Bryan K. Chan

发表

Comparative evaluation of 11 in silico models for the prediction of small molecule mutagenicity: role of steric hindrance and electron-withdrawing groups

Gregory A. Ryslik, Kevin A. Ford, Gregory Ryslik, 2017, Toxicology mechanisms and methods.

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

Paula Katavolos, Brian K. Fiske, Reina N. Fuji, 2015, Science Translational Medicine.

Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor.

Siew K. Yeap, C. Eigenbrot, Ivana Yen, 2016, Journal of medicinal chemistry.

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR.

C. Eigenbrot, Ivana Yen, S. Sideris, 2016, ACS medicinal chemistry letters.

Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.

Belen Dominguez-Fernandez, C. Eigenbrot, Ivana Yen, 2015, Journal of medicinal chemistry.

Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation

Siew K. Yeap, C. Eigenbrot, Ivana Yen, 2014, Journal of medicinal chemistry.

Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer.

BinQing Wei, Y. Franke, E. Day, 2019, Structure.

Synthetic studies toward spiroleucettadine

M. Ciufolini, Bryan K. Chan, B. Chan, 2006 .

Reactions of 6,6′-dimethyl-2,2′-bipyridyl with iron(II) in aqueous and non-aqueous media ☆

Bryan K. Chan, B. Chan, M. C. Baird, 2004 .

Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2014, Journal of medicinal chemistry.

Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2012, Journal of medicinal chemistry.

Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond - Part 2.

A. Beresford, A. Medhurst, Xingrong Liu, 2019, Bioorganic & medicinal chemistry letters.

Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2013, ACS medicinal chemistry letters.

Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling.

Jason Drummond, Xingrong Liu, Yichin Liu, 2012, Journal of medicinal chemistry.

Potent and highly selective benzimidazole inhibitors of PI3-kinase delta.

P. Savy, E. Bradley, M. Ultsch, 2012, Journal of medicinal chemistry.

Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).

Hoai An Le Thi, E. Gancia, Weiru Wang, 2021, ACS medicinal chemistry letters.

Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition.

P. Savy, Steve Price, A. Nadin, 2012, Journal of medicinal chemistry.