptor suppresses gene expression of Rev‐erbα (Nr1d1) through interaction with the CLOCK complex

Y. Izumida, H. Shimano, N. Yahagi, 2019, FEBS letters.

Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy.

H. Sone, H. Shimano, N. Yahagi, 2015, Biochemical and biophysical research communications.

An Exploratory Study of the Effects of Continuous Intake of Olive Leaf Tea on Physique and Glucose and Lipid Metabolism

H. Isoda, Y. Nakata, Hiroaki Suzuki, 2018 .

CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF2.

R. Takano, H. Shimano, N. Yahagi, 2021, Biochemical and biophysical research communications.

CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα

H. Sone, H. Shimano, N. Yahagi, 2016, Scientific Reports.

Mouse Elovl-6 promoter is an SREBP target.

H. Shimano, N. Yahagi, N. Yamada, 2008, Biochemical and biophysical research communications.

Transgenic Mice Overexpressing Nuclear SREBP-1 c in Pancreatic-Cells

H. Sone, H. Shimano, N. Yahagi, 2005 .

Transgenic Mice Overexpressing Nuclear SREBP-1c in Pancreatic β-Cells

H. Sone, H. Shimano, N. Yahagi, 2005 .

Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion.

H. Sone, H. Shimano, N. Yahagi, 2014, Biochemical and biophysical research communications.

SREBP-1 Interacts with Hepatocyte Nuclear Factor-4α and Interferes with PGC-1 Recruitment to Suppress Hepatic Gluconeogenic Genes*

H. Sone, H. Shimano, N. Yahagi, 2004, Journal of Biological Chemistry.

Plasma chloride concentration as a new diagnostic indicator of insulin insufficiency.

H. Sone, H. Shimano, N. Yamada, 2005, Diabetes research and clinical practice.

Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice.

H. Sone, N. Yahagi, T. Matsuzaka, 2022, Biochimica et biophysica acta. Molecular basis of disease.

New balance capability index as a screening tool for mild cognitive impairment

N. Yahagi, Yasushi Hada, Hiroaki Suzuki, 2021, BMC Geriatrics.

Exploratory analysis using machine learning of predictive factors for falls in type 2 diabetes

Yasunori Yamada, N. Yahagi, Yasushi Hada, 2022, Scientific Reports.

Involvement of glomerular SREBP-1c in diabetic nephropathy.

H. Sone, H. Shimano, N. Yamada, 2007, Biochemical and biophysical research communications.

Effect of partially-abraded brown rice consumption on body weight and the indicators of glucose and lipid metabolism in pre-diabetic adults: A randomized controlled trial

Y. Nakata, Hiroaki Suzuki, K. Hashimoto, 2017 .

Olive leaf tea is beneficial for lipid metabolism in adults with prediabetes: an exploratory randomized controlled trial.

H. Isoda, Y. Nakata, Hiroaki Suzuki, 2019, Nutrition research.

Effects of Branched-Chain Amino Acids on Skeletal Muscle, Glycemic Control, and Neuropsychological Performance in Elderly Persons with Type 2 Diabetes Mellitus: An Exploratory Randomized Controlled Trial

N. Yahagi, Yasushi Hada, Hiroaki Suzuki, 2022, Nutrients.

Cyclin-dependent Kinase Inhibitor, p21 WAF1/CIP1 , Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to

H. Shimano, N. Yahagi, N. Yamada, 2008 .

Cyclin-dependent Kinase Inhibitor , p 21 WAF 1 / CIP 1 , Is Involved in Adipocyte Differentiation and Hypertrophy , Linking to Obesity , and Insulin Resistance *

H. Shimano, N. Yahagi, N. Yamada, 2008 .

Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells.

H. Sone, H. Shimano, N. Yahagi, 2005, Diabetes.

Estimated Stearoyl-CoA-desaturase (SCD)-1 and Elongase of Very Long Chain Fatty Acids (Elovl) 6 Activities From Serum Fatty Acids Are Reciprocally Associated with Visceral Fat Area in Type 2 Diabetic Patients

H. Shimano, T. Matsuzaka, Ommega Internationals, 2018, Journal of Diabetes and Obesity.

Macrophage Elovl6 Deficiency Ameliorates Foam Cell Formation and Reduces Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

R. Matsumori, H. Sone, H. Shimano, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis.

H. Sone, N. Yahagi, T. Matsuzaka, 2023, BBA advances.

A case of early-onset diabetes with impaired insulin secretion carrying a PAX6 gene Gln135* mutation

Hiroaki Suzuki, H. Iwasaki, Motohiro Sekiya, 2022, Endocrinology, diabetes & metabolism case reports.

TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes

H. Sone, H. Shimano, N. Yahagi, 2006, Nature Medicine.

Insulin Inhibits Apoptosis of Macrophage Cell Line, THP-1 Cells, via Phosphatidylinositol-3-Kinase–Dependent Pathway

T. Asano, H. Sone, H. Shimano, 2002, Arteriosclerosis, thrombosis, and vascular biology.

p57Kip2 Regulates Actin Dynamics by Binding and Translocating LIM-kinase 1 to the Nucleus*

Keiji Tanaka, H. Sone, H. Shimano, 2003, Journal of Biological Chemistry.

Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry.

Y. Izumida, T. Kadowaki, H. Shimano, 2017, Biochemical and biophysical research communications.

Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP-1c in Pancreatic Islets

H. Sone, H. Shimano, N. Yahagi, 2008, Diabetes.

Vascular endothelial growth factor gene expression in a retinal pigmented cell is up-regulated by glucose deprivation through 3' UTR.

H. Sone, N. Yamada, K. Takekoshi, 2002, Life sciences.

A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C‐FOS in hepatocytes

Y. Izumida, H. Shimano, N. Yahagi, 2018, FEBS letters.

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

Hitoshi Shimano, Mayumi Ishikawa, Takashi Matsuzaka, 2007, Nature Medicine.

Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity

Hui Zhao, H. Sone, H. Shimano, 2017, Diabetes.

Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr−/− mouse model

T. Fujimura, R. Matsumori, H. Sone, 2015, Scientific Reports.

Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.

H. Sone, H. Shimano, N. Yahagi, 2014, Endocrinology.

National Cholesterol Awareness Month Article Macrophage Elovl 6 Deficiency Ameliorates Foam Cell Formation and Reduces Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

R. Matsumori, H. Sone, H. Shimano, 2011 .

Identification of human ELOVL5 enhancer regions controlled by SREBP.

Y. Izumida, H. Shimano, N. Yahagi, 2015, Biochemical and biophysical research communications.

Cyclin-dependent Kinase Inhibitor, p21WAF1/CIP1, Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to Obesity, and Insulin Resistance*

Hitoshi Shimano, Mayumi Ishikawa, Takashi Matsuzaka, 2008, Journal of Biological Chemistry.

Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells.

H. Shimano, N. Yahagi, N. Yamada, 2012, Biochemical and biophysical research communications.

An Exploratory Randomized Crossover Trial to Investigate the Palatability of Partially Abraded Brown Rice

Y. Nakata, Hiroaki Suzuki, K. Hashimoto, 2016 .

Cerebral hemorrhagic infarction after radiation for pituitary adenoma.

H. Sone, H. Shimano, N. Yamada, 2002, Internal medicine.

The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice.

N. Aoki, H. Shimano, N. Yahagi, 2009, Biochemical and biophysical research communications.

Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery stenosis in patients with asymptomatic type 2 diabetes

A. Sato, K. Fujihara, H. Sone, 2014, Journal of atherosclerosis and thrombosis.

WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney.

H. Sone, H. Shimano, N. Yamada, 2004, Biochemical and biophysical research communications.

Myocardial dysfunction identified by three-dimensional speckle tracking echocardiography in type 2 diabetes patients relates to complications of microangiopathy.

K. Aonuma, Y. Seo, T. Ishizu, 2016, Journal of cardiology.

A Rare Coexistence of Pheochromocytoma and Parkinson's Disease With Diagnostic Challenges

H. Shimano, K. Takekoshi, Hiroaki Suzuki, 2017, Internal medicine.

PPARγ ligands, troglitazone and pioglitazone, up‐regulate expression of HMG‐CoA synthase and HMG‐CoA reductase gene in THP‐1 macrophages

H. Sone, H. Shimano, N. Yamada, 2002 .

Different impacts of metabolic profiles on future risk of cardiovascular disease between diabetes with and without established cardiovascular disease: the Japan diabetes complication and its prevention prospective study 7 (JDCP study 7)

Y. Yamasaki, N. Tajima, Y. Hayashino, 2021, Acta Diabetologica.

Subendocardial Systolic Dysfunction in Asymptomatic Normotensive Diabetic Patients.

