J. Yau

发表

11β-Hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics

Ian J. Deary, Alasdair M.J. MacLullich, I. Deary, 2004 .

Cholestenoic acids regulate motor neuron survival via liver X receptors.

R. Schüle, L. Schöls, J. Gustafsson, 2014, The Journal of clinical investigation.

11β-Hydroxysteroid Dehydrogenase Type 1 Deficiency Prevents Memory Deficits with Aging by Switching from Glucocorticoid Receptor to Mineralocorticoid Receptor-Mediated Cognitive Control

J. Seckl, J. Yau, J. Noble, 2011, The Journal of Neuroscience.

11β-Hydroxysteroid Dehydrogenase Type 1 Expression Is Increased in the Aged Mouse Hippocampus and Parietal Cortex and Causes Memory Impairments

J. Seckl, J. Mullins, M. Holmes, 2010, The Journal of Neuroscience.

11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics.

I. Deary, A. MacLullich, B. Walker, 2004, Proceedings of the National Academy of Sciences of the United States of America.

The Antidepressant Desipramine Requires the ABCB1 (Mdr1)-Type p-Glycoprotein to Upregulate the Glucocorticoid Receptor in Mice

R. Kerwin, C. Pariante, S. Lightman, 2007, Neuropsychopharmacology.

11β‐Hydroxysteroid Dehydrogenases in the Brain

J. Seckl, J. Mullins, M. Holmes, 2003 .

Mining for Oxysterols in Cyp7b1−/− Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5

E. Arenas, J. Seckl, W. Griffiths, 2019, Biomolecules.

24S,25-Epoxycholesterol in mouse and rat brain

J. Seckl, W. Griffiths, Yuqin Wang, 2014, Biochemical and biophysical research communications.

Explorer 24 S , 25-Epoxycholesterol in mouse and rat brain

J. Seckl, W. Griffiths, Yuqin Wang, 2014 .

Midlife stress alters memory and mood-related behaviors in old age: Role of locally activated glucocorticoids

J. Seckl, C. Cairns, A. Harris, 2018, Psychoneuroendocrinology.

Forebrain‐Specific Transgene Rescue of 11β‐HSD1 Associates with Impaired Spatial Memory and Reduced Hippocampal Brain‐Derived Neurotrophic Factor mRNA Levels in Aged 11β‐HSD1 Deficient Mice

J. Seckl, A. Harris, M. Holmes, 2017, Journal of neuroendocrinology.

Partial Deficiency or Short-Term Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Improves Cognitive Function in Aging Mice

B. Walker, J. Seckl, M. Binnie, 2010, The Journal of Neuroscience.

Central Administration of a Cytochrome P450-7B Product 7α-Hydroxypregnenolone Improves Spatial Memory Retention in Cognitively Impaired Aged Rats

J. Seckl, J. Yau, J. Noble, 2006, The Journal of Neuroscience.

Central administration of a cytochrome P450-7 alpha product 7 alpha-hydroxypregnenolone improves spatial memory retention in cognitively impaired aged rats

J. Seckl, J. Yau, J. Noble, 2006 .

11 beta-Hydroxysteroid dehydrogenase in the rat ovary: high expression in the oocyte.

R. Benediktsson, C. Edwards, J. Seckl, 1992, The Journal of endocrinology.

11 beta-Hydroxysteroid dehydrogenase mRNA expression in rat kidney.

C. Edwards, J. Seckl, M. Moisan, 1991, The American journal of physiology.

Impact of adrenalectomy on 5-HT6 and 5-HT7 receptor gene expression in the rat hippocampus.

J. Seckl, J. Yau, J. Noble, 1997, Brain research. Molecular brain research.

11β-Hydroxysteroid dehydrogenase 1 deficiency prevents PTSD-like memory in young adult mice

J. Seckl, J. Yau, Nicola Wheelan, 2022, Psychoneuroendocrinology.

Chronic amitriptyline administration increases serotonin transporter binding sites in the hippocampus of aged rats

T. Olsson, J. Seckl, J. Yau, 1999, Neuroscience Letters.

Postnatal Handling Increases the Expression of cAMP-Inducible Transcription Factors in the Rat Hippocampus: The Effects of Thyroid Hormones and Serotonin

M. Meaney, J. Seckl, D. Francis, 2000, The Journal of Neuroscience.

Serotonin receptor subtype gene expression in the hippocampus of aged rats following chronic amitriptyline treatment.

