B. Cox

发表

Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI

Jill M. Wetter, G. Fox, Chih-Liang Chin, 2008, British journal of pharmacology.

Utility of hERG Assays as Surrogate Markers of Delayed Cardiac Repolarization and QT Safety

Gary A Gintant, Zhi Su, G. Gintant, 2006, Toxicologic pathology.

Block of hERG channel by ziprasidone: biophysical properties and molecular determinants.

G. Gintant, M. Gopalakrishnan, Ruth L. Martin, 2006, Biochemical pharmacology.

Predictive, non-GLP models of secondary pharmacodynamics: putting the best compounds forward.

G. Gintant, R. Fryer, B. Cox, 2005, Current opinion in chemical biology.

Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers.

G. Gintant, G. Diaz, Ruth L. Martin, 2012, Life sciences.

Mesoridazine: an open-channel blocker of human ether-a-go-go-related gene K+ channel.

G. Gintant, Ruth L. Martin, B. Cox, 2004, Journal of molecular and cellular cardiology.

Tumor selective antivascular effects of the novel antimitotic compound ABT-751: an in vivo rat regional hemodynamic study

J. Segreti, S. Rosenberg, H. Sham, 2004, Cancer Chemotherapy and Pharmacology.

Potentiation of Temozolomide Cytotoxicity by Poly(ADP)Ribose Polymerase Inhibitor ABT-888 Requires a Conversion of Single-Stranded DNA Damages to Double-Stranded DNA Breaks

Eric F. Johnson, X. Liu, V. Giranda, 2008, Molecular Cancer Research.

Importance of Species Selection in Arrythmogenic Models of Q-T Interval Prolongation

G. Gintant, B. Cox, J. Mcdermott, 2002, Antimicrobial Agents and Chemotherapy.

Pharmacological characterization of AMP 579, a novel adenosine A1/A2 receptor agonist and cardioprotective

A. Spada, K. Clark, M. Jarvis, 1998 .

Regional hemodynamic dose-response of lemakalim and glybenclamide in anesthetized rats.

B. Cox, M. Perrone, G. Smits, 1997, Journal of cardiovascular pharmacology.

Preischemic and Postischemic Administration of AEOL10113 Reduces Infarct Size in a Rat Model of Myocardial Ischemia and Reperfusion

J. Crapo, C. Wegner, B. Cox, 2003, Journal of cardiovascular pharmacology.

Ischaemia/reperfusion selectively attenuates coronary vasodilatation to an adenosine A2‐ but not to an A1‐agonist in the dog

B. Cox, M. Perrone, L. Merkel, 1994, British journal of pharmacology.

Hypertension induced by blockade of ET(B) receptors in conscious nonhuman primates: role of ET(A) receptors.

C. Wegner, B. Cox, G. Reinhart, 2002, American journal of physiology. Heart and circulatory physiology.

Evidence for vasoconstriction mediated by the endothelin-B receptor in domestic swine.

C. Wegner, B. Cox, S. Burke, 2000, Journal of cardiovascular pharmacology.

Vitamin D Receptor Activation Mitigates the Impact of Uremia on Endothelial Function in the 5/6 Nephrectomized Rats

M. Nakane, J. Segreti, J. R. Wu-wong, 2010, International journal of endocrinology.

Distinct spatiotemporal pattern of CNS lesions revealed by USPIO-enhanced MRI in MOG-induced EAE rats implicates the involvement of spino-olivocerebellar pathways

G. Fox, Chih-Liang Chin, P. Bousquet, 2009, Journal of Neuroimmunology.

Cardiovascular and antilipolytic effects of the adenosine agonist GR79236.

D. Colussi, B. Cox, M. Perrone, 1995, Pharmacology.

Cardiovascular and metabolic effects of adenosine A1-receptor agonists in streptozotocin-treated rats.

