T. Takai

发表

Cystatin A inhibits IL-8 production by keratinocytes stimulated with Der p 1 and Der f 1: biochemical skin barrier against mite cysteine proteases.

K. Mitsuishi, H. Ogawa, K. Okumura, 2005, The Journal of allergy and clinical immunology.

Flagellin Induces the Expression of Thymic Stromal Lymphopoietin in Human Keratinocytes via Toll-Like Receptor 5

H. Ogawa, K. Okumura, T. Takai, 2010, International Archives of Allergy and Immunology.

Epicutaneous challenge with protease allergen requires its protease activity to recall TH2 and TH17/TH22 responses in mice pre-sensitized via distant skin

D. Basketter, H. Yokozeki, H. Sakaguchi, 2021, Journal of immunotoxicology.

Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2-Toll-like receptor 6 pathway.

H. Ogawa, K. Okumura, T. Baba, 2010, The Journal of allergy and clinical immunology.

Epitope Analysis and Primary Structures of Variable Regions of Anti-human FcεRI Monoclonal Antibodies, and Expression of the Chimeric Antibodies Fused with Human Constant Regions

C. Ra, K. Okumura, T. Takai, 2000, Bioscience, biotechnology, and biochemistry.

Immunization of Rabbits with Nematode Ascaris lumbricoides Antigens Induces Antibodies Cross-Reactive to House Dust Mite Dermatophagoides farinae Antigens

M. Yunus, A. Saito, K. Akiyama, 2013, Bioscience, biotechnology, and biochemistry.

Non-anaphylactic combination of partially deleted fragments of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy.

A. Mori, H. Okudaira, T. Takai, 1999, Molecular immunology.

Production of Humanized Antibody against Human Hig in a Serum-free Culture of CHO Cells , and Purificationh-aMnity IgE Receptor of the Fab Fragments

K. Okumura, Kyoko Takahashi, T. Takai, 2018 .

Production of Humanized Antibody against Human High-affinity IgE Receptor in a Serum-free Culture of CHO Cells, and Purification of the Fab Fragments

C. Ra, K. Okumura, T. Takai, 2001, Bioscience, biotechnology, and biochemistry.

Extracellular double-stranded RNA induces TSLP via an endosomal acidification- and NF-κB-dependent pathway in human keratinocytes.

K. Okumura, M. Hara, T. Takai, 2011, The Journal of investigative dermatology.

Staphylococcus aureus extracellular protease causes epidermal barrier dysfunction.

H. Gunawan, Toshinobu Nakamura, K. Mitsuishi, 2010, The Journal of investigative dermatology.

Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA.

H. Gunawan, K. Okumura, M. Hara, 2009, The Journal of allergy and clinical immunology.

Expression : Cellular Sources , Triggers , and Regulatory Mechanisms

T. Takai, 2010 .

Epicutaneous vaccination with protease inhibitor-treated papain prevents papain-induced Th2-mediated airway inflammation without inducing Th17 in mice.

K. Okumura, T. Takai, S. Ikeda, 2021, Biochemical and biophysical research communications.

Biologically active recombinant forms of a major house dust mite group 1 allergen Der f 1 with full activities of both cysteine protease and IgE binding

H. Okudaira, T. Takai, T. Yasuhara, 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Hyposensitization to allergic reaction in rDer f 2‐sensitized mice by the intranasal administration of a mutant of rDer f 2, C8/119S

M. Suko, H. Okudaira, T. Takai, 1998, Clinical and experimental immunology.

Juntendo Medical Journal

T. Takai, 2016 .

Immunotherapy to Treat Allergies: Recent Advances and Future Prospects

T. Takai, 2015 .

Engineering of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy

A. Mori, H. Okudaira, C. Nishiyama, 1997, Nature Biotechnology.

Pectate Lyase Pollen Allergens: Sensitization Profiles and Cross-Reactivity Pattern

P. Briza, H. Behrendt, A. Mari, 2015, PloS one.

Cupressaceae Pollen Grains Modulate Dendritic Cell Response and Exhibit IgE-Inducing Adjuvant Activity In Vivo1

K. Okumura, N. Harada, T. Takai, 2009, The Journal of Immunology.

NADPH oxidase activity in allergenic pollen grains of different plant species.

