T. Tomiyama

发表

A microneutralization enzyme immunoassay for antibody to human cytomegalovirus.

Y. Matsumoto, T. Tomiyama, T. Sugano, 1993, Journal of immunological methods.

A human monoclonal antibody against varicella-zoster virus glycoprotein III.

Y. Masuho, Y. Matsumoto, B. Forghani, 1991, The Journal of general virology.

Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography

Tetsuya Suhara, Nobuhisa Iwata, Jun Maeda, 2007, The Journal of Neuroscience.

Intranasal rifampicin for Alzheimer's disease prevention

A. Yamamoto, T. Tomiyama, T. Umeda, 2018, Alzheimer's & dementia.

A novel presenilin-1 mutation (Leu85Pro) in early-onset Alzheimer disease with spastic paraparesis.

H. Mori, H. Takuma, T. Tomiyama, 2004, Archives of neurology.

Distinguishable effects of Presenilin-1 and APP717 mutations on amyloid plaque deposition

D. Pollen, P. Lantos, M. Rossor, 2001, Neurobiology of Aging.

Improved Long-Term Potentiation and Memory in Young Tau-P301L Transgenic Mice before Onset of Hyperphosphorylation and Tauopathy

Ger J. A. Ramakers, Paul J. Lucassen, Hiroshi Mori, 2006, The Journal of Neuroscience.

Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of βAPP in neuronal cells

K. Akagawa, H. Mori, T. Tomiyama, 2005, Journal of neurochemistry.

The E693Δ (Osaka) mutation in amyloid precursor protein potentiates cholesterol‐mediated intracellular amyloid β toxicity via its impaired cholesterol efflux

S. Nomura, H. Mori, T. Tomiyama, 2013, Journal of neuroscience research.

The distributions of tau short and long isoforms fused with EGFP in cultured cells.

H. Mori, H. Takuma, T. Tomiyama, 2004, Osaka city medical journal.

Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production.

K. Akagawa, H. Mori, T. Tomiyama, 2004, The Biochemical journal.

Hypercholesterolemia accelerates intraneuronal accumulation of Aβ oligomers resulting in memory impairment in Alzheimer's disease model mice.

W. Klein, M. Lambert, S. Nomura, 2012, Life Science.

Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice

A. Takashima, H. Mori, Tetsuya Kimura, 2014, Acta Neuropathologica.

Regulation of tau exon 10 splicing by a double stem–loop structure in mouse intron 10

H. Mori, H. Numata, Qiang Li, 2005, FEBS letters.

Distinct functions of tau isoforms in Alzheimer's disease

H. Mori, T. Tomiyama, S. Arawaka, 2003 .

Decreased levels of PDI and P5 in oligodendrocytes in Alzheimer's disease

R. Takahashi, H. Mori, T. Horibe, 2017, Neuropathology : official journal of the Japanese Society of Neuropathology.

Oligomer-Targeting Prevention of Neurodegenerative Dementia by Intranasal Rifampicin and Resveratrol Combination – A Preclinical Study in Model Mice

T. Tomiyama, T. Umeda, Ayumi Sakai, 2021, Frontiers in Neuroscience.

Nasal Rifampicin Improves Cognition in a Mouse Model of Dementia with Lewy Bodies by Reducing α-Synuclein Oligomers

T. Tomiyama, T. Umeda, Ayumi Sakai, 2021, International journal of molecular sciences.

Intraneuronal amyloid-beta oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

M. Lambert, H. Mori, T. Tomiyama, 2011, Alzheimer's & Dementia.

Inhibition of Amyloid Protein Aggregation and Neurotoxicity by Rifampicin

S. Asano, Y. Suwa, T. Tomiyama, 1996, The Journal of Biological Chemistry.

C9orf72 Hexanucleotide Repeat Expansion-Related Neuropathology Is Attenuated by Nasal Rifampicin in Mice

T. Takeuchi, T. Tomiyama, T. Umeda, 2022, Biomedicines.

Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes.

S. Hébert, H. Mori, G. Lévesque, 2003, Biochemical and biophysical research communications.

Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer’s disease: analysis of Osaka mutation-knockin mice

T. Miyakawa, A. Takashima, H. Mori, 2017, Acta Neuropathologica Communications.

Rearrangement of microtubule networks by tau bearing missense mutations

N. Sahara, H. Mori, T. Tomiyama, 2001 .

Missense point mutations of tau to segregate with FTDP‐17 exhibit site‐specific effects on microtubule structure in COS cells: A novel action of R406W mutation

N. Sahara, H. Mori, T. Tomiyama, 2000, Journal of neuroscience research.

Development of a Human Monoclonal Antibody against Cytomegalovirus with the Aim of a Passive Immunotherapy

Y. Masuho, Y. Matsumoto, T. Tomiyama, 1990 .

The preclinical safety evaluation of human monoclonal antibody against cytomegalovirus.