K. Clark, D. Colussi, B. Cox, 1997, Journal of cardiovascular pharmacology.

Diacylglycerol Acyltransferase 1 Inhibition Lowers Serum Triglycerides in the Zucker Fatty Rat and the Hyperlipidemic Hamster

A. Souers, J. Segreti, A. King, 2009, Journal of Pharmacology and Experimental Therapeutics.

Pharmacological MRI in awake rats predicts selective binding of α4β2 nicotinic receptors

G. Fox, Chih-Liang Chin, J. R. Pauly, 2008 .

Demonstration of vasorelaxant activity with an A1-selective adenosine agonist in porcine coronary artery: involvement of potassium channels.

B. Cox, R. Lappe, M. Perrone, 1992, The Journal of pharmacology and experimental therapeutics.

(−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a Novel ATP-Sensitive Potassium Channel Opener: Hemodynamic Comparison to ZD-6169, WAY-133537, and Nifedipine in the Anesthetized Canine

R. Fryer, Yanhui Hu, M. Gopalakrishnan, 2004, Journal of cardiovascular pharmacology.

In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia.

A. Souers, J. Segreti, A. King, 2010, European journal of pharmacology.

A novel secretagogue increases cardiac contractility by enhancement of L-type Ca2+ current.

G. Gintant, G. Diaz, Ruth L. Martin, 2010, Biochemical pharmacology.

Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin‐mediated angioedema

J. Segreti, R. Fryer, J. Trevillyan, 2008, British journal of pharmacology.

An improved method of evaluation of drug-evoked changes in gastric emptying in mice.

G. Gintant, T. Seifert, B. Cox, 2002, Journal of pharmacological and toxicological methods.

Profile of Recombinant Pro-urokinase Given by Intraarterial versus Intravenous Routes of Administration in a Canine Thrombosis Model

C. Wegner, B. Cox, S. Burke, 1999, Thrombosis and Haemostasis.

Selective Adenosine-2 Agonist Produces Both Direct and Reflex Tachycardia in Normotensive Rats

B. Cox, R. Lappe, J. Sheldon, 1992, Journal of cardiovascular pharmacology.

Postischemic Administration of CGX-1051, a Peptide from Cone Snail Venom, Reduces Infarct Size in Both Rat and Dog Models of Myocardial Ischemia and Reperfusion

G. Gross, G. Bulaj, R. Layer, 2005, Journal of cardiovascular pharmacology.

Direct evidence for the role of neuropeptide Y in sympathetic nerve stimulation-induced vasoconstriction.

B. Cox, T. Westfall, L. Naes, 1998, American journal of physiology. Heart and circulatory physiology.

ABT-751, a novel tubulin-binding agent, decreases tumor perfusion and disrupts tumor vasculature

G. Gordon, S. Rosenberg, G. Fox, 2009, Anti-cancer drugs.

ETA Receptor Blockade With Atrasentan Prevents Hypertension With the Multitargeted Tyrosine Kinase Inhibitor ABT-869 in Telemetry-instrumented Rats

S. Davidsen, G. Gintant, J. Segreti, 2009, Journal of cardiovascular pharmacology.

Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1.

Steven C. Cullen, P. Hajduk, A. Souers, 2012, Journal of medicinal chemistry.

Electrophysiologic characterization of a novel hERG channel activator.

G. Gintant, A. Souers, G. Diaz, 2009, Biochemical pharmacology.

Functional consequences of methionine oxidation of hERG potassium channels.

G. Gintant, S. Heinemann, R. Xu, 2007, Biochemical pharmacology.

ALTERING EXTRACELLULAR POTASSIUM CONCENTRATION DOES NOT MODULATE DRUG BLOCK OF HUMAN ETHER‐A‐GO‐GO‐RELATED GENE (hERG) CHANNELS

G. Gintant, Ruth L. Martin, B. Cox, 2006, Clinical and experimental pharmacology & physiology.

Hydroxypropyl β-Cyclodextrins: A Misleading Vehicle for the In Vitro hERG Current Assay

G. Gintant, Ruth L. Martin, M. Long, 2007, Journal of cardiovascular pharmacology.

Differential effects of the adenosine A1 receptor allosteric enhancer PD 81,723 on agonist binding to brain and adipocyte membranes

M. Jarvis, B. Cox, G. Martin, 1999, Brain Research.

Blood pressure regulation by ETA and ETB receptors in conscious, telemetry-instrumented mice and role of ETA in hypertension produced by selective ETB blockade.