H. Gunawan, K. Okumura, T. Takai, 2009, Biochemical and biophysical research communications.

Glycosylation of Recombinant Proforms of Major House Dust Mite Allergens Der p 1 and Der f 1 Decelerates the Speed of Maturation

Teruyuki Nagamune, K. Okumura, T. Takai, 2006, International Archives of Allergy and Immunology.

Analysis of the structure and allergenicity of recombinant pro- and mature Der p 1 and Der f 1: major conformational IgE epitopes blocked by prodomains.

K. Okumura, Takeshi Kato, T. Takai, 2005, The Journal of allergy and clinical immunology.

Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases.

T. Takai, S. Ikeda, 2011, Allergology international : official journal of the Japanese Society of Allergology.

Interaction with an Endogenous Ligand Dust Mite Allergens Der f 1 and Der p 1 by Modulation of Allergenicity of Major House

H. Hatanaka, K. Mitsuishi, Takeshi Kato, 2009 .

Innate IL-17A enhances IL-33-independent skin eosinophilia and IgE response on subcutaneous papain sensitization.

S. Nakae, K. Okumura, M. Hara, 2020, The Journal of investigative dermatology.

Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice.

S. Nakae, K. Okumura, M. Hara, 2016, The Journal of investigative dermatology.

Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes

S. Nakae, H. Suto, K. Okumura, 2016, The Journal of Immunology.

This information is current as Subcutaneous and Intranasal Routes but Not IL-33 : Distinct Mechanisms between CellsProtease Allergen Is Dependent on Mast Subcutaneous Allergic Sensitization to

S. Nakae, H. Suto, K. Okumura, 2016 .

Cysteine protease antigens cleave CD123, the α subunit of murine IL-3 receptor, on basophils and suppress IL-3-mediated basophil expansion.

T. Fujimura, K. Okumura, T. Takai, 2015, Biochemical and biophysical research communications.

IL-33–Mediated Innate Response and Adaptive Immune Cells Contribute to Maximum Responses of Protease Allergen–Induced Allergic Airway Inflammation

S. Nakae, H. Suto, K. Sudo, 2013, The Journal of Immunology.

[Three faces of allergen].

T. Takai, 2012, Arerugi = [Allergy].

The Squamous Cell Carcinoma Antigen 2 Inhibits the Cysteine Proteinase Activity of a Major Mite Allergen, Der p 1*

F. Kishi, K. Izuhara, K. Fujimoto, 2004, Journal of Biological Chemistry.

Development of Transgenic Rice Expressing Mite Antigen for a New Concept of Immunotherapy

O. Kaminuma, A. Mori, K. Okumura, 2009, International Archives of Allergy and Immunology.

Effects of Site-Directed Mutagenesis in the Cysteine Residues and the N-Glycosylation Motif in Recombinant Der f 1 on Secretion and Protease Activity

Kyoko Takahashi, T. Yasuhara, T. Takai, 2001, International Archives of Allergy and Immunology.

Production of Enzymatically and Immunologically Active Der f 1 in Escherichia coli

Kyoko Takahashi, T. Yasuhara, Y. Ohtake, 2000, International Archives of Allergy and Immunology.

Inhibition of Both Cyclooxygenase-1 and -2 Promotes Epicutaneous Th2 and Th17 Sensitization and Allergic Airway Inflammation on Subsequent Airway Exposure to Protease Allergen in Mice

Y. Sugimoto, K. Okumura, T. Yokomizo, 2021, International Archives of Allergy and Immunology.

Cyclooxygenase inhibition in mice heightens adaptive‐ and innate‐type responses against inhaled protease allergen and IL‐33

S. Nakae, K. Sudo, K. Okumura, 2019, Allergy.

Airway inflammation after epicutaneous sensitization of mice requires protease activity of low-dose allergen inhalation.

K. Sudo, K. Okumura, T. Takai, 2018, The Journal of allergy and clinical immunology.

Mite Endopeptidase 1

T. Takai, 2013 .

Serine Endopeptidase Allergens from Dermatophagoides Species

T. Takai, 2013 .

Missions of Protease Allergens in the Epithelium

T. Takai, 2010, International Archives of Allergy and Immunology.

Recombinant Der p 1 and Der f 1 exhibit cysteine protease activity but no serine protease activity.

