K. Iwase

发表

Phosphodiesterase inhibitors. Part 3: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-dihydropyridazinones with anti-inflammatory and bronchodilatory activity.

D. Adams, Koji Ochiai, Satoshi Takita, 2012, Bioorganic & medicinal chemistry.

Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast.

D. Adams, G. Rosair, K. Iwase, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and antibacterial activity of 1-(2-fluorovinyl)-7-substituted-4-quinolone-3-carboxylic acid derivatives, conformationally restricted analogues of fleroxacin.

K. Iwase, M. Hosaka, Y. Asahina, 2005, Journal of medicinal chemistry.

Synthesis and antibacterial activity of the 4-quinolone-3-carboxylic acid derivatives having a trifluoromethyl group as a novel N-1 substituent.

K. Iwase, M. Hosaka, Y. Asahina, 2005, Journal of medicinal chemistry.

LpxC Inhibitors: Design, Synthesis, and Biological Evaluation of Oxazolidinones as Gram-negative Antibacterial Agents.

Y. Yamaguchi, K. Iwase, Y. Kohno, 2016, ACS medicinal chemistry letters.

Phosphodiesterase inhibitors. Part 6: design, synthesis, and structure-activity relationships of PDE4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory activity.

Koji Ochiai, Satoshi Takita, A. Kojima, 2013, Bioorganic & medicinal chemistry letters.

Phosphodiesterase inhibitors. Part 5: hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration.

D. Adams, Koji Ochiai, Satoshi Takita, 2013, Bioorganic & medicinal chemistry letters.

Phosphodiesterase inhibitors. Part 4: design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-4,4-dimethylpyrazolones.

D. Adams, Koji Ochiai, Satoshi Takita, 2012, Bioorganic & medicinal chemistry letters.

Phosphodiesterase inhibitors. Part 2: design, synthesis, and structure-activity relationships of dual PDE3/4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory and bronchodilatory activity.

D. Adams, Koji Ochiai, K. Iwase, 2011, Bioorganic & medicinal chemistry letters.

Structure-activity study of pyridine derivatives inhibiting thromboxane synthetase

I. Moriguchi, K. Iwase, K. Akahane, 1984 .

Novel nikkomycin analogues: inhibitors of the fungal cell wall biosynthesis enzyme chitin synthase.

A. Matsuda, K. Iwase, J. Uda, 2000, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of novel nikkomycin analogs: inhibitors of the fungal cell wall biosynthesis enzyme chitin synthase.

A. Matsuda, K. Iwase, J. Uda, 1999, Nucleic acids symposium series.

Estimation of active conformations of drugs by a new molecular superposing procedure

Shuichi Hirono, Kazuhiko Iwase, S. Hirono, 1999, J. Comput. Aided Mol. Des..