Marion Dorsch

Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

Fang Wang, Erica Hansen, Francesco G. Salituro, 2013, Science.

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

Jing Yuan, William R. Sellers, Christoph Lengauer, 2010, Science Translational Medicine.

AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.

Hua Yang, Fang Wang, Zenon Konteatis, 2017, Cancer discovery.

Validating cancer drug targets

Sunkyu Kim, J. D. Benson, William R. Sellers, 2006, Nature.

Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway

Pablo Tamayo, Justin Klekota, Jill P Mesirov, 2010, Nature Medicine.

IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition.

Wei Liu, Fang Wang, Hua Yang, 2014, Blood.

A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro.

Giovanni Parmigiani, Luigi Marchionni, D Neil Watkins, 2009, Cancer research.