Pascal D. Fortin

发表

High-Throughput Screening Identifies Inhibitors of the SARS Coronavirus Main Proteinase

Eric D. Brown, Nadine H. Elowe, Jan E. Blanchard, 2004, Chemistry & Biology.

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ping Zhu, Gang Liu, Peter Fekkes, 2016, Nature.

A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines

C. Walsh, N. Magarvey, Pascal D. Fortin, 2007, Nature.

Andrimid producers encode an acetyl-CoA carboxyltransferase subunit resistant to the action of the antibiotic

C. Walsh, Xinyu Liu, Pascal D. Fortin, 2008, Proceedings of the National Academy of Sciences.

Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity.

D. Sage, R. Pagliarini, Pascal D. Fortin, 2017, Structure.

Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1.

Michael D. Jones, B. Firestone, R. Pagliarini, 2017, ACS medicinal chemistry letters.

Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro.

J. Vederas, D. Wishart, M. James, 2004, Journal of medicinal chemistry.

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.

Sarah L. Williams, W. Sellers, Z. Deng, 2020, Journal of medicinal chemistry.

Supplemental Information Allosteric Mutant IDH 1 Inhibitors Reveal Mechanisms for IDH 1 Mutant and Isoform Selectivity

Pascal D. Fortin, D. Baird, H. Yin, 2017 .

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.

Sarah L. Williams, W. Sellers, F. Lombardo, 2016, Journal of medicinal chemistry.

Structures of Ternary Complexes of BphK, a Bacterial Glutathione S-Transferase That Reductively Dechlorinates Polychlorinated Biphenyl Metabolites*

M. Murphy, E. Tocheva, L. Eltis, 2006, Journal of Biological Chemistry.

The Mechanism-based Inactivation of 2,3-Dihydroxybiphenyl 1,2-Dioxygenase by Catecholic Substrates*

L. Eltis, Pascal D. Fortin, G. Labbé, 2002, The Journal of Biological Chemistry.

A Glutathione S-Transferase Catalyzes the Dehalogenation of Inhibitory Metabolites of Polychlorinated Biphenyls

L. Eltis, Geoff P. Horsman, Pascal D. Fortin, 2006, Journal of bacteriology.

Directed Evolution of a Ring-cleaving Dioxygenase for Polychlorinated Biphenyl Degradation*

J. Bolin, L. Eltis, Pascal D. Fortin, 2005, Journal of Biological Chemistry.

Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.

Xiang Xu, S. Blacklow, R. Chopra, 2016, Biochemistry.

In-Depth Characterization and Validation in BRG1-Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling

Joshua M. Korn, W. Sellers, J. Korn, 2019, bioRxiv.

The novolactone natural product disrupts the allosteric regulation of Hsp70.

Roman Kityk, M. Mayer, R. Riedl, 2015, Chemistry & biology.

Enzyme-dependent lysine deprotonation in EZH2 catalysis.

Pascal D. Fortin, C. Quinn, D. R. Kipp, 2013, Biochemistry.

Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor.

D. Chin, B. Lagu, B. Firestone, 2013, Journal of medicinal chemistry.

Molecular basis for the substrate selectivity of bicyclic and monocyclic extradiol dioxygenases.

N. Agar, L. Eltis, Pascal D. Fortin, 2005, Biochemical and biophysical research communications.

Molecular Basis for the Stabilization and Inhibition of 2,3-Dihydroxybiphenyl 1,2-Dioxygenase by t-Butanol*

J. Bolin, L. Eltis, Seungil Han, 1998, The Journal of Biological Chemistry.

beta-Hydroxylation of the aspartyl residue in the phytotoxin syringomycin E: characterization of two candidate hydroxylases AspH and SyrP in Pseudomonas syringae.

C. Walsh, Gitanjali M Singh, Pascal D. Fortin, 2008, Biochemistry.

Evolutionarily Divergent Extradiol Dioxygenases Possess Higher Specificities for Polychlorinated Biphenyl Metabolites

L. Eltis, W. Reineke, S. Kaschabek, 2005, Journal of bacteriology.

Characterization of a C—C Bond Hydrolase from Sphingomonas wittichii RW1 with Novel Specificities towards Polychlorinated Biphenyl Metabolites

S. Seah, C. Whiting, L. Eltis, 2007, Journal of bacteriology.

Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line.

N. Kelleher, C. Walsh, P. Thomas, 2008, ACS chemical biology.

FenF: Servicing the Mycosubtilin Synthetase Assembly Line in trans

Christopher T Walsh, C. Walsh, C. Calderone, 2007, Chembiochem : a European journal of chemical biology.

[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.

D. Chin, W. Shao, Yun Feng, 2012, Journal of medicinal chemistry.

Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases.

D. Chin, W. Shao, Yun Feng, 2013, Journal of medicinal chemistry.

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.

Sarah L. Williams, W. Sellers, F. Lombardo, 2016, Journal of medicinal chemistry.