J. Seckl, J. Yau, J. Noble, 1999, Brain research. Molecular brain research.

Local amplification of glucocorticoids in the aging brain and impaired spatial memory

J. Seckl, J. Yau, 2012, Front. Ag. Neurosci..

Chronic Treatment with the Antidepressant Amitriptyline Prevents Impairments in Water Maze Learning in Aging Rats

R. Morris, M. Meaney, J. Seckl, 2002, The Journal of Neuroscience.

Chronic 3,4-methylenedioxymethamphetamine administration decreases glucocorticoid and mineralocorticoid receptor, but increases 5-hydroxytryptamine1c receptor gene expression in the rat hippocampus

J. Seckl, J. Yau, J. Sharkey, 1994, Neuroscience.

Edinburgh Research Explorer Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2

C. Edwards, J. Seckl, J. Mullins, 2022 .

Site-specific regulation of corticosteroid and serotonin receptor subtype gene expression in the rat hippocampus following 3,4-methylenedioxymethamphetamine: role of corticosterone and serotonin

J. Seckl, J. Yau, J. Noble, 1997, Neuroscience.

The effect of adrenalectomy on 5-hydroxytryptamine and corticosteroid receptor subtype messenger RNA expression in rat hippocampus

J. Seckl, M. Holmes, J. Yau, 1995, Neuroscience.

Enhanced Hippocampal Long-Term Potentiation and Spatial Learning in Aged 11β-Hydroxysteroid Dehydrogenase Type 1 Knock-Out Mice

R. Morris, S. Cobb, J. Seckl, 2007, The Journal of Neuroscience.

11β-hydroxysteroid dehydrogenase type I in the brain; thickening the glucocorticoid soup

J. Seckl, J. Yau, 2001, Molecular Psychiatry.

Medial septal cholinergic lesions increase hippocampal mineralocorticoid and glucocorticoid receptor messenger RNA expression

G. Fink, J. Seckl, J. Yau, 1992, Brain Research.

Obese Zucker rats have reduced mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type 1 expression in hippocampus-implications for dysregulation of the hypothalamic-pituitary-adrenal axis in obesity.

B. Walker, J. Seckl, E. McKinney, 2003, Endocrinology.

Forebrain-specific transgene rescue of 11-HSD1 associates with impaired spatial memory and reduced hippocampal BDNF mRNA levels in aged 11-HSD1 deficient mice

J. Seckl, A. Harris, M. Holmes, 2016 .

Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease

B. Walker, J. Seckl, M. Binnie, 2015, Endocrinology.

Short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged mice

B. Walker, J. Seckl, M. Holmes, 2015, Neuropharmacology.

Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice

B. Walker, J. Seckl, M. Ludwig, 2015, Neurobiology of Aging.

Targeting 11β-hydroxysteroid dehydrogenase type 1 in brain: therapy for cognitive aging?

A. MacLullich, J. Seckl, J. Yau, 2006, Expert review of endocrinology & metabolism.

The effect of chronic fluoxetine treatment on brain corticosteroid receptor mRNA expression and spatial memory in young and aged rats.

J. Seckl, C. Hibberd, J. Yau, 2002, Brain research. Molecular brain research.

Lack of tissue glucocorticoid reactivation in 11β-hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments

J. Seckl, J. Mullins, C. Hibberd, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Glucocorticoids and the ageing hippocampus

J. Seckl, C. Hibberd, J. Yau, 2000, Journal of anatomy.

Continuous blockade of brain mineralocorticoid receptors impairs spatial learning in rats

J. Seckl, J. Yau, J. Noble, 1999, Neuroscience Letters.

Dehydroepiandrosterone 7-hydroxylase cyp7b: predominant expression in primate hippocampus and reduced expression in alzheimer's disease☆

J. Seckl, R. Andrew, R. Lathe, 2003, Neuroscience.

5'-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early-life events.

