P. Davis

发表

Design synthesis and structure-activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands.

V. Hruby, T. Vanderah, J. Lai, 2016, Bioorganic & medicinal chemistry.

Opioid Peptides: Simultaneous δ Agonism and μ Antagonism in Somatostatin Analogues

V. Hruby, H. Yamamura, F. Porreca, 1997, Peptides.

Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain.

V. Hruby, Yue Wang, T. Vanderah, 2015, Journal of medicinal chemistry.

Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.

V. Hruby, H. Yamamura, F. Porreca, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Benzomorphan alkaloids: Natural peptidomimetics of opioid peptide pharmacophores

V. Hruby, A. Lipkowski, A. Misicka, 1995, Letters in Peptide Science.

Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans.

N. Khare, R. Rothman, C. Dersch, 2003, Bioorganic & medicinal chemistry letters.

Novel ligands for the opioid receptors: synthesis and structure-activity relationships among 5'-aryl and 5'-heteroaryl 17-cyclopropylmethyl-4,5 alpha-epoxypyrido[2',3':6,7]morphinans.

N. Khare, R. Rothman, C. Dersch, 2003, Bioorganic & medicinal chemistry.

Conformational restriction of Tyr and Phe side chains in opioid peptides: information about preferred and bioactive side-chain topology.

V. Hruby, K. Verschueren, F. Porreca, 1996 .

Solid-phase synthetic strategy and bioevaluation of a labeled delta-opioid receptor ligand Dmt-Tic-Lys for in vivo imaging.

R. Gillies, V. Hruby, D. Morse, 2009, Organic letters.

Synthesis and biological properties of β‐MePhe3 analogues of deltorphin I and dermenkephalin: influence of biased X1 of Phe3 residues on peptide recognition for δ‐opioid receptors

R. Horváth, V. Hruby, A. Misicka, 2009 .

Dermorphin sequence with high δ-afinity by fixing the phe sidechain to trans at ξ1

V. Hruby, K. Verschueren, F. Porreca, 1992 .

Biological active analogues of the opioid peptide biphalin: mixed α/β(3)-peptides.

V. Hruby, A. Mollica, M. Locatelli, 2013, Journal of medicinal chemistry.

New potent biphalin analogues containing p-fluoro-l-phenylalanine at the 4,4′ positions and non-hydrazine linkers

V. Hruby, A. Mollica, A. Stefanucci, 2011, Amino Acids.

Synthesis and biological activity of the first cyclic biphalin analogues.

V. Hruby, A. Mollica, F. Porreca, 2006, Bioorganic & medicinal chemistry letters.

Novel design of bicyclic beta-turn dipeptides on solid-phase supports and synthesis of [3.3.0]-Bicyclo([2,3])-leu-enkephalin analogues.

Jinfa Ying, V. Hruby, E. Navratilova, 2004, Organic letters.

Synthesis and biological activities of YkFA analogues: effects of position 4 substitutions and altered ring size on in vitro opioid activity.

F. Porreca, A. Spatola, P. Davis, 2002, Bioorganic & medicinal chemistry letters.

Synthesis and biological activities of position one and three transposed analogs of the opioid peptide YKFA.

F. Porreca, A. Spatola, P. Davis, 1999, Bioorganic & medicinal chemistry letters.

Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide.

V. Hruby, R. Hughes, B. Lou, 1998, Bioorganic & Medicinal Chemistry Letters.

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands.

V. Hruby, T. Vanderah, F. Porreca, 2011, Bioorganic & medicinal chemistry.

The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.

V. Hruby, H. Yamamura, T. Vanderah, 2009, Bioorganic & medicinal chemistry.

Glycosylation Improves the Central Effects of DAMGO

J. Bidlack, F. Porreca, P. Davis, 2007, Chemical biology & drug design.

Antinociceptive Structure-Activity Studies with Enkephalin-Based Opioid Glycopeptides

V. Hruby, E. Navratilova, H. Yamamura, 2004, Journal of Pharmacology and Experimental Therapeutics.

Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors.