R. Fryer, B. Cox, G. Reinhart, 2006, American journal of physiology. Heart and circulatory physiology.

The Canine Purkinje Fiber: An In Vitro Model System for Acquired Long QT Syndrome and Drug-Induced Arrhythmogenesis

G. Gintant, C. Wegner, B. Cox, 2001, Journal of cardiovascular pharmacology.

The effects of plasma proteins on delayed repolarization in vitro with cisapride, risperidone, and D, L-sotalol.

G. Gintant, Ruth L. Martin, B. Cox, 2007, Journal of pharmacological and toxicological methods.

The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o.

Gary A Gintant, Zhi Su, G. Gintant, 2004, Journal of pharmacological and toxicological methods.

Pharmacological MRI in awake rats predicts selective binding of alpha4beta2 nicotinic receptors.

G. Fox, Chih-Liang Chin, J. R. Pauly, 2008, Synapse.

Dose–response effects of sotalol on cardiovascular function in conscious, freely moving cynomolgus monkeys

K. Marsh, J. J. Lynch, S. Mittelstadt, 2008, British journal of pharmacology.

Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets

M. Nakane, J. Brioni, R. Moreland, 2005, Pharmacology Biochemistry and Behavior.

Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O2 consumption in dogs.

R. Fryer, K. Marsh, B. Cox, 2008, American journal of physiology. Heart and circulatory physiology.

Role of Neuropeptide Y in Cold Stress-Induced Hypertension

B. Cox, T. Westfall, L. Naes, 1998, Peptides.

Angiotensin II-dependent hypertension and the arterial baroreflex.

Y. Nishida, B. Cox, V. S. Bishop, 1995, Clinical and experimental hypertension.

Endothelin and ET(A) receptors in long-term arterial pressure homeostasis in conscious nonhuman primates.

C. Wegner, B. Cox, G. Reinhart, 2000, American journal of physiology. Regulatory, integrative and comparative physiology.

ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders.

D. Donnelly-roberts, G. Gintant, J. Sullivan, 2006, CNS drug reviews.

Angiotensin subtype 1 blockade selectively potentiates adenosine subtype 2-mediated vasodilation.

B. Cox, M. Perrone, G. Smits, 1993, Hypertension.

ABT-888 , an OrallyActive Poly ( ADP-Ribose ) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in PreclinicalTumorModels

Eric F. Johnson, T. DeWeese, X. Liu, 2007 .

EFFECTS OF INTRAVENOUS ABT‐870 (IRON (III)‐HYDROXIDE OLIGOSACCHARIDE) ON MEAN ARTERIAL PRESSURE AND HEART RATE IN THE ANAESTHETIZED BEAGLE: COMPARISON WITH OTHER IRON‐CONTAINING HAEMATINIC AGENTS

R. Fryer, Yanhui Hu, J. Melnick, 2005, Clinical and experimental pharmacology & physiology.

A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat

T. Brennan, J. Sullivan, M. Williams, 2002, Proceedings of the National Academy of Sciences of the United States of America.

ABT-963 [2-(3,4-Difluoro-phenyl)-4-(3-hydroxy-3-methyl-butoxy)-5-(4-methanesulfonyl-phenyl)-2H-pyridazin-3-one], A Highly Potent and Selective Disubstituted Pyridazinone Cyclooxgenase-2 Inhibitor

G. Carter, S. Surapaneni, K. Marsh, 2004, Journal of Pharmacology and Experimental Therapeutics.

ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models

Eric F. Johnson, T. DeWeese, X. Liu, 2007, Clinical Cancer Research.

Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitor

Chih-Hung Lee, M. Jarvis, J. Mikusa, 2002, Pain.