S. Sugawara, S. Asano, T. Tomiyama, 1992, Fundamental and applied toxicology : official journal of the Society of Toxicology.

In Vivo Positron Emission Tomographic Imaging of Glial Responses to Amyloid-β and Tau Pathologies in Mouse Models of Alzheimer's Disease and Related Disorders

J. Trojanowski, V. Lee, Ming-Rong Zhang, 2011, The Journal of Neuroscience.

Enhanced Aβ40 Deposition Was Associated with Increased Aβ42/43 in Cerebral Vasculature with Dutch‐Type Hereditary Cerebral Hemorrhage with Amyloidosis (HCHWA‐D)

R. Roos, H. Mori, T. Tomiyama, 2002, Annals of the New York Academy of Sciences.

Structure-activity relationship of chalcones and related derivatives as ligands for detecting of beta-amyloid plaques in the brain.

H. Mori, M. Haratake, M. Ono, 2007, Bioorganic & medicinal chemistry.

Rifampicin inhibits the toxicity of pre-aggregated amyloid peptides by binding to peptide fibrils and preventing amyloid-cell interaction.

S. Asano, T. Tomiyama, N Endo, 1997, The Biochemical journal.

The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells.

W. Klein, M. Lambert, Kazuhiro Ito, 2009, The American journal of pathology.

Corrigendum to “DCP-LA neutralizes mutant amyloid β peptide-induced impairment of long-term potentiation and spatial learning” [Behav. Brain Res. 206 (1) (2010) 151–154]

T. Yaguchi, T. Nagata, T. Nishizaki, 2010, Behavioural Brain Research.

Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice

T. Tomiyama, T. Umeda, H. Eguchi, 2022, Biomedicines.

Aβ levels in the jugular vein and high molecular weight Aβ oligomer levels in CSF can be used as biomarkers to indicate the anti-amyloid effect of IVIg for Alzheimer’s disease

T. Tokuda, D. Allsop, M. Taylor, 2017, PloS one.

Racemization of Asp23 residue affects the aggregation properties of Alzheimer amyloid beta protein analogues.

T. Shirasawa, H. Mori, Y. Furiya, 1994, The Journal of biological chemistry.

The Syntaxin 5 isoforms Syx5 and Syx5L have distinct effects on the processing of {beta}-amyloid precursor protein.

K. Akagawa, H. Mori, T. Tomiyama, 2009, Journal of biochemistry.

Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain

Mamoru Ito, Y. Ihara, A. Takashima, 2018, The Journal of Neuroscience.

Amyloid Beta Peptide‐Induced Cerebral Neuronal Loss Is Mediated By Caspase‐3 In Vivo

H. Mori, H. Takuma, K. Kuida, 2004, Journal of neuropathology and experimental neurology.

Racemization: its biological significance on neuropathogenesis of Alzheimer's disease.

T. Shirasawa, N. Sahara, H. Mori, 1994, The Tohoku journal of experimental medicine.

Preparation of human monoclonal antibodies against a cytomegalovirus glycoprotein complex of 130 and 55 kDa.

Y. Masuho, Y. Matsumoto, T. Tomiyama, 1990, Journal of immunological methods.

Tau‐4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/ knockout mice

G. Ramakers, C. Schmitz, F. van Leuven, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

APP Osaka Mutation in Familial Alzheimer’s Disease—Its Discovery, Phenotypes, and Mechanism of Recessive Inheritance

T. Tomiyama, H. Shimada, 2020, International journal of molecular sciences.

Mutations in the β-amyloid precursor protein in familial Alzheimer’s disease increase Aβ oligomer production in cellular models

Masaki Tanaka, T. Tokuda, F. Kametani, 2018, Heliyon.

Erratum: Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons

T. Tomiyama, T. Umeda, M. Yamashita, 2016, Acta Neuropathologica Communications.

The domestic cat as a natural animal model of Alzheimer’s disease

T. Tokuda, H. Nakayama, Y. Une, 2015, Acta neuropathologica communications.

Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons

H. Mori, K. Nakajima, T. Tomiyama, 2015, Acta neuropathologica communications.

A Mouse Model of Amyloid β Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo

Rie Teraoka, Kazuhiro Ito, Kenichi Ishibashi, 2010, The Journal of Neuroscience.

OLIGOMERIC Aβ IS THE SOLE CULPRIT MOLECULE TO CAUSE ALZHEIMER’S DISEASE?