V. Hruby, F. Porreca, J. Lai, 2015, Bioorganic & medicinal chemistry letters.

Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502).

S. Salvadori, G. Balboni, F. Porreca, 2008, Bioorganic & medicinal chemistry.

α‐Azido acids for direct use in solid‐phase peptide synthesis

M. Meldal, C. W. Tornøe, F. Porreca, 2000 .

New paradigms and tools in drug design for pain and addiction

I. Alves, Z. Salamon, G. Tollin, 2006, The AAPS Journal.

Morphiceptin and β‐casomorphin‐5 analogues containing a reduced peptide bond: Selective μ‐receptor agonists and a novel μ antagonist, H‐Tyr‐Proψ(CH2‐NH)Phe‐Pro‐Gly‐OH

T. Burks, D. Tourwé, P. Davis, 1992 .

Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations.

V. Hruby, T. Vanderah, J. Lai, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue.

V. Hruby, A. Mollica, D. Torino, 2009, Bioorganic & medicinal chemistry letters.

Solid-Phase Synthetic Strategy & Bioevaluation of a Labeled δ Opioid Receptor Ligand Dmt-Tic-Lys for In Vivo Imaging

R. Gillies, V. Hruby, D. Morse, 2009 .

Cyclic enkephalin analogs that are hybrids of DPDPE-related peptides and metenkephalin-Arg-Gly-Leu: prohormone analogs that retain good potency and selectivity for delta opioid receptors.

V. Hruby, H. Yamamura, F. Porreca, 1999, The journal of peptide research : official journal of the American Peptide Society.

Conformational restriction of Tyr and Phe side chains in opioid peptides: information about preferred and bioactive side-chain topology.

K. Verschueren, F. Porreca, D. Tourwé, 1996, Biopolymers.

Synthesis of Stable and Potent δ/μ Opioid Peptides: Analogues of H-Tyr-c[d-Cys-Gly-Phe-d-Cys]-OH by Ring-Closing Metathesis

V. Hruby, A. Mollica, L. Mannina, 2007 .

Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers.

V. Hruby, A. Mollica, F. Porreca, 2005, Bioorganic & medicinal chemistry letters.

De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the δ-Opioid Receptor‖

V. Hruby, H. Yamamura, F. Porreca, 1998 .

delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole.

K. Rice, A. Coop, R. Rothman, 1999, Journal of medicinal chemistry.

Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.

S K Saini, K. Rice, R. Rothman, 1999, Journal of medicinal chemistry.

Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands.

K. Rice, A. Coop, R. Rothman, 1999, Journal of medicinal chemistry.

Probes for Narcotic Receptor-Mediated Phenomena. 25.1 Synthesis and Evaluation of N-Alkyl-Substituted (α-Piperazinylbenzyl)benzamides as Novel, Highly Selective δ Opioid Receptor Agonists

Koichi Homma, Judith L. Flippen-Anderson, Richard B. Rothman, 1997 .

Probes for narcotic receptor mediated phenomena. 23.1 Synthesis, opioid receptor binding, and bioassay of the highly selective δ agonist (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80) and related novel nonpeptide δ opioid receptor ligands

Robert Horvath, Judith L. Flippen-Anderson, Richard B. Rothman, 1997 .

Probing the Stereochemical Requirements for Receptor Recognition of δ Opioid Agonists through Topographic Modifications in Position 1

R. Horváth, V. Hruby, H. Yamamura, 1996 .

Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands.

J. Flippen-Anderson, K. Rice, R. Rothman, 1995, Journal of medicinal chemistry.

cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: part 2.

V. Hruby, A. Mollica, L. Mannina, 2012, Journal of medicinal chemistry.

Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2.

V. Hruby, A. Mollica, A. Masi, 2010, European journal of medicinal chemistry.

Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.

