T. Shepherd

发表

Development of in vitro peptide substrates for human rhinovirus-14 2A protease.

W. Sommergruber, Q. Wang, R. Johnson, 1998, Archives of biochemistry and biophysics.

Progress toward the discovery and development of efficacious BACE inhibitors.

T. Shepherd, T. Durham, Timothy B Durham, 2006, Current opinion in drug discovery & development.

A new selective estrogen receptor modulator with potent uterine antagonist activity, agonist activity in bone, and minimal ovarian stimulation.

A. Geiser, J. Dodge, J. Henck, 2005, Endocrinology.

Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Can

Brandon J. Margolis, S. Atwell, Matthew R. Lee, 2017, Journal of Medicinal Chemistry.

Site-specific prodrug activation by antibody-beta-lactamase conjugates: regression and long-term growth inhibition of human colon carcinoma xenograft models.

S. Briggs, J. J. Starling, T. Shepherd, 1993, Cancer research.

Synthesis of a cephalosporin-doxorubicin antitumor prodrug: a substrate for an antibody-targeted enzyme

T. Shepherd, L. N. Jungheim, J. K. Kling, 1993 .

Synthesis of acylhydrazido-substituted cephems. Design of cephalosporin-vinca alkaloid prodrugs: substrates for an antibody targeted enzyme

D. Meyer, T. Shepherd, L. N. Jungheim, 1992 .

Site-specific prodrug activation by antibody-beta-lactamase conjugates: preclinical investigation of the efficacy and toxicity of doxorubicin delivered by antibody directed catalysis.

J. J. Starling, T. Shepherd, S. Mikolajczyk, 1995, Bioconjugate chemistry.

Preparation and characterization of a beta-lactamase-Fab' conjugate for the site-specific activation of oncolytic agents.

J. J. Starling, T. Shepherd, S. Mikolajczyk, 1992, Bioconjugate chemistry.

A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats.

A. Geiser, J. Dodge, H. Bryant, 2005, Journal of medicinal chemistry.

A novel targeted delivery system utilizing a cephalosporin-oncolytic prodrug activated by an antibody β-lactamase conjugate for the treatment of cancer

D. Meyer, J. J. Starling, T. Shepherd, 1991 .

Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication.

S. Venkatraman, J. Aubé, Q. Wang, 1998, Journal of medicinal chemistry.

Small peptidic aldehyde inhibitors of human rhinovirus 3C protease

T. Shepherd, E. Villarreal, M. Wakulchik, 1996 .

Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication.

S. Venkatraman, J. Aubé, Q. Wang, 1998, Journal of medicinal chemistry.

Synthesis and pharmacokinetics of potent carbamate HIV-1 protease inhibitors containing novel high affinity hydroxyethylamine isosteres

J. Colacino, M. Muesing, T. Shepherd, 1995 .

Design and synthesis of a novel series of 1,2-disubstituted cyclopentanes as small, potent potentiators of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) receptors.

G. Stephenson, D. Bleakman, B. Cantrell, 2002, Journal of medicinal chemistry.

Potent human immunodeficiency virus type 1 protease inhibitors that utilize noncoded D-amino acids as P2/P3 ligands.

M. Muesing, T. Shepherd, L. N. Jungheim, 1996, Journal of medicinal chemistry.

1,3-Dipolar cycloaddition reactions of pyrazolidinium ylides with vinyl sulfones. A regioselective synthesis of bicyclic pyrazolidinone antibacterial agents

C. J. Barnett, J. E. Gray, S. Sigmund, 1988 .

Synthesis and biological activity of the putative metabolites of the atypical antipsychotic agent tiospirone.

D. W. Smith, J. Yevich, T. Shepherd, 1991, Journal of medicinal chemistry.

Potent, orally bioavailable HIV-1 protease inhibitors containing noncoded D-amino acids

J. Colacino, M. Muesing, T. Shepherd, 1995 .

Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38alpha MAP kinase inhibitors with excellent in vivo antiinflammatory properties.

R. Campbell, Carlos Jaramillo, B. Anderson, 2008, Bioorganic & medicinal chemistry letters.

Development of analytical and preparative chromatographic separations of novel growth hormone secretagogue compounds.

J. Dodge, T. Shepherd, J. Kennedy, 2000, Journal of chromatography. A.

Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models

P. Iversen, Y. Qian, Matthew R. Lee, 2018, Scientific Reports.

D-amino acids as novel P2/P3 ligands for inhibitors of HIV-1 protease

T. Shepherd, A. J. Baxter, Louis Nickolaus Jungheim, 1994 .

Design of Antitumor Prodrugs: Substrates for Antibody Targeted Enzymes

T. Shepherd, L. N. Jungheim, 1994 .

Design of Antitumor Prodrugs: Substrates for Antibody Targeted Enzymes.

T. Shepherd, Louis Nickolaus Jungheim, 1995 .

Thioaldehydes in cycloaddition reactions: synthesis of nuclear analogues of pyrazolidinone antibacterial agents

T. Shepherd, L. N. Jungheim, 1988 .

Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety.

Daniel G Rudmann, A. Geiser, J. Dodge, 2007, Bioorganic & medicinal chemistry letters.

Thioaldehydes in Cycloaddition Reactions. Synthesis of Nuclear Analogues of Pyrazolidinone Antibacterial Agents.

T. Shepherd, L. N. Jungheim, 1989 .

Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models

P. Iversen, Y. Qian, Matthew R. Lee, 2018, Scientific Reports.