Dennis Colussi

Identification of a small molecule beta-secretase inhibitor that binds without catalytic aspartate engagement.

Paul Zuck, Georgia McGaughey, Amy S. Espeseth, 2009, Bioorganic & medicinal chemistry letters.

Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering.

Jian Sun, D. M. Penny, Wanli Lu, 2009, Biochemistry.

SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition.

Adam J. Simon, Georgia B. McGaughey, Philippe G. Nantermet, 2010, Bioorganic & medicinal chemistry letters.

Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase.

Paul Zuck, Georgia B McGaughey, M Katharine Holloway, 2008, Journal of medicinal chemistry.