V. Molteni

发表

The nuclear receptor LXR is a glucose sensor

N. Mitro, A. Kreusch, Leo Vargas, 2007, Nature.

(R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors.

Nanxin Li, Jennifer L. Harris, Jianwei Che, 2015, ACS medicinal chemistry letters.

TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts

Nanxin Li, G. Brodeur, W. P. Gordon, 2014, Cancer Chemotherapy and Pharmacology.

Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.

Nanxin Li, A. Kreusch, Shenlin Huang, 2012, ACS medicinal chemistry letters.

Liver X receptor modulators: a review of recently patented compounds (2007 – 2009)

V. Molteni, V. Yeh, Xiaolin Li, 2010, Expert opinion on therapeutic patents.

Lead Identification to Clinical Candidate Selection

F. Supek, J. Gut, A. Renslo, 2015, Journal of biomolecular screening.

A new class of HIV-1 integrase inhibitors: the 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol family.

F. Bushman, K. Rubins, J. Siegel, 2000, Journal of medicinal chemistry.

One-Pot Electrochemical Nickel-Catalyzed Decarboxylative Sp2-Sp3 Cross-Coupling.

A. Herath, V. Molteni, Takaoki Koyanagi, 2019, Organic letters.

Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis (NASH).

I. Sancho-Martinez, P. McNamara, S. Joseph, 2020, Journal of medicinal chemistry.

Nidufexor, a non-bile acid FXR agonist, decreases ALT and hepatic fat fraction in patients with NASH after 12 weeks dosing

C. Ukomadu, M. Martic, V. Molteni, 2020, Journal of Hepatology.

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).

P. McNamara, S. Joseph, B. Laffitte, 2017, Journal of medicinal chemistry.

Identification of novel potent bicyclic peptide deformylase inhibitors.

A. Kreusch, T. Shin, B. Bursulaya, 2004, Bioorganic & medicinal chemistry letters.

High prevalence of hepatitis C virus type 1b in Italian patients with Porphyria cutanea tarda.

M. Mattioli, S. Fargion, A. Fracanzani, 1997, Italian journal of gastroenterology and hepatology.

Generation and Cross-Coupling of Organozinc Reagents in Flow.

A. Herath, V. Molteni, Shifeng Pan, 2018, Organic letters.

Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis.

F. Supek, M. Gelb, F. Buckner, 2014, Journal of medicinal chemistry.

Peptide deformylase inhibitors: a survey of the patent literature

A. Kreusch, V. Molteni, 2005 .

Discovery of 5-(3,4-Difluorophenyl)-3-(pyrazol-4-yl)-7-azaindole (GNF3809) for β-Cell Survival in Type 1 Diabetes

Matthew S. Tremblay, Shanshan Yan, B. Laffitte, 2019, ACS Omega.

Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis

F. Supek, M. Gelb, F. Buckner, 2014, Chemical reviews.

Optically Active Aminoalcohol Promoted Addition of 2-Pyridylthioester Boron Enolates to Imines: Enantioselective One-pot Synthesis of β-Lactams

L. Raimondi, M. Benaglia, F. Cozzi, 1995 .

Aqueous One-Pot Synthesis of Pyrazoles, Pyrimidines and Isoxazoles Promoted by Microwave Irradiation

A. Termin, V. Molteni, Dean M. Wilson, 2002 .

Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133.