K. Izuhara, K. Okumura, Y. Sakata, 2005, Biochemical and biophysical research communications.

Presensitization to Ascaris antigens promotes induction of mite-specific IgE upon mite antigen inhalation in mice.

H. Hatanaka, K. Akiyama, K. Okumura, 2016, Allergology international : official journal of the Japanese Society of Allergology.

Proinflammatory Response in Human Keratinocytes Stimulated with Ligands for TLR2, TLR1, and TLR6

H. Suto, K. Okumura, M. Hara, 2010 .

IgE-Inducing Adjuvant Activity In Vivo Dendritic Cell Response and Exhibit Cupressaceae Pollen Grains Modulate

K. Okumura, N. Harada, T. Takai, 2009 .

Crystallization and preliminary X-ray analysis of Der f 2, a potent allergen derived from the house dust mite (Dermatophagoides farinae).

A. Achari, D. Scott, T. Takai, 2003, Acta crystallographica. Section D, Biological crystallography.

Japanese Society of Allergology task force report on standardization of house dust mite allergen vaccines - secondary publication.

Y. Okamoto, A. Saito, Y. Fukutomi, 2015, Allergology international : official journal of the Japanese Society of Allergology.

Protease activity of allergenic pollen of cedar, cypress, juniper, birch and ragweed.

H. Gunawan, K. Okumura, T. Takai, 2008, Allergology international : official journal of the Japanese Society of Allergology.

Long TSLP transcript expression and release of TSLP induced by TLR ligands and cytokines in human keratinocytes.

K. Okumura, T. Takai, Xue Chen, 2012, Journal of dermatological science.

Characterization of Proteases, Proteins, and Eicosanoid-Like Substances in Soluble Extracts from Allergenic Pollen Grains

H. Gunawan, K. Okumura, T. Takai, 2008, International Archives of Allergy and Immunology.

Upregulation of the Release of Granulocyte-Macrophage Colony-Stimulating Factor from Keratinocytes Stimulated with Cysteine Protease Activity of Recombinant Major Mite Allergens, Der f 1 and Der p 1

F. Niyonsaba, K. Okumura, Takeshi Kato, 2007, International Archives of Allergy and Immunology.

Reduction of skin barrier function by proteolytic activity of a recombinant house dust mite major allergen Der f 1.

Toshinobu Nakamura, K. Mitsuishi, K. Okumura, 2006, The Journal of investigative dermatology.

Crucial Commitment of Proteolytic Activity of a Purified Recombinant Major House Dust Mite Allergen Der p1 to Sensitization toward IgE and IgG Responses1

H. Hatanaka, K. Mitsuishi, K. Okumura, 2006, The Journal of Immunology.

IgE and IgG Responses Mite Allergen Der p1 to Sensitization toward Dust of a Purified Recombinant Major House Crucial Commitment of Proteolytic Activity

H. Hatanaka, K. Mitsuishi, H. Akiba, 2006 .

Recombinant Der p 1 and Der f 1 with in vitro Enzymatic Activity to Cleave Human CD23, CD25 and α1-Antitrypsin, and in vivo IgE-Eliciting Activity in Mice

K. Okumura, Takeshi Kato, T. Takai, 2005, International Archives of Allergy and Immunology.

The Epithelium Takes Center Stage in Allergic Keratoconjunctivitis

A. Murakami, N. Ebihara, T. Takai, 2010, Cornea.

Skin Treatment with Detergent Induces Dermatitis with H1-Antihistamine-Refractory Itch and Upregulates IL-4 and Th17/Th22 Cytokine Gene Expression in C57BL/6 Mice

H. Suto, K. Takamori, T. Takai, 2022, International Archives of Allergy and Immunology.

Skin Treatment with Detergent Promotes Protease Allergen-Dependent Epicutaneous Sensitization in a Manner Different from Tape Stripping in Mice.

S. Nakae, K. Okumura, T. Takai, 2017, The Journal of investigative dermatology.

Epicutaneous administration of papain induces IgE and IgG responses in a cysteine protease activity-dependent manner.