V. Hruby, F. Porreca, J. Lai, 2007, Journal of medicinal chemistry.

Structure-activity relationship of biphalin. The synthesis and biological activities of new analogues with modifications in positions 3 and 4.

R. Horváth, V. Hruby, A. Lipkowski, 1997, Life sciences.

Highly kappa receptor-selective dynorphin A analogues with modifications in position 3 of dynorphin A(1-11)-NH2.

V. Hruby, B. Lou, H. Yamamura, 1995, Journal of medicinal chemistry.

Structure-Activity Relationships of [des-Arg7]Dynorphin A Analogues at the κ Opioid Receptor.

V. Hruby, T. Vanderah, J. Streicher, 2016, Journal of medicinal chemistry.

A novel 3-step enantioselective synthesis of pyrenylalanine with subsequent incorporation into opioid, CCK, and melanotropin ligands.

I. Alves, V. Hruby, F. Porreca, 2004, Biochemical and biophysical research communications.

Structure–activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors

Jinfa Ying, V. Hruby, K. Kövér, 2008, Peptides.

Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors.

V. Hruby, F. Porreca, J. Lai, 2006, Journal of medicinal chemistry.

Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain.

V. Hruby, T. Vanderah, F. Porreca, 2003, Life sciences.

Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2009, Journal of medicinal chemistry.

Synthesis, biology, NMR and conformation studies of the topographically constrained delta-opioid selective peptide analogs of [beta-iPrPhe(3)]deltorphin I.

H. Yamamura, K. Kövér, F. Porreca, 2001, The journal of peptide research : official journal of the American Peptide Society.

Design, Synthesis, and Biological Evaluation of Novel Bifunctional C-Terminal-Modified Peptides for δ/μ Opioid Receptor Agonists and Neurokinin-1 Receptor Antagonists

V. Hruby, E. Navratilova, H. Yamamura, 2007 .

Effect of anchoring 4-anilidopiperidines to opioid peptides.

V. Hruby, T. Vanderah, F. Porreca, 2013, Bioorganic & medicinal chemistry letters.

SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist.

V. Hruby, R. Rothman, F. Porreca, 1995, The Journal of pharmacology and experimental therapeutics.

Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist.

J. Flippen-Anderson, K. Rice, R. Rothman, 1994, Journal of medicinal chemistry.

Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors.

V. Hruby, H. Yamamura, T. Zalewska, 1994, Journal of medicinal chemistry.

Synthesis of constrained analogues of cholecystokinin/opioid chimeric peptides.

James P. Cain, J. Ndungu, V. Hruby, 2006, Tetrahedron letters.

Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain.

R. Gillies, V. Hruby, F. Porreca, 2010, Bioorganic & medicinal chemistry letters.

Cyclic enkephalin analogues with exceptional potency and selectivity for δ-opioid receptors

V. Hruby, H. Yamamura, T. Zalewska, 1997 .

Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors.

V. Hruby, H. Yamamura, T. Zalewska, 1997, Journal of medicinal chemistry.

Topographically designed analogues of [D-Pen,D-Pen5]enkephalin.

V. Hruby, T. Burks, R. Knapp, 1991, Journal of medicinal chemistry.

Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.

Isuru R. Kumarasinghe, V. Hruby, T. Vanderah, 2009, Bioorganic & Medicinal Chemistry.

A Structure–Activity Relationship Study and Combinatorial Synthetic Approach of C-Terminal Modified Bifunctional Peptides That Are δ / μ Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists

V. Hruby, E. Navratilova, T. Vanderah, 2009 .

Opioid and melanocortin receptors: Do they have overlapping pharmacophores?

James P. Cain, V. Hruby, M. Cai, 2008, Biopolymers.

