Matthäus Getlik

发表

Proteus in the World of Proteins: Conformational Changes in Protein Kinases

Daniel Rauh, D. Rauh, Matthäus Getlik, 2010, Archiv der Pharmazie.

Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).

G. Poda, C. Arrowsmith, M. Schapira, 2016, Journal of medicinal chemistry.

Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma

Roman K. Thomas, G. Kéri, M. Peifer, 2017, Cell reports.

Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis.

Tiffany L. Kinnibrugh, S. Renner, S. Rogelj, 2011, Journal of medicinal chemistry.

Displacement assay for the detection of stabilizers of inactive kinase conformations.

C. Grütter, D. Rauh, M. Rabiller, 2010, Journal of Medicinal Chemistry.

An Unusual Intramolecular Halogen Bond Guides Conformational Selection.

M. E. Beck, M. D. Polêto, F. Ferreira, 2018, Angewandte Chemie.

Rearrangement of 4-amino-3-halo-pyridines by nucleophilic aromatic substitution.

R. Al-awar, I. D. Watson, Matthäus Getlik, 2013, The Journal of organic chemistry.

Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc.

C. Grütter, D. Rauh, M. Rabiller, 2009, Journal of medicinal chemistry.

Chemogenomic profiling provides insights into the limited activity of irreversible EGFR Inhibitors in tumor cells expressing the T790M EGFR resistance mutation.

Martin Peifer, Daniel Rauh, Lars Ruddigkeit, 2010, Cancer research.

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

William Pao, Thomas Zander, Martin Peifer, 2009, Proceedings of the National Academy of Sciences.

Prevalent p53 mutants co-opt chromatin pathways to drive cancer growth

Cheryl H. Arrowsmith, Greg Donahue, Ali Shilatifard, 2015, Nature.

Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.

Daniel Rauh, Jeffrey R. Simard, C. Grütter, 2009, Journal of the American Chemical Society.

Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction.

G. Poda, C. Arrowsmith, M. Schapira, 2013, ACS medicinal chemistry letters.

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

G. Poda, G. Superti-Furga, K. Bennett, 2015, Nature chemical biology.

Structure-based design, synthesis and biological evaluation of N-pyrazole, N'-thiazole urea inhibitors of MAP kinase p38α.

H. Nguyen, W. V. van Otterlo, C. Grütter, 2012, European journal of medicinal chemistry.

Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations.

C. Grütter, D. Rauh, Matthäus Getlik, 2010, Journal of the American Chemical Society.

A new screening assay for allosteric inhibitors of cSrc.

Daniel Rauh, C. Grütter, D. Rauh, 2009, Nature chemical biology.

Targeting gain of function and resistance mutations in Abl and KIT by hybrid compound design.

Roman K. Thomas, M. Sos, Anu Gupta, 2013, Journal of medicinal chemistry.

Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.

Jochen Heil, Franziska Hoffgaard, Julian Engel, 2015, Journal of medicinal chemistry.

Fluorophore Labeled Kinase Detects Ligands That Bind within the MAPK Insert of p38α Kinase

W. V. van Otterlo, C. Grütter, D. Rauh, 2012, PloS one.

Direct binding assay for the detection of type IV allosteric inhibitors of Abl.

P. Janning, D. Rauh, Matthäus Getlik, 2012, Journal of the American Chemical Society.

Targeting GSK3 from Ustilago maydis: type-II kinase inhibitors as potential antifungals.

M. E. Beck, P. Schreier, J. Pérez-Martín, 2012, ACS chemical biology.

Direct binding assay for the detection of type IV allosteric inhibitors of Abl.

P. Janning, D. Rauh, Matthäus Getlik, 2012, Journal of the American Chemical Society.

A new screening assay for allosteric inhibitors of cSrc.

C. Grütter, D. Rauh, M. Rabiller, 2009, Nature chemical biology.