Yasuyoshi Watanabe, T. Nagata, T. Nishizaki, 2010 .

A new amyloid β variant favoring oligomerization in Alzheimer's‐type dementia

Yasuyoshi Watanabe, Ryozo Kuwano, Rie Teraoka, 2008, Annals of neurology.

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

W. Klein, M. Lambert, H. Mori, 2011, Journal of neuroscience research.

Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form

H. Mori, T. Tomiyama, H. Kanemitsu, 2003, Neuroscience Letters.

Keto form of curcumin derivatives strongly binds to Aβ oligomers but not fibrils.

D. Yanagisawa, I. Tooyama, Y. Hirahara, 2021, Biomaterials.

Amyloid-&bgr; E22Δ variant induces synaptic alteration in mouse hippocampal slices

Rie Teraoka, Hiroshi Mori, H. Mori, 2008, Neuroreport.

Passive immunotherapy of tauopathy targeting pSer413-tau: a pilot study in mice

H. Mori, T. Tomiyama, T. Umeda, 2015, Annals of clinical and translational neurology.

Antiviral activities of a human monoclonal antibody against human cytomegalovirus.

Y. Masuho, T. Tomiyama, 1990, Advances in Experimental Medicine and Biology.

Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers.

W. Klein, H. Mori, M. Mizuguchi, 2016, Brain : a journal of neurology.

Heavy Tau Burden with Subtle Amyloid β Accumulation in the Cerebral Cortex and Cerebellum in a Case of Familial Alzheimer’s Disease with APP Osaka Mutation

Yasuyoshi Watanabe, T. Suhara, M. Higuchi, 2020, International journal of molecular sciences.

Increased GADD34 in oligodendrocytes in Alzheimer’s disease

R. Takahashi, H. Mori, T. Horibe, 2015, Neuroscience Letters.

Regulation of cholesterol efflux by amyloid β secretion

Hui Zheng, H. Mori, T. Tomiyama, 2010, Journal of neuroscience research.

Oligomeric amyloid-beta induces MAPK-mediated activation of brain cytosolic and calcium-independent phospholipase A2 in a spatial-specific manner

Xianlin Han, H. Mori, Linyuan Chen, 2017, Acta neuropathologica communications.

Molecular pathogenesis of apolipoprotein E-mediated amyloidosis in late-onset Alzheimer’s disease

E. Corder, H. Mori, T. Tomiyama, 1999, Cellular and Molecular Life Sciences CMLS.

Peripheral Aβ acts as a negative modulator of insulin secretion

S. Nomura, T. Tomiyama, T. Umeda, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Neurodegenerative Disorder FTDP-17 e Related Tau Intron 10 D 16C / T Mutation Increases Tau Exon 10 Splicing and Causes Tauopathy in Transgenic Mice

A. Takashima, H. Mori, H. Takuma, 2022 .

Cerebral vascular accumulation of Dutch‐type Aβ42, but not wild‐type Aβ42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type

Kazuhiro Iwai, Raymund A C Roos, Kenichi Ishibashi, 2007, Journal of neuroscience research.

Inverse correlation between amyloid precursor protein and synaptic plasticity in transgenic mice

H. Mori, T. Tomiyama, S. Matsuyama, 2007, Neuroreport.

Absence of synaptophysin near cortical neurons containing oligomer Aβ in Alzheimer's disease brain

H. Mori, M. Hara, T. Tomiyama, 2006, Journal of neuroscience research.

Lack of amyloid plaque formation in the central nervous system of a patient with Werner syndrome

K. Wakasa, H. Mori, T. Tomiyama, 2003, Neuropathology : official journal of the Japanese Society of Neuropathology.

Oligomeric amyloid-beta induces MAPK-mediated activation of brain cytosolic and calcium-independent phospholipase A2 in a spatial-specific manner

Xianlin Han, H. Mori, Linyuan Chen, 2017, Acta Neuropathologica Communications.

E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity

A. Akaike, T. Nagata, T. Nishizaki, 2010, International journal of Alzheimer's disease.

Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain

K. Tsumoto, Y. Anraku, K. Kataoka, 2023, Journal of Nanobiotechnology.

Mutation (D472Y) in the type 3 repeat domain of cartilage oligomeric matrix protein affects its early vesicle trafficking in endoplasmic reticulum and induces apoptosis.

H. Mori, T. Tomiyama, Y. Hashimoto, 2003, The American journal of pathology.

Rivastigmine Improves Appetite by Increasing the Plasma Acyl/Des-Acyl Ghrelin Ratio and Cortisol in Alzheimer Disease

Y. Furiya, S. Ueno, T. Tomiyama, 2018, Dementia and Geriatric Cognitive Disorders Extra.

Rifampicin prevents the aggregation and neurotoxicity of amyloid beta protein in vitro.