K. Aonuma, H. Shimano, Y. Seo, 2015, Circulation journal : official journal of the Japanese Circulation Society.

Effect of biological factors on successful measurements with skeletal-muscle 1H-MRS

T. Isobe, Hiroaki Suzuki, Y. Okamoto, 2016, Therapeutics and clinical risk management.

Type 1 diabetes mellitus associated with Graves' disease and Vogt-Koyanagi-Harada syndrome.

Hiroaki Suzuki, M. Isaka, Seiji Suzuki, 2008, Internal medicine.

The Possibility of Suppression of Increased Postprandial Blood Glucose Levels by Gamma-Polyglutamic Acid-Rich Natto in the Early Phase after Eating: A Randomized Crossover Pilot Study

K. Maruo, Hiroaki Suzuki, K. Hashimoto, 2020, Nutrients.

Gamma-Polyglutamic Acid-Rich Natto Suppresses Postprandial Blood Glucose Response in the Early Phase after Meals: A Randomized Crossover Study

Akihiro Araki, K. Maruo, Hiroaki Suzuki, 2020, Nutrients.

Relationships between Cognitive Function and Odor Identification, Balance Capability, and Muscle Strength in Middle-Aged Persons with and without Type 2 Diabetes

H. Shimano, K. Nemoto, Yasushi Hada, 2021, Journal of diabetes research.

Background to discuss guidelines for control of plasma HDL-cholesterol in Japan.

S. Yamashita, H. Sone, H. Arai, 2012, Journal of atherosclerosis and thrombosis.

Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1.

H. Shimano, N. Yahagi, T. Matsuzaka, 2019, Biochemical and biophysical research communications.

Selective peroxisome proliferator‐activated receptor‐α modulator K‐877 efficiently activates the peroxisome proliferator‐activated receptor‐α pathway and improves lipid metabolism in mice

H. Shimano, N. Yahagi, N. Yamada, 2017, Journal of diabetes investigation.

Physiological changes in circulating mannose levels in normal, glucose-intolerant, and diabetic subjects.

Hitoshi Shimano, Yuichi Noguchi, Hirohito Sone, 2003, Metabolism: clinical and experimental.

Logistic regression analysis for identifying the factors affecting development of non-invasive blood glucose calibration model by near-infrared spectroscopy

Yoshio Nakata, Hitoshi Shimano, Akifumi Ikehata, 2015 .

The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha.

H. Shimano, N. Yamada, T. Matsuzaka, 2010, Biochemical and biophysical research communications.

Deciphering genetic signatures by whole exome sequencing in a case of co-prevalence of severe renal hypouricemia and diabetes with impaired insulin secretion

H. Shimano, N. Yahagi, Hiroaki Suzuki, 2020, BMC Medical Genetics.

SPARC is a major secretory gene expressed and involved in the development of proliferative diabetic retinopathy.

H. Shimano, N. Yamada, H. Toyoshima, 2009, Journal of atherosclerosis and thrombosis.

Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function.

N. Yahagi, T. Matsuzaka, H. Ohno, 2023, Cell Reports.

Takotsubo cardiomyopathy with left ventricle thrombus caused by subacute thyroiditis

Daichi Yamazaki, Hiroaki Suzuki, Yoshinori Osaki, 2023, BMJ Case Reports.

L-Asparaginase-Induced Continuous Hyperglycemia With Type 1 Diabetes-Related Antibodies and HLA Genotypes: A Case Study

Hiroaki Suzuki, H. Iwasaki, Motohiro Sekiya, 2022, Cureus.

Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system

Satoru Takahashi, H. Sone, H. Shimano, 2016, Scientific Reports.

Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity

N. Yahagi, T. Matsuzaka, Kenji Saito, 2023, The Journal of biological chemistry.

Changes in skeletal muscle diffusion parameters owing to intramyocellular lipid.

T. Sakae, T. Isobe, Hiroaki Suzuki, 2020, Magnetic resonance imaging.

R46Q mutation in the succinate dehydrogenase B gene (SDHB) in a Japanese family with both abdominal and thoracic paraganglioma following metastasis.

N. Yamada, K. Takekoshi, Hiroaki Suzuki, 2008, Endocrine journal.

Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion.

H. Shimano, N. Yahagi, N. Yamada, 2009, Biochemical and biophysical research communications.

Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis.

H. Sone, N. Yahagi, T. Matsuzaka, 2023, BBA advances.