H. M. Petrassi, P. McNamara, Minhua Qiu, 2020, Journal of medicinal chemistry.

Conformationally constrained dipeptides: Synthesis of 7,5- and 6,5-fused bicyclic lactams by stereoselective radical cyclizations

L. Belvisi, V. Molteni, L. Manzoni, 1995 .

Soluble polymer-supported synthesis of imines and β-lactams

M. Benaglia, F. Cozzi, M. Cinquini, 1998 .

Stereoselective one-pot synthesis of β-lactams by reaction of 2-pyridylthioesters with imines in the presence of AlBr3 or EtAlCl2

M. Benaglia, F. Cozzi, M. Cinquini, 1996 .

Stereoselective one-pot synthesis of β-lactams by Lewis acid promoted condensation of silylketene thioacetals with imines

F. Cozzi, M. Cinquini, R. Annunziata, 1996 .

A NEW MULTICOMPONENT SYNTHESIS OF 1,2,3,4-TETRAHYDROQUINOLINES

F. Cozzi, M. Cinquini, R. Annunziata, 1997 .

Yb(OTf)(3)-Catalyzed One-Pot Synthesis of beta-Lactams from Silyl Ketene Thioacetals by a Two- or a Three-Component Reaction.

F. Cozzi, M. Cinquini, R. Annunziata, 1996, The Journal of organic chemistry.

Arylamidrazones as novel corticotropin releasing factor receptor antagonists.

P. Grootenhuis, A. Termin, M. Ramirez-Weinhouse, 2002, Journal of medicinal chemistry.

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

Glen Spraggon, Badry Bursulaya, Todd Groessl, 2016, Nature.

Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases

F. Supek, D. Caridha, Yen-Liang Chen, 2020, Journal of medicinal chemistry.

Integration complexes derived from HIV vectors for rapid assays in vitro

F. Bushman, T. Kafri, J. Siegel, 1999, Nature Biotechnology.

Efficacy and Tolerability of Pyrazolo[1,5-a]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma.

Nanxin Li, J. Shaffer, S. Kasibhatla, 2020, ACS medicinal chemistry letters.

Liver X receptor modulators: a review of recently patented compounds (2009 – 2012)

B. Laffitte, Zhihong Huang, V. Molteni, 2013, Expert opinion on therapeutic patents.

Tropifexor‐Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents

P. McNamara, W. Dietrich, J. Walker, 2019, Hepatology communications.

Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease

F. Supek, R. Glynne, B. Wen, 2015, Antimicrobial Agents and Chemotherapy.

Plaque control and halitosis management using a two-phase mouthwash. A study on healthy volunteers

V. Molteni, E. Corti, M. Piacentini, 2020 .

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease

F. Supek, M. Phillips, M. Arkin, 2015, PLoS pathogens.

Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis

F. Supek, M. Barrett, J. Mottram, 2020, Tropical medicine and infectious disease.

Optimization of Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for Duration of Action, as an Inhaled Therapy for Lung Remodeling in Pulmonary Arterial Hypertension.

P. Furet, I. Konstantinova, A. Saunders, 2016, Journal of medicinal chemistry.

Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain.

F. Bushman, W. Kwiatkowski, S. Choe, 2001, Acta crystallographica. Section D, Biological crystallography.

N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta.

Peter Tontonoz, Tove Tuntland, Ansgar Brock, 2007, Journal of medicinal chemistry.

N-phenylphenylglycines as novel corticotropin releasing factor receptor antagonists.

J. Penzotti, P. Grootenhuis, H. Wong, 2004, Journal of medicinal chemistry.

TATA-box mutant in the promoter of the uridine diphosphate glucuronosyltransferase gene in Italian patients with Gilbert's syndrome.

R. Romano, V. Molteni, G. Fiorelli, 1998, Italian journal of gastroenterology and hepatology.

Double-blind trial of pirenzepine versus sucralfate in the treatment of endoscopic duodenitis.

V. Molteni, M. Guslandi, E. Ballarín, 1990, Clinical therapeutics.

A Dual Inhibitor of DYRK1A and GSK3β for β-Cell Proliferation: Aminopyrazine Derivative GNF4877.

P. McNamara, G. Harb, Shanshan Yan, 2020, ChemMedChem.

Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3-d]pyrimidine RET Inhibitors.

Nanxin Li, J. Shaffer, S. Kasibhatla, 2021, ACS medicinal chemistry letters.