Oliver Poeschke

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease

Gary Box, Julian Blagg, Paul Workman, 2015, Nature chemical biology.

2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19

F. Rohdich, P. Workman, D. Musil, 2016, ACS medicinal chemistry letters.

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19

Julian Blagg, Paul Workman, Florence I. Raynaud, 2016, Journal of medicinal chemistry.

Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen

F. Rohdich, T. Dale, P. Workman, 2015, Journal of medicinal chemistry.

Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore.

Julian Blagg, Djordje Musil, Paul Czodrowski, 2016, Bioorganic & medicinal chemistry letters.

A Microfluidic 3D Endothelium-on-a-Chip Model to Study Transendothelial Migration of T Cells in Health and Disease

Lenie J. van den Broek, E. Petrova, J. Suijker, 2021, International journal of molecular sciences.

Abstract 3499: M1069 as dual A2A/A2B adenosine receptor antagonist counteracts immune-suppressive mechanisms of adenosine and reduces tumor growth in vivo

B. Huck, E. Petrova, A. Matevossian, 2022, Cancer Research.