G. Offerhaus

发表

The morphogenetic code and colon cancer development.

G. R. van den Brink, G. Offerhaus, Gijs R van den Brink, 2007, Cancer cell.

Depletion of the colonic epithelial precursor cell compartment upon conditional activation of the hedgehog pathway.

G. Boeckxstaens, D. Hommes, G. R. van den Brink, 2008, Gastroenterology.

De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine

Hans Clevers, Harry Begthel, H. Clevers, 2004, Science.

Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon.

J. Keller, M. Peppelenbosch, G. R. van den Brink, 2003, Gastroenterology.

Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

D. Hommes, J. Hoogenboom, H. Morreau, 2014, Gastroenterology.

Evaluation of the prognostic value of pSMAD immunohistochemistry in colorectal cancer

H. Morreau, C. V. van Noesel, N. D. de Miranda, 2013, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus

M. Kasper, D. Hommes, H. Verspaget, 2012, Gut.

Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice.

G. D'Haens, J. Medema, F. D. de Sauvage, 2015, Gastroenterology.

Stromal Indian Hedgehog Signaling Is Required for Adenoma Formation in Mice 67 68 69 70 71 72 73 74 75 76 77 78 79

J. Medema, F. Sauvage, M. Jansen, 2014 .

The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer

D. Hommes, H. Verspaget, G. R. van den Brink, 2010, Carcinogenesis.

Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation

William Gaffield, D. Roberts, S. Deventer, 2004, Nature Genetics.

NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps

S. Deventer, M. Peppelenbosch, G. R. van den Brink, 2001, Oncogene.

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

E. Cuppen, H. Clevers, O. Sansom, 2017, Proceedings of the National Academy of Sciences.

Sequential cancer mutations in cultured human intestinal stem cells

Hans Clevers, Edwin Cuppen, Geert J. P. L. Kops, 2015, Nature.

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

P. Borst, A. Berns, A. Groen, 1993, Cell.

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research

Hans Clevers, Johan H van Es, Harry Begthel, 2016, Proceedings of the National Academy of Sciences.

Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice.

Xi C. He, Linheng Li, D. Hommes, 2007, Cancer research.

The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer

D. Hommes, M. Peppelenbosch, G. R. van den Brink, 2008, Cancer.

Leptin is a growth factor for colonic epithelial cells.

S. Deventer, M. Peppelenbosch, J. C. Hardwick, 2001, Gastroenterology.

Indiann Hedgehog is a novel regulator of colonic epitheliall differentiation

D. Roberts, S. Deventer, J. Keller, 2007 .

Adenomatous polyposis coli‐deficient zebrafish are susceptible to digestive tract neoplasia

Hans C Clevers, Adam Hurlstone, Harry Begthel, 2006, EMBO reports.

Long‐term expanding human airway organoids for disease modeling

A. Oudenaarden, S. Tans, A. van Oudenaarden, 2019, The EMBO journal.

The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers.

D. Hommes, E. Dekker, H. Morreau, 2008, Gastroenterology.

LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.

H. Clevers, M. Jansen, G. Offerhaus, 2009, Physiological reviews.

Timing and sequence of differentiation of embryonic rat hepatocytes along the biliary epithelial lineage

C. Reutelingsperger, R. Willemsen, W. Lamers, 2003, Hepatology.

LKB 1 and AMPK Family Signaling : The Intimate Link Between Cell Polarity and Energy Metabolism

H. Clevers, M. Jansen, G. Offerhaus, 2009 .

Grading gastrointestinal dysplasia and what to call it when you don't know what it is

G. Offerhaus, 2007, The Journal of pathology.

Direct visualization of Smad1/5/8‐mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys

C. Mummery, R. Goldschmeding, S. M. Chuva de Sousa Lopes, 2011, The Journal of pathology.

Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine.

W. D. de Jonge, D. Hommes, B. Lanske, 2010, Gastroenterology.

Bone morphogenetic protein signalling in colorectal cancer

G. R. van den Brink, J. C. Hardwick, J. Hardwick, 2008, Nature Reviews Cancer.

Effects of Ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene.

G. Tytgat, A. Groen, G. Offerhaus, 1996, Gastroenterology.

No evidence for functional inactivation of wild‐type p53 protein by MDM2 overexpression in gastric carcinogenesis

P. Blok, G. Offerhaus, G. Offerhaus, 1998, The Journal of pathology.

Inhibition of angiogenesis and HGF-cMET-elicited malignant processes in human hepatocellular carcinoma cells using adenoviral vector-mediated NK4 gene therapy

C. Meijer, P. Snijders, W. Lamers, 2005, Cancer Gene Therapy.