P. Sivaprakasam

发表

Pharmacophore Modeling, Ensemble Docking, Virtual Screening, and Biological Evaluation on Glycogen Synthase Kinase‐3β

Gang Fu, R. J. Doerksen, S. Cutler, 2014, Molecular informatics.

Probing the physicochemical and structural requirements for glycogen synthase kinase-3alpha inhibition: 2D-QSAR for 3-anilino-4-phenylmaleimides.

R. J. Doerksen, A. Xie, P. Sivaprakasam, 2006, Bioorganic & medicinal chemistry.

Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action

N. Meanwell, D. Langley, M. Krystal, 2014, Proteins.

Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates.

A. Mathur, B. Warrack, A. Rajpal, 2020, Journal of medicinal chemistry.

Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors.

K. Kish, N. Meanwell, M. Krystal, 2022, Bioorganic & medicinal chemistry.

Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.

K. Kish, N. Meanwell, C. Cianci, 2022, ACS medicinal chemistry letters.

Przewalskinone-B from the Stem Bark of Ochna obtusata.

P. Sivaprakasam, E. Sukumar, V. Vijayasekaran, 1998 .

Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.

J. Macor, K. Kish, E. Baldwin, 2015, Bioorganic & medicinal chemistry letters.

Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors.

J. Macor, K. Kish, V. Arora, 2016, Journal of medicinal chemistry.

Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.

K. Kish, G. Trainor, N. Meanwell, 2020, Journal of medicinal chemistry.

Synthesis, structure-activity relationship studies and evaluation of a TLR 3/8/9 agonist and its analogues

D. Boger, J. Naglich, Anindya Sarkar, 2021, Medicinal Chemistry Research.

Uncialamycin as a novel payload for antibody drug conjugate (ADC) based targeted cancer therapy.

D. Langley, Yichong Wang, P. Sivaprakasam, 2019, Bioorganic & medicinal chemistry letters.

Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT₆ antagonists.

D. Langley, R. Westphal, P. Sivaprakasam, 2014, Bioorganic & medicinal chemistry.

Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-b]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) Inhibitors.

Vijay T. Ahuja, J. Macor, K. Kish, 2023, Journal of medicinal chemistry.

DNA-Model-Based Design and Execution of Some Fused Benzodiazepine Hybrid Payloads for Antibody-Drug Conjugate Modality.

Martin D. Eastgate, D. Langley, I. Mcdonald, 2021, ACS medicinal chemistry letters.

Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase.

Stephen R. Johnson, N. Meanwell, D. Langley, 2020, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs.

K. Kish, N. Meanwell, H. Lewis, 2022, Journal of medicinal chemistry.

Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors.

Vijay T. Ahuja, J. Tokarski, J. Macor, 2023, Journal of medicinal chemistry.

Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.

Murugaiah A. M. Subbaiah, G. Schieven, A. Mathur, 2024, ACS medicinal chemistry letters.

Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology.

G. Schieven, A. Mathur, D. Critton, 2024, ACS medicinal chemistry letters.