M. Meaney, J. Seckl, J. Diorio, 2000, Molecular endocrinology.

Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia

M. Macleod, J. Seckl, C. Gomez-Sanchez, 2007, The European journal of neuroscience.

Acute restraint stress increases 5-HT7 receptor mRNA expression in the rat hippocampus

J. Seckl, J. Yau, J. Noble, 2001, Neuroscience Letters.

Central 6-hydroxydopamine lesions decrease mineralocorticoid, but not glucocorticoid receptor gene expression in the rat hippocampus

J. Seckl, J. Yau, 1992, Neuroscience Letters.

11 Beta-hydroxysteroid dehydrogenases in the brain: two enzymes two roles.

J. Seckl, J. Mullins, M. Holmes, 2003, Annals of the New York Academy of Sciences.

11 beta-hydroxysteroid dehydrogenase in vascular smooth muscle and heart: implications for cardiovascular responses to glucocorticoids.

B. Walker, C. Edwards, J. Seckl, 1991, Endocrinology.

Inhibiting 11β-hydroxysteroid dehydrogenase type 1 prevents stress effects on hippocampal synaptic plasticity and impairs contextual fear conditioning

M. Joëls, B. Walker, J. Seckl, 2014, Neuropharmacology.

Inhibiting 11b-hydroxysteroid dehydrogenase type 1 prevents stress effects on hippocampal synaptic plasticity and impairs contextual fear conditioning

M. Joëls, B. Walker, J. Seckl, 2014 .

Glucocorticoids, hippocampal corticosteroid receptor gene expression and antidepressant treatment: relationship with spatial learning in young and aged rats

R. Morris, R. Morris, M. Meaney, 1995, Neuroscience.

Hippocampal corticosteroid receptor mRNA expression and spatial learning in the aged Wistar rat

R. Morris, J. Seckl, J. Yau, 1994, Brain Research.

The role of 11β-hydroxysteroid dehydrogenases in the regulation of corticosteroid activity in the brain

J. Seckl, M. Holmes, J. Yau, 2005 .

Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal culture

P. Kelly, J. Seckl, J. McCormick, 2003, Neuroscience.

Edinburgh Research Explorer 24S,25-Epoxycholesterol in mouse and rat brain

J. Seckl, W. Griffiths, Yuqin Wang, 2014 .

Decreased Npas4 and Arc mRNA Levels in the Hippocampus of Aged Memory‐Impaired Wild‐Type But Not Memory Preserved 11β‐HSD1 Deficient Mice

J. Seckl, C. Cairns, R. Carter, 2016, Journal of neuroendocrinology.

Manganese-enhanced magnetic resonance imaging (MEMRI) of rat brain after systemic administration of MnCl2: Hippocampal signal enhancement without disruption of hippocampus-dependent behavior

Ian Marshall, Maurits A. Jansen, Tobias Bast, 2011, Behavioural Brain Research.

Diurnal and stress‐induced intra‐hippocampal corticosterone rise attenuated in 11β‐HSD1‐deficient mice: a microdialysis study in young and aged mice

J. Seckl, M. Ludwig, J. Yau, 2015, The European journal of neuroscience.

11β-HYDROXYSTEROID DEHYDROGENASES: A NOVEL CONTROL OF GLUCOCORTICOID ACTION IN THE BRAIN

J. Seckl, M. Holmes, J. Yau, 2002, Endocrine research.

Short-term administration of fluoxetine and venlafaxine decreases corticosteroid receptor mRNA expression in the rat hippocampus

J. Seckl, C. Hibberd, J. Yau, 2001, Neuroscience Letters.

Antidepressant Actions on Glucocorticoid Receptors

J. Seckl, J. Yau, 2007 .

Differential regulation of variant glucocorticoid receptor mRNAs in the rat hippocampus by the antidepressant fluoxetine.

J. Seckl, J. Yau, J. Noble, 2004, Brain research. Molecular brain research.

Decreased NGFI-A gene expression in the hippocampus of cognitively impaired aged rats.

R. Morris, J. Seckl, J. Yau, 1996, Brain research. Molecular brain research.

Increased glucocorticoid receptor gene expression in the rat hippocampus following combined serotonergic and medial septal cholinergic lesions.

J. Seckl, J. Yau, P. Kelly, 1994, Brain research. Molecular brain research.

11β-Hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics

I. Deary, A. MacLullich, B. Walker, 2004 .

Cognitive and disease-modifying effects of 11ß-hydroxysteroid dehydrogenase type 1 inhibition in male Tg2576 mice, a model of Alzheimer's disease

B. Walker, J. Seckl, M. Binnie, 2015 .

Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2.

J. Seckl, J. Mullins, Y. Kotelevtsev, 1996, The Biochemical journal.