Design and Synthesis of Novel Hydrazide-Linked Bifunctional Peptides as δ/μ Opioid Receptor Agonists and CCK-1/CCK-2 Receptor Antagonists

V. Hruby, F. Porreca, J. Lai, 2006 .

Analogues of cholecystokinin 26–33 selective for B-type CCK receptors possess δ opioid receptor agonist activity in vitro and in vivo: Evidence for similarities in CCK-B and δ opioid receptor requirements

V. Hruby, G. Nikiforovich, T. Burks, 1994 .

Para-substituted phenylalanine-4 analogues of [L-Ala3]DPDPE: highly selective delta opioid receptor ligands.

V. Hruby, H. Yamamura, T. Zalewska, 2009, The journal of peptide research : official journal of the American Peptide Society.

Analogs of Multifunctional Ligands for Opioid and CCK Receptors

V. Hruby, F. Porreca, J. Lai, 2006 .

Design and Synthesis of Bifunctional Peptides: Antagonists at CCKA/CCKB Receptors and Agonists at μ/δ Opioid Receptors

V. Hruby, F. Porreca, J. Lai, 2001 .

Topographical requirements for delta opioid ligands: presence of a carboxyl group in position 4 is not critical for deltorphin high delta receptor affinity and analgesic activity.

V. Hruby, T. Burks, R. Knapp, 1991, Biochemical and biophysical research communications.

Differentiation between rat brain and mouse vas deferens δ opioid receptors

T. Burks, Y. Shimohigashi, R. Knapp, 1990 .

Development of μ/δ Opioid Ligands: Enkephalin Analogues Containing 4-Anilidopiperidine Moiety

V. Hruby, T. Vanderah, F. Porreca, 2009 .

Practical glycopeptide analgesics: Blood-brain barrier transport and binding of glycosylated enkephalin analogs

V. Hruby, H. Yamamura, R. Egleton, 2002 .

Influence of peptidase inhibitors on the apparent agonist potency of delta selective opioid peptides in vitro.

V. Hruby, T. Burks, P. Davis, 1991, Life sciences.

Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors.

V J Hruby, R. Horváth, V. Hruby, 1994, Journal of medicinal chemistry.

[D-Pen2,D-Pen5]enkephalin analogues with increased affinity and selectivity for delta opioid receptors.

V. Hruby, T. Burks, R. Knapp, 1990, Journal of medicinal chemistry.

Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted beta-turn bicyclic dipeptide mimetics.

Jinfa Ying, C. Xiong, V. Hruby, 2003, Chemical communications.

Topographical design of message domain pharmacophores of δ opioid agonists provide insights into the stereochemical requirements for recognizing δ opioid receptor subtypes

R. Horváth, V. Hruby, B. Lou, 1995 .

Biousian glycopeptides penetrate the blood-brain barrier

I. Alves, G. Tollin, H. Yamamura, 2005 .

The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2008, Journal of medicinal chemistry.

Identification of Opioid Ligands Possessing Mixed μ Agonist/δ Antagonist Activity among Pyridomorphinans Derived from Naloxone, Oxymorphone, and Hydropmorphone

N. Khare, R. Rothman, C. Dersch, 2004 .

Extraordinary potency of a novel delta opioid receptor agonist is due in part to increased efficacy.

V. Hruby, F. Porreca, P. Davis, 1997, Life sciences.

Novel cyclic biphalin analogue with improved antinociceptive properties.

E. Novellino, V. Hruby, A. Mollica, 2014, ACS medicinal chemistry letters.

The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues.

V. Hruby, A. Mollica, Cristina Campestre, 2012, Journal of medicinal chemistry.

Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin.

V. Hruby, A. Lipkowski, A. Misicka, 1999, Bioorganic & medicinal chemistry letters.

In vitro potency, affinity and agonist efficacy of highly selective delta opioid receptor ligands.

V. Hruby, T. Burks, F. Porreca, 1993, The Journal of pharmacology and experimental therapeutics.

Afferent drive elicits ongoing pain in a model of advanced osteoarthritis

Jennifer Xie, Ping Liu, Jiyang Ren, 2012, PAIN®.

