Y. Kohno

发表

Phosphodiesterase inhibitors. Part 3: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-dihydropyridazinones with anti-inflammatory and bronchodilatory activity.

D. Adams, Koji Ochiai, Satoshi Takita, 2012, Bioorganic & medicinal chemistry.

Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast.

D. Adams, G. Rosair, K. Iwase, 2011, Bioorganic & medicinal chemistry letters.

Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure.

Y. Saito, D. Gordon, R. Wexler, 2020, Journal of medicinal chemistry.

LpxC Inhibitors: Design, Synthesis, and Biological Evaluation of Oxazolidinones as Gram-negative Antibacterial Agents.

Y. Yamaguchi, K. Iwase, Y. Kohno, 2016, ACS medicinal chemistry letters.

Discovery of benzo[f]pyrido[4,3-b][1,4]oxazepin-10-one derivatives as orally available bromodomain and extra-terminal domain (BET) inhibitors with efficacy in an in vivo psoriatic animal model.

Y. Kohno, M. Sato, Takekazu Kondo, 2021, Bioorganic & medicinal chemistry.

Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase.

J. Kozarich, E. Okerberg, Yi Hu, 2009, Bioorganic & medicinal chemistry letters.

Phosphodiesterase inhibitors. Part 6: design, synthesis, and structure-activity relationships of PDE4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory activity.

Koji Ochiai, Satoshi Takita, A. Kojima, 2013, Bioorganic & medicinal chemistry letters.

Phosphodiesterase inhibitors. Part 5: hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration.

D. Adams, Koji Ochiai, Satoshi Takita, 2013, Bioorganic & medicinal chemistry letters.

Phosphodiesterase inhibitors. Part 4: design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-4,4-dimethylpyrazolones.

D. Adams, Koji Ochiai, Satoshi Takita, 2012, Bioorganic & medicinal chemistry letters.

Phosphodiesterase inhibitors. Part 2: design, synthesis, and structure-activity relationships of dual PDE3/4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory and bronchodilatory activity.

D. Adams, Koji Ochiai, K. Iwase, 2011, Bioorganic & medicinal chemistry letters.

Amides of xanthurenic acid as zinc-dependent inhibitors of Lp-PLA(2).

Y. Hu, J. Kozarich, E. Okerberg, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3β.

J. Kozarich, J. Rosenblum, Qiang Li, 2011, Bioorganic & medicinal chemistry letters.

Novel selective allosteric and bitopic ligands for the S1P(3) receptor.

Steven J Brown, S. Schürer, M. Guerrero, 2012, ACS chemical biology.

Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction

Steven J Brown, A. McCulloch, P. Gonzalez-Cabrera, 2016, Molecular Pharmacology.

Quinolone derivatives containing strained spirocycle as orally active glycogen synthase kinase 3β (GSK-3β) inhibitors for type 2 diabetics.

Y. Kohno, K. Murakami, K. Yumoto, 2012, Bioorganic & medicinal chemistry.

Chemoselective displacement of methylsulfinyl group with amines to provide 2-alkylamino-4,6-disubstituted pyrimidine-5-carboxylic acid

Y. Kohno, S. Seto, 2009 .

SYNTHESIS OF ()-STEMONAMIDE BY THE APPLICATION OF OXIDATIVE COUPLING REACTIONS OF STANNYL COMPOUNDS WITH SILYL ENOL ETHERS

Y. Kohno, K. Narasaka, 1996 .

Novel pyrazolo[1,5-a]pyridines as orally active EP1 receptor antagonists: Synthesis, structure-activity relationship studies, and biological evaluation.

Y. Kohno, N. Tanaka, K. Tatani, 2017, Bioorganic & medicinal chemistry.

Efficient total synthesis of AI-77-B, A gastroprotective substance from bacillus pumilus AI-77

O. Hara, Y. Kohno, Y. Hamada, 1991 .

Oxidative Generation of α-Radicals of Carbonyl Compounds from the α-Stannyl Derivatives and Their Reactions with Electron-Rich Olefins

Y. Kohno, K. Narasaka, 1995 .

Synthesis and antirheumatic activity of novel tetrahydro-6-quinolineacetic acid derivatives

Y. Kohno, S. Kudoh, K. Awano, 1997 .

Generation of α-Radicals of Acetic Acid Derivatives from α-Stannyl Ester and Amide and Their Reactions with Electron-Rich Olefins

Y. Kohno, K. Narasaka, 1993 .

Oxidative Generation of N-Acyliminium Ions from N-1-(Tributylstannyl)alkyl Carboxamides and Carbamates and Their Reactions with Carbon Nucleophiles.

Y. Kohno, K. Narasaka, K. Narasaka*, 1993 .

Generation of a cation radical from 2-pivaloyl-1-tributylstannyl-1,2,3,4-tetrahydroisoquinoline and the reaction with carbon nucleophiles

Y. Kohno, K. Narasaka, S. Shimada, 1993 .

Amides of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid as zinc-dependent inhibitors of Lp-PLA₂.

Y. Hu, J. Kozarich, E. Okerberg, 2013, Bioorganic & medicinal chemistry letters.

PBr3-mediated unexpected reductive deoxygenation of α-aryl-pyridinemethanols: synthesis of arylmethylpyridines

Y. Kohno, Kentaro Umei, S. Seto, 2016 .

Design, synthesis, and structure-activity relationship studies of novel 2,4,6-trisubstituted-5-pyrimidinecarboxylic acids as peroxisome proliferator-activated receptor gamma (PPARgamma) partial agonists with comparable antidiabetic efficacy to rosiglitazone.

Y. Kohno, Y. Kitamura, K. Murakami, 2010, Journal of medicinal chemistry.

[Research and development of clarithromycin].

T. Adachi, Y. Kohno, S. Omura, 1992, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Discovery of novel pyrazolo[1,5-a]pyridine-based EP1 receptor antagonists by scaffold hopping: Design, synthesis, and structure-activity relationships.

Y. Saito, Y. Kohno, N. Tanaka, 2017, Bioorganic & medicinal chemistry letters.

Concise routes to pyrazolo[1,5-a]pyridin-3-yl pyridazin-3-ones.

D. Adams, G. Rosair, Robert W. Allcock, 2008, Organic & biomolecular chemistry.

Concise Routes to Pyrazolo[1,5-a]pyridin-3-yl Pyridazin-3-ones

D. Adams, G. Rosair, Robert W. Allcock, 2008 .

Identification of novel 1,2,3,6-tetrahydropyridyl-substituted benzo[d]thiazoles: Lead generation and optimization toward potent and orally active EP1 receptor antagonists.

Y. Kohno, N. Tanaka, Kentaro Umei, 2017, Bioorganic & medicinal chemistry.

Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents.

Y. Yamaguchi, Y. Kohno, Ryuta Kishii, 2017, Bioorganic & Medicinal Chemistry Letters.

Characteristics of the association of brotizolam, a thieno-triazolo diazepine derivative, with the benzodiazepine receptor: a selective and high affinity ligand of the central type I benzodiazepine receptor.

Y. Kohno, K. Kuriyama, M. Hirouchi, 1992, Japanese journal of pharmacology.