Tumour‐selective antivascular effects of the novel anti‐mitotic compound A‐318315: An in vivo rat regional haemodynamic study

J. Segreti, S. Rosenberg, H. Sham, 2010, Clinical and experimental pharmacology & physiology.

Regional Delivery of CAR-T Effectively Controls Tumor Growth in Colorectal Liver Metastasis Model.

S. Katz, B. Cox, P. Guha, 2021, The Journal of surgical research.

Pharmacological Characterization of the Novel Dihydropyridine Potassium Channel Opener, (9R)-9-(3-Iodo-4-methylphenyl)-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione (A-325100), and the Regulation of Cardiovascular Function in Conscious and Anesthetized Beagle Dogs

C. Shieh, R. Fryer, M. Gopalakrishnan, 2005, Journal of cardiovascular pharmacology.

In vitro and in vivo characterization of an A1-selective adenosine agonist, RG14202.

D. Colussi, B. Cox, M. Perrone, 1993, The Journal of pharmacology and experimental therapeutics.

Translational neuroimaging of the CNS: novel pathways to drug development.

M. Day, F. Luo, G. Fox, 2009, Molecular interventions.

Regional Delivery of Anti-PD-1 Agent for Colorectal Liver Metastases Improves Therapeutic Index and Anti-Tumor Activity

S. Katz, B. Cox, P. Guha, 2021, Vaccines.

PII: S0304-3959(01)00435-3

Chih-Hung Lee, M. Jarvis, J. Mikusa, 2002 .

ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat.

A. Gomtsyan, E. Schweitzer, M. Williams, 2000, The Journal of pharmacology and experimental therapeutics.

In Vitro Preclinical Cardiac Assessment of Tolterodine and Terodiline: Multiple Factors Predict the Clinical Experience

Gary A Gintant, Zhi Su, G. Gintant, 2006, Journal of cardiovascular pharmacology.

Pressure-enabled delivery of gemcitabine in an orthotopic pancreatic cancer mouse model.

P. Ray, S. Katz, D. Vicente, 2020, Surgery.

Effect of the Multitargeted Receptor Tyrosine Kinase Inhibitor, ABT-869 [N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N′-(2-fluoro-5-methylphenyl)urea], on Blood Pressure in Conscious Rats and Mice: Reversal with Antihypertensive Agents and Effect on Tumor Growth Inhibition

S. Davidsen, G. Gintant, J. Segreti, 2009, Journal of Pharmacology and Experimental Therapeutics.

Neural and humoral mechanisms of angiotensin-dependent hypertension.

B. Cox, V. S. Bishop, Vernon S. Bishop, 1991, The American journal of physiology.

Tidal Volume Affects the Response to Inactivation of the Rostral Ventrolateral Medulla

M. Brody, B. Cox, B. F. Cox, 1988, Hypertension.

Regional infusion of a class C TLR9 agonist enhances liver tumor microenvironment reprogramming and MDSC reduction to improve responsiveness to systemic checkpoint inhibition

S. Katz, B. Cox, P. Guha, 2022, Cancer gene therapy.

Pharmacological MRI in awake rats reveals neural activity in area postrema and nucleus tractus solitarius: Relevance as a potential biomarker for detecting drug-induced emesis

Chih-Liang Chin, Gerard B. Fox, Vincent P. Hradil, 2006, NeuroImage.

K-ATP opener-mediated attenuation of spontaneous bladder contractions in ligature-intact, partial bladder outlet obstructed rats.

J. Sullivan, J. Brioni, J. J. Lynch, 2003, Life sciences.

Cardioprotective effects of the novel adenosine A1/A2 receptor agonist AMP 579 in a porcine model of myocardial infarction.

M. McVey, K. Clark, B. Cox, 1998, The Journal of pharmacology and experimental therapeutics.

A novel multi-targeted tyrosine kinase inhibitor, linifanib (ABT-869), produces functional and structural changes in tumor vasculature in an orthotopic rat glioma model

Gerard B. Fox, Vincent P. Hradil, Bryan F. Cox, 2012, Cancer Chemotherapy and Pharmacology.