H. Mori, S. Asano, Y. Suwa, 1994, Biochemical and biophysical research communications.

Proteomic analysis of the brain tissues from a transgenic mouse model of amyloid β oligomers

H. Mori, T. Tomiyama, S. Tokuyama, 2012, Neurochemistry International.

Inhibition of Amyloid Protein Aggregation and Neurotoxicity by Rifampicin

S. Asano, Y. Suwa, T. Tomiyama, 1996, The Journal of Biological Chemistry.

Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer’s disease: analysis of Osaka mutation-knockin mice

T. Miyakawa, A. Takashima, H. Mori, 2017, Acta neuropathologica communications.

Fluorine-19 Magnetic Resonance Imaging for Detection of Amyloid β Oligomers Using a Keto Form of Curcumin Derivative in a Mouse Model of Alzheimer’s Disease

D. Yanagisawa, S. Morikawa, I. Tooyama, 2021, Molecules.

Erratum: Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons

H. Mori, K. Nakajima, T. Tomiyama, 2016, Acta neuropathologica communications.

Clinical Course of Patients with Familial Early-Onset Alzheimer’s Disease Potentially Lacking Senile Plaques Bearing the E693Δ Mutation in Amyloid Precursor Protein

H. Mori, T. Tomiyama, T. Miki, 2011, Dementia and Geriatric Cognitive Disorders.

The relationship of renal histopathological lesions to immunoglobulin classes and complement fixation of anti-native DNA antibodies in systemic lupus erythematosus.

H. Hashimoto, Y. Shiokawa, T. Tomiyama, 1983, Scandinavian journal of rheumatology.

[Involvement of beta-amyloid in the etiology of Alzheimer's disease].

T. Tomiyama, 2010, Brain and nerve = Shinkei kenkyu no shinpo.

Proteomic analysis involved with synaptic plasticity improvement by GABAA receptor blockade in hippocampus of a mouse model of Alzheimer’s disease

H. Mori, T. Tomiyama, M. Takano, 2020, Neuroscience Research.

Proteomic analysis of the hippocampus in Alzheimer's disease model mice by using two-dimensional fluorescence difference in gel electrophoresis

Y. Tsutsumi, H. Kamada, H. Mori, 2013, Neuroscience Letters.

The domestic cat as a natural animal model of Alzheimer’s disease

T. Tokuda, H. Nakayama, Y. Une, 2015, Acta neuropathologica communications.

Recognition of human immunodeficiency virus glycoproteins by natural anti-carbohydrate antibodies in human serum.

Y. Masuho, E. Hersh, T. Tomiyama, 1991, Biochemical and biophysical research communications.

Regulation of cholesterol efflux by amyloid β secretion

Hui Zheng, H. Mori, T. Tomiyama, 2010, Alzheimer's & Dementia.

Characterization of human anti-cytomegalovirus monoclonal antibody as biologics.

Y. Masuho, Y. Matsumoto, S. Ono, 1990, Developments in biological standardization.

A Mouse Model of Amyloid β Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo

W. Klein, M. Lambert, Kazuhiro Ito, 2010, The Journal of Neuroscience.

Regulation of cholesterol efflux by amyloid β secretion

Hui Zheng, H. Mori, T. Tomiyama, 2010, Alzheimer's & Dementia.

In Vivo Positron Emission Tomographic Imaging of Glial Responses to Amyloid-β and Tau Pathologies in Mouse Models of Alzheimer's Disease and Related Disorders

J. Trojanowski, V. Lee, T. Suhara, 2011, The Journal of Neuroscience.

Hawaiian native herb Mamaki prevents dementia by ameliorating neuropathology and repairing neurons in four different mouse models of neurodegenerative diseases.

T. Tomiyama, T. Umeda, Keiko Shigemori, 2023, GeroScience.

Neurodegenerative Disorder FTDP-17 e Related Tau Intron 10 D 16C / T Mutation Increases Tau Exon 10 Splicing and Causes Tauopathy in Transgenic Mice

A. Takashima, H. Mori, H. Takuma, 2022 .

Investigating the efficacy of nasal administration for delivering magnetic nanoparticles into the brain for magnetic particle imaging.

S. Seino, T. Tomiyama, T. Umeda, 2024, Journal of controlled release : official journal of the Controlled Release Society.

Oligomeric amyloid beta-protein as a therapeutic target in Alzheimer's disease: its significance based on its distinct localization and the occurrence of a familial variant form.

Kazuhiro Ito, H. Mori, T. Tomiyama, 2009, Current Alzheimer research.