P. Leandro

发表

The lytic cassette of mycobacteriophage Ms6 encodes an enzyme with lipolytic activity.

M. McNeil, J. Moniz-Pereira, Maria João Catalão, 2008, Microbiology.

The V388M mutation results in a kinetic variant form of phenylalanine hydroxylase.

I. Rivera, I. T. de Almeida, I. T. Almeida, 2000, Molecular genetics and metabolism.

Heterotetrameric forms of human phenylalanine hydroxylase: co-expression of wild-type and mutant forms in a bicistronic system.

T. Flatmark, J. Leandro, P. Leandro, 2011, Biochimica et biophysica acta.

Phenylketonuria as a protein misfolding disease: The mutation pG46S in phenylalanine hydroxylase promotes self-association and fibril formation.

T. Flatmark, J. Leandro, P. Leandro, 2011, Biochimica et biophysica acta.

Structure of full-length wild-type human phenylalanine hydroxylase by small angle X-ray scattering reveals substrate-induced conformational stability

H. Mertens, J. B. Vicente, J. Leandro, 2019, Scientific Reports.

The G46S-hPAH mutant protein: a model to study the rescue of aggregation-prone PKU mutations by chaperones.

T. Flatmark, J. Leandro, P. Leandro, 2011, Molecular genetics and metabolism.

Dry powder inhaler formulation of Cu,Zn-superoxide dismutase by spray drying: A proof-of-concept

M. L. Corvo, P. Leandro, D. Fernandes, 2021 .

Chapter 4 Deciphering Protein Arginine Methylation in Mammals

R. Castro, Ruben Esse, I. Rivera, 2018 .

Unveiling the Pathogenic Molecular Mechanisms of the Most Common Variant (p.K329E) in Medium-Chain Acyl-CoA Dehydrogenase Deficiency by in Vitro and in Silico Approaches.

R. Guedes, J. Leandro, P. Leandro, 2016, Biochemistry.

Insights into Medium‐chain Acyl‐CoA Dehydrogenase Structure by Molecular Dynamics Simulations

R. Guedes, P. Leandro, F. V. Ventura, 2016, Chemical biology & drug design.

Population genetics of hyperphenylalaninaemia resulting from phenylalanine hydroxylase deficiency in Portugal.

I. Rivera, M. Lechner, I. T. Almeida, 1998, Journal of medical genetics.

Mutation Analysis of phenylketonuria in South and Central Portugal: Prevalence of V388M mutation

I. Rivera, I. T. de Almeida, M. Lechner, 1995, Human mutation.

Albumin-binding domain from Streptococcus zooepidemicus protein Zag as a novel strategy to improve the half-life of therapeutic proteins.

J. Goncalves, J. Correia, M. Serrano, 2017, Journal of biotechnology.

S-Adenosyl-l-methionine Modulates CO and NO• Binding to the Human H2S-generating Enzyme Cystathionine β-Synthase*

J. B. Vicente, P. Sarti, P. Leandro, 2015, The Journal of Biological Chemistry.

NO• Binds Human Cystathionine β-Synthase Quickly and Tightly*

J. B. Vicente, P. Sarti, P. Leandro, 2014, The Journal of Biological Chemistry.

Conclusion: Results support the physiological role of NO in CBS regulation. Significance: CBS may integrate the cross-talk among NO, CO, and H2S, major modulators in human (patho)physiology.

P. Sarti, P. Leandro, A. Giuffrè, 2014 .

Modulation of Human Phenylalanine Hydroxylase by 3-Hydroxyquinolin-2(1H)-One Derivatives

Pedro M. P. Gois, J. B. Vicente, M. Teixeira, 2021, Biomolecules.

Glycerol increases the yield and activity of human phenylalanine hydroxylase mutant enzymes produced in a prokaryotic expression system.

M. Lechner, D. Konecki, P. Leandro, 2001, Molecular genetics and metabolism.

Polyol Additives Modulate the In Vitro Stability and Activity of Recombinant Human Phenylalanine Hydroxylase

I. T. Almeida, J. Leandro, P. Leandro, 2010, Applied biochemistry and biotechnology.

Modulation of the Activity of Newly Synthesized Human Phenylalanine Hydroxylase Mutant Proteins by Low-Molecular-Weight Compounds

J. Leandro, P. Leandro, I. Tavares de Almeida, 2008, The protein journal.

Formulation of Spray Dried Enzymes for Dry Powder Inhalers: An Integrated Methodology.

D. A. Fernandes, P. Leandro, M. Luísa Corvo, 2022, International journal of pharmaceutics.

Insights into the Regulatory Domain of Cystathionine Beta‐Synthase: Characterization of Six Variant Proteins

I. Rivera, H. Blom, J. B. Vicente, 2014, Human mutation.

Engineering Organoids for in vitro Modeling of Phenylketonuria

Tiago G Fernandes, T. Fernandes, K. Broersen, 2022, Frontiers in Molecular Neuroscience.