Capsaicin-induced inhibition of platelet aggregation is not mediated by transient receptor potential vanilloid type 1

A. King, P. Kym, M. Kort, 2012, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Regional hemodynamic effects of purinergic P2 receptor subtype agonists in rats.

B. Cox, G. Smits, 1996, The Journal of pharmacology and experimental therapeutics.

The Utility of hERG and Repolarization Assays in Evaluating Delayed Cardiac Repolarization: Influence of Multi-Channel Block

Gary A Gintant, G. Gintant, Ruth L. Martin, 2004, Journal of cardiovascular pharmacology.

Evaluation of tissue perfusion in a rat model of hind‐limb muscle ischemia using dynamic contrast‐enhanced magnetic resonance imaging

J. Segreti, Yanping Luo, V. Hradil, 2002, Journal of magnetic resonance imaging : JMRI.

Computer-assisted imaging algorithms facilitate histomorphometric quantification of kidney damage in rodent renal failure models

Bryan F. Cox, Kelly J. Larson, E. Blomme, 2012, Journal of pathology informatics.

Cardiovascular Effects of Torcetrapib in Conscious and Pentobarbital-anesthetized Dogs

G. Gintant, A. King, K. Marsh, 2009, Journal of Cardiovascular Pharmacology.

Effects of selective dopamine receptor subtype agonists on cardiac contractility and regional haemodynamics in rats

J. Segreti, J. Brioni, R. Moreland, 2004, Clinical and experimental pharmacology & physiology.

Pharmacological characterization of P2X7 receptors in rat peritoneal cells

D. Donnelly-roberts, G. Gintant, M. Jarvis, 2005, Inflammation Research.

Magnetic Resonance Imaging Detection and Time Course of Cerebral Microhemorrhages during Passive Immunotherapy in Living Amyloid Precursor Protein Transgenic Mice

Jean M. Severin, D. Llano, M. Day, 2010, Journal of Pharmacology and Experimental Therapeutics.

Systemic Activation of the Calcium Sensing Receptor Produces Acute Effects on Vascular Tone and Circulatory Function in Uremic and Normal Rats: Focus on Central versus Peripheral Control of Vascular Tone and Blood Pressure by Cinacalcet

M. Nakane, J. Segreti, R. Fryer, 2007, Journal of Pharmacology and Experimental Therapeutics.

BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction.

B. Cox, F. Garcia-Ladona, 2006, CNS drug reviews.

Bimoclomol elevates heat shock protein 70 and cytoprotects rat neonatal cardiomyocytes.

C. Wegner, B. Cox, J. Polakowski, 2002, European journal of pharmacology.

Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats.

G. Diaz, C. Wegner, B. Cox, 2002, European journal of pharmacology.

Negative inotropic effect of a CB2 agonist A-955840 in isolated rabbit ventricular myocytes is independent of CB1 and CB2 receptors.

G. Gintant, G. Diaz, Ruth L. Martin, 2011, Current Drug Safety.

Models of renal insufficiency: the anti-thy-1.1 model of acute proliferative glomerulonephritis.

B. Cox, G. Reinhart, 2001, Current protocols in pharmacology.

Neurons in area postrema mediate vasopressin-induced enhancement of the baroreflex.

B. Cox, V. S. Bishop, M. Hay, 1990, The American journal of physiology.

Ventricular rate adaptation: a novel, rapid, cellular-based in-vitro assay to identify proarrhythmic and torsadogenic compounds.

G. Gintant, G. Diaz, Stan Kantor, 2011, Journal of pharmacological and toxicological methods.

Cardiovascular pharmacology of the adenosine A1/A2-receptor agonist AMP 579: coronary hemodynamic and cardioprotective effects in the canine myocardium.

M. McVey, K. Clark, B. Cox, 1999, Journal of cardiovascular pharmacology.

Effects of BW245C, a prostaglandin dp receptor agonist, on systemic and regional haemodynamics in the anaesthetized rat

B. Cox, R. Moreland, G. Reinhart, 2005, Clinical and experimental pharmacology & physiology.