Synthesis, opioid activities and binding affinities of dynorphin A analogues with position-3 conformational constraints: New insights into requirements for κ receptors

V. Hruby, B. Lou, H. Yamamura, 1995 .

A phase I study of imexon plus gemcitabine as first-line therapy for advanced pancreatic cancer

E. Hersh, M. Zalupski, R. Dorr, 2010, Cancer Chemotherapy and Pharmacology.

The fine tuning of high affinity and selective non-peptide agonists of the δ-opioid receptor via solution and solid-phase

V. Hruby, H. Yamamura, F. Porreca, 2002 .

Exploring the Structure−Activity Relationships of [1-(4-tert-Butyl-3‘-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), A High-Affinity and Selective δ-Opioid Receptor Nonpeptide Agonist Ligand†

V. Hruby, H. Yamamura, F. Porreca, 1999 .

Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability.

V. Hruby, H. Yamamura, F. Porreca, 2000, Journal of medicinal chemistry.

A new approach to enhance bioavailability of biologically active peptides: conjugation of a δ opioid agonist to β-cyclodextrin

R. Horváth, V. Hruby, H. Yamamura, 1993 .

Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2007, Journal of medicinal chemistry.

Development of potent μ and δ opioid agonists with high lipophilicity.

V. Hruby, T. Vanderah, F. Porreca, 2011, Journal of medicinal chemistry.

Parallel synthesis and biological evaluation of different sizes of bicyclo[2,3]‐Leu‐enkephalin analogues

Jinfa Ying, V. Hruby, E. Navratilova, 2005, Biopolymers.

Synthesis and biological activities of linear and cyclic enkephalin analogues containing a psi (E,CH = CH) or psi (CH2CH2) isosteric replacement.

J. Leysen, T. Burks, H. Yamamura, 2009, International journal of peptide and protein research.

Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.

V. Hruby, H. Yamamura, T. Vanderah, 2011, Journal of medicinal chemistry.

Development of Novel Enkephalin Analogues that Have Enhanced Opioid Activities at Both μ and δ Opioid Receptors

V. Hruby, Chad K. Park, F. Porreca, 2007 .

Glycopeptides related to beta-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers.

I. Alves, G. Tollin, V. Hruby, 2005, Journal of the American Chemical Society.

Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives.

V. Hruby, T. Vanderah, F. Porreca, 2015, Bioorganic & medicinal chemistry letters.

Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands.

V. Hruby, T. Vanderah, F. Porreca, 2015, Bioorganic & medicinal chemistry.

Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at μ and δ opioid receptors

V. Hruby, F. Porreca, J. Lai, 2007 .

The stereochemical requirements of the novel δ-opioid selective dipeptide antagonist TMT-Tic

V. Hruby, H. Yamamura, F. Porreca, 1997 .

Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines.

V. Hruby, E. Navratilova, H. Yamamura, 2010, Journal of medicinal chemistry.

Novel bifunctional peptides as opioid agonists and NK-1 antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2009, Advances in experimental medicine and biology.

Synthesis using a Fmoc-based strategy and biological activities of some reduced peptide bond pseudopeptide analogues of dynorphin A1.

V. Hruby, H. Yamamura, F. Porreca, 1995, Journal of medicinal chemistry.

Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays.

V. Hruby, H. Yamamura, F. Porreca, 2000, Journal of medicinal chemistry.

Differentiation between rat brain and mouse vas deferens delta opioid receptors.

V. Hruby, T. Burks, Y. Shimohigashi, 1990, European journal of pharmacology.

Design, Synthesis, and Biological Activities of Cyclic Lactam Peptide Analogues of Dynorphin A(1−11)-NH21

V. Hruby, H. Yamamura, F. Porreca, 1996 .

Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors.

V. Hruby, F. Porreca, J. Lai, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity.

V. Hruby, F. Porreca, J. Lai, 2006, Bioorganic & medicinal chemistry letters.

Probes for Narcotic Receptor Mediated Phenomena. Part 19. Synthesis of (+)-4-((αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)- 3-methoxybenzyl)-N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide δ Opioid Receptor Agonist.