Functional and structural impact of the most prevalent missense mutations in classic galactosemia

R. Ramos, I. Rivera, J. B. Vicente, 2014, Molecular genetics & genomic medicine.

Arginine Functionally Improves Clinically Relevant Human Galactose-1-Phosphate Uridylyltransferase (GALT) Variants Expressed in a Prokaryotic Model.

I. Rivera, I. T. de Almeida, J. B. Vicente, 2015, JIMD reports.

Lack of Aquaporin 3 in bovine erythrocyte membranes correlates with low glycerol permeation.

G. Soveral, P. Leandro, A. Oliva, 2011, Biochemical and biophysical research communications.

Metabolism-Guided Optimization of Tryptophanol-Derived Isoindolinone p53 Activators

Maria M. M. Santos, L. Saraíva, J. Loureiro, 2023, Pharmaceuticals.

Tyrosinaemia type I with normal levels of plasma tyrosine

M. Durán, P. Leandro, M. F. Silva, 1990, Journal of Inherited Metabolic Disease.

Deciphering Protein Arginine Methylation in Mammals

R. Castro, I. Rivera, H. Blom, 2012 .

The correlation of genotype and phenotype in Portuguese hyperphenylalaninemic patients.

I. Rivera, I. T. de Almeida, M. Lechner, 2000, Molecular genetics and metabolism.

Small aminothiol compounds improve the function of Arg to Cys variant proteins: effect on the human cystathionine β-synthase p.R336C.

I. Rivera, H. Blom, J. B. Vicente, 2015, Human molecular genetics.

Reduced response of Cystathionine Beta-Synthase (CBS) to S-Adenosylmethionine (SAM): Identification and functional analysis of CBS gene mutations in Homocystinuria patients

R. Ramos, I. Rivera, H. Blom, 2014, Journal of Inherited Metabolic Disease.

Protein Arginine Methylation Is More Prone to Inhibition by S-Adenosylhomocysteine than DNA Methylation in Vascular Endothelial Cells

R. Castro, Madalena Barroso, I. Rivera, 2013, PloS one.

Structural and functional impact of clinically relevant E1α variants causing pyruvate dehydrogenase complex deficiency.

I. Rivera, I. T. de Almeida, J. B. Vicente, 2021, Biochimie.

Co-expression of different subunits of human phenylalanine hydroxylase: evidence of negative interallelic complementation.

I. T. de Almeida, J. Leandro, P. Leandro, 2006, Biochimica et biophysica acta.

Impact of Fluorinated Ionic Liquids on Human Phenylalanine Hydroxylase—A Potential Drug Delivery System

H. Mertens, M. Archer, A. B. Pereiro, 2022, Nanomaterials.

Correction: Protein Arginine Methylation Is More Prone to Inhibition by S-Adenosylhomocysteine than DNA Methylation in Vascular Endothelial Cells

R. Castro, Madalena Barroso, I. Rivera, 2013, PLoS ONE.

Systematic Modification and Evaluation of Enzyme-Loaded Chitosan Nanoparticles

Lídia M D Gonçalves, A. Almeida, J. Leandro, 2021, International journal of molecular sciences.

Protein misfolding in conformational disorders: rescue of folding defects and chemical chaperoning.

C. Gomes, P. Leandro, 2008, Mini reviews in medicinal chemistry.

In Silico and In Vitro Tailoring of a Chitosan Nanoformulation of a Human Metabolic Enzyme

Lídia M D Gonçalves, J. Leandro, P. Leandro, 2021, Pharmaceutics.

A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β-Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity?

J. B. Vicente, P. Leandro, A. Giuffrè, 2017, Oxidative medicine and cellular longevity.

Primary systemic carnitine deficiency

P. Leandro, F. Ventura, I. D. Almeida, 2003 .

Functional and structural impact of 10 ACADM missense mutations on human medium chain acyl-Coa dehydrogenase.

Ricardo J. Ferreira, R. Wanders, J. B. Vicente, 2023, Biochimica et biophysica acta. Molecular basis of disease.

Author Correction: Structure of full-length wild-type human phenylalanine hydroxylase by small angle X-ray scattering reveals substrate-induced conformational stability

H. Mertens, J. B. Vicente, J. Leandro, 2019, Scientific Reports.

Annual Symposium of the Society for the Study of Inborn Errors of Metabolism

S. D. Jong, C. Pérez-Cerdá, M. Ugarte, 2010, Journal of Inherited Metabolic Disease.

Albumin-binding domain from Streptococcus zooepidemicus protein Zag as a novel strategy to improve the half-life of therapeutic proteins.

J. Correia, M. Serrano, A. Henriques, 2017, Journal of biotechnology.

Polyol Additives Modulate the In Vitro Stability and Activity of Recombinant Human Phenylalanine Hydroxylase

I. T. Almeida, J. Leandro, P. Leandro, 2010, Applied biochemistry and biotechnology.

Retrospective study of the medium‐chain acyl‐CoA dehydrogenase deficiency in Portugal

R. Ramos, I. Rivera, E. Martins, 2014, Clinical genetics.