K. Okumura, T. Takai, S. Ikeda, 2014, Allergology international : official journal of the Japanese Society of Allergology.

SLPI prevents cytokine release in mite protease-exposed conjunctival epithelial cells.

A. Murakami, K. Okumura, N. Ebihara, 2009, Biochemical and biophysical research communications.

Enzyme-linked immunosorbent assays with high sensitivity for antigen-specific and total murine IgE: a useful tool for the study of allergies in mouse models.

H. Hatanaka, K. Okumura, T. Takai, 2009, Allergology international : official journal of the Japanese Society of Allergology.

Maturation of the activities of recombinant mite allergens Der p 1 and Der f 1, and its implication in the blockade of proteolytic activity

K. Murayama, K. Okumura, T. Takai, 2002, FEBS letters.

Production of Humanized Fab Fragment against Human High Affinity IgE Receptor in Pichia pastoris

C. Ra, K. Okumura, T. Takai, 2000, Bioscience, biotechnology, and biochemistry.

Innate basophil IL-4 responses against allergens, endotoxin, and cytokines require the Fc receptor γ-chain.

Yusuke Suzuki, C. Ra, K. Okumura, 2016, The Journal of allergy and clinical immunology.

Characterization of novel squamous cell carcinoma antigen-related molecules in mice.

K. Izuhara, K. Arima, Y. Sakata, 2004, Biochemical and biophysical research communications.

Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression.

Hideoki Ogawa, Lijun Yang, Ko Okumura, 2011, Plant biotechnology journal.

NMR study on the major mite allergen Der f 2: its refined tertiary structure, epitopes for monoclonal antibodies and characteristics shared by ML protein group members.

K. Ogura, F. Inagaki, H. Hatanaka, 2005, Journal of biochemistry.

Unlocking the allergenic structure of the major house dust mite allergen Der f 2 by elimination of key intramolecular interactions

T. Takai, T. Yokota, Y. Okumura, 2000, FEBS letters.

Determination of the N- and C-terminal sequences required to bind human IgE of the major house dust mite allergen Der f 2 and epitope mapping for monoclonal antibodies.

A. Mori, H. Okudaira, T. Takai, 1997, Molecular immunology.

Modulation of Allergenicity of Major House Dust Mite Allergens Der f 1 and Der p 1 by Interaction with an Endogenous Ligand1

H. Hatanaka, K. Mitsuishi, K. Okumura, 2009, The Journal of Immunology.

Application of Immunoreaction Enhancer Solutions to an Enzyme-Linked Immunosorbent Assay for Antigen-Specific IgE in Mice Immunized with Recombinant Major Mite Allergens or Ovalbumin

K. Mitsuishi, K. Okumura, Takeshi Kato, 2006, International Archives of Allergy and Immunology.

Cloning and Expression of cDNA Encoding the Complete Prepro-Form of an Isoform of Der f 1, the Major Group 1 Allergen from House Dust Mite Dermatophagoides farinae

H. Okudaira, T. Yasuhara, T. Takai, 2001, Bioscience, biotechnology, and biochemistry.

Effects of Double Mutation at Two Distant IgE-binding Sites in the Three-dimensional Structure of the Major House Dust Mite Allergen Der f 2 on IgE-binding and Histamine-releasing Activity

F. Inagaki, H. Hatanaka, T. Takai, 2001, Bioscience, biotechnology, and biochemistry.

Effects of proline mutations in the major house dust mite allergen Der f 2 on IgE-binding and histamine-releasing activity.

F. Inagaki, H. Hatanaka, T. Takai, 2000, European journal of biochemistry.

Lipopolysaccharide binding of the mite allergen Der f 2

D. Kohda, H. Hatanaka, K. Okumura, 2009, Genes to cells : devoted to molecular & cellular mechanisms.

Repeated antigen painting and sublingual immunotherapy in mice convert sublingual dendritic cell subsets.

M. Azuma, T. Takai, Chenyang Zhang, 2014, Vaccine.

TSLP expression induced via Toll-like receptor pathways in human keratinocytes.

K. Okumura, T. Baba, K. Hiramatsu, 2014, Methods in enzymology.

Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes.