J. Flippen-Anderson, K. Rice, R. Rothman, 1994 .

Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency.

V. Hruby, B. Lou, H. Yamamura, 1996, Journal of medicinal chemistry.

Chiral Effect of a Phe Residue in Position 3 of the Dmt1-L(or D)-Tic2 Analogues on Opioid Functional Activities.

V. Hruby, F. Porreca, Hongchang Qu, 2013, ACS Medicinal Chemistry Letters.

Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities.

V. Hruby, E. Navratilova, T. Vanderah, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues.

V. Hruby, A. Mollica, D. Torino, 2010, Journal of medicinal chemistry.

Ring substituted and other conformationally constrained tyrosine analogues of [D-Pen2,D-Pen5]enkephalin with delta opioid receptor selectivity.

G. Landis, V. Hruby, T. Burks, 1992, Journal of medicinal chemistry.

Topographical requirements for delta opioid ligands: common structural features of dermenkephalin and deltorphin.

R. Horváth, V. Hruby, A. Lipkowski, 1992, Life sciences.

Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.

T. Ullrich, K. Rice, A. Coop, 2001, Journal of medicinal chemistry.

Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.

K. Rice, R. Rothman, S. Ananthan, 1998, Journal of medicinal chemistry.

Delta opioid receptor selective ligands; DPLPE-deltorphin chimeric peptide analogues.

R. Horváth, V. Hruby, A. Lipkowski, 2009, International journal of peptide and protein research.

The synthesis and opioid receptor binding affinities of analogues of dermorphin and its N-terminal tetrapeptide fragment with dibasic acids in position 2.

V. Hruby, A. Lipkowski, A. Misicka, 1995, Life sciences.

Topographical requirements for δ-opioid ligands: The synthesis and biological properties of β-MePhe containing deltorphin I and dermenkephalin analogs

R. Horváth, V. Hruby, S. Cavagnero, 1993 .

Delta opioid receptor-selective ligands: [D-Pen2,D-Pen5]enkephalin-dermenkephalin chimeric peptides.

V. Hruby, T. Burks, S. Cavagnero, 1991, Life sciences.

Topographical requirements for delta opioid ligands: The synthesis and biological properties of a cyclic analogue of deltorphin I

R. Horváth, V. Hruby, G. Nikiforovich, 1992 .

Topographical requirements for δ opioid ligands: The synthesis and biological properties of cyclic analogues of deltorphins and dermenkephalin

R. Horváth, V. Hruby, A. Lipkowski, 1993 .

Topographic model of delta opioid selective ligands; DPLPE-deltorphin hybrid analogues

R. Horváth, V. Hruby, A. Lipkowski, 1994, Regulatory Peptides.

Amino acids with amphiphilic side chains: Deltorphin analogues with Phe3 replaced by all β-hydroxyphenylalanine diastereoisomers

V. Hruby, A. Lipkowski, A. Misicka, 1995, Letters in Peptide Science.

α-Helical Glycopeptide Analgesics: β-Endorphin Mimics with Good in vivo Potency

V. Hruby, H. Yamamura, R. Egleton, 2001 .

Design of a δ opioid peptide mimetic based on a topographically constrained cyclic enkephalin

V. Hruby, H. Yamamura, F. Porreca, 2002 .

A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2008, Journal of medicinal chemistry.

Design, synthesis, and biological properties of highly potent cyclic dynorphin A analogues. Analogues cyclized between positions 5 and 11.

V. Hruby, H. Yamamura, T. Zalewska, 1994, Journal of medicinal chemistry.

Newly discovered stereochemical requirements in the side-chain conformation of delta opioid agonists for recognizing opioid delta receptors.

R. Horváth, B. Lou, A. Misicka, 1994, Journal of medicinal chemistry.

Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis.

V. Hruby, A. Mollica, L. Mannina, 2007, Journal of medicinal chemistry.