Hideoki Ogawa, Ko Okumura, Toshiro Takai, 2013, Biochemical and biophysical research communications.

Glucocorticoids Inhibit Double-Stranded RNA-Induced Thymic Stromal Lymphopoietin Release from Keratinocytes in an Atopic Cytokine Milieu More Effectively than Tacrolimus

K. Okumura, T. Takai, S. Ikeda, 2010, International Archives of Allergy and Immunology.

Inhibition of IgE-Dependent Histamine Release from Human Peripheral Blood Basophils by Humanized Fab Fragments That Recognize the Membrane Proximal Domain of the Human FcεRI α-Chain

C. Ra, T. Takai, T. Yuuki, 2000, International Archives of Allergy and Immunology.

Determination of three disulfide bonds in a major house dust mite allergen, Der f II.

H. Okudaira, C. Nishiyama, T. Takai, 1993, International archives of allergy and immunology.

Dilution Method to Refold Bacterially Expressed Recombinant Der f 2 and Der p 2 to Exhibit the Secondary Structure and Histamine-Releasing Activity of Natural Allergens

K. Okumura, T. Takai, M. Takaoka, 2005, International Archives of Allergy and Immunology.

Reactivities of Mutants of a Major House Dust Mite Allergen Der f 2 to Mouse Anti-Der f 2 Monoclonal Antibodies Analyzed by Immunoblotting

T. Takai, T. Yokota, Y. Okumura, 2001, Bioscience, biotechnology, and biochemistry.

Allergens in modern society: Updated catalogs and future prospects.

Toshiro Takai, Kenji Izuhara, K. Izuhara, 2015, Allergology international : official journal of the Japanese Society of Allergology.

Cedar Allergen Harvest from Tobacco: Plant Biotechnology for Recombinant Allergens

T. Takai, 2010, International Archives of Allergy and Immunology.

Multiple‐mutation at a potential ligand‐binding region decreased allergenicity of a mite allergen Der f 2 without disrupting global structure

Hideoki Ogawa, Ko Okumura, Teruyuki Nagamune, 2005, FEBS letters.

Inhibition of Allergen-Induced Airway Inflammation by Low-Dose Oral Immunotherapy with Transgenic Rice Seeds Independently of Immunoglobulin E Synthesis

O. Kaminuma, A. Mori, K. Takada, 2012, International Archives of Allergy and Immunology.

Antigen protease activity with a detergent induces severe skin inflammation with itch and robust Th17/Th22 differentiation in mice.

K. Takamori, T. Takai, S. Ikeda, 2023, The Journal of investigative dermatology.

Direct Expression of the Extracellular Portion of Human FcεRIα Chain as Inclusion Bodies in Escherichia coli

C. Ra, K. Okumura, T. Takai, 2001 .

Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice.

S. Nakae, K. Okumura, M. Hara, 2016, The Journal of investigative dermatology.

Antigen Protease Activity on Intact or Tape-Stripped Skin Induces Acute Itch and T Helper Sensitization Leading to Airway Eosinophilia in Mice

T. Takai, Tomoko Yoshimura, S. Kamijo, 2023, JID Innovations.

Airway inflammation after epicutaneous sensitization of mice requires protease activity of low-dose allergen inhalation.

K. Sudo, K. Okumura, T. Takai, 2018, The Journal of allergy and clinical immunology.

Mite serine protease activates protease‐activated receptor‐2 and induces cytokine release in human keratinocytes

H. Ogawa, K. Okumura, Takeshi Kato, 2009, Allergy.

Repeated antigen painting and sublingual immunotherapy in mice convert sublingual dendritic cell subsets.

M. Azuma, T. Takai, Chenyang Zhang, 2014, Vaccine.

Inhibition of double‐stranded RNA‐induced TSLP in human keratinocytes by glucocorticoids

T. Takai, S. Ikeda, K. Okumura, 2009, Allergy.

Cysteine protease antigens cleave CD123, the α subunit of murine IL-3 receptor, on basophils and suppress IL-3-mediated basophil expansion.

T. Fujimura, K. Okumura, T. Takai, 2015, Biochemical